Thomas E. Prisinzano - Publications

Affiliations: 
University of Kansas, Lawrence, KS, United States 
Area:
Opioids, Pain, Drug abuse
Website:
http://medchem.ku.edu/thomas-prisinzano

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Butelman ER, McElroy BD, Prisinzano TE, Kreek MJ. Impact of Pharmacological Manipulation of the -Opioid Receptor System on Self-grooming and Anhedonic-like Behaviors in Male Mice. The Journal of Pharmacology and Experimental Therapeutics. 370: 1-8. PMID 30975792 DOI: 10.1124/jpet.119.256354  0.52
2018 Ronnebaum TA, McFarlane JS, Prisinzano TE, Booker SJ, Lamb AL. Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis. Biochemistry. PMID 30525512 DOI: 10.1021/acs.biochem.8b00716  0.8
2018 Kivell BM, Paton KF, Kumar N, Morani AS, Culverhouse A, Shepherd A, Welsh SA, Biggerstaff A, Crowley RS, Prisinzano TE. Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents. Molecules (Basel, Switzerland). 23. PMID 30314288 DOI: 10.3390/molecules23102602  0.4
2018 Tai S, Vasiljevik T, Sherwood AM, Eddington S, Wilson CD, Prisinzano TE, Fantegrossi WE. Assessment of rimonabant-like adverse effects of purported CB1R neutral antagonist / CB2R agonist aminoalkylindole derivatives in mice. Drug and Alcohol Dependence. 192: 285-293. PMID 30300803 DOI: 10.1016/j.drugalcdep.2018.08.011  0.76
2018 Sherwood AM, Prisinzano TE. Novel psychotherapeutics - a cautiously optimistic focus on Hallucinogens. Expert Review of Clinical Pharmacology. 11: 1-3. PMID 29224406 DOI: 10.1080/17512433.2018.1415755  0.48
2017 Sherwood AM, Williamson SE, Johnson SN, Yilmaz A, Day VW, Prisinzano TE. Scalable Regio- and Stereoselective Synthesis of Functionalized (E)-4-iodobut-3-en-1-ols: Gram-scale Total Synthesis of Fungal Decanolides and Derivatives. The Journal of Organic Chemistry. PMID 29271194 DOI: 10.1021/acs.joc.7b02324  0.48
2017 Sherwood AM, Williamson SE, Crowley RS, Abbott LM, Day VW, Prisinzano TE. Modular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands. Organic Letters. PMID 28910112 DOI: 10.1021/acs.orglett.7b02684  0.48
2017 Yilmaz A, Crowley RS, Sherwood AM, Prisinzano TE. Semisynthesis and Kappa-Opioid Receptor Activity of Derivatives of Columbin, a Furanolactone Diterpene. Journal of Natural Products. PMID 28718638 DOI: 10.1021/acs.jnatprod.7b00327  0.48
2017 Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Correction to "Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias". Acs Chemical Neuroscience. PMID 28541028 DOI: 10.1021/acschemneuro.7b00157  0.96
2017 Ewald AWM, Bosch PJ, Culverhouse A, Crowley RS, Neuenswander B, Prisinzano TE, Kivell BM. The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects. Psychopharmacology. PMID 28536865 DOI: 10.1007/s00213-017-4637-2  0.4
2017 Sherwood AM, Crowley RS, Paton KF, Biggerstaff A, Neuenswander B, Day VW, Kivell BM, Prisinzano TE. Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa Opioid Agonist with Enhanced Metabolic Stability. Journal of Medicinal Chemistry. PMID 28376298 DOI: 10.1021/acs.jmedchem.7b00148  0.48
2017 Zhou Y, Cowley RS, Ben K, Prisinzano TE, Kreek MJ. Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. Brain Research. PMID 28263712 DOI: 10.1016/j.brainres.2017.02.027  0.52
