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Pradipsinh K. Rathod, PhD - Publications

Affiliations: 
1986-2000 Biology The Catholic University of America, Washington, DC 
 2001- Chemistry University of Washington, Seattle, Seattle, WA 
Area:
Malaria Pharmacology, Functional Genomics
Website:
http://depts.washington.edu/chem/people/faculty/rathod.html
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107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chery-Karschney L, Patrapuvich R, Mudeppa DG, Kokkonda S, Chakrabarti R, Sriwichai P, O'Connor RM, Rathod PK, White J. Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual . Antimicrobial Agents and Chemotherapy. e0068423. PMID 38193705 DOI: 10.1128/aac.00684-23  0.786
2023 Momoh EO, Ghag SK, White J, Mudeppa DG, Rathod PK. Multiplex Assays for Analysis of Antibody Responses to South Asian and Malaria Infections. Vaccines. 12. PMID 38276660 DOI: 10.3390/vaccines12010001  0.367
2023 Dash R, Skillman KM, Pereira L, Mascarenhas A, Dass S, Walke J, Almeida A, Fernandes M, Gomes E, White J, Chery-Karschney L, Khandeparkar A, Rathod PK, Duraisingh MT, Kanjee U. Development of a Plasmodium vivax biobank for functional ex vivo assays. Malaria Journal. 22: 250. PMID 37653486 DOI: 10.1186/s12936-023-04668-2  0.835
2023 Dash R, Skillman KM, Pereira L, Mascarenhas A, Dass S, Walke J, Almeida A, Fernandes M, Gomes E, White J, Chery-Karschney L, Khandeparkar A, Rathod PK, Duraisingh MT, Kanjee U. Development of a biobank for functional assays. Biorxiv : the Preprint Server For Biology. PMID 36993272 DOI: 10.1101/2023.03.17.533128  0.829
2022 Russo TA, Umland TC, Deng X, El Mazouni F, Kokkonda S, Olson R, Carlino-MacDonald U, Beanan J, Alvarado CL, Tomchick DR, Hutson A, Chen H, Posner B, Rathod PK, Charman SA, et al. Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant . Proceedings of the National Academy of Sciences of the United States of America. 119: e2213116119. PMID 36512492 DOI: 10.1073/pnas.2213116119  0.813
2022 Chakrabarti R, Chery-Karschney L, White J, Mascarenhas A, Skillman KM, Kanjee U, Babar PH, Patrapuvich R, Mohapatra PK, Patankar S, Smith JD, Anvikar A, Valecha N, Rahi M, Duraisingh MT, ... Rathod PK, et al. Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India. The American Journal of Tropical Medicine and Hygiene. 107: 107-117. PMID 36228910 DOI: 10.4269/ajtmh.21-1344  0.834
2022 Mascarenhas A, Chakrabarti R, Chery-Karschney L, White J, Skillman KM, Kanjee U, Babar PH, Patrapuvich R, Mohanty AK, Duraisingh MT, Rathod PK. International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India. The American Journal of Tropical Medicine and Hygiene. 107: 118-123. PMID 36228906 DOI: 10.4269/ajtmh.22-0005  0.806
2021 Tan S, Mudeppa DG, Kokkonda S, White J, Patrapuvich R, Rathod PK. Properties of with a deleted apicoplast DNA gyrase. Antimicrobial Agents and Chemotherapy. AAC0058621. PMID 34152814 DOI: 10.1128/AAC.00586-21  0.827
2021 Mohanty AK, de Souza C, Harjai D, Ghavanalkar P, Fernandes M, Almeida A, Walke J, Manoharan SK, Pereira L, Dash R, Mascarenhas A, Gomes E, Thita T, Chery L, Anvikar AR, ... ... Rathod PK, et al. Optimization of Plasmodium vivax sporozoite production from Anopheles stephensi in South West India. Malaria Journal. 20: 221. PMID 34006297 DOI: 10.1186/s12936-021-03767-2  0.832
