Steven Thomas Staben - Publications

Affiliations: 
2007 University of California, Berkeley, Berkeley, CA 

26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dragovich PS, Adhikari P, Blake RA, Blaquiere N, Chen J, Cheng YX, den Besten W, Han J, Hartman SJ, He J, He M, Rei Ingalla E, Kamath AV, Kleinheinz T, Lai T, ... ... Staben ST, et al. Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα). Bioorganic & Medicinal Chemistry Letters. 126907. PMID 31902710 DOI: 10.1016/j.bmcl.2019.126907  0.36
2018 Blaquiere N, Castanedo G, Burch J, Berezhkovskiy L, Brightbill H, Brown S, Chan C, Chiang PC, Crawford JJ, Dong T, Fan P, Feng J, Ghilardi N, Godemann R, Gogol E, ... ... Staben ST, et al. A scaffold-hopping approach to discover potent, selective and efficacious inhibitors of NF-κB inducing kinase. Journal of Medicinal Chemistry. PMID 29940120 DOI: 10.1021/acs.jmedchem.8b00678  0.36
2018 Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, Lesch J, Bents K, Everett C, Kohli PB, Linge S, ... ... Staben ST, et al. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nature Communications. 9: 179. PMID 29330524 DOI: 10.1038/s41467-017-02672-0  0.36
2016 Castanedo GM, Blaquiere N, Beresini MH, Bravo B, Brightbill H, Chen J, Cui H, Eigenbrot C, Everett C, Feng JA, Godemann R, Gogol E, Hymowitz SG, Johnson AR, Kayagaki N, ... ... Staben ST, et al. Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K). Journal of Medicinal Chemistry. PMID 28005357 DOI: 10.1021/acs.jmedchem.6b01363  0.36
2016 Heffron TP, Heald RA, Ndubaku CO, Wei B, Augustin M, Do S, Edgar K, Eigenbrot C, Lori F, Gancia E, Jackson P, Jones G, Kolesnikov A, Lee L, Lesnick J, ... ... Staben ST, et al. The Rational Design of Selective Benzoxazepin Inhibitors of the -Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). Journal of Medicinal Chemistry. PMID 26741947 DOI: 10.1021/acs.jmedchem.5b01483  0.8
2015 Gesinski MR, Brenzovich WE, Staben ST, Srinilta DJ, Toste FD. A divergent/convergent approach to dolabriferol: The Kornblum-DeLaMare enantiomeric resolution Tetrahedron Letters. DOI: 10.1016/j.tetlet.2015.02.067  0.8
2014 Staben ST, Feng JA, Lyle K, Belvin M, Boggs J, Burch JD, Chua CC, Cui H, DiPasquale AG, Friedman LS, Heise C, Koeppen H, Kotey A, Mintzer R, Oh A, et al. Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors. Journal of Medicinal Chemistry. 57: 1033-45. PMID 24432870 DOI: 10.1021/jm401768t  0.8
2013 Ndubaku CO, Heffron TP, Staben ST, Baumgardner M, Blaquiere N, Bradley E, Bull R, Do S, Dotson J, Dudley D, Edgar KA, Friedman LS, Goldsmith R, Heald RA, Kolesnikov A, et al. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. Journal of Medicinal Chemistry. 56: 4597-610. PMID 23662903 DOI: 10.1021/jm4003632  0.8
2013 Staben ST, Ndubaku C, Blaquiere N, Belvin M, Bull RJ, Dudley D, Edgar K, Gray D, Heald R, Heffron TP, Jones GE, Jones M, Kolesnikov A, Lee L, Lesnick J, et al. Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform. Bioorganic & Medicinal Chemistry Letters. 23: 2606-13. PMID 23540645 DOI: 10.1016/j.bmcl.2013.02.102  0.8
2013 Staben ST, Blaquiere N, Tsui V, Kolesnikov A, Do S, Bradley EK, Dotson J, Goldsmith R, Heffron TP, Lesnick J, Lewis C, Murray J, Nonomiya J, Olivero AG, Pang J, et al. Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase. Bioorganic & Medicinal Chemistry Letters. 23: 897-901. PMID 23265894 DOI: 10.1016/j.bmcl.2012.10.121  0.8
2012 de Leon-Boenig G, Bowman KK, Feng JA, Crawford T, Everett C, Franke Y, Oh A, Stanley M, Staben ST, Starovasnik MA, Wallweber HJ, Wu J, Wu LC, Johnson AR, Hymowitz SG. The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site. Structure (London, England : 1993). 20: 1704-14. PMID 22921830 DOI: 10.1016/j.str.2012.07.013  0.8
