Steven Thomas Staben - Publications

Affiliations: 
2007 University of California, Berkeley, Berkeley, CA, United States 

19/56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Blaquiere N, Villemure E, Staben ST. Medicinal chemistry of inhibiting RING-type E3 ubiquitin ligases. Journal of Medicinal Chemistry. PMID 32142281 DOI: 10.1021/Acs.Jmedchem.9B01451  0.303
2017 Schempp TT, Daniels BE, Staben ST, Stivala CE. A General Strategy for the Construction of Functionalized Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki Coupling. Organic Letters. PMID 28653542 DOI: 10.1021/Acs.Orglett.7B01606  0.498
2015 Gesinski MR, Brenzovich WE, Staben ST, Srinilta DJ, Toste FD. A divergent/convergent approach to dolabriferol: The Kornblum-DeLaMare enantiomeric resolution Tetrahedron Letters. DOI: 10.1016/J.Tetlet.2015.02.067  0.733
2013 Staben ST, Blaquiere N, Tsui V, Kolesnikov A, Do S, Bradley EK, Dotson J, Goldsmith R, Heffron TP, Lesnick J, Lewis C, Murray J, Nonomiya J, Olivero AG, Pang J, et al. Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase. Bioorganic & Medicinal Chemistry Letters. 23: 897-901. PMID 23265894 DOI: 10.1016/J.Bmcl.2012.10.121  0.356
2012 Gosselin F, Savage SJ, Blaquiere N, Staben ST. Heteroarylation of azine N-oxides. Organic Letters. 14: 862-5. PMID 22260711 DOI: 10.1021/Ol203388J  0.325
2011 Castanedo GM, Seng PS, Blaquiere N, Trapp S, Staben ST. Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines. The Journal of Organic Chemistry. 76: 1177-9. PMID 21235245 DOI: 10.1021/Jo1023393  0.521
2011 Castanedo GM, Seng PS, Blaquiere N, Trapp S, Staben ST. Metal-Free Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles Synfacts. 2011: 477-477. DOI: 10.1055/S-0030-1259845  0.383
2010 Staben ST, Blaquiere N. Four-component synthesis of fully substituted 1,2,4-triazoles. Angewandte Chemie (International Ed. in English). 49: 325-8. PMID 19998301 DOI: 10.1002/Anie.200905897  0.53
2009 Sethofer SG, Staben ST, Hung OY, Toste FD. Synthesis of Ventricosene Synfacts. 2009: 364-364. DOI: 10.1055/S-0028-1088094  0.807
2008 Sethofer SG, Staben ST, Hung OY, Toste FD. Au(I)-catalyzed ring expanding cycloisomerizations: total synthesis of ventricosene. Organic Letters. 10: 4315-8. PMID 18759435 DOI: 10.1021/Ol801760W  0.773
2007 Toste F, Staben S, Kennedy-Smith J, Huang D, Corkey B, LaLonde R. Synthesis of (+)-Lycopladine A Synfacts. 2007: 0123-0123. DOI: 10.1055/S-2006-955762  0.742
2006 Staben ST, Linghu X, Toste FD. Enantioselective synthesis of gamma-hydroxyenones by chiral base-catalyzed Kornblum DeLaMare rearrangement. Journal of the American Chemical Society. 128: 12658-9. PMID 17002354 DOI: 10.1021/Ja065464X  0.794
2006 Staben ST, Kennedy-Smith JJ, Huang D, Corkey BK, Lalonde RL, Toste FD. Gold(I)-catalyzed cyclizations of silyl enol ethers: application to the synthesis of (+)-lycopladine A. Angewandte Chemie (International Ed. in English). 45: 5991-4. PMID 16888820 DOI: 10.1002/Anie.200602035  0.748
2006 Toste F, Staben S, Linghu X. Organocatalytic Asymmetric Kornblum-DeLaMare Rearrangement Synfacts. 2006: 1175-1175. DOI: 10.1055/S-2006-949454  0.76
