Andrew Coop, Ph.D. - Publications

Affiliations: 
1999- Pharmaceutical Sciences University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Opioid synthesis
Website:
http://faculty.rx.umaryland.edu/acoop/

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Ansari MI, Healy JR, Hom K, Deschamps JR, Matsumoto RR, Coop A. Synthesis and Structural Elucidation of a Pyranomorphinan Opioid and in Vitro Studies. Organic Letters. PMID 29737176 DOI: 10.1021/acs.orglett.8b01025  0.48
2016 Healy JR, Bezawada P, Griggs NW, Devereaux AL, Matsumoto RR, Traynor JR, Coop A, Cunningham CW. Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28011222 DOI: 10.1016/j.bmcl.2016.11.057  1
2016 Huang J, Lakkaraju SK, Coop A, MacKerell AD. Conformational Heterogeneity of Intracellular Loop 3 of the µ-Opioid G-Protein Coupled Receptor. The Journal of Physical Chemistry. B. PMID 27801588 DOI: 10.1021/acs.jpcb.6b09351  0.4
2016 Cavalier MC, Ansari MI, Pierce AD, Wilder PT, McKnight LE, Raman EP, Neau DB, Bezawada P, Alasady MJ, Charpentier TH, Varney K, Toth EA, MacKerell AD, Coop A, Weber DJ. Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. Journal of Medicinal Chemistry. PMID 26727270 DOI: 10.1021/acs.jmedchem.5b01369  1
2014 Ben Haddou T, Malfacini D, Calo G, Aceto MD, Harris LS, Traynor JR, Coop A, Schmidhammer H, Spetea M. Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor. Molecular Pain. 10: 48. PMID 25059282 DOI: 10.1186/1744-8069-10-48  1
2014 Metcalf MD, Rosicky AD, Hassan HE, Eddington ND, Coop A, Cunningham CW, Mercer SL. Opioids and efflux transporters. Part 4: influence of N-substitution on P-glycoprotein substrate activity of noroxymorphone analogues. Bioorganic & Medicinal Chemistry Letters. 24: 3592-5. PMID 24915880 DOI: 10.1016/j.bmcl.2014.05.033  1
2013 Motel WC, Healy JR, Viard E, Pouw B, Martin KE, Matsumoto RR, Coop A. Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands. Bioorganic & Medicinal Chemistry Letters. 23: 6920-2. PMID 24211020 DOI: 10.1016/j.bmcl.2013.09.038  1
2013 Stavitskaya L, Seminerio MJ, Healy JR, Noorbakhsh B, Matsumoto RR, Coop A. Effect of ring-constrained phenylpropyloxyethylamines on sigma receptors. Bioorganic & Medicinal Chemistry. 21: 4923-7. PMID 23896610 DOI: 10.1016/j.bmc.2013.06.068  1
2013 Shim J, Coop A, MacKerell AD. Molecular details of the activation of the μ opioid receptor. The Journal of Physical Chemistry. B. 117: 7907-17. PMID 23758404 DOI: 10.1021/jp404238n  1
2013 Robson MJ, Seminerio MJ, McCurdy CR, Coop A, Matsumoto RR. σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation. Pharmacological Reports : Pr. 65: 343-9. PMID 23744418  1
2013 Healy JR, Bezawada P, Shim J, Jones JW, Kane MA, MacKerell AD, Coop A, Matsumoto RR. Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities. Acs Chemical Neuroscience. 4: 1256-66. PMID 23713721 DOI: 10.1021/cn4000428  1
2013 Motel WC, Coop A, Cunningham CW. Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease. Mini Reviews in Medicinal Chemistry. 13: 456-66. PMID 22931533  1
2012 McKnight LE, Raman EP, Bezawada P, Kudrimoti S, Wilder PT, Hartman KG, Godoy-Ruiz R, Toth EA, Coop A, Mackerell AD, Weber DJ. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. Acs Medicinal Chemistry Letters. 3: 975-979. PMID 23264854 DOI: 10.1021/ml300166s  1
2012 Stavitskaya L, Shim J, Healy JR, Matsumoto RR, MacKerell AD, Coop A. Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors. Bioorganic & Medicinal Chemistry. 20: 4556-63. PMID 22677527 DOI: 10.1016/j.bmc.2012.05.006  1
2012 Kaushal N, Elliott M, Robson MJ, Iyer AK, Rojanasakul Y, Coop A, Matsumoto RR. AC927, a σ receptor ligand, blocks methamphetamine-induced release of dopamine and generation of reactive oxygen species in NG108-15 cells. Molecular Pharmacology. 81: 299-308. PMID 22101517 DOI: 10.1124/mol.111.074120  1
