Wendell A. Lim - Publications

1996- Cellular and Molecular Pharmacology University of California, San Francisco, San Francisco, CA 
Cellular Signaling Systems

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA. DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nature Nanotechnology. PMID 33318641 DOI: 10.1038/s41565-020-00813-z  0.32
2020 Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science (New York, N.Y.). 370: 1099-1104. PMID 33243890 DOI: 10.1126/science.abc6270  0.32
2019 Gerardin J, Reddy NR, Lim WA. The Design Principles of Biochemical Timers: Circuits that Discriminate between Transient and Sustained Stimulation. Cell Systems. PMID 31521602 DOI: 10.1016/J.Cels.2019.07.008  0.72
2018 Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science (New York, N.Y.). 361. PMID 30166458 DOI: 10.1126/Science.Aao3048  0.72
2017 Zhang ZB, Wang QY, Ke YX, Liu SY, Ju JQ, Lim WA, Tang C, Wei P. Design of Tunable Oscillatory Dynamics in a Synthetic NF-κB Signaling Circuit. Cell Systems. PMID 29102361 DOI: 10.1016/J.Cels.2017.09.016  0.72
2017 Wilson MZ, Ravindran PT, Lim WA, Toettcher JE. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Molecular Cell. PMID 28826673 DOI: 10.1016/J.Molcel.2017.07.016  0.72
2017 Roybal KT, Lim WA. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annual Review of Immunology. 35: 229-253. PMID 28446063 DOI: 10.1146/Annurev-Immunol-051116-052302  0.32
2017 Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Scientific Reports. 7: 737. PMID 28389661 DOI: 10.1038/S41598-017-00462-8  0.32
2016 Gordley RM, Williams RE, Bashor CJ, Toettcher JE, Yan S, Lim WA. Engineering dynamical control of cell fate switching using synthetic phospho-regulons. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821768 DOI: 10.1073/Pnas.1610973113  0.72
2016 Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. PMID 27693353 DOI: 10.1016/J.Cell.2016.09.011  1
2016 Mitchell A, Lim W. Cellular perception and misperception: Internal models for decision-making shaped by evolutionary experience. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 27461864 DOI: 10.1002/Bies.201600090  1
2016 Gordley RM, Bugaj LJ, Lim WA. Modular engineering of cellular signaling proteins and networks. Current Opinion in Structural Biology. 39: 106-114. PMID 27423114 DOI: 10.1016/J.Sbi.2016.06.012  1
2016 Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. PMID 26830879 DOI: 10.1016/J.Cell.2016.01.011  1
2016 Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. PMID 26830878 DOI: 10.1016/J.Cell.2016.01.012  1
2016 Coyle S, Lim WA. Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution. Elife. 5. PMID 26765565 DOI: 10.7554/Elife.12435  1
2015 Mitchell A, Wei P, Lim WA. Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Science (New York, N.Y.). PMID 26586187 DOI: 10.1126/Science.Aab0892  1
2015 Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science (New York, N.Y.). PMID 26405231 DOI: 10.1126/Science.Aab4077  1
2015 Wu CY, Rupp LJ, Roybal KT, Lim WA. Synthetic biology approaches to engineer T cells. Current Opinion in Immunology. 35: 123-130. PMID 26218616 DOI: 10.1016/J.Coi.2015.06.015  1
2015 Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell. 160: 339-50. PMID 25533786 DOI: 10.1016/J.Cell.2014.11.052  1
2014 Ji W, Lee D, Wong E, Dadlani P, Dinh D, Huang V, Kearns K, Teng S, Chen S, Haliburton J, Heimberg G, Heineike B, Ramasubramanian A, Stevens T, Helmke KJ, ... ... Lim WA, et al. Specific gene repression by CRISPRi system transferred through bacterial conjugation. Acs Synthetic Biology. 3: 929-31. PMID 25409531 DOI: 10.1021/Sb500036Q  1
2014 Youk H, Lim WA. Sending mixed messages for cell population control. Cell. 158: 973-5. PMID 25171399 DOI: 10.1016/J.Cell.2014.08.013  1