2016 Crowley RS, Riley AP, Sherwood AM, Groer CE, Shivaperumal N, Biscaia M, Paton K, Schneider S, Provasi D, Kivell BM, Filizola M, Prisinzano TE. Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. Journal of Medicinal Chemistry. PMID 27958743 DOI: 10.1021/acs.jmedchem.6b01235  0.64
2016 Meneely KM, Ronnebaum TA, Riley AP, Prisinzano TE, Lamb AL. Holo-structure and steady state kinetics of the thiazolinyl imine reductases for siderophore biosynthesis. Biochemistry. PMID 27601130 DOI: 10.1021/acs.biochem.6b00735  0.8
2016 Mereu M, Chun LE, Prisinzano T, Newman AH, Katz JL, Tanda G. The Unique Psychostimulant Profile of (±)-Modafinil: Investigation of Behavioral and Neurochemical Effects in Mice. The European Journal of Neuroscience. PMID 27545285 DOI: 10.1111/ejn.13376  0.72
2016 Marchant NJ, Campbell EJ, Whitaker LR, Harvey BK, Kaganovsky K, Adhikary S, Hope BT, Heins RC, Prisinzano TE, Vardy E, Bonci A, Bossert JM, Shaham Y. Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3281-94. PMID 26985037 DOI: 10.1523/JNEUROSCI.4299-15.2016  1
2016 Johnson MW, MacLean KA, Caspers MJ, Prisinzano TE, Griffiths RR. Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans. Journal of Psychopharmacology (Oxford, England). PMID 26880225 DOI: 10.1177/0269881116629125  1
2015 Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharmacology. PMID 26318102 DOI: 10.1016/j.neuropharm.2015.08.027  1
2015 Jamshidi RJ, Jacobs BA, Sullivan LC, Chavera TA, Saylor RM, Prisinzano TE, Clarke WP, Berg KA. Functional Selectivity of Kappa Opioid Receptor (KOR) Agonists in Peripheral Sensory Neurons. The Journal of Pharmacology and Experimental Therapeutics. PMID 26297384 DOI: 10.1124/jpet.115.225896  1
2015 Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting. Neuropharmacology. PMID 26160155 DOI: 10.1016/j.neuropharm.2015.07.001  1
2015 Marchant NJ, Whitaker LR, Bossert JM, Harvey BK, Hope BT, Kaganovsky K, Adhikary S, Prisinzano TE, Vardy E, Roth BL, Shaham Y. Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26019014 DOI: 10.1038/npp.2015.149  1
2015 Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias. Acs Chemical Neuroscience. PMID 25891774 DOI: 10.1021/acschemneuro.5b00092  1
2015 Paranjape SR, Riley AP, Somoza AD, Oakley CE, Wang CC, Prisinzano TE, Oakley BR, Gamblin TC. Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro. Acs Chemical Neuroscience. 6: 751-60. PMID 25822288 DOI: 10.1021/acschemneuro.5b00013  1
2015 Winefield RD, Heemskerk AA, Kaul S, Williams TD, Caspers MJ, Prisinzano TE, McCance-Katz EF, Lunte CE, Faiman MD. N-acetyl-S-(N,N-diethylcarbamoyl) cysteine in rat nucleus accumbens, medial prefrontal cortex, and in rat and human plasma after disulfiram administration. Journal of Pharmaceutical and Biomedical Analysis. 107: 518-25. PMID 25720821 DOI: 10.1016/j.jpba.2015.01.036  0.52
2015 Zolkowska D, Andres-Mach M, Prisinzano TE, Baumann MH, Luszczki JJ. Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Psychopharmacology. 232: 2463-79. PMID 25697861 DOI: 10.1007/s00213-015-3884-3  1
2015 Frankowski KJ, Slauson SR, Lovell KM, Phillips AM, Streicher JM, Zhou L, Whipple DA, Schoenen FJ, Prisinzano TE, Bohn LM, Aubé J. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif. Bioorganic & Medicinal Chemistry. 23: 3948-56. PMID 25593096 DOI: 10.1016/j.bmc.2014.12.033  1