2011 Stavitskaya L, Coop A. Most recent developments and modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan derivatives. Mini Reviews in Medicinal Chemistry. 11: 1002-8. PMID 21861811 DOI: 10.2174/138955711797247752  1
2011 Shim J, Coop A, MacKerell AD. Consensus 3D model of μ-opioid receptor ligand efficacy based on a quantitative Conformationally Sampled Pharmacophore. The Journal of Physical Chemistry. B. 115: 7487-96. PMID 21563754 DOI: 10.1021/jp202542g  1
2011 Matsumoto RR, Li SM, Katz JL, Fantegrossi WE, Coop A. Effects of the selective sigma receptor ligand, 1-(2-phenethyl)piperidine oxalate (AC927), on the behavioral and toxic effects of cocaine. Drug and Alcohol Dependence. 118: 40-7. PMID 21420799 DOI: 10.1016/j.drugalcdep.2011.02.017  1
2011 Seminerio MJ, Kaushal N, Shaikh J, Huber JD, Coop A, Matsumoto RR. Sigma (σ) receptor ligand, AC927 (N-phenethylpiperidine oxalate), attenuates methamphetamine-induced hyperthermia and serotonin damage in mice. Pharmacology, Biochemistry, and Behavior. 98: 12-20. PMID 21130800 DOI: 10.1016/j.pbb.2010.11.023  1
2011 Mercer SL, Coop A. Opioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance. Current Topics in Medicinal Chemistry. 11: 1157-64. PMID 21050174 DOI: 10.2174/156802611795371288  1
2011 Acharya C, Coop A, Polli JE, Mackerell AD. Recent advances in ligand-based drug design: relevance and utility of the conformationally sampled pharmacophore approach. Current Computer-Aided Drug Design. 7: 10-22. PMID 20807187 DOI: 10.2174/157340911793743547  1
2010 Cunningham CW, Hom K, Acharya C, Wilks A, Mackerell AD, Coop A. Synthesis and Characterization of a Novel Diels - Alder Adduct of Codeine. Helvetica Chimica Acta. 93: 220-226. PMID 23378668 DOI: 10.1002/hlca.200900234  1
2010 Wilder PT, Charpentier TH, Liriano MA, Gianni K, Varney KM, Pozharski E, Coop A, Toth EA, Mackerell AD, Weber DJ. In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction. International Journal of High Throughput Screening. 2010: 109-126. PMID 21132089 DOI: 10.2147/IJHTS.S8210  0.4
2010 Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD, Privé GG, et al. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell. 17: 400-11. PMID 20385364 DOI: 10.1016/j.ccr.2009.12.050  0.4
2010 Stavitskaya L, Seminerio MJ, Matthews-Tsourounis MM, Matsumoto RR, Coop A. The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands. Bioorganic & Medicinal Chemistry Letters. 20: 2564-5. PMID 20338757 DOI: 10.1016/j.bmcl.2010.02.087  1
2010 Hassan HE, Myers AL, Lee IJ, Chen H, Coop A, Eddington ND. Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 157-67. PMID 19786507 DOI: 10.1124/dmd.109.029199  1
2009 Koek W, Mercer SL, Coop A, France CP. Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348). The Journal of Pharmacology and Experimental Therapeutics. 330: 876-83. PMID 19564487 DOI: 10.1124/jpet.109.151845  1
2009 Hassan HE, Mercer SL, Cunningham CW, Coop A, Eddington ND. Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions. International Journal of Pharmaceutics. 375: 48-54. PMID 19481690 DOI: 10.1016/j.ijpharm.2009.03.037  1
2009 Charpentier TH, Wilder PT, Liriano MA, Varney KM, Zhong S, Coop A, Pozharski E, MacKerell AD, Toth EA, Weber DJ. Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography. Biochemistry. 48: 6202-12. PMID 19469484 DOI: 10.1021/bi9005754  1
2009 Hassan HE, Myers AL, Coop A, Eddington ND. Differential involvement of P-glycoprotein (ABCB1) in permeability, tissue distribution, and antinociceptive activity of methadone, buprenorphine, and diprenorphine: in vitro and in vivo evaluation. Journal of Pharmaceutical Sciences. 98: 4928-40. PMID 19370547 DOI: 10.1002/jps.21770  1
