Derek S. Tan, PhD

2002- Chemical Biology Memorial Sloan Kettering Cancer Center, Rockville Centre, NY, United States 
organic synthesis, chemical biology
"Derek Tan"
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Dale Gene Drueckhammer research assistant 1993-1995 Stanford
David A. Oare research assistant 1995-1995 Genentech, Inc.
 (Summer intern)
Stuart L. Schreiber grad student 1995-2000 Harvard
 (Diversity-oriented synthesis targeted to chemical genetics)
Samuel J. Danishefsky post-doc 2000-2002 Memorial Sloan Kettering Cancer Center
 (Total synthesis of guanacastepene)
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Leus IV, Adamiak J, Chandar B, et al. (2023) Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics. Antimicrobial Agents and Chemotherapy. e0137722
Gardner TJ, Lee JP, Bourne CM, et al. (2021) Engineering CAR-T cells to activate small-molecule drugs in situ. Nature Chemical Biology
Kinarivala N, Standke LC, Guney T, et al. (2020) Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes. Methods in Enzymology. 638: 69-87
Xu Y, Tan DS. (2019) Total Synthesis of the Bacterial Diisonitrile Chalkophore SF2768. Organic Letters
Minuesa G, Albanese SK, Xie W, et al. (2019) Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nature Communications. 10: 2691
Lux MC, Boby ML, Brooks JL, et al. (2019) Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction. Chemical Communications (Cambridge, England)
Ji C, Sharma I, Pratihar D, et al. (2019) Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. Acs Chemical Biology
Lux MC, Standke LC, Tan DS. (2019) Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors. The Journal of Antibiotics
Evans CE, Si Y, Matarlo JS, et al. (2019) Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE. Biochemistry
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, et al. (2018) Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741
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