2015 Simonson B, Morani AS, Ewald AW, Walker L, Kumar N, Simpson D, Miller JH, Prisinzano TE, Kivell BM. Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. British Journal of Pharmacology. 172: 515-31. PMID 24641310 DOI: 10.1111/bph.12692  1
2015 Prisinzano TE. The importance of molecular design principles in delivering high quality pharmaceutical candidates Discovering and Developing Molecules With Optimal Drug-Like Properties. 177-191. DOI: 10.1007/978-1-4939-1399-2_5  1
2015 Templeton AC, Byrn SR, Haskell RJ, Prisinzano TE. Discovering and developing molecules with optimal drug-like properties Discovering and Developing Molecules With Optimal Drug-Like Properties. 1-511. DOI: 10.1007/978-1-4939-1399-2  1
2014 Riley AP, Groer CE, Young D, Ewald AW, Kivell BM, Prisinzano TE. Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues. Journal of Medicinal Chemistry. 57: 10464-75. PMID 25426797 DOI: 10.1021/jm501521d  1
2014 Meneely KM, Luo Q, Riley AP, Taylor B, Roy A, Stein RL, Prisinzano TE, Lamb AL. Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorganic & Medicinal Chemistry. 22: 5961-9. PMID 25282647 DOI: 10.1016/j.bmc.2014.09.010  1
2014 Kivell B, Uzelac Z, Sundaramurthy S, Rajamanickam J, Ewald A, Chefer V, Jaligam V, Bolan E, Simonson B, Annamalai B, Mannangatti P, Prisinzano TE, Gomes I, Devi LA, Jayanthi LD, et al. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology. 86: 228-40. PMID 25107591 DOI: 10.1016/j.neuropharm.2014.07.016  1
2014 Vasiljevik T, Groer CE, Lehner K, Navarro H, Prisinzano TE. Studies toward the Development of Antiproliferative Neoclerodanes from Salvinorin A. Journal of Natural Products. 77: 1817-24. PMID 25075762 DOI: 10.1021/np5002048  1
2014 Kivell BM, Ewald AW, Prisinzano TE. Salvinorin A analogs and other κ-opioid receptor compounds as treatments for cocaine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 481-511. PMID 24484985 DOI: 10.1016/B978-0-12-420118-7.00012-3  1
2014 Freeman KB, Naylor JE, Prisinzano TE, Woolverton WL. Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys. Psychopharmacology. 231: 2751-8. PMID 24481567 DOI: 10.1007/s00213-014-3436-2  1
2013 Caspers MJ, Williams TD, Lovell KM, Lozama A, Butelman ER, Kreek MJ, Johnson M, Griffiths R, Maclean K, Prisinzano TE. LC-MS/MS quantification of salvinorin A from biological fluids. Analytical Methods : Advancing Methods and Applications. 5. PMID 24416081 DOI: 10.1039/C3AY40810H  1
2013 Riley AP, Day VW, Navarro HA, Prisinzano TE. Palladium-catalyzed transformations of salvinorin A, a neoclerodane diterpene from Salvia divinorum. Organic Letters. 15: 5936-9. PMID 24246026 DOI: 10.1021/ol4027528  1
2013 Morani AS, Ewald A, Prevatt-Smith KM, Prisinzano TE, Kivell BM. The 2-methoxy methyl analogue of salvinorin A attenuates cocaine-induced drug seeking and sucrose reinforcements in rats. European Journal of Pharmacology. 720: 69-76. PMID 24201308 DOI: 10.1016/j.ejphar.2013.10.050  1
2013 Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aubé J, Bohn LM. Development of functionally selective, small molecule agonists at kappa opioid receptors. The Journal of Biological Chemistry. 288: 36703-16. PMID 24187130 DOI: 10.1074/jbc.M113.504381  1
2013 Quisenberry AJ, Prisinzano T, Baker LE. Combined effects of modafinil and d-amphetamine in male Sprague-Dawley rats trained to discriminate d-amphetamine. Pharmacology, Biochemistry, and Behavior. 110: 208-15. PMID 23880213 DOI: 10.1016/j.pbb.2013.07.011  1