2021 Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, ... ... Rathod PK, et al. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. Journal of Medicinal Chemistry. PMID 33876936 DOI: 10.1021/acs.jmedchem.1c00173  0.821
2021 Clark MA, Kanjee U, Rangel GW, Chery L, Mascarenhas A, Gomes E, Rathod PK, Brugnara C, Ferreira MU, Duraisingh MT. Plasmodium vivax infection compromises reticulocyte stability. Nature Communications. 12: 1629. PMID 33712609 DOI: 10.1038/s41467-021-21886-x  0.812
2020 McDaniels JM, Huckaby AC, Carter SA, Lingeman S, Francis A, Congdon M, Santos W, Rathod PK, Guler JL. Extra-chromosomal DNA amplicons in antimalarial resistant Plasmodium falciparum. Molecular Microbiology. PMID 33053232 DOI: 10.1111/mmi.14624  0.746
2020 Kanjee U, Grüring C, Babar P, Meyers A, Dash R, Pereira L, Mascarenhas A, Chaand M, Rangel GW, Clark MA, Chery L, Gomes E, Rathod PK, Duraisingh MT. Plasmodium vivax strains use alternative pathways for invasion. The Journal of Infectious Diseases. PMID 32941614 DOI: 10.1093/Infdis/Jiaa592  0.786
2020 O'Connor RM, Nepveux V FJ, Abenoja J, Bowden G, Reis P, Beaushaw J, Bone Relat RM, Driskell I, Gimenez F, Riggs MW, Schaefer DA, Schmidt EW, Lin Z, Distel DL, Clardy J, ... ... Rathod P, et al. A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity. Plos Pathogens. 16: e1008600. PMID 32453775 DOI: 10.1371/Journal.Ppat.1008600  0.839
2020 Kokkonda S, Deng X, White KL, El Mazouni F, White J, Shackleford DM, Katneni K, Chiu FCK, Barker H, McLaren J, Crighton E, Chen G, Angulo-Barturen I, Jimenez-Diaz MB, Ferrer S, ... ... Rathod PK, et al. Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria. Journal of Medicinal Chemistry. PMID 32248693 DOI: 10.1021/Acs.Jmedchem.0C00311  0.837
2019 Chakrabarti R, White J, Babar PH, Kumar S, Mudeppa DG, Mascarenhas A, Pereira L, Dash R, Maki JN, Sharma A, Gogoi K, Sarma DK, Pal Bhowmick I, Manoharan SK, Gomes E, ... ... Rathod PK, et al. Decreased artemisinin sensitivity of across India. Antimicrobial Agents and Chemotherapy. PMID 31332065 DOI: 10.1128/Aac.00101-19  0.768
2019 Duffy F, Bernabeu M, Babar PH, Kessler A, Wang CW, Vaz M, Chery L, Mandala WL, Rogerson SJ, Taylor TE, Seydel KB, Lavstsen T, Gomes E, Kim K, Lusingu J, ... Rathod PK, et al. Meta-analysis of Plasmodium falciparum Signatures Contributing to Severe Malaria in African Children and Indian Adults. Mbio. 10. PMID 31040236 DOI: 10.1128/Mbio.00217-19  0.831
2019 Venkatesh A, Jain A, Davies H, Periera L, Maki JN, Gomes E, Felgner PL, Srivastava S, Patankar S, Rathod PK. Hospital-derived antibody profiles of malaria patients in Southwest India. Malaria Journal. 18: 138. PMID 30995911 DOI: 10.1186/S12936-019-2771-5  0.761
2018 White J, Dhingra S, Deng X, El Mazouni F, Lee M, Afanador G, Lawong A, Tomchick DR, Ng CL, Bath J, Rathod PK, Fidock DA, Phillips MA. Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265. Acs Infectious Diseases. PMID 30375858 DOI: 10.1021/Acsinfecdis.8B00211  0.662
2018 Kaushansky A, Hedstrom L, Goldman A, Singh J, Yang PL, Rathod PK, Cynamon M, Wodarz D, Mahadevan D, Tomaras A, Navia MA, Schiffer CA. A call to arms: Unifying the fight against resistance. Science Signaling. 11. PMID 30352947 DOI: 10.1126/Scisignal.Aav0442  0.574
2018 Kokkonda S, El Mazouni F, White KL, White J, Shackleford DM, Lafuente-Monasterio MJ, Rowland P, Manjalanagara K, Joseph JT, Garcia-Pérez A, Fernandez J, Gamo FJ, Waterson D, Burrows JN, Palmer MJ, ... ... Rathod PK, et al. Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity. Acs Omega. 3: 9227-9240. PMID 30197997 DOI: 10.1021/acsomega.8b01573  0.823