2014 Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proceedings of the National Academy of Sciences of the United States of America. 111: 5896-901. PMID 24711398 DOI: 10.1073/Pnas.1402087111  1
2014 Youk H, Lim WA. Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Science (New York, N.Y.). 343: 1242782. PMID 24503857 DOI: 10.1126/Science.1242782  1
2013 Lee CM, Gong S, Tang C, Lim WA. Bridging cross-cultural gaps in scientific exchange through innovative team challenge workshops. Quantitative Biology. 1: 3-8. PMID 25339992 DOI: 10.1007/s40484-013-0004-4  0.72
2013 Toettcher JE, Weiner OD, Lim WA. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 155: 1422-34. PMID 24315106 DOI: 10.1016/J.Cell.2013.11.004  1
2013 Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nature Protocols. 8: 2180-96. PMID 24136345 DOI: 10.1038/Nprot.2013.132  1
2013 Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20130008. PMID 24062580 DOI: 10.1098/Rstb.2013.0008  1
2013 Puchner EM, Walter JM, Kasper R, Huang B, Lim WA. Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory. Proceedings of the National Academy of Sciences of the United States of America. 110: 16015-20. PMID 24043832 DOI: 10.1073/Pnas.1309676110  1
2013 Moser F, Horwitz A, Chen J, Lim W, Voigt CA. Genetic sensor for strong methylating compounds. Acs Synthetic Biology. 2: 614-24. PMID 24032656 DOI: 10.1021/Sb400086P  1
2013 Coyle SM, Flores J, Lim WA. Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation. Cell. 154: 875-87. PMID 23953117 DOI: 10.1016/J.Cell.2013.07.019  1
2013 Lee S, Lim WA, Thorn KS. Improved blue, green, and red fluorescent protein tagging vectors for S. cerevisiae. Plos One. 8: e67902. PMID 23844123 DOI: 10.1371/Journal.Pone.0067902  1
2013 Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massagué J, Pawson T. Signalling change: signal transduction through the decades. Nature Reviews. Molecular Cell Biology. 14: 393-8. PMID 23636498 DOI: 10.1038/Nrm3581  1
2013 Fischbach MA, Bluestone JA, Lim WA. Cell-based therapeutics: the next pillar of medicine. Science Translational Medicine. 5: 179ps7. PMID 23552369 DOI: 10.1126/Scitranslmed.3005568  1
2013 Lim WA, Lee CM, Tang C. Design principles of regulatory networks: searching for the molecular algorithms of the cell. Molecular Cell. 49: 202-12. PMID 23352241 DOI: 10.1016/J.Molcel.2012.12.020  1
2012 Lim WA, Alvania R, Marshall WF. Cell biology 2.0. Trends in Cell Biology. 22: 611-2. PMID 23142093 DOI: 10.1016/J.Tcb.2012.10.004  1
2012 Chau AH, Walter JM, Gerardin J, Tang C, Lim WA. Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell. 151: 320-32. PMID 23039994 DOI: 10.1016/J.Cell.2012.08.040  1
2012 Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Lim JC, Sim CP, ... ... Lim WA, et al. The first World Cell Race. Current Biology : Cb. 22: R673-5. PMID 22974990 DOI: 10.1016/J.Cub.2012.07.052  1
2012 Zalatan JG, Coyle SM, Rajan S, Sidhu SS, Lim WA. Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science (New York, N.Y.). 337: 1218-22. PMID 22878499 DOI: 10.1126/Science.1220683  1
2012 Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 488: 384-8. PMID 22820255 DOI: 10.1038/Nature11259  1
2012 Beltrao P, Albanèse V, Kenner LR, Swaney DL, Burlingame A, Villén J, Lim WA, Fraser JS, Frydman J, Krogan NJ. Systematic functional prioritization of protein posttranslational modifications. Cell. 150: 413-25. PMID 22817900 DOI: 10.1016/J.Cell.2012.05.036  1
2012 Thompson KE, Bashor CJ, Lim WA, Keating AE. Synzip protein interaction toolbox: In vitro and in vivo specifications of heterospecific coiled-coil interaction domains Acs Synthetic Biology. 1: 118-129. PMID 22558529 DOI: 10.1021/Sb200015U  1
2012 Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proceedings of the National Academy of Sciences of the United States of America. 109: 5277-82. PMID 22403064 DOI: 10.1073/Pnas.1114487109  1