2013 Quisenberry AJ, Prisinzano TE, Baker LE. Modafinil alone and in combination with low dose amphetamine does not establish conditioned place preference in male Sprague-Dawley rats. Experimental and Clinical Psychopharmacology. 21: 252-8. PMID 23647093 DOI: 10.1037/a0031832  1
2013 Vasiljevik T, Franks LN, Ford BM, Douglas JT, Prather PL, Fantegrossi WE, Prisinzano TE. Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse. Journal of Medicinal Chemistry. 56: 4537-50. PMID 23631463 DOI: 10.1021/jm400268b  1
2013 Prisinzano TE. Neoclerodanes as atypical opioid receptor ligands. Journal of Medicinal Chemistry. 56: 3435-43. PMID 23548164 DOI: 10.1021/jm400388u  1
2013 Negri A, Rives ML, Caspers MJ, Prisinzano TE, Javitch JA, Filizola M. Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening. Journal of Chemical Information and Modeling. 53: 521-6. PMID 23461591 DOI: 10.1021/ci400019t  1
2013 Timmermann BN, Prisinzano TE. Special issue in honor of Lester A. Mitscher. Journal of Natural Products. 76: 303-4. PMID 23391393 DOI: 10.1021/np400090f  1
2013 Franklin JM, Vasiljevik T, Prisinzano TE, Carrasco GA. Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 68: 46-58. PMID 23174265 DOI: 10.1016/j.phrs.2012.11.002  1
2013 MacLean KA, Johnson MW, Reissig CJ, Prisinzano TE, Griffiths RR. Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects. Psychopharmacology. 226: 381-92. PMID 23135605 DOI: 10.1007/s00213-012-2912-9  1
2013 Franklin JM, Vasiljevik T, Prisinzano TE, Carrasco GA. Cannabinoid 2 receptor- and beta Arrestin 2-dependent upregulation of serotonin 2A receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 760-7. PMID 22841827 DOI: 10.1016/j.euroneuro.2012.06.012  1
2012 Moore BP, Chung DH, Matharu DS, Golden JE, Maddox C, Rasmussen L, Noah JW, Sosa MI, Ananthan S, Tower NA, White EL, Jia F, Prisinzano TE, Aubé J, Jonsson CB, et al. (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. Journal of Medicinal Chemistry. 55: 8582-7. PMID 23043370 DOI: 10.1021/jm300612z  1
2012 Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. Acs Chemical Neuroscience. 3: 221-236. PMID 22737280 DOI: 10.1021/cn200128x  1
2012 Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH. R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biological Psychiatry. 72: 405-13. PMID 22537794 DOI: 10.1016/j.biopsych.2012.03.022  1
2012 Lovell KM, Vasiljevik T, Araya JJ, Lozama A, Prevatt-Smith KM, Day VW, Dersch CM, Rothman RB, Butelman ER, Kreek MJ, Prisinzano TE. Semisynthetic neoclerodanes as kappa opioid receptor probes. Bioorganic & Medicinal Chemistry. 20: 3100-10. PMID 22464684 DOI: 10.1016/j.bmc.2012.02.040  1
2012 Butelman ER, Caspers M, Lovell KM, Kreek MJ, Prisinzano TE. Behavioral effects and central nervous system levels of the broadly available κ-agonist hallucinogen salvinorin A are affected by P-glycoprotein modulation in vivo. The Journal of Pharmacology and Experimental Therapeutics. 341: 802-8. PMID 22434677 DOI: 10.1124/jpet.112.193227  1
2012 Zhang H, Prisinzano TE, Donovan MD. Permeation and metabolism of cocaine in the nasal mucosa. European Journal of Drug Metabolism and Pharmacokinetics. 37: 255-62. PMID 22351075 DOI: 10.1007/s13318-012-0085-x  1
