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James C. Errey, Ph.D - Publications

Affiliations: 
1995-1999 Biology University of Kent at Canterbury 
 1999-2001 BMS University of St Andrews, Saint Andrews, Scotland, United Kingdom 
 2001-2003 Chemistry University of East Anglia, Norwich, England, United Kingdom 
 2003-2008 Biochemistry Albert Einstein College of Medicine, New York, New York, United States 
 2006-2008 Chemistry University of Oxford, Oxford, United Kingdom 
 2008- BMS Heptares 
Area:
Biochemistry, enzymology, membrane protein, GPCR, carbohydrates
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22/49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Dadová J, Wu KJ, Isenegger PG, Errey JC, Bernardes GJL, Chalker JM, Raich L, Rovira C, Davis BG. Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites. Acs Central Science. 3: 1168-1173. PMID 29202018 DOI: 10.1021/Acscentsci.7B00341  0.649
2014 Monrad RN, Errey JC, Barry CS, Iqbal M, Meng X, Iddon L, Perrie JA, Harding JR, Wilson ID, Stachulski AV, Davis BG. Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein Chemical Science. 5: 3789-3794. DOI: 10.1039/C4Sc01329H  0.498
2011 Lee SS, Hong SY, Errey JC, Izumi A, Davies GJ, Davis BG. Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase. Nature Chemical Biology. 7: 631-8. PMID 21822275 DOI: 10.1038/Nchembio.628  0.58
2010 Errey JC, Lee SS, Gibson RP, Martinez Fleites C, Barry CS, Jung PM, O'Sullivan AC, Davis BG, Davies GJ. Mechanistic insight into enzymatic glycosyl transfer with retention of configuration through analysis of glycomimetic inhibitors. Angewandte Chemie (International Ed. in English). 49: 1234-7. PMID 20077550 DOI: 10.1002/Anie.200905096  0.547
2010 Kemper S, Patel MK, Errey JC, Davis BG, Jones JA, Claridge TD. Group epitope mapping considering relaxation of the ligand (GEM-CRL): including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 203: 1-10. PMID 20022272 DOI: 10.1016/J.Jmr.2009.11.015  0.469
2010 Fernández-González M, Boutureira O, Bernardes GJL, Chalker JM, Young MA, Errey JC, Davis BG. Site-selective chemoenzymatic construction of synthetic glycoproteins using endoglycosidases Chemical Science. 1: 709-715. DOI: 10.1039/C0Sc00265H  0.633
2009 Pérez-Victoria I, Kemper S, Patel MK, Edwards JM, Errey JC, Primavesi LF, Paul MJ, Claridge TD, Davis BG. Saturation transfer difference NMR reveals functionally essential kinetic differences for a sugar-binding repressor protein. Chemical Communications (Cambridge, England). 5862-4. PMID 19787122 DOI: 10.1039/B913489A  0.509
2009 Errey JC, Mann MC, Fairhurst SA, Hill L, McNeil MR, Naismith JH, Percy JM, Whitfield C, Field RA. Sugar nucleotide recognition by Klebsiella pneumoniae UDP-D-galactopyranose mutase: fluorinated substrates, kinetics and equilibria. Organic & Biomolecular Chemistry. 7: 1009-16. PMID 19225684 DOI: 10.1039/B815549F  0.474
2008 Vetting MW, Errey JC, Blanchard JS. Rv0802c from Mycobacterium tuberculosis: The first structure of a succinyltransferase with the GNAT fold Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 64: 978-985. PMID 18997321 DOI: 10.1107/S1744309108031679  0.502
2008 Lucas R, Balbuena P, Errey JC, Squire MA, Gurcha SS, McNeil M, Besra GS, Davis BG. Glycomimetic inhibitors of mycobacterial glycosyltransferases: targeting the TB cell wall. Chembiochem : a European Journal of Chemical Biology. 9: 2197-9. PMID 18780384 DOI: 10.1002/Cbic.200800189  0.527
2008 Bernardes GJ, Chalker JM, Errey JC, Davis BG. Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: versatile and switchable access to functionalized proteins. Journal of the American Chemical Society. 130: 5052-3. PMID 18357986 DOI: 10.1021/Ja800800P  0.601
2008 Bernardes GJ, Grayson EJ, Thompson S, Chalker JM, Errey JC, El Oualid F, Claridge TD, Davis BG. From disulfide- to thioether-linked glycoproteins. Angewandte Chemie (International Ed. in English). 47: 2244-7. PMID 18275052 DOI: 10.1002/Anie.200704381  0.614
2007 Hong SY, Tobias G, Ballesteros B, El Oualid F, Errey JC, Doores KJ, Kirkland AI, Nellist PD, Green ML, Davis BG. Atomic-scale detection of organic molecules coupled to single-walled carbon nanotubes. Journal of the American Chemical Society. 129: 10966-7. PMID 17696530 DOI: 10.1021/Ja069080I  0.545
2007 Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH. RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. Journal of Molecular Biology. 365: 146-59. PMID 17046787 DOI: 10.1016/J.Jmb.2006.09.063  0.507