2018 Mohanty AK, Nina PB, Ballav S, Vernekar S, Parkar S, D'souza M, Zuo W, Gomes E, Chery L, Tuljapurkar S, Valecha N, Rathod PK, Kumar A. Susceptibility of wild and colonized Anopheles stephensi to Plasmodium vivax infection. Malaria Journal. 17: 225. PMID 29871629 DOI: 10.1186/S12936-018-2343-0  0.789
2018 White J, Rathod PK. Indispensable malaria genes. Science (New York, N.Y.). 360: 490-491. PMID 29724941 DOI: 10.1126/Science.Aat5092  0.709
2018 Rangel GW, Clark MA, Kanjee U, Lim C, Shaw-Saliba K, Menezes MJ, Mascarenhas A, Chery L, Gomes E, Rathod PK, Ferreira MU, Duraisingh MT. Enhanced ex vivo Plasmodium vivax intraerythrocytic enrichment and maturation for rapid and sensitive parasite growth assays. Antimicrobial Agents and Chemotherapy. PMID 29378713 DOI: 10.1128/Aac.02519-17  0.832
2017 Patankar S, Sharma S, Rathod PK, Duraisingh M. Malaria in India: The Need for New Targets for Diagnosis And Detection of Plasmodium vivax. Proteomics. Clinical Applications. PMID 29193853 DOI: 10.1002/Prca.201700024  0.474
2017 Balabaskaran Nina P, Mohanty AK, Ballav S, Vernekar S, Bhinge S, D'souza M, Walke J, Manoharan SK, Mascarenhas A, Gomes E, Chery L, Valecha N, Kumar A, Rathod PK. Dynamics of Plasmodium vivax sporogony in wild Anopheles stephensi in a malaria-endemic region of Western India. Malaria Journal. 16: 284. PMID 28693607 DOI: 10.1186/S12936-017-1931-8  0.837
2016 Chery L, Maki JN, Mascarenhas A, Walke JT, Gawas P, Almeida A, Fernandes M, Vaz M, Ramanan R, Shirodkar D, Bernabeu M, Manoharan SK, Pereira L, Dash R, Sharma A, ... ... Rathod PK, et al. Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malaria Journal. 15: 569. PMID 27884146 DOI: 10.1186/S12936-016-1619-5  0.798
2016 Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, et al. Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications. Plos Neglected Tropical Diseases. 10: e0005091. PMID 27798646 DOI: 10.1371/Journal.Pntd.0005091  0.795
2016 Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh KC, Tomchick DR, Manjalanagara K, Rudra KR, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Shackleford DM, ... ... Rathod PK, et al. A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria. Acs Infectious Diseases. PMID 27641613 DOI: 10.1021/Acsinfecdis.6B00144  0.838
2016 Kumar S, Mudeppa D, Sharma A, Mascarenhas A, Dash R, Pereira L, Shaik RB, Maki JN, White J, Zuo W, Tuljapurkar S, Duraisingh MT, Gomes E, Chery L, Rathod PK. Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Molecular and Biochemical Parasitology. PMID 27457272 DOI: 10.1016/J.Molbiopara.2016.07.005  0.803
2016 Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT. Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. International Journal For Parasitology. PMID 27456552 DOI: 10.1016/J.Ijpara.2016.06.003  0.837
2016 Lim C, Pereira L, Saliba KS, Macarenhas A, Maki J, Chery L, Gomes E, Rathod PK, Duraisingh MT. Brief Report: Reticulocyte preference and stage development of Plasmodium vivax isolates. The Journal of Infectious Diseases. PMID 27432121 DOI: 10.1093/Infdis/Jiw303  0.825
2016 Bernabeu M, Danziger SA, Avril M, Vaz M, Babar PH, Brazier AJ, Herricks T, Maki JN, Pereira L, Mascarenhas A, Gomes E, Chery L, Aitchison JD, Rathod PK, Smith JD. Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass. Proceedings of the National Academy of Sciences of the United States of America. PMID 27185931 DOI: 10.1073/Pnas.1524294113  0.816