2005 Johansson MJ, Gorin DJ, Staben ST, Toste FD. Gold(I)-catalyzed stereoselective olefin cyclopropanation. Journal of the American Chemical Society. 127: 18002-3. PMID 16366541 DOI: 10.1021/Ja0552500  0.789
2005 Markham JP, Staben ST, Toste FD. Gold(I)-catalyzed ring expansion of cyclopropanols and cyclobutanols. Journal of the American Chemical Society. 127: 9708-9. PMID 15998074 DOI: 10.1021/Ja052831G  0.674
2004 Staben ST, Kennedy-Smith JJ, Toste FD. Gold(I)-catalyzed 5-endo-dig carbocyclization of acetylenic dicarbonyl compounds. Angewandte Chemie (International Ed. in English). 43: 5350-2. PMID 15468061 DOI: 10.1002/Anie.200460844  0.782
2004 Kennedy-Smith JJ, Staben ST, Toste FD. Gold(I)-catalyzed Conia-ene reaction of beta-ketoesters with alkynes. Journal of the American Chemical Society. 126: 4526-7. PMID 15070364 DOI: 10.1021/Ja049487S  0.764
2004 Vyvyan JR, Loitz C, Looper RE, Mattingly CS, Peterson EA, Staben ST. Synthesis of aromatic bisabolene natural products via palladium-catalyzed cross-couplings of organozinc reagents. The Journal of Organic Chemistry. 69: 2461-8. PMID 15049646 DOI: 10.1021/Jo035778S  0.483
Low-probability matches (unlikely to be authored by this person)
2017 Staben ST. Abstract DDT02-01: Discovery of GDC-0077, a highly isoform selective inhibitor of PI3Kα that promotes selective loss of mutant-p110α Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Ddt02-01  0.279
2012 Sutherlin DP, Baker S, Bisconte A, Blaney PM, Brown A, Chan BK, Chantry D, Castanedo G, DePledge P, Goldsmith P, Goldstein DM, Hancox T, Kaur J, Knowles D, Kondru R, ... ... Staben S, et al. Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf. Bioorganic & Medicinal Chemistry Letters. 22: 4296-302. PMID 22672799 DOI: 10.1016/J.Bmcl.2012.05.027  0.274
2013 Olivero AG, Heffron TP, Baumgardner M, Belvin M, Ross LB, Blaquiere N, Bradley E, Castanedo G, Derynck M, Do S, Dotson J, Dudley D, Edgar K, Folkes A, Francis R, ... ... Staben S, et al. Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Ddt02-01  0.271
2011 Heffron TP, Wei B, Olivero A, Staben ST, Tsui V, Do S, Dotson J, Folkes AJ, Goldsmith P, Goldsmith R, Gunzner J, Lesnick J, Lewis C, Mathieu S, Nonomiya J, et al. Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform. Journal of Medicinal Chemistry. 54: 7815-33. PMID 21985639 DOI: 10.1021/Jm2007084  0.266
2019 Feng JA, Lee P, Alaoui MH, Barrett K, Castanedo G, Godemann R, McEwan P, Wang X, Wu P, Zhang Y, Harris SF, Staben ST. Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1). Acs Medicinal Chemistry Letters. 10: 1260-1265. PMID 31531194 DOI: 10.1021/Acsmedchemlett.8B00658  0.266
2017 Safina BS, Elliott RL, Forrest AK, Heald RA, Murray JM, Nonomiya J, Pang J, Salphati L, Seward EM, Staben ST, Ultsch M, Wei B, Yang W, Sutherlin DP. Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles. Acs Medicinal Chemistry Letters. 8: 936-940. PMID 28947940 DOI: 10.1021/Acsmedchemlett.7B00170  0.265
2018 Blaquiere N, Castanedo G, Burch J, Berezhkovskiy L, Brightbill H, Brown S, Chan C, Chiang PC, Crawford JJ, Dong T, Fan P, Feng J, Ghilardi N, Godemann R, Gogol E, ... ... Staben ST, et al. A scaffold-hopping approach to discover potent, selective and efficacious inhibitors of NF-κB inducing kinase. Journal of Medicinal Chemistry. PMID 29940120 DOI: 10.1021/Acs.Jmedchem.8B00678  0.264