2012 Morani AS, Schenk S, Prisinzano TE, Kivell BM. A single injection of a novel κ opioid receptor agonist salvinorin A attenuates the expression of cocaine-induced behavioral sensitization in rats. Behavioural Pharmacology. 23: 162-70. PMID 22293826 DOI: 10.1097/FBP.0b013e3283512c1e  1
2012 Brents LK, Gallus-Zawada A, Radominska-Pandya A, Vasiljevik T, Prisinzano TE, Fantegrossi WE, Moran JH, Prather PL. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity Biochemical Pharmacology. 83: 952-961. PMID 22266354 DOI: 10.1016/j.bcp.2012.01.004  1
2012 Lamb K, Tidgewell K, Simpson DS, Bohn LM, Prisinzano TE. Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: new concepts in mu opioid receptor pharmacology: from a symposium on new concepts in mu-opioid pharmacology. Drug and Alcohol Dependence. 121: 181-8. PMID 22119134 DOI: 10.1016/j.drugalcdep.2011.10.026  1
2012 Holtz NA, Lozama A, Prisinzano TE, Carroll ME. Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone. Drug and Alcohol Dependence. 120: 233-7. PMID 21820819 DOI: 10.1016/j.drugalcdep.2011.07.010  1
2011 Prevatt-Smith KM, Lovell KM, Simpson DS, Day VW, Douglas JT, Bosch P, Dersch CM, Rothman RB, Kivell B, Prisinzano TE. Potential Drug Abuse Therapeutics Derived from the Hallucinogenic Natural Product Salvinorin A. Medchemcomm. 2: 1217-1222. PMID 22442751 DOI: 10.1039/C1MD00192B  1
2011 Lovell KM, Prevatt-Smith KM, Lozama A, Prisinzano TE. Synthesis of neoclerodane diterpenes and their pharmacological effects. Topics in Current Chemistry. 299: 141-85. PMID 21630517 DOI: 10.1007/128_2010_82  1
2011 Araya JJ, Zhang H, Prisinzano TE, Mitscher LA, Timmermann BN. Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach. Phytochemistry. 72: 935-41. PMID 21497863 DOI: 10.1016/j.phytochem.2011.03.007  1
2011 Cunningham CW, Rothman RB, Prisinzano TE. Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A. Pharmacological Reviews. 63: 316-47. PMID 21444610 DOI: 10.1124/pr.110.003244  1
2011 Lozama A, Cunningham CW, Caspers MJ, Douglas JT, Dersch CM, Rothman RB, Prisinzano TE. Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A. Journal of Natural Products. 74: 718-26. PMID 21338114 DOI: 10.1021/np1007872  1
2011 Johnson MW, MacLean KA, Reissig CJ, Prisinzano TE, Griffiths RR. Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum. Drug and Alcohol Dependence. 115: 150-5. PMID 21131142 DOI: 10.1016/j.drugalcdep.2010.11.005  1
2010 Cao J, Prisinzano TE, Okunola OM, Kopajtic T, Shook M, Katz JL, Newman AH. Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues. Acs Medicinal Chemistry Letters. 2: 48-52. PMID 21344069 DOI: 10.1021/ml1002025  1
2010 Newman JL, Negus SS, Lozama A, Prisinzano TE, Mello NK. Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys. Experimental and Clinical Psychopharmacology. 18: 395-408. PMID 20939643 DOI: 10.1037/a0021042  1
2010 Drinkwater N, Vu H, Lovell KM, Criscione KR, Collins BM, Prisinzano TE, Poulsen SA, McLeish MJ, Grunewald GL, Martin JL. Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. The Biochemical Journal. 431: 51-61. PMID 20642456 DOI: 10.1042/BJ20100651  1
2010 Cunningham CW, Mukhopadhyay A, Lushington GH, Blagg BS, Prisinzano TE, Krise JP. Uptake, distribution and diffusivity of reactive fluorophores in cells: implications toward target identification. Molecular Pharmaceutics. 7: 1301-10. PMID 20557111 DOI: 10.1021/mp100089k  1