2016 Kokkonda S, Deng X, White KL, Coterón JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, ... ... Rathod PK, et al. Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidines targeting Plasmodium falciparum dihydroorotate dehydrogenase display potent and selective antimalarial activity. Journal of Medicinal Chemistry. PMID 27127993 DOI: 10.1021/Acs.Jmedchem.6B00275  0.832
2016 Lim C, Pereira L, Shardul P, Mascarenhas A, Maki J, Rixon J, Shaw-Saliba K, White J, Silveira M, Gomes E, Chery L, Rathod PK, Duraisingh MT. Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia. American Journal of Hematology. PMID 27074559 DOI: 10.1002/Ajh.24383  0.777
2016 Kumar A, Hosmani R, Jadhav S, de Sousa T, Mohanty A, Naik M, Shettigar A, Kale S, Valecha N, Chery L, Rathod PK. Anopheles subpictus carry human malaria parasites in an urban area of Western India and may facilitate perennial malaria transmission. Malaria Journal. 15: 124. PMID 26919828 DOI: 10.1186/S12936-016-1177-X  0.816
2016 White J, Mascarenhas A, Pereira L, Dash R, Walke JT, Gawas P, Sharma A, Manoharan SK, Guler JL, Maki JN, Kumar A, Mahanta J, Valecha N, Dubhashi N, Vaz M, ... ... Rathod PK, et al. In vitro adaptation of Plasmodium falciparum reveal variations in cultivability. Malaria Journal. 15: 33. PMID 26794408 DOI: 10.1186/S12936-015-1053-0  0.811
2015 Mullowney MW, Hwang CH, Newsome AG, Wei X, Tanouye U, Wan B, Carlson S, Barranis NJ, hAinmhire E, Chen WL, Krishnamoorthy K, White J, Blair R, Lee H, Burdette JE, ... Rathod PK, et al. Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis. Acs Infectious Diseases. 1: 168-174. PMID 26594660 DOI: 10.1021/Acsinfecdis.5B00005  0.688
2015 Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. The American Journal of Tropical Medicine and Hygiene. 93: 57-68. PMID 26259943 DOI: 10.4269/Ajtmh.15-0007  0.411
2015 Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD. Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. The American Journal of Tropical Medicine and Hygiene. 93: 42-56. PMID 26259939 DOI: 10.4269/Ajtmh.14-0841  0.433
2015 Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, ... ... Rathod PK, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science Translational Medicine. 7: 296ra111. PMID 26180101 DOI: 10.1126/Scitranslmed.Aaa6645  0.839
2015 Mudeppa DG, Kumar S, Kokkonda S, White J, Rathod PK. Topoisomerase II from Human Malaria Parasites: Expression, Purification, and Selective Inhibition. The Journal of Biological Chemistry. PMID 26055707 DOI: 10.1074/Jbc.M115.639039  0.827
2015 Kumar S, Krishnamoorthy K, Mudeppa DG, Rathod PK. Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions. Acta Crystallographica. Section F, Structural Biology Communications. 71: 600-8. PMID 25945715 DOI: 10.1107/S2053230X1500549X  0.832
2015 Deng X, Matthews D, Rathod PK, Phillips MA. The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions. Acta Crystallographica. Section F, Structural Biology Communications. 71: 553-9. PMID 25945708 DOI: 10.1107/S2053230X15000989  0.459
2015 Guler JL, White J, Phillips MA, Rathod PK. Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor. Antimicrobial Agents and Chemotherapy. 59: 686-9. PMID 25331708 DOI: 10.1128/Aac.02347-14  0.833