2008 Matthews MM, Weber DJ, Shapiro PS, Coop A, Mackerell AD. Inhibition of protein-protein interactions with low molecular weight compounds. Current Trends in Medicinal Chemistry. 5: 21-32. PMID 21927717  0.4
2008 Burks SR, Ni J, Muralidharan S, Coop A, Kao JP, Rosen GM. Optimization of labile esters for esterase-assisted accumulation of nitroxides into cells: a model for in vivo EPR imaging. Bioconjugate Chemistry. 19: 2068-71. PMID 18783260 DOI: 10.1021/bc8001562  1
2008 Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A. Attenuation of methamphetamine-induced effects through the antagonism of sigma (sigma) receptors: Evidence from in vivo and in vitro studies. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 18: 871-81. PMID 18755577 DOI: 10.1016/j.euroneuro.2008.07.006  1
2008 Charpentier TH, Wilder PT, Liriano MA, Varney KM, Pozharski E, MacKerell AD, Coop A, Toth EA, Weber DJ. Divalent metal ion complexes of S100B in the absence and presence of pentamidine. Journal of Molecular Biology. 382: 56-73. PMID 18602402 DOI: 10.1016/j.jmb.2008.06.047  1
2008 Mercer SL, Cunningham CW, Eddington ND, Coop A. Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs. Bioorganic & Medicinal Chemistry Letters. 18: 3638-40. PMID 18499452 DOI: 10.1016/j.bmcl.2008.04.046  1
2008 Smith TA, Yang X, Wu H, Pouw B, Matsumoto RR, Coop A. Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions. Journal of Medicinal Chemistry. 51: 3322-5. PMID 18461921 DOI: 10.1021/jm7013666  1
2008 Cunningham CW, Mercer SL, Hassan HE, Traynor JR, Eddington ND, Coop A. Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. Journal of Medicinal Chemistry. 51: 2316-20. PMID 18311899 DOI: 10.1021/jm701457j  1
2008 Mercer SL, Shaikh J, Traynor JR, Matsumoto RR, Coop A. Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands. European Journal of Medicinal Chemistry. 43: 1304-8. PMID 17988766 DOI: 10.1016/j.ejmech.2007.09.026  1
2008 Metcalf MD, Aceto MD, Harris LS, Woods JH, Traynor JR, Coop A, May EL. The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans. Bioorganic & Medicinal Chemistry. 16: 869-73. PMID 17962026 DOI: 10.1016/j.bmc.2007.10.030  1
2007 Metcalf MD, Coop A. 5'-halogenated analogs of oxymorphindole. Bioorganic & Medicinal Chemistry Letters. 17: 5916-7. PMID 17826993 DOI: 10.1016/j.bmcl.2007.07.098  1
2007 Smith TA, Thatcher LN, Coop A. 3-Hydroxy-4-methoxyindolomorphinans as delta opioid selective ligands. Bioorganic & Medicinal Chemistry Letters. 17: 5175-6. PMID 17659872 DOI: 10.1016/j.bmcl.2007.06.087  1
2007 Yarosh HL, Katz EB, Coop A, Fantegrossi WE. MDMA-like behavioral effects of N-substituted piperazines in the mouse Pharmacology Biochemistry and Behavior. 88: 18-27. PMID 17651790 DOI: 10.1016/j.pbb.2007.06.007  1
2007 Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, et al. Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series. Journal of Medicinal Chemistry. 50: 3765-76. PMID 17625813 DOI: 10.1021/jm061325e  1
2007 Wu H, Smith TA, Huang H, Wang JB, Deschamps JR, Coop A. Functionalization of the 6,14-bridge of the orvinols. Part 3: preparation and pharmacological evaluation of 18- and 19-hydroxyl substituted orvinols. Bioorganic & Medicinal Chemistry Letters. 17: 4829-31. PMID 17601735 DOI: 10.1016/j.bmcl.2007.06.050  1
2007 Hassan HE, Myers AL, Lee IJ, Coop A, Eddington ND. Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats. Journal of Pharmaceutical Sciences. 96: 2494-506. PMID 17593551 DOI: 10.1002/jps.20893  1