2010 Kivell B, Prisinzano TE. Kappa opioids and the modulation of pain. Psychopharmacology. 210: 109-19. PMID 20372880 DOI: 10.1007/s00213-010-1819-6  1
2010 Butelman ER, Rus S, Prisinzano TE, Kreek MJ. The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology. 210: 253-62. PMID 20084367 DOI: 10.1007/s00213-009-1771-5  1
2010 Prevatt-Smith KM, Prisinzano TE. New therapeutic potential for psychoactive natural products. Natural Product Reports. 27: 23-31. PMID 20024092 DOI: 10.1039/b912196j  1
2010 Sally EJ, Xu H, Dersch CM, Hsin LW, Chang LT, Prisinzano TE, Simpson DS, Giuvelis D, Rice KC, Jacobson AE, Cheng K, Bilsky EJ, Rothman RB. Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor. Synapse (New York, N.Y.). 64: 280-8. PMID 19953652 DOI: 10.1002/syn.20723  1
2009 Fontana G, Savona G, Rodríguez B, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies on neoclerodane diterpenes from Salvia splendens: oxidative modifications of ring A. Tetrahedron. 65: 1708-1715. PMID 21544261 DOI: 10.1016/j.tet.2008.12.009  1
2009 Lovell KM, Simpson DS, Cunningham CW, Prisinzano TE. Utilizing nature as a source of new probes for opioid pharmacology. Future Medicinal Chemistry. 1: 285-301. PMID 21425970 DOI: 10.4155/fmc.09.22  1
2009 Morani AS, Kivell B, Prisinzano TE, Schenk S. Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. Pharmacology, Biochemistry, and Behavior. 94: 244-9. PMID 19747933 DOI: 10.1016/j.pbb.2009.09.002  1
2009 Simpson DS, Lovell KM, Lozama A, Han N, Day VW, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: role of the furan in affinity for opioid receptors. Organic & Biomolecular Chemistry. 7: 3748-56. PMID 19707679 DOI: 10.1039/b905148a  1
2009 Lozama A, Prisinzano TE. Chemical methods for the synthesis and modification of neoclerodane diterpenes. Bioorganic & Medicinal Chemistry Letters. 19: 5490-5. PMID 19679471 DOI: 10.1016/j.bmcl.2009.07.069  1
2009 Teksin ZS, Lee IJ, Nemieboka NN, Othman AA, Upreti VV, Hassan HE, Syed SS, Prisinzano TE, Eddington ND. Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 72: 471-7. PMID 19462483 DOI: 10.1016/j.ejpb.2009.01.002  1
2009 Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. The Journal of Pharmacology and Experimental Therapeutics. 329: 738-46. PMID 19197004 DOI: 10.1124/jpet.108.146142  1
2009 Fink BD, O'Malley Y, Dake BL, Ross NC, Prisinzano TE, Sivitz WI. Mitochondrial targeted coenzyme Q, superoxide, and fuel selectivity in endothelial cells. Plos One. 4: e4250. PMID 19158951 DOI: 10.1371/journal.pone.0004250  1
2009 Prisinzano TE. Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse. Journal of Natural Products. 72: 581-7. PMID 19099466 DOI: 10.1021/np8005748  1
2009 Butelman ER, Prisinzano TE, Deng H, Rus S, Kreek MJ. Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid. The Journal of Pharmacology and Experimental Therapeutics. 328: 588-97. PMID 19001155 DOI: 10.1124/jpet.108.145342  1
2008 Fontana G, Savona G, Rodríguez B, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenoids from Salvia splendens and evaluation of Opioid Receptor affinity. Tetrahedron. 64: 10041-10048. PMID 20027203 DOI: 10.1016/j.tet.2008.08.043  1