2014 Deng X, Kokkonda S, El Mazouni F, White J, Burrows JN, Kaminsky W, Charman SA, Matthews D, Rathod PK, Phillips MA. Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. Journal of Medicinal Chemistry. 57: 5381-94. PMID 24801997 DOI: 10.1021/Jm500481T  0.794
2013 Mudeppa DG, Rathod PK. Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free system. Eukaryotic Cell. 12: 1653-63. PMID 24123271 DOI: 10.1128/Ec.00222-13  0.811
2013 Mailu BM, Ramasamay G, Mudeppa DG, Li L, Lindner SE, Peterson MJ, DeRocher AE, Kappe SH, Rathod PK, Gardner MJ. A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway. The Journal of Biological Chemistry. 288: 32539-52. PMID 24072705 DOI: 10.1074/Jbc.M113.507467  0.84
2013 Herricks T, Avril M, Janes J, Smith JD, Rathod PK. Clonal variants of Plasmodium falciparum exhibit a narrow range of rolling velocities to host receptor CD36 under dynamic flow conditions. Eukaryotic Cell. 12: 1490-8. PMID 24014767 DOI: 10.1128/Ec.00148-13  0.804
2013 Guler JL, Freeman DL, Ahyong V, Patrapuvich R, White J, Gujjar R, Phillips MA, DeRisi J, Rathod PK. Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications. Plos Pathogens. 9: e1003375. PMID 23717205 DOI: 10.1371/Journal.Ppat.1003375  0.836
2012 Herricks T, Seydel KB, Molyneux M, Taylor T, Rathod PK. Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients. Cellular Microbiology. 14: 1880-91. PMID 22892025 DOI: 10.1111/Cmi.12007  0.828
2012 Marwaha A, White J, El Mazouni F, Creason SA, Kokkonda S, Buckner FS, Charman SA, Phillips MA, Rathod PK. Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. Journal of Medicinal Chemistry. 55: 7425-36. PMID 22877245 DOI: 10.1021/Jm300351W  0.832
2012 Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, ... ... Rathod PK, et al. Malaria evolution in South Asia: knowledge for control and elimination. Acta Tropica. 121: 256-66. PMID 22266213 DOI: 10.1016/J.Actatropica.2012.01.008  0.805
2012 Kumar A, Chery L, Biswas C, Dubhashi N, Dutta P, Dua VK, Kacchap M, Kakati S, Khandeparkar A, Kour D, Mahajan SN, Maji A, Majumder P, Mohanta J, Mohapatra PK, ... ... Rathod PK, et al. Malaria in South Asia: prevalence and control. Acta Tropica. 121: 246-55. PMID 22248528 DOI: 10.1016/J.Actatropica.2012.01.004  0.838
2011 Herricks T, Seydel KB, Turner G, Molyneux M, Heyderman R, Taylor T, Rathod PK. A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells. Lab On a Chip. 11: 2994-3000. PMID 21743938 DOI: 10.1039/C1Lc20131J  0.816
2011 Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford DM, Angulo-Barturen I, Ferrer SB, Jiménez-Díaz MB, ... ... Rathod PK, et al. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. Journal of Medicinal Chemistry. 54: 5540-61. PMID 21696174 DOI: 10.1021/Jm200592F  0.82
2011 Gujjar R, El Mazouni F, White KL, White J, Creason S, Shackleford DM, Deng X, Charman WN, Bathurst I, Burrows J, Floyd DM, Matthews D, Buckner FS, Charman SA, Phillips MA, ... Rathod PK, et al. Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. Journal of Medicinal Chemistry. 54: 3935-49. PMID 21517059 DOI: 10.1021/Jm200265B  0.626
2011 Ganesan SM, Morrisey JM, Ke H, Painter HJ, Laroiya K, Phillips MA, Rathod PK, Mather MW, Vaidya AB. Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. Molecular and Biochemical Parasitology. 177: 29-34. PMID 21251930 DOI: 10.1016/J.Molbiopara.2011.01.004  0.651