2012 Sutherlin DP, Baker S, Bisconte A, Blaney PM, Brown A, Chan BK, Chantry D, Castanedo G, DePledge P, Goldsmith P, Goldstein DM, Hancox T, Kaur J, Knowles D, Kondru R, ... ... Staben S, et al. Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Bioorganic & Medicinal Chemistry Letters. 22: 4296-302. PMID 22672799 DOI: 10.1016/j.bmcl.2012.05.027  0.8
2012 Gosselin F, Savage SJ, Blaquiere N, Staben ST. Heteroarylation of azine N-oxides. Organic Letters. 14: 862-5. PMID 22260711 DOI: 10.1021/ol203388j  0.8
2011 Heffron TP, Wei B, Olivero A, Staben ST, Tsui V, Do S, Dotson J, Folkes AJ, Goldsmith P, Goldsmith R, Gunzner J, Lesnick J, Lewis C, Mathieu S, Nonomiya J, et al. Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform. Journal of Medicinal Chemistry. 54: 7815-33. PMID 21985639 DOI: 10.1021/jm2007084  0.8
2011 Staben ST, Siu M, Goldsmith R, Olivero AG, Do S, Burdick DJ, Heffron TP, Dotson J, Sutherlin DP, Zhu BY, Tsui V, Le H, Lee L, Lesnick J, Lewis C, et al. Structure-based design of thienobenzoxepin inhibitors of PI3-kinase. Bioorganic & Medicinal Chemistry Letters. 21: 4054-8. PMID 21636270 DOI: 10.1016/j.bmcl.2011.04.124  0.8
2011 Castanedo GM, Seng PS, Blaquiere N, Trapp S, Staben ST. Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines. The Journal of Organic Chemistry. 76: 1177-9. PMID 21235245 DOI: 10.1021/jo1023393  0.8
2010 Staben ST, Heffron TP, Sutherlin DP, Bhat SR, Castanedo GM, Chuckowree IS, Dotson J, Folkes AJ, Friedman LS, Lee L, Lesnick J, Lewis C, Murray JM, Nonomiya J, Olivero AG, et al. Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase. Bioorganic & Medicinal Chemistry Letters. 20: 6048-51. PMID 20822905 DOI: 10.1016/j.bmcl.2010.08.067  0.8
2010 Staben ST, Blaquiere N. Four-component synthesis of fully substituted 1,2,4-triazoles. Angewandte Chemie (International Ed. in English). 49: 325-8. PMID 19998301 DOI: 10.1002/anie.200905897  0.8
2008 Sethofer SG, Staben ST, Hung OY, Toste FD. Au(I)-catalyzed ring expanding cycloisomerizations: total synthesis of ventricosene. Organic Letters. 10: 4315-8. PMID 18759435 DOI: 10.1021/ol801760w  0.8
2006 Staben ST, Linghu X, Toste FD. Enantioselective synthesis of gamma-hydroxyenones by chiral base-catalyzed Kornblum DeLaMare rearrangement. Journal of the American Chemical Society. 128: 12658-9. PMID 17002354 DOI: 10.1021/ja065464x  0.8
2006 Staben ST, Kennedy-Smith JJ, Huang D, Corkey BK, Lalonde RL, Toste FD. Gold(I)-catalyzed cyclizations of silyl enol ethers: application to the synthesis of (+)-lycopladine A. Angewandte Chemie (International Ed. in English). 45: 5991-4. PMID 16888820 DOI: 10.1002/anie.200602035  0.8
2005 Johansson MJ, Gorin DJ, Staben ST, Toste FD. Gold(I)-catalyzed stereoselective olefin cyclopropanation. Journal of the American Chemical Society. 127: 18002-3. PMID 16366541 DOI: 10.1021/ja0552500  0.8
2005 Markham JP, Staben ST, Toste FD. Gold(I)-catalyzed ring expansion of cyclopropanols and cyclobutanols. Journal of the American Chemical Society. 127: 9708-9. PMID 15998074 DOI: 10.1021/ja052831g  0.8
2004 Staben ST, Kennedy-Smith JJ, Toste FD. Gold(I)-catalyzed 5-endo-dig carbocyclization of acetylenic dicarbonyl compounds. Angewandte Chemie (International Ed. in English). 43: 5350-2. PMID 15468061 DOI: 10.1002/anie.200460844  0.8
2004 Kennedy-Smith JJ, Staben ST, Toste FD. Gold(I)-catalyzed Conia-ene reaction of beta-ketoesters with alkynes. Journal of the American Chemical Society. 126: 4526-7. PMID 15070364 DOI: 10.1021/ja049487s  0.8
2004 Vyvyan JR, Loitz C, Looper RE, Mattingly CS, Peterson EA, Staben ST. Synthesis of aromatic bisabolene natural products via palladium-catalyzed cross-couplings of organozinc reagents. The Journal of Organic Chemistry. 69: 2461-8. PMID 15049646 DOI: 10.1021/jo035778s  0.8
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