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Derek A. Pratt, Ph.D.

Affiliations: 
2003-2005 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 2010- Chemistry University of Ottawa, Ottawa, ON, Canada 
Area:
Free radicals, antioxidants
Website:
http://dpra24.wix.com/theprattgroup#!derek/c41f
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"Derek Pratt"
Mean distance: 7.9
 
SNBCP

Parents

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Keith U. Ingold research assistant 1999 Carleton College
Ned A. Porter grad student 2003 Vanderbilt
 (New insights into the reactions of peroxyl radicals, phenolic antioxidants and prostaglandin H synthases; and, towards a visible light labile serine protease inhibitor.)
Wilfred A. van der Donk post-doc 2003-2005 UIUC
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Publications

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Wu Z, Vlaming R, Donohoe M, et al. (2023) Interrupted Homolytic Substitution Enables Organoboron Compounds to Inhibit Radical Chain Reactions Rather than Initiate Them. Journal of the American Chemical Society
Saraev DD, Wu Z, Kim HH, et al. (2023) Intramolecular H-Atom Transfers in Alkoxyl Radical Intermediates Underlie the Apparent Oxidation of Lipid Hydroperoxides by Fe(II). Acs Chemical Biology
Roldan BJ, Hammerstad TA, Galliher MS, et al. (2023) Leveraging the Persistent Radical Effect in the Synthesis of trans-2,3-Diaryl-Dihydrobenzofurans. Angewandte Chemie (International Ed. in English). e202305801
Wu Z, Barayeu U, Schilling D, et al. (2023) Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death. Current Opinion in Chemical Biology. 76: 102353
Wu Z, Pratt DA. (2023) Radical approaches to C-S bonds. Nature Reviews. Chemistry
Wu Z, Khodade VS, Chauvin JR, et al. (2022) Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis. Journal of the American Chemical Society
Zilka O, Poon JF, Pratt DA. (2021) Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. Journal of the American Chemical Society. 143: 19043-19057
Wu Z, Pratt DA. (2021) A Divergent Strategy for Site-Selective Radical Disulfuration of Carboxylic Acids with Trisulfide-1,1-Dioxides. Angewandte Chemie (International Ed. in English)
Shah R, Poon JF, Haidasz EA, et al. (2021) Temperature-Dependent Effects of Alkyl Substitution on Diarylamine Antioxidant Reactivity. The Journal of Organic Chemistry
Porter NA, Xu L, Pratt DA. (2020) Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with Proteins and Amino Acid Nucleophiles. Chemistry (Basel, Switzerland). 2: 390-417
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