2010 Essaka DC, White J, Rathod P, Whitmore CD, Hindsgaul O, Palcic MM, Dovichi NJ. Monitoring the uptake of glycosphingolipids in Plasmodium falciparum-infected erythrocytes using both fluorescence microscopy and capillary electrophoresis with laser-induced fluorescence detection. Analytical Chemistry. 82: 9955-8. PMID 21043509 DOI: 10.1021/Ac1021776  0.589
2010 Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, ... ... Rathod PK, et al. Chemical genetics of Plasmodium falciparum. Nature. 465: 311-5. PMID 20485428 DOI: 10.1038/Nature09099  0.827
2010 Phillips MA, Rathod PK. Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infectious Disorders Drug Targets. 10: 226-39. PMID 20334617 DOI: 10.2174/187152610791163336  0.482
2010 Sun XE, Sharling L, Muthalagi M, Mudeppa DG, Pankiewicz KW, Felczak K, Rathod PK, Mead J, Striepen B, Hedstrom L. Prodrug activation by Cryptosporidium thymidine kinase. The Journal of Biological Chemistry. 285: 15916-22. PMID 20231284 DOI: 10.1074/Jbc.M110.101543  0.82
2010 Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, ... ... Rathod PK, et al. The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. Journal of Molecular Biology. 396: 1244-59. PMID 20070944 DOI: 10.1016/J.Jmb.2010.01.013  0.794
2009 Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist NA, Goldsmith EJ, Rathod PK, Phillips MA. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. The Journal of Biological Chemistry. 284: 26999-7009. PMID 19640844 DOI: 10.1074/Jbc.M109.028589  0.43
2009 Pang CK, Hunter JH, Gujjar R, Podutoori R, Bowman J, Mudeppa DG, Rathod PK. Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase. Molecular and Biochemical Parasitology. 168: 74-83. PMID 19591883 DOI: 10.1016/J.Molbiopara.2009.06.011  0.79
2009 Herricks T, Antia M, Rathod PK. Deformability limits of Plasmodium falciparum-infected red blood cells. Cellular Microbiology. 11: 1340-53. PMID 19438513 DOI: 10.1111/J.1462-5822.2009.01334.X  0.807
2009 Gujjar R, Marwaha A, El Mazouni F, White J, White KL, Creason S, Shackleford DM, Baldwin J, Charman WN, Buckner FS, Charman S, Rathod PK, Phillips MA. Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. Journal of Medicinal Chemistry. 52: 1864-72. PMID 19296651 DOI: 10.1021/jm801343r  0.579
2008 Ganesan K, Ponmee N, Jiang L, Fowble JW, White J, Kamchonwongpaisan S, Yuthavong Y, Wilairat P, Rathod PK. A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. Plos Pathogens. 4: e1000214. PMID 19023412 DOI: 10.1371/Journal.Ppat.1000214  0.818
2008 Gonzales JM, Patel JJ, Ponmee N, Jiang L, Tan A, Maher SP, Wuchty S, Rathod PK, Ferdig MT. Regulatory hotspots in the malaria parasite genome dictate transcriptional variation. Plos Biology. 6: e238. PMID 18828674 DOI: 10.1371/Journal.Pbio.0060238  0.494
2008 Antia M, Herricks T, Rathod PK. Microfluidic approaches to malaria pathogenesis. Cellular Microbiology. 10: 1968-74. PMID 18754851 DOI: 10.1111/J.1462-5822.2008.01216.X  0.824
2008 Phillips MA, Gujjar R, Malmquist NA, White J, El Mazouni F, Baldwin J, Rathod PK. Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. Journal of Medicinal Chemistry. 51: 3649-53. PMID 18522386 DOI: 10.1021/Jm8001026  0.666
2008 Hunter JH, Gujjar R, Pang CK, Rathod PK. Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX. Plos One. 3: e2237. PMID 18493582 DOI: 10.1371/Journal.Pone.0002237  0.749
2008 Cui L, Miao J, Furuya T, Fan Q, Li X, Rathod PK, Su XZ, Cui L. Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development. Eukaryotic Cell. 7: 1200-10. PMID 18487348 DOI: 10.1128/Ec.00063-08  0.362