2008 Brandt GE, Schmidt MD, Prisinzano TE, Blagg BS. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. Journal of Medicinal Chemistry. 51: 6495-502. PMID 18816111 DOI: 10.1021/jm8007486  1
2008 Xu H, Wang X, Partilla JS, Bishop-Mathis K, Benaderet TS, Dersch CM, Simpson DS, Prisinzano TE, Rothman RB. Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain Research Bulletin. 77: 49-54. PMID 18639745 DOI: 10.1016/j.brainresbull.2008.05.003  1
2008 Butelman ER, Rus S, Simpson DS, Wolf A, Prisinzano TE, Kreek MJ. The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates. The Journal of Pharmacology and Experimental Therapeutics. 327: 154-60. PMID 18593955 DOI: 10.1124/jpet.108.140079  1
2008 Prisinzano TE, Rothman RB. Salvinorin A analogs as probes in opioid pharmacology. Chemical Reviews. 108: 1732-43. PMID 18476672 DOI: 10.1021/cr0782269  1
2008 Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE. Herkinorin analogues with differential beta-arrestin-2 interactions. Journal of Medicinal Chemistry. 51: 2421-31. PMID 18380425 DOI: 10.1021/jm701162g  1
2008 Rothman RB, Baumann MH, Prisinzano TE, Newman AH. Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. Biochemical Pharmacology. 75: 2-16. PMID 17897630 DOI: 10.1016/j.bcp.2007.08.007  1
2008 Prisinzano TE, Tidgewell K, Harding WW. κ opioids as potential treatments for stimulant dependence Drug Addiction: From Basic Research to Therapy. 231-245. DOI: 10.1007/978-0-387-76678-2_15  1
2007 Holden KG, Tidgewell K, Marquam A, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position. Bioorganic & Medicinal Chemistry Letters. 17: 6111-5. PMID 17904842 DOI: 10.1016/j.bmcl.2007.09.050  1
2007 Katavic PL, Lamb K, Navarro H, Prisinzano TE. Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships. Journal of Natural Products. 70: 1278-82. PMID 17685652 DOI: 10.1021/np070194x  1
2007 Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. Journal of Medicinal Chemistry. 50: 3596-603. PMID 17580847 DOI: 10.1021/jm070393d  1
2007 Xu H, Partilla JS, Wang X, Rutherford JM, Tidgewell K, Prisinzano TE, Bohn LM, Rothman RB. A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence. Synapse (New York, N.Y.). 61: 166-75. PMID 17152090 DOI: 10.1002/syn.20356  1
2007 Gilbert KM, Boos TL, Dersch CM, Greiner E, Jacobson AE, Lewis D, Matecka D, Prisinzano TE, Zhang Y, Rothman RB, Rice KC, Venanzi CA. DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. Bioorganic & Medicinal Chemistry. 15: 1146-59. PMID 17127069 DOI: 10.1016/j.bmc.2006.09.070  1
2007 Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Molecular Pharmacology. 71: 549-57. PMID 17090705 DOI: 10.1124/mol.106.028258  1
2007 Butelman ER, Mandau M, Tidgewell K, Prisinzano TE, Yuferov V, Kreek MJ. Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans. The Journal of Pharmacology and Experimental Therapeutics. 320: 300-6. PMID 17060493 DOI: 10.1124/jpet.106.112417  1
2007 Rothman RB, Murphy DL, Xu H, Godin JA, Dersch CM, Partilla JS, Tidgewell K, Schmidt M, Prisinzano TE. Salvinorin A: allosteric interactions at the mu-opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 320: 801-10. PMID 17060492 DOI: 10.1124/jpet.106.113167  1
2006 O'Malley Y, Fink BD, Ross NC, Prisinzano TE, Sivitz WI. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. The Journal of Biological Chemistry. 281: 39766-75. PMID 17060316 DOI: 10.1074/jbc.M608268200  1