2006 Wing C, Errey JC, Mukhopadhyay B, Blanchard JS, Field RA. Expression and initial characterization of WbbI, a putative d-Galf:α-d-Glc β-1,6-galactofuranosyltransferase from Escherichia coli K-12 Organic and Biomolecular Chemistry. 4: 3945-3950. PMID 17047874 DOI: 10.1039/B609455D  0.589
2006 Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA. Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chemical Communications (Cambridge, England). 1079-81. PMID 16514445 DOI: 10.1039/B515763C  0.434
2006 Errey JC, Blanchard JS. Functional annotation and kinetic characterization of PhnO from Salmonella enterica Biochemistry. 45: 3033-3039. PMID 16503658 DOI: 10.1021/bi052297p  0.484
2005 Yang M, Proctor MR, Bolam DN, Errey JC, Field RA, Gilbert HJ, Davis BG. Probing the breadth of macrolide glycosyltransferases: in vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency. Journal of the American Chemical Society. 127: 9336-7. PMID 15984838 DOI: 10.1021/Ja051482N  0.53
2005 Errey JC, Blanchard JS. Functional characterization of a novel ArgA from Mycobacterium tuberculosis Journal of Bacteriology. 187: 3039-3044. PMID 15838030 DOI: 10.1128/Jb.187.9.3039-3044.2005  0.443
2004 Errey JC, Mukhopadhyay B, Kartha KP, Field RA. Flexible enzymatic and chemo-enzymatic approaches to a broad range of uridine-diphospho-sugars. Chemical Communications (Cambridge, England). 2706-7. PMID 15568077 DOI: 10.1039/B410184G  0.406
2004 Merkel AB, Major LL, Errey JC, Burkart MD, Field RA, Walsh CT, Naismith JH. The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme. The Journal of Biological Chemistry. 279: 32684-91. PMID 15159413 DOI: 10.1074/Jbc.M404091200  0.518
2002 Errey JC, Newbury GD, Ballell L, Field RA. Amino alditols as inhibitors of mycobacterial cell wall biosynthesis Biochemical Society Transactions. 30: A27-A27. DOI: 10.1042/Bst030A027A  0.392
Low-probability matches (unlikely to be authored by this person)
2015 Errey JC, Doré AS, Zhukov A, Marshall FH, Cooke RM. Purification of Stabilized GPCRs for Structural and Biophysical Analyses. Methods in Molecular Biology (Clifton, N.J.). 1335: 1-15. PMID 26260590 DOI: 10.1007/978-1-4939-2914-6_1  0.217
2016 Jazayeri A, Doré AS, Lamb D, Krishnamurthy H, Southall SM, Baig AH, Bortolato A, Koglin M, Robertson NJ, Errey JC, Andrews SP, Teobald I, Brown AJ, Cooke RM, Weir M, et al. Extra-helical binding site of a glucagon receptor antagonist. Nature. PMID 27111510 DOI: 10.1038/nature17414  0.177
2011 Zhukov A, Andrews SP, Errey JC, Robertson N, Tehan B, Mason JS, Marshall FH, Weir M, Congreve M. Biophysical mapping of the adenosine A2A receptor. Journal of Medicinal Chemistry. 54: 4312-23. PMID 21661720 DOI: 10.1021/jm2003798  0.175
2016 Oswald C, Rappas M, Kean J, Doré AS, Errey JC, Bennett K, Deflorian F, Christopher JA, Jazayeri A, Mason JS, Congreve M, Cooke RM, Marshall FH. Intracellular allosteric antagonism of the CCR9 receptor. Nature. PMID 27926729 DOI: 10.1038/nature20606  0.161
2012 Chen D, Errey JC, Heitman LH, Marshall FH, Ijzerman AP, Siegal G. Fragment screening of GPCRs using biophysical methods: identification of ligands of the adenosine A(2A) receptor with novel biological activity. Acs Chemical Biology. 7: 2064-73. PMID 23013674 DOI: 10.1021/cb300436c  0.161
2013 Christopher JA, Brown J, Doré AS, Errey JC, Koglin M, Marshall FH, Myszka DG, Rich RL, Tate CG, Tehan B, Warne T, Congreve M. Biophysical fragment screening of the β1-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug design. Journal of Medicinal Chemistry. 56: 3446-55. PMID 23517028 DOI: 10.1021/jm400140q  0.16
2015 Christopher JA, Aves SJ, Bennett KA, Doré AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M. Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). Journal of Medicinal Chemistry. PMID 26225459 DOI: 10.1021/acs.jmedchem.5b00892  0.156
2013 Cooke RM, Koglin M, Errey JC, Marshall FH. Preparation of purified GPCRs for structural studies. Biochemical Society Transactions. 41: 185-90. PMID 23356281 DOI: 10.1042/BST20120240  0.154
2020 Errey JC, Fiez-Vandal C. Production of membrane proteins in industry: The example of GPCRs. Protein Expression and Purification. 169: 105569. PMID 31945417 DOI: 10.1016/j.pep.2020.105569  0.151
2011 Rich RL, Errey J, Marshall F, Myszka DG. Biacore analysis with stabilized G-protein-coupled receptors. Analytical Biochemistry. 409: 267-72. PMID 20969829 DOI: 10.1016/j.ab.2010.10.008  0.146