2008 Mui EJ, Schiehser GA, Milhous WK, Hsu H, Roberts CW, Kirisits M, Muench S, Rice D, Dubey JP, Fowble JW, Rathod PK, Queener SF, Liu SR, Jacobus DP, McLeod R. Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo. Plos Neglected Tropical Diseases. 2: e190. PMID 18320016 DOI: 10.1371/Journal.Pntd.0000190  0.8
2008 Malmquist NA, Gujjar R, Rathod PK, Phillips MA. Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase. Biochemistry. 47: 2466-75. PMID 18225919 DOI: 10.1021/Bi702218C  0.33
2007 Antia M, Herricks T, Rathod PK. Microfluidic modeling of cell-cell interactions in malaria pathogenesis. Plos Pathogens. 3: e99. PMID 17658948 DOI: 10.1371/Journal.Ppat.0030099  0.818
2007 Eastman RT, White J, Hucke O, Yokoyama K, Verlinde CL, Hast MA, Beese LS, Gelb MH, Rathod PK, Van Voorhis WC. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Molecular and Biochemical Parasitology. 152: 66-71. PMID 17208314 DOI: 10.1016/J.Molbiopara.2006.11.012  0.8
2007 Mudeppa DG, Pang CK, Tsuboi T, Endo Y, Buckner FS, Varani G, Rathod PK. Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase. Molecular and Biochemical Parasitology. 151: 216-9. PMID 17157934 DOI: 10.1016/J.Molbiopara.2006.10.016  0.787
2005 Pang CK, De SK, White J, Buckner FS, Varani G, Rathod PK. Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase. Molecular and Biochemical Parasitology. 143: 121-4. PMID 15978681 DOI: 10.1016/J.Molbiopara.2005.02.016  0.731
2005 Baldwin J, Michnoff CH, Malmquist NA, White J, Roth MG, Rathod PK, Phillips MA. High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. The Journal of Biological Chemistry. 280: 21847-53. PMID 15795226 DOI: 10.1074/Jbc.M501100200  0.651
2005 Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. The Journal of Biological Chemistry. 280: 13554-9. PMID 15661734 DOI: 10.1074/Jbc.M413556200  0.796
2003 Shelby JP, White J, Ganesan K, Rathod PK, Chiu DT. A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes. Proceedings of the National Academy of Sciences of the United States of America. 100: 14618-22. PMID 14638939 DOI: 10.1073/Pnas.2433968100  0.574
2003 Rathod PK, Phillips MA. Prized malaria drug target nailed. Nature Structural Biology. 10: 316-8. PMID 12714998 DOI: 10.1038/Nsb0503-316  0.39
2002 Ganesan K, Jiang L, Rathod PK. Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays. International Journal For Parasitology. 32: 1543-50. PMID 12435438 DOI: 10.1016/S0020-7519(02)00182-0  0.487
2002 Baldwin J, Farajallah AM, Malmquist NA, Rathod PK, Phillips MA. Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. The Journal of Biological Chemistry. 277: 41827-34. PMID 12189151 DOI: 10.1074/Jbc.M206854200  0.385
2002 Zhang K, Rathod PK. Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Science (New York, N.Y.). 296: 545-7. PMID 11964483 DOI: 10.1126/Science.1068274  0.54
2002 Rathod PK, Ganesan K, Hayward RE, Bozdech Z, DeRisi JL. DNA microarrays for malaria. Trends in Parasitology. 18: 39-45. PMID 11850013 DOI: 10.1016/S1471-4922(01)02153-5  0.303
2000 Alfadhli S, Rathod PK. Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli. Molecular and Biochemical Parasitology. 110: 283-91. PMID 11071283 DOI: 10.1016/S0166-6851(00)00282-6  0.701
2000 Jiang L, Lee PC, White J, Rathod PK. Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 44: 1047-50. PMID 10722510 DOI: 10.1128/AAC.44.4.1047-1050.2000  0.385