2007 Cheng K, Kim IJ, Lee MJ, Adah SA, Raymond TJ, Bilsky EJ, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists. Organic & Biomolecular Chemistry. 5: 1177-90. PMID 17406716 DOI: 10.1039/b618875c  1
2007 Wang J, Mack AL, Coop A, Matsumoto RR. Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 17: 708-16. PMID 17376658 DOI: 10.1016/j.euroneuro.2007.02.007  1
2007 Bernard D, Coop A, MacKerell AD. Quantitative conformationally sampled pharmacophore for delta opioid ligands: reevaluation of hydrophobic moieties essential for biological activity. Journal of Medicinal Chemistry. 50: 1799-809. PMID 17367120 DOI: 10.1021/jm0612463  1
2007 Koek W, Mercer SL, Coop A. Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348. Psychopharmacology. 192: 407-14. PMID 17277933 DOI: 10.1007/s00213-007-0718-y  1
2007 Mercer SL, Hassan HE, Cunningham CW, Eddington ND, Coop A. Opioids and efflux transporters. Part 1: P-glycoprotein substrate activity of N-substituted analogs of meperidine. Bioorganic & Medicinal Chemistry Letters. 17: 1160-2. PMID 17251015 DOI: 10.1016/j.bmcl.2006.12.042  1
2007 Matsumoto RR, Pouw B, Mack AL, Daniels A, Coop A. Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice. Pharmacology, Biochemistry, and Behavior. 86: 86-91. PMID 17241657 DOI: 10.1016/j.pbb.2006.12.011  1
2007 Newman AH, Coop A. Medicinal chemistry: New chemical classes and subtype-selective ligands Sigma Receptors: Chemistry, Cell Biology and Clinical Implications. 25-44. DOI: 10.1007/978-0-387-36514-5_2  1
2006 Daniels A, Ayala E, Chen W, Coop A, Matsumoto RR. N-[2-(m-methoxyphenyl)ethyl]-N-ethyl-2-(1-pyrrolidinyl)ethylamine (UMB 116) is a novel antagonist for cocaine-induced effects. European Journal of Pharmacology. 542: 61-8. PMID 16797004 DOI: 10.1016/j.ejphar.2006.03.062  1
2006 Balakrishnan A, Wring SA, Coop A, Polli JE. Influence of charge and steric bulk in the C-24 region on the interaction of bile acids with human apical sodium-dependent bile acid transporter. Molecular Pharmaceutics. 3: 282-92. PMID 16749860 DOI: 10.1021/mp0600135  1
2006 Carter LP, Chen W, Coop A, Koek W, France CP. Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348. European Journal of Pharmacology. 538: 85-93. PMID 16647701 DOI: 10.1016/j.ejphar.2006.03.039  1
2006 Koek W, Carter LP, Wu H, Coop A, France CP. Discriminative stimulus effects of flumazenil: perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone. Behavioural Pharmacology. 17: 239-47. PMID 16572002 DOI: 10.1097/00008877-200605000-00005  1
2006 Fantegrossi WE, Harrington AW, Kiessel CL, Eckler JR, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH. Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Pharmacology, Biochemistry, and Behavior. 83: 122-9. PMID 16460788 DOI: 10.1016/j.pbb.2005.12.015  1
2006 Cook CD, Biddlestone L, Coop A, Beardsley PM. Effects of combining ethanol (EtOH) with gamma-hydroxybutyrate (GHB) on the discriminative stimulus, locomotor, and motor-impairing functions of GHB in mice. Psychopharmacology. 185: 112-22. PMID 16453156 DOI: 10.1007/s00213-005-0276-0  1
2006 Koek W, Chen W, Mercer SL, Coop A, France CP. Discriminative stimulus effects of gamma-hydroxybutyrate: role of training dose. The Journal of Pharmacology and Experimental Therapeutics. 317: 409-17. PMID 16330491 DOI: 10.1124/jpet.105.096909  1
2006 Cunningham CW, Thatcher LN, Coop A. Methylation of non-acidic alcohols of alkaloids with TMS-diazomethane: Conversion of codeine to codeine-6-methyl ether Heterocycles. 68: 837-840. DOI: 10.3987/COM-06-10694  1
2006 Cunningham CW, Coop A. Therapeutic applications of opioid antagonists Chimica Oggi. 24: 54-57.  1
2005 Metcalf MD, Coop A. Kappa opioid antagonists: past successes and future prospects. The Aaps Journal. 7: E704-22. PMID 16353947 DOI: 10.1208/aapsj070371  1