2016 Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Dore AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. Controlling the dissociation of ligands from the Adenosine A2A receptor through modulation of salt bridge strength. Journal of Medicinal Chemistry. PMID 27312113 DOI: 10.1021/acs.jmedchem.6b00653  0.144
2016 Jazayeri A, Doré A, Lamb D, Krishnamurthy H, Southall S, Baig A, Bortolato A, Koglin M, Robertson N, Errey J, Andrews S, Brown A, Cooke R, Weir M, Marshall F. Structural elucidation of ligand binding sites in family B GPCRs and their application in drug discovery  Acta Crystallographica Section a Foundations and Advances. 72: s24-s24. DOI: 10.1107/S2053273316099605  0.142
2018 Christopher J, Orgován Z, Congreve M, Dore AS, Errey JC, Marshall FH, Mason JS, Okrasa K, Rucktooa P, Serrano-Vega MJ, Ferenczy GG, Keseru GM. Structure Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu) X-ray structures. Journal of Medicinal Chemistry. PMID 29455526 DOI: 10.1021/acs.jmedchem.7b01722  0.141
2011 Robertson N, Jazayeri A, Errey J, Baig A, Hurrell E, Zhukov A, Langmead CJ, Weir M, Marshall FH. The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery. Neuropharmacology. 60: 36-44. PMID 20624408 DOI: 10.1016/j.neuropharm.2010.07.001  0.139
2018 Rucktooa P, Cheng RKY, Segala E, Geng T, Errey JC, Brown GA, Cooke RM, Marshall FH, Doré AS. Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals. Scientific Reports. 8: 41. PMID 29311713 DOI: 10.1038/s41598-017-18570-w  0.137
2011 Doré AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH. Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine. Structure (London, England : 1993). 19: 1283-93. PMID 21885291 DOI: 10.1016/j.str.2011.06.014  0.136
2019 Rappas M, Ali A, Bennett KA, Brown JD, Bucknell SJ, Congreve M, Cooke RM, Cseke G, de Graaf C, Dore AS, Errey JC, Jazayeri A, Marshall FH, Mason JS, Mould R, et al. Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis. Journal of Medicinal Chemistry. PMID 31860301 DOI: 10.1021/acs.jmedchem.9b01787  0.13
2014 Doré AS, Okrasa K, Patel JC, Serrano-Vega M, Bennett K, Cooke RM, Errey JC, Jazayeri A, Khan S, Tehan B, Weir M, Wiggin GR, Marshall FH. Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature. 511: 557-62. PMID 25042998 DOI: 10.1038/nature13396  0.128
2017 Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Doré AS, Weir M, et al. Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature. PMID 28562585 DOI: 10.1038/nature22800  0.114
2019 O'Brien A, Andrews S, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, et al. TEMPORARY REMOVAL: Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design. Bioorganic & Medicinal Chemistry Letters. 126611. PMID 31447084 DOI: 10.1016/J.Bmcl.2019.08.015  0.109
2015 Segala E, Errey JC, Fiez-Vandal C, Zhukov A, Cooke RM. Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A(2A) receptor reconstituted in HDL like particles. Febs Letters. 589: 1399-405. PMID 25935416 DOI: 10.1016/j.febslet.2015.04.030  0.107
2017 Cheng RKY, Segala E, Robertson N, Deflorian F, Doré AS, Errey JC, Fiez-Vandal C, Marshall FH, Cooke RM. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure (London, England : 1993). PMID 28712806 DOI: 10.1016/j.str.2017.06.012  0.104
2021 Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, et al. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell. 184: 5886-5901.e22. PMID 34822784 DOI: 10.1016/j.cell.2021.11.001  0.099
2012 Langmead CJ, Andrews SP, Congreve M, Errey JC, Hurrell E, Marshall FH, Mason JS, Richardson CM, Robertson N, Zhukov A, Weir M. Identification of novel adenosine A(2A) receptor antagonists by virtual screening. Journal of Medicinal Chemistry. 55: 1904-9. PMID 22250781 DOI: 10.1021/jm201455y  0.096
2010 Errey JC, Marshall FH. New Techniques to Express and Crystallize G Protein-Coupled Receptors Gpcr Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. 324-384. DOI: 10.1002/9780470627327.ch14  0.092
2017 Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Doré AS, Weir M, et al. Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature. PMID 28700581 DOI: 10.1038/nature23311  0.076
2015 Christopher JA, Aves SJ, Brown J, Errey JC, Klair SS, Langmead CJ, Mace OJ, Mould R, Patel JC, Tehan BG, Zhukov A, Marshall FH, Congreve M. Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties Medchemcomm. 6: 947-955. DOI: 10.1039/c5md00027k  0.032
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