2000 Hayward RE, Derisi JL, Alfadhli S, Kaslow DC, Brown PO, Rathod PK. Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria. Molecular Microbiology. 35: 6-14. PMID 10632873 DOI: 10.1046/J.1365-2958.2000.01730.X  0.705
1999 Shallom S, Zhang K, Jiang L, Rathod PK. Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains. The Journal of Biological Chemistry. 274: 37781-6. PMID 10608839 DOI: 10.1074/Jbc.274.53.37781  0.738
1997 Hekmat-Nejad M, Rathod PK. Plasmodium falciparum: kinetic interactions of WR99210 with pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase. Experimental Parasitology. 87: 222-8. PMID 9371087 DOI: 10.1006/Expr.1997.4228  0.775
1997 Lauer SA, Rathod PK, Ghori N, Haldar K. A membrane network for nutrient import in red cells infected with the malaria parasite. Science (New York, N.Y.). 276: 1122-5. PMID 9148808 DOI: 10.1126/Science.276.5315.1122  0.455
1997 Hekmat-Nejad M, Lee PC, Rathod PK. Plasmodium falciparum: direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains. Experimental Parasitology. 85: 303-5. PMID 9085928 DOI: 10.1006/Expr.1997.4145  0.752
1994 Creedon KA, Rathod PK, Wellems TE. Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli. The Journal of Biological Chemistry. 269: 16364-70. PMID 8206944  0.371
1994 Rathod PK, Reshmi S. Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase. Antimicrobial Agents and Chemotherapy. 38: 476-80. PMID 8203840  0.32
1994 Rathod PK, Khosla M, Gassis S, Young RD, Lutz C. Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 38: 2871-6. PMID 7695275  0.314
1993 Young RD, Rathod PK. Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate. Antimicrobial Agents and Chemotherapy. 37: 1102-7. PMID 8517698  0.424
1992 Rathod PK, Leffers NP, Young RD. Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 36: 704-11. PMID 1503432  0.782
1991 Rathod PK, Gomez ZM. Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice. Experimental Parasitology. 73: 512-4. PMID 1959576 DOI: 10.1016/0014-4894(91)90075-8  0.799
1990 Gómez ZM, Rathod PK. Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. Antimicrobial Agents and Chemotherapy. 34: 1371-5. PMID 2386369  0.787
1989 Rathod PK, Khatri A, Hubbert T, Milhous WK. Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro. Antimicrobial Agents and Chemotherapy. 33: 1090-4. PMID 2675756  0.349
1986 Rathod PK, Tashjian AH, Abeles RH. Incorporation of beta-fluoroasparagine into peptides prevents N-linked glycosylation. In vitro studies with synthetic fluoropeptides. The Journal of Biological Chemistry. 261: 6461-9. PMID 3084484  0.453
1985 Rathod PK, Fellman JH. Identification of mammalian aspartate-4-decarboxylase. Archives of Biochemistry and Biophysics. 238: 435-46. PMID 3994382 DOI: 10.1016/0003-9861(85)90184-5  0.575
1985 Rathod PK, Fellman JH. Regulation of mammalian aspartate-4-decarboxylase: its possible role in oxaloacetate and energy metabolism. Archives of Biochemistry and Biophysics. 238: 447-51. PMID 2859839 DOI: 10.1016/0003-9861(85)90185-7  0.576
1983 Rathod PK, Reyes P. Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes. The Journal of Biological Chemistry. 258: 2852-5. PMID 6338005  0.367
1982 Reyes P, Rathod PK, Sanchez DJ, Mrema JE, Rieckmann KH, Heidrich HG. Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum. Molecular and Biochemical Parasitology. 5: 275-90. PMID 6285190 DOI: 10.1016/0166-6851(82)90035-4  0.309
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