2011 Toettcher JE, Gong D, Lim WA, Weiner OD. Light-based feedback for controlling intracellular signaling dynamics. Nature Methods. 8: 837-9. PMID 21909100 DOI: 10.1038/Nmeth.1700  1
2011 Won AP, Garbarino JE, Lim WA. Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 108: 9809-14. PMID 21628578 DOI: 10.1073/Pnas.1016337108  1
2011 Toettcher JE, Gong D, Lim WA, Weiner OD. Light control of plasma membrane recruitment using the Phy-PIF system. Methods in Enzymology. 497: 409-23. PMID 21601096 DOI: 10.1016/B978-0-12-385075-1.00017-2  1
2011 Good MC, Zalatan JG, Lim WA. Scaffold proteins: hubs for controlling the flow of cellular information. Science (New York, N.Y.). 332: 680-6. PMID 21551057 DOI: 10.1126/Science.1198701  1
2011 Toettcher JE, Voigt CA, Weiner OD, Lim WA. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nature Methods. 8: 35-8. PMID 21191370 DOI: 10.1038/Nmeth.F.326  1
2011 Tan CSH, Schoof EM, Creixell P, Pasculescu A, Lim WA, Pawson T, Bader GD, Linding R. Response to comment on "positive selection of tyrosine loss in metazoan evolution" Science. 332: 917-b. DOI: 10.1126/Science.1188535  1
2010 Elowitz M, Lim WA. Build life to understand it. Nature. 468: 889-90. PMID 21164460 DOI: 10.1038/468889A  1
2010 Lim WA, Pawson T. Phosphotyrosine signaling: evolving a new cellular communication system. Cell. 142: 661-7. PMID 20813250 DOI: 10.1016/J.Cell.2010.08.023  1
2010 Ahmad KF, Lim WA. The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. Plos One. 5: e11291. PMID 20585582 DOI: 10.1371/Journal.Pone.0011291  1
2010 Lim WA. Designing customized cell signalling circuits. Nature Reviews. Molecular Cell Biology. 11: 393-403. PMID 20485291 DOI: 10.1038/Nrm2904  1
2010 Peisajovich SG, Garbarino JE, Wei P, Lim WA. Rapid diversification of cell signaling phenotypes by modular domain recombination. Science (New York, N.Y.). 328: 368-72. PMID 20395511 DOI: 10.1126/Science.1182376  1
2010 Bashor CJ, Horwitz AA, Peisajovich SG, Lim WA. Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems. Annual Review of Biophysics. 39: 515-37. PMID 20192780 DOI: 10.1146/Annurev.Biophys.050708.133652  1
2010 Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, ... ... Lim WA, et al. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Science Signaling. 3: ra12. PMID 20159853 DOI: 10.1126/Scisignal.2000482  1
2009 Arkin A, Berry D, Church G, Arnold F, Boldt J, Müller O, Ellington AD, Endy D, Fussenegger M, Gold ER, Greenwood J, Lee SY, Lim W, Minshull J, Murray TH, et al. What's in a name? Nature Biotechnology. 27: 1071-1073. PMID 20010573 DOI: 10.1038/nbt1209-1071  1
2009 Rivera GM, Vasilescu D, Papayannopoulos V, Lim WA, Mayer BJ. A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. Molecular Cell. 36: 525-35. PMID 19917259 DOI: 10.1016/J.Molcel.2009.10.025  1
2009 Yadav SS, Yeh BJ, Craddock BP, Lim WA, Miller WT. Reengineering the signaling properties of a Src family kinase. Biochemistry. 48: 10956-62. PMID 19827767 DOI: 10.1021/Bi900978F  1
2009 Levskaya A, Weiner OD, Lim WA, Voigt CA. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 461: 997-1001. PMID 19749742 DOI: 10.1038/Nature08446  1
2009 Ma W, Trusina A, El-Samad H, Lim WA, Tang C. Defining network topologies that can achieve biochemical adaptation. Cell. 138: 760-73. PMID 19703401 DOI: 10.1016/J.Cell.2009.06.013  1
2009 Zeke A, Lukács M, Lim WA, Reményi A. Scaffolds: interaction platforms for cellular signalling circuits. Trends in Cell Biology. 19: 364-74. PMID 19651513 DOI: 10.1016/J.Tcb.2009.05.007  1
2009 Tan CS, Pasculescu A, Lim WA, Pawson T, Bader GD, Linding R. Positive selection of tyrosine loss in metazoan evolution. Science (New York, N.Y.). 325: 1686-8. PMID 19589966 DOI: 10.1126/Science.1174301  1