2005 Bernard D, Coop A, MacKerell Jr AD. Conformationally sampled pharmacophore for peptidic delta opioid ligands. Journal of Medicinal Chemistry. 48: 7773-80. PMID 16302816 DOI: 10.1021/jm050785p  1
2005 Spetea M, Greiner E, Aceto MD, Harris LS, Coop A, Schmidhammer H. Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency. Journal of Medicinal Chemistry. 48: 5052-5. PMID 16033285 DOI: 10.1021/jm0580205  1
2005 Fantegrossi WE, Harrington AW, Eckler JR, Arshad S, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH. Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats. Psychopharmacology. 181: 496-503. PMID 15983786 DOI: 10.1007/s00213-005-0009-4  1
2005 Wu H, Thatcher LN, Bernard D, Parrish DA, Deschamps JR, Rice KC, MacKerell AD, Coop A. Position of coordination of the lithium ion determines the regioselectivity of demethylations of 3,4-dimethoxymorphinans with L-selectride. Organic Letters. 7: 2531-4. PMID 15957883 DOI: 10.1021/ol050433c  1
2005 Chen W, Wu H, Hernandez RJ, Mehta AK, Ticku MK, France CP, Coop A. Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands. Bioorganic & Medicinal Chemistry Letters. 15: 3201-2. PMID 15927467 DOI: 10.1016/j.bmcl.2005.05.011  1
2005 Koek W, Carter LP, Lamb RJ, Chen W, Wu H, Coop A, France CP. Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam. The Journal of Pharmacology and Experimental Therapeutics. 314: 170-9. PMID 15774716 DOI: 10.1124/jpet.105.083394  1
2005 Carter LP, Wu H, Chen W, Matthews MM, Mehta AK, Hernandez RJ, Thomson JA, Ticku MK, Coop A, Koek W, France CP. Novel gamma-hydroxybutyric acid (GHB) analogs share some, but not all, of the behavioral effects of GHB and GABAB receptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 313: 1314-23. PMID 15769868 DOI: 10.1124/jpet.104.077578  1
2005 Carter LP, Chen W, Wu H, Mehta AK, Hernandez RJ, Ticku MK, Coop A, Koek W, France CP. Comparison of the behavioral effects of gamma-hydroxybutyric acid (GHB) and its 4-methyl-substituted analog, gamma-hydroxyvaleric acid (GHV). Drug and Alcohol Dependence. 78: 91-9. PMID 15769562 DOI: 10.1016/j.drugalcdep.2004.10.002  1
2005 Wu H, Bernard D, Chen W, Strahan GD, Deschamps JR, Parrish DA, Lewis JW, MacKerell AD, Coop A. Functionalization of the 6,14-bridge of the orvinols. 2. Preparation of 18- and 19-hydroxyl-substituted thevinols and their treatment with benzyl bromide. The Journal of Organic Chemistry. 70: 1907-10. PMID 15730320 DOI: 10.1021/jo048388u  1
2005 Fantegrossi WE, Winger G, Woods JH, Woolverton WL, Coop A. Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys. Drug and Alcohol Dependence. 77: 161-8. PMID 15664717 DOI: 10.1016/j.drugalcdep.2004.07.014  1
2005 Bernard D, Coop A, MacKerell AD. Computer-aided drug design: Structure-activity relationships of delta opioid ligands Drug Design Reviews Online. 2: 277-291. DOI: 10.2174/1567269054087596  1
2005 Parrish DA, Thatcher LN, Wu HF, Coop A, Deschamps JR. (9R,13R,14R)-7-(E)-Benzylidene-14-hydroxy-3,4-dimethoxy-17-methylmorphinan- 6-one Acta Crystallographica Section E: Structure Reports Online. 61: o2617-o2618. DOI: 10.1107/S1600536805019987  1
2005 Chen W, Strahan GD, Parrish DA, Deschamps JR, Coop A. Studies into the Diels-Alder reactions of 5-trimethylsilylthebaine Tetrahedron Letters. 46: 131-133. DOI: 10.1016/j.tetlet.2004.11.010  1
2005 Chen W, Parrish DA, Deschamps JR, Coop A. Functionalization of the 6,14-bridge of the orvinols 1. Preparation and Diels - Alder reaction of 7-phenylsilylthebaines Helvetica Chimica Acta. 88: 822-829. DOI: 10.1002/hlca.200590060  1
