Adam Hardy
Affiliations: | University of Oxford, Oxford, United Kingdom |
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| Leissing TM, Hardy AP, Chan H, et al. (2022) Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins. The Journal of Biological Chemistry. 102020 |
| Choi H, Hardy AP, Leissing TM, et al. (2020) A human protein hydroxylase that accepts D-residues. Communications Chemistry. 3: 52 |
| Liu T, Abboud MI, Chowdhury R, et al. (2020) Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. The Journal of Biological Chemistry |
| Choi H, Hardy AP, Leissing TM, et al. (2020) A human protein hydroxylase that accepts D-residues Communications Chemistry. 3 |
| Chowdhury R, Leung IK, Tian YM, et al. (2016) Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nature Communications. 7: 12673 |
| Tarhonskaya H, Hardy AP, Howe EA, et al. (2015) Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-Inducible Factor (FIH) as an Oxygen Sensor. The Journal of Biological Chemistry |
| Jayatunga MK, Thompson S, McKee TC, et al. (2015) Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). European Journal of Medicinal Chemistry. 94: 509-16 |
| Yang M, Hardy AP, Chowdhury R, et al. (2013) Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. Angewandte Chemie (International Ed. in English). 52: 1700-4 |
| Leung IK, Demetriades M, Hardy AP, et al. (2013) Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. Journal of Medicinal Chemistry. 56: 547-55 |
| Ge W, Wolf A, Feng T, et al. (2012) Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2 |