2009 Good M, Tang G, Singleton J, Reményi A, Lim WA. The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell. 136: 1085-97. PMID 19303851 DOI: 10.1016/J.Cell.2009.01.049  1
2009 Lim WA. Frederic M Richards 1925-2009. Nature Structural & Molecular Biology. 16: 230-2. PMID 19259121 DOI: 10.1038/Nsmb0309-230  1
2008 Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim WA. The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature. 454: 1005-8. PMID 18650806 DOI: 10.1038/Nature07170  1
2008 Pincus D, Letunic I, Bork P, Lim WA. Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages. Proceedings of the National Academy of Sciences of the United States of America. 105: 9680-4. PMID 18599463 DOI: 10.1073/Pnas.0803161105  1
2008 Bashor CJ, Helman NC, Yan S, Lim WA. Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science (New York, N.Y.). 319: 1539-43. PMID 18339942 DOI: 10.1126/Science.1151153  1
2008 King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, ... ... Lim WA, et al. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature. 451: 783-8. PMID 18273011 DOI: 10.1038/Nature06617  1
2008 Lee PJ, Helman NC, Lim WA, Hung PJ. A microfluidic system for dynamic yeast cell imaging. Biotechniques. 44: 91-5. PMID 18254385 DOI: 10.2144/000112673  1
2007 Yeh BJ, Lim WA. Synthetic biology: lessons from the history of synthetic organic chemistry. Nature Chemical Biology. 3: 521-5. PMID 17710092 DOI: 10.1038/Nchembio0907-521  1
2007 Yeh BJ, Rutigliano RJ, Deb A, Bar-Sagi D, Lim WA. Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature. 447: 596-600. PMID 17515921 DOI: 10.1038/Nature05851  1
2007 Dueber JE, Mirsky EA, Lim WA. Engineering synthetic signaling proteins with ultrasensitive input/output control. Nature Biotechnology. 25: 660-2. PMID 17515908 DOI: 10.1038/Nbt1308  1
2007 Sallee NA, Yeh BJ, Lim WA. Engineering modular protein interaction switches by sequence overlap. Journal of the American Chemical Society. 129: 4606-11. PMID 17381089 DOI: 10.1021/Ja0672728  1
2007 Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF. Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. The Journal of Biological Chemistry. 282: 8446-53. PMID 17229736 DOI: 10.1074/Jbc.M609902200  1
2006 Hammond MC, Harris BZ, Lim WA, Bartlett PA. Beta strand peptidomimetics as potent PDZ domain ligands. Chemistry & Biology. 13: 1247-51. PMID 17185220 DOI: 10.1016/J.Chembiol.2006.11.010  1
2006 Reményi A, Good MC, Lim WA. Docking interactions in protein kinase and phosphatase networks. Current Opinion in Structural Biology. 16: 676-85. PMID 17079133 DOI: 10.1016/J.Sbi.2006.10.008  1
2006 Bhattacharyya RP, Reményi A, Yeh BJ, Lim WA. Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annual Review of Biochemistry. 75: 655-80. PMID 16756506 DOI: 10.1146/Annurev.Biochem.75.103004.142710  1
2006 Bhattacharyya RP, Reményi A, Good MC, Bashor CJ, Falick AM, Lim WA. The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science (New York, N.Y.). 311: 822-6. PMID 16424299 DOI: 10.1126/Science.1120941  1
2005 Reményi A, Good MC, Bhattacharyya RP, Lim WA. The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Molecular Cell. 20: 951-62. PMID 16364919 DOI: 10.1016/J.Molcel.2005.10.030  1
2005 Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA. A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. The Journal of Biological Chemistry. 280: 38528-36. PMID 16147993 DOI: 10.1074/Jbc.M506536200  1
2005 Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Molecular Cell. 17: 181-91. PMID 15664188 DOI: 10.1016/J.Molcel.2004.11.054  1
2004 Dueber JE, Yeh BJ, Bhattacharyya RP, Lim WA. Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry. Current Opinion in Structural Biology. 14: 690-9. PMID 15582393 DOI: 10.1016/J.Sbi.2004.10.004  1