2013 Staben ST, Ndubaku C, Blaquiere N, Belvin M, Bull RJ, Dudley D, Edgar K, Gray D, Heald R, Heffron TP, Jones GE, Jones M, Kolesnikov A, Lee L, Lesnick J, et al. Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform. Bioorganic & Medicinal Chemistry Letters. 23: 2606-13. PMID 23540645 DOI: 10.1016/J.Bmcl.2013.02.102  0.263
2019 Dragovich PS, Adhikari P, Blake RA, Blaquiere N, Chen J, Cheng YX, den Besten W, Han J, Hartman SJ, He J, He M, Rei Ingalla E, Kamath AV, Kleinheinz T, Lai T, ... ... Staben ST, et al. Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα). Bioorganic & Medicinal Chemistry Letters. 126907. PMID 31902710 DOI: 10.1016/J.Bmcl.2019.126907  0.261
2017 Edgar K, Hanan E, Staben S, Schmidt S, Hong R, Song K, Young A, Hamilton P, Arrazate A, Cruz Cdl, Belvin M, Nannini M, Friedman LS, Sampath D. Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development Cancer Research. 77: 156-156. DOI: 10.1158/1538-7445.Am2017-156  0.256
2016 Heffron TP, Heald RA, Ndubaku CO, Wei B, Augustin M, Do S, Edgar K, Eigenbrot C, Lori F, Gancia E, Jackson P, Jones G, Kolesnikov A, Lee L, Lesnick J, ... ... Staben ST, et al. The Rational Design of Selective Benzoxazepin Inhibitors of the -Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). Journal of Medicinal Chemistry. PMID 26741947 DOI: 10.1021/Acs.Jmedchem.5B01483  0.25
2014 Staben ST, Feng JA, Lyle K, Belvin M, Boggs J, Burch JD, Chua CC, Cui H, DiPasquale AG, Friedman LS, Heise C, Koeppen H, Kotey A, Mintzer R, Oh A, et al. Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors. Journal of Medicinal Chemistry. 57: 1033-45. PMID 24432870 DOI: 10.1021/Jm401768T  0.248
2016 Castanedo GM, Blaquiere N, Beresini MH, Bravo B, Brightbill H, Chen J, Cui H, Eigenbrot C, Everett C, Feng JA, Godemann R, Gogol E, Hymowitz SG, Johnson AR, Kayagaki N, ... ... Staben ST, et al. Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K). Journal of Medicinal Chemistry. PMID 28005357 DOI: 10.1021/Acs.Jmedchem.6B01363  0.247
2010 Staben ST, Heffron TP, Sutherlin DP, Bhat SR, Castanedo GM, Chuckowree IS, Dotson J, Folkes AJ, Friedman LS, Lee L, Lesnick J, Lewis C, Murray JM, Nonomiya J, Olivero AG, et al. Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase. Bioorganic & Medicinal Chemistry Letters. 20: 6048-51. PMID 20822905 DOI: 10.1016/J.Bmcl.2010.08.067  0.233
2011 Staben ST, Siu M, Goldsmith R, Olivero AG, Do S, Burdick DJ, Heffron TP, Dotson J, Sutherlin DP, Zhu BY, Tsui V, Le H, Lee L, Lesnick J, Lewis C, et al. Structure-based design of thienobenzoxepin inhibitors of PI3-kinase. Bioorganic & Medicinal Chemistry Letters. 21: 4054-8. PMID 21636270 DOI: 10.1016/J.Bmcl.2011.04.124  0.231
2013 Ndubaku CO, Heffron TP, Staben ST, Baumgardner M, Blaquiere N, Bradley E, Bull R, Do S, Dotson J, Dudley D, Edgar KA, Friedman LS, Goldsmith R, Heald RA, Kolesnikov A, et al. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. Journal of Medicinal Chemistry. 56: 4597-610. PMID 23662903 DOI: 10.1021/Jm4003632  0.228
2018 Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, Lesch J, Bents K, Everett C, Kohli PB, Linge S, ... ... Staben ST, et al. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nature Communications. 9: 179. PMID 29330524 DOI: 10.1038/S41467-017-02672-0  0.226