2006 Vyas PM, Roychowdhury S, Khan FD, Prisinzano TE, Lamba J, Schuetz EG, Blaisdell J, Goldstein JA, Munson KL, Hines RN, Svensson CK. Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450. The Journal of Pharmacology and Experimental Therapeutics. 319: 488-96. PMID 16857728 DOI: 10.1124/jpet.106.105858  1
2006 Tidgewell K, Harding WW, Lozama A, Cobb H, Shah K, Kannan P, Dersch CM, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Synthesis of salvinorin A analogues as opioid receptor probes. Journal of Natural Products. 69: 914-8. PMID 16792410 DOI: 10.1021/np060094b  1
2006 Chemuturi NV, Haraldsson JE, Prisinzano T, Donovan M. Role of dopamine transporter (DAT) in dopamine transport across the nasal mucosa Life Sciences. 79: 1391-1398. PMID 16733058 DOI: 10.1016/j.lfs.2006.04.021  1
2006 Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. Bioorganic & Medicinal Chemistry Letters. 16: 3170-4. PMID 16621556 DOI: 10.1016/j.bmcl.2006.03.062  1
2006 Boos TL, Greiner E, Calhoun WJ, Prisinzano TE, Nightingale B, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. Bioorganic & Medicinal Chemistry. 14: 3967-73. PMID 16563775 DOI: 10.1016/j.bmc.2006.01.065  1
2006 Greiner E, Boos TL, Prisinzano TE, De Martino MG, Zeglis B, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. Journal of Medicinal Chemistry. 49: 1766-72. PMID 16509591 DOI: 10.1021/jm050766f  1
2006 Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A. Journal of Natural Products. 69: 107-12. PMID 16441078 DOI: 10.1021/np050398i  1
2006 Prisinzano T, Gebhart GF. Pain overview Comprehensive Medicinal Chemistry Ii. 6: 321-326.  1
2005 Harding WW, Hodge M, Wang Z, Woolverton WL, Parrish D, Deschamps JR, Prisinzano TE. Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine. Tetrahedron, Asymmetry. 16: 2249-2256. PMID 16841092 DOI: 10.1016/j.tetasy.2005.06.012  1
2005 Prisinzano TE, Tidgewell K, Harding WW. Kappa opioids as potential treatments for stimulant dependence. The Aaps Journal. 7: E592-9. PMID 16353938 DOI: 10.1208/aapsj070361  1
2005 Prisinzano TE. Psychopharmacology of the hallucinogenic sage Salvia divinorum. Life Sciences. 78: 527-31. PMID 16213533 DOI: 10.1016/j.lfs.2005.09.008  1
2005 Schmidt MD, Schmidt MS, Butelman ER, Harding WW, Tidgewell K, Murry DJ, Kreek MJ, Prisinzano TE. Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates. Synapse (New York, N.Y.). 58: 208-10. PMID 16138318 DOI: 10.1002/syn.20191  1
2005 Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE. Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. Journal of Medicinal Chemistry. 48: 4765-71. PMID 16033256 DOI: 10.1021/jm048963m  1
2005 Sulima A, Prisinzano TE, Spande T, Deschamps JR, Whittaker N, Hochberg Z, Jacobson AE, Rice KC. A concise method for the preparation of deuterium-labeled cortisone: synthesis of [6,7-2H]cortisone. Steroids. 70: 763-9. PMID 16005918 DOI: 10.1016/j.steroids.2005.04.006  1
2005 Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum. Organic Letters. 7: 3017-20. PMID 15987194 DOI: 10.1021/ol0510522  1
2005 Schmidt MS, Prisinzano TE, Tidgewell K, Harding W, Butelman ER, Kreek MJ, Murry DJ. Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 818: 221-5. PMID 15734162 DOI: 10.1016/j.jchromb.2004.12.041  1
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