2004 Zarrinpar A, Bhattacharyya RP, Nittler MP, Lim WA. Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway. Molecular Cell. 14: 825-32. PMID 15200959 DOI: 10.1016/J.Molcel.2004.06.011  1
2003 Zarrinpar A, Park SH, Lim WA. Optimization of specificity in a cellular protein interaction network by negative selection. Nature. 426: 676-80. PMID 14668868 DOI: 10.1038/Nature02178  1
2003 Dueber JE, Yeh BJ, Chak K, Lim WA. Reprogramming control of an allosteric signaling switch through modular recombination. Science (New York, N.Y.). 301: 1904-8. PMID 14512628 DOI: 10.1126/Science.1085945  1
2003 Zarrinpar A, Bhattacharyya RP, Lim WA. The structure and function of proline recognition domains. Science's Stke : Signal Transduction Knowledge Environment. 2003: RE8. PMID 12709533 DOI: 10.1126/Stke.2003.179.Re8  1
2003 Carlton VE, Harris BZ, Puffenberger EG, Batta AK, Knisely AS, Robinson DL, Strauss KA, Shneider BL, Lim WA, Salen G, Morton DH, Bull LN. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Nature Genetics. 34: 91-6. PMID 12704386 DOI: 10.1038/Ng1147  1
2003 Harris BZ, Lau FW, Fujii N, Guy RK, Lim WA. Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry. 42: 2797-805. PMID 12627945 DOI: 10.1021/Bi027061P  1
2003 Park SH, Zarrinpar A, Lim WA. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science (New York, N.Y.). 299: 1061-4. PMID 12511654 DOI: 10.1126/Science.1076979  1
2002 Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell. 111: 565-76. PMID 12437929 DOI: 10.1016/S0092-8674(02)01076-0  1
2002 Yu TW, Hao JC, Lim W, Tessier-Lavigne M, Bargmann CI. Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function. Nature Neuroscience. 5: 1147-54. PMID 12379860 DOI: 10.1038/Nn956  1
2002 Harris BZ, Venkatasubrahmanyam S, Lim WA. Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. The Journal of Biological Chemistry. 277: 34902-8. PMID 12110687 DOI: 10.1074/Jbc.M205856200  1
2002 Prehoda KE, Lim WA. How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2. Current Opinion in Cell Biology. 14: 149-54. PMID 11891112 DOI: 10.1016/S0955-0674(02)00307-1  1
2002 Lim WA. The modular logic of signaling proteins: building allosteric switches from simple binding domains. Current Opinion in Structural Biology. 12: 61-8. PMID 11839491 DOI: 10.1016/S0959-440X(02)00290-7  1
2002 Baker D, Lim WA. Folding and binding: From folding towards function Current Opinion in Structural Biology. 12: 11-13. DOI: 10.1016/S0959-440X(02)00282-8  1
2001 McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE. Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Molecular Cell. 8: 1291-301. PMID 11779504 DOI: 10.1016/S1097-2765(01)00411-7  1
2001 Harris BZ, Lim WA. Mechanism and role of PDZ domains in signaling complex assembly. Journal of Cell Science. 114: 3219-31. PMID 11591811  1
2001 Wang W, Lim WA, Jakalian A, Wang J, Wang J, Luo R, Bayly CI, Kollman PA. An analysis of the interactions between the Sem-5 SH3 domain and its ligands using molecular dynamics, free energy calculations, and sequence analysis. Journal of the American Chemical Society. 123: 3986-94. PMID 11457149 DOI: 10.1021/Ja003164O  1
2001 Prehoda KE, Lim WA. The double life of PX domains. Nature Structural Biology. 8: 570-2. PMID 11427879 DOI: 10.1038/89586  1
2001 Harris BZ, Hillier BJ, Lim WA. Energetic determinants of internal motif recognition by PDZ domains. Biochemistry. 40: 5921-30. PMID 11352727 DOI: 10.1021/Bi010142L  1
2000 Prehoda KE, Scott JA, Mullins RD, Lim WA. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science (New York, N.Y.). 290: 801-6. PMID 11052943 DOI: 10.1126/Science.290.5492.801  1
2000 Zarrinpar A, Lim WA. Converging on proline: the mechanism of WW domain peptide recognition. Nature Structural Biology. 7: 611-3. PMID 10932238 DOI: 10.1038/77891  1