2019 Vande Walle L, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubrt V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, et al. MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. Plos Biology. 17: e3000354. PMID 31525186 DOI: 10.1371/Journal.Pbio.3000354  0.221
2019 Ladi E, Everett C, Stivala CE, Daniels BE, Durk MR, Harris SF, Huestis M, Purkey HE, Staben ST, Augustin M, Blaesse M, Steinbacher S, Eidenschenk C, Pappu R, Siu M. Design and Evaluation of Highly-Selective Human Immunoproteasome Inhibitors Reveals a Compensatory Process that Preserves Immune Cell Viability. Journal of Medicinal Chemistry. PMID 31283222 DOI: 10.1021/Acs.Jmedchem.9B00509  0.221
2020 Hanan EJ, Liang J, Wang X, Blake R, Blaquiere N, Staben ST. Monomeric targeted protein degraders. Journal of Medicinal Chemistry. PMID 32352776 DOI: 10.1021/Acs.Jmedchem.0C00093  0.221
2019 Yamazoe S, Tom J, Fu Y, Wu W, Zeng L, Sun C, Liu Q, Lin J, Lin K, Fairbrother WJ, Staben ST. Heterobifunctional molecules induce dephosphorylation of kinases - a proof of concept study. Journal of Medicinal Chemistry. PMID 31874036 DOI: 10.1021/Acs.Jmedchem.9B01167  0.219
2013 Hoeflich K, Ong C, Lyle K, Jubb A, Zhou W, Harris A, Belvin M, Friedman L, Koeppen H, Rudolph J, Staben S. Abstract A067: Targeting p21-activated kinases in breast cancer Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A067  0.214
2012 de Leon-Boenig G, Bowman KK, Feng JA, Crawford T, Everett C, Franke Y, Oh A, Stanley M, Staben ST, Starovasnik MA, Wallweber HJ, Wu J, Wu LC, Johnson AR, Hymowitz SG. The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site. Structure (London, England : 1993). 20: 1704-14. PMID 22921830 DOI: 10.1016/J.Str.2012.07.013  0.211
2022 McBride C, Trzoss L, Povero D, Lazic M, Ambrus-Aikelin G, Santini A, Pranadinata R, Bain G, Stansfield R, Stafford JA, Veal J, Takahashi R, Ly J, Chen S, Liu L, ... ... Staben ST, et al. Overcoming Preclinical Safety Obstacles to Discover ()--((1,2,3,5,6,7-Hexahydro--indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5-pyrazolo[5,1-][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor. Journal of Medicinal Chemistry. PMID 36279149 DOI: 10.1021/acs.jmedchem.2c01250  0.137
2022 Hanan EJ, Braun MG, Heald RA, MacLeod C, Chan C, Clausen S, Edgar KA, Eigenbrot C, Elliott R, Endres N, Friedman LS, Gogol E, Gu XH, Thibodeau RH, Jackson PS, ... ... Staben ST, et al. Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα. Journal of Medicinal Chemistry. PMID 36455032 DOI: 10.1021/acs.jmedchem.2c01422  0.114
2021 Besten WD, Verma K, Yamazoe S, Blaquiere N, Phung W, Izrael-Tomasevic A, Mulvihill MM, Helgason E, Prakash S, Goncharov T, Vucic D, Dueber E, Fairbrother WJ, Wertz I, Yu K, ... Staben ST, et al. Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein. Journal of the American Chemical Society. PMID 34236858 DOI: 10.1021/jacs.1c05269  0.111
2021 Hu DX, Patel S, Chen H, Wang S, Staben ST, Dimitrova YN, Wallweber HA, Lee JY, Chan GKY, Sneeringer CJ, Prangley MS, Moffat JG, Wu KC, Schutt LK, Salphati L, et al. Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 34779204 DOI: 10.1021/acs.jmedchem.1c01180  0.11