2000 Nguyen JT, Porter M, Amoui M, Miller WT, Zuckermann RN, Lim WA. Improving SH3 domain ligand selectivity using a non-natural scaffold. Chemistry & Biology. 7: 463-73. PMID 10903934 DOI: 10.1016/S1074-5521(00)00130-7  1
1999 Christopherson KS, Hillier BJ, Lim WA, Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. The Journal of Biological Chemistry. 274: 27467-73. PMID 10488080 DOI: 10.1074/Jbc.274.39.27467  1
1999 Prehoda KE, Lee DJ, Lim WA. Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly. Cell. 97: 471-80. PMID 10338211 DOI: 10.1016/S0092-8674(00)80757-6  1
1999 Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science (New York, N.Y.). 284: 812-5. PMID 10221915 DOI: 10.1126/Science.284.5415.812  1
1998 Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science (New York, N.Y.). 282: 2088-92. PMID 9851931 DOI: 10.1126/Science.282.5396.2088  1
1997 Nguyen JT, Lim WA. How Src exercises self-restraint. Nature Structural Biology. 4: 256-60. PMID 9095189 DOI: 10.1038/Nsb0497-256  1
1996 Lim WA. Reading between the lines: SH3 recognition of an intact protein. Structure (London, England : 1993). 4: 657-9. PMID 8805558 DOI: 10.1016/S0969-2126(96)00071-8  1
1994 Lim WA, Hodel A, Sauer RT, Richards FM. The crystal structure of a mutant protein with altered but improved hydrophobic core packing. Proceedings of the National Academy of Sciences of the United States of America. 91: 423-7. PMID 8278404 DOI: 10.1073/Pnas.91.1.423  1
1994 Lim WA, Fox RO, Richards FM. Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem-5. Protein Science : a Publication of the Protein Society. 3: 1261-6. PMID 7987221 DOI: 10.1002/Pro.5560030812  1
1994 Lim WA, Richards FM, Fox RO. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature. 372: 375-9. PMID 7802869 DOI: 10.1038/372375A0  1
1994 Lim WA, Richards FM. Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition. Nature Structural Biology. 1: 221-5. PMID 7656049 DOI: 10.1038/Nsb0494-221  1
1993 Richards FM, Lim WA. An analysis of packing in the protein folding problem. Quarterly Reviews of Biophysics. 26: 423-98. PMID 8058892 DOI: 10.1017/S0033583500002845  1
1992 Lim WA, Farruggio DC, Sauer RT. Structural and energetic consequences of disruptive mutations in a protein core. Biochemistry. 31: 4324-33. PMID 1567879 DOI: 10.1021/Bi00132A025  1
1992 Sauer RT, Lim WA. Mutational analysis of protein stability Current Biology. 2: 81. DOI: 10.1016/0960-9822(92)90210-2  0.32
1992 Sauer RT, Lim WA. Mutational analysis of protein stability. Current Opinion in Structural Biology 1992, 2:46...-51 Current Opinion in Structural Biology. 2: 46-51. DOI: 10.1016/0959-440X(92)90175-7  1
1991 Lim WA, Sauer RT. The role of internal packing interactions in determining the structure and stability of a protein. Journal of Molecular Biology. 219: 359-76. PMID 2038061 DOI: 10.1016/0022-2836(91)90570-V  1
1991 Lim WA, Sauer RT, Lander AD. Analysis of DNA-protein interactions by affinity coelectrophoresis. Methods in Enzymology. 208: 196-210. PMID 1838134 DOI: 10.1016/0076-6879(91)08014-9  1
1991 Reidhaar-Olson JF, Bowie JU, Breyer RM, Hu JC, Knight KL, Lim WA, Mossing MC, Parsell DA, Shoemaker KR, Sauer RT. Random mutagenesis of protein sequences using oligonucleotide cassettes. Methods in Enzymology. 208: 564-86. PMID 1779849 DOI: 10.1016/0076-6879(91)08029-H  1
1990 Bowie JU, Reidhaar-Olson JF, Lim WA, Sauer RT. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science (New York, N.Y.). 247: 1306-10. PMID 2315699 DOI: 10.1126/Science.2315699  1
1989 Lim WA, Sauer RT. Alternative packing arrangements in the hydrophobic core of lambda repressor. Nature. 339: 31-6. PMID 2524006 DOI: 10.1038/339031A0  1
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