2023 Crawford JJ, Feng J, Brightbill HD, Johnson AR, Wright M, Kolesnikov A, Lee W, Castanedo GM, Do S, Blaquiere N, Staben ST, Chiang PC, Fan PW, Baumgardner M, Wong S, et al. Filling a nick in NIK: extending the half-life of a NIK inhibitor through structure-based drug design. Bioorganic & Medicinal Chemistry Letters. 129277. PMID 37105490 DOI: 10.1016/j.bmcl.2023.129277  0.11
2022 Bashore C, Prakash S, Johnson MC, Conrad RJ, Kekessie IA, Scales SJ, Ishisoko N, Kleinheinz T, Liu PS, Popovych N, Wecksler AT, Zhou L, Tam C, Zilberleyb I, Srinivasan R, ... ... Staben ST, et al. Targeted degradation via direct 26S proteasome recruitment. Nature Chemical Biology. 19: 55-63. PMID 36577875 DOI: 10.1038/s41589-022-01218-w  0.109
2022 Steffek M, Helgason E, Popovych N, Rougé L, Bruning JM, Li KS, Burdick DJ, Cai J, Crawford T, Xue J, Decurtins W, Fang C, Grubers F, Holliday MJ, Langley A, ... ... Staben ST, et al. A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands. Biochemistry. PMID 34985287 DOI: 10.1021/acs.biochem.1c00682  0.103
2021 Song KW, Edgar KA, Hanan EJ, Hafner M, Oeh J, Merchant M, Sampath D, Nannini MA, Hong R, Phu L, Forrest WF, Stawiski E, Schmidt S, Endres N, Guan J, ... ... Staben ST, et al. RTK-dependent inducible degradation of mutant PI3Kα drives GDC-0077 (Inavolisib) efficacy. Cancer Discovery. PMID 34544753 DOI: 10.1158/2159-8290.CD-21-0072  0.088
2023 Rosenberg SC, Shanahan F, Yamazoe S, Kschonsak M, Zeng YJ, Lee J, Plise E, Yen I, Rose CM, Quinn JG, Gazzard LJ, Walters BT, Kirkpatrick DS, Staben ST, Foster SA, et al. Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation. Cell Chemical Biology. PMID 36773603 DOI: 10.1016/j.chembiol.2023.01.007  0.082
2021 Dragovich PS, Pillow TH, Blake RA, Sadowsky JD, Adaligil E, Adhikari P, Bhakta S, Blaquiere N, Chen J, Dela Cruz-Chuh J, Gascoigne KE, Hartman SJ, He M, Kaufman S, Kleinheinz T, ... ... Staben ST, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties. Journal of Medicinal Chemistry. PMID 33596065 DOI: 10.1021/acs.jmedchem.0c01845  0.078
2021 Chang MT, Shanahan F, Nguyen TTT, Staben ST, Gazzard L, Yamazoe S, Wertz IE, Piskol R, Yang YA, Modrusan Z, Haley B, Evangelista M, Malek S, Foster SA, Ye X. Identifying transcriptional programs underlying cancer drug response with TraCe-seq. Nature Biotechnology. PMID 34531539 DOI: 10.1038/s41587-021-01005-3  0.051
2012 Gosselin F, Savage SJ, Blaquiere N, Staben ST. ChemInform Abstract: Heteroarylation of Azine N-Oxides. Cheminform. 43: no-no. DOI: 10.1002/chin.201224144  0.051
2019 Walle LV, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubr V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, et al. Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. Plos Biology. 17: e3000529. PMID 31618263 DOI: 10.1371/journal.pbio.3000529  0.04
2021 Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, Kollman JM, Ma T, Yu K, Lai Z, Sangaraju D, Kayagaki N, Newton K, Bogyo M, Staben ST, Dixit VM. Selective activation of PFKL suppresses the phagocytic oxidative burst. Cell. PMID 34320407 DOI: 10.1016/j.cell.2021.07.004  0.04
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