2004 Tolle-Sander S, Lentz KA, Maeda DY, Coop A, Polli JE. Increased acyclovir oral bioavailability via a bile acid conjugate. Molecular Pharmaceutics. 1: 40-8. PMID 15832499  1
2004 Spetea M, Schüllner F, Moisa RC, Berzetei-Gurske IP, Schraml B, Dörfler C, Aceto MD, Harris LS, Coop A, Schmidhammer H. Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonist cyprodime. Journal of Medicinal Chemistry. 47: 3242-7. PMID 15163203 DOI: 10.1021/jm031126k  1
2004 Matsumoto RR, Gilmore DL, Pouw B, Bowen WD, Williams W, Kausar A, Coop A. Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice. European Journal of Pharmacology. 492: 21-6. PMID 15145701 DOI: 10.1016/j.ejphar.2004.03.037  1
2004 Calderon SN, Coop A. SNC 80 and related delta opioid agonists. Current Pharmaceutical Design. 10: 733-42. PMID 15032699 DOI: 10.2174/1381612043453054  1
2004 Macias AT, Hernandez RJ, Mehta AK, MacKerell AD, Ticku MK, Coop A. 3-chloropropanoic acid (UMB66): a ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group. Bioorganic & Medicinal Chemistry. 12: 1643-7. PMID 15028257 DOI: 10.1016/j.bmc.2004.01.025  1
2004 Carter LP, Unzeitig AW, Wu H, Chen W, Coop A, Koek W, France CP. The Discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: The role of GABA(B) and GABA(A) receptors. The Journal of Pharmacology and Experimental Therapeutics. 309: 540-7. PMID 14742739 DOI: 10.1124/jpet.103.062950  1
2004 Koek W, Flores LR, Carter LP, Lamb RJ, Chen W, Wu H, Coop A, France CP. Discriminative stimulus effects of gamma-hydroxybutyrate in pigeons: role of diazepam-sensitive and -insensitive GABA(A) and GABA(B) receptors. The Journal of Pharmacology and Experimental Therapeutics. 308: 904-11. PMID 14718595 DOI: 10.1124/jpet.103.056093  1
2004 Carter LP, Wu H, Chen W, Cruz CM, Lamb RJ, Koek W, Coop A, France CP. Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors. The Journal of Pharmacology and Experimental Therapeutics. 308: 182-8. PMID 14569056 DOI: 10.1124/jpet.103.058909  1
2004 Parrish D, Chen W, Coop A, Deschamps JR. 7β-Chloro-6,14-endo-etheno-6,7,8,14-tetrahydrothebaine Acta Crystallographica Section E: Structure Reports Online. 60: o793-o794. DOI: 10.1107/S1600536804008670  1
2004 Deschamps JR, Coop A, Parrish DA, Rice KC. 7β,14β-Epoxyhydrocodone-6,6-dimethoxy ketal: An unusual oxetane-containing opioid Acta Crystallographica Section E: Structure Reports Online. 60: o331-o333. DOI: 10.1107/S1600536804002077  1
2003 Schütz J, Spetea M, Koch M, Aceto MD, Harris LS, Coop A, Schmidhammer H. Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic. Journal of Medicinal Chemistry. 46: 4182-7. PMID 12954070 DOI: 10.1021/jm030878b  1
2003 Lamb RJ, Munn J, Duiker NJ, Coop A, Wu H, Koek W, France CP. Interactions of gamma-hydroxy butyrate with ethanol and NCS 382. European Journal of Pharmacology. 470: 157-62. PMID 12798953 DOI: 10.1016/S0014-2999(03)01791-6  1
2003 Janetka JW, Furness MS, Zhang X, Coop A, Folk JE, Mattson MV, Jacobson AE, Rice KC. Enantioconvergent synthesis of (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine, an intermediate to δ-opioid receptor ligands Journal of Organic Chemistry. 68: 3976-3980. PMID 12737580  1
2003 Greiner E, Spetea M, Krassnig R, Schüllner F, Aceto M, Harris LS, Traynor JR, Woods JH, Coop A, Schmidhammer H. Synthesis and biological evaluation of 14-alkoxymorphinans. 18. N-substituted 14-phenylpropyloxymorphinan-6-ones with unanticipated agonist properties: extending the scope of common structure-activity relationships. Journal of Medicinal Chemistry. 46: 1758-63. PMID 12699394 DOI: 10.1021/jm021118o  1
2003 McMahon LR, Coop A, France CP, Winger G, Woolverton WL. Evaluation of the reinforcing and discriminative stimulus effects of 1,4-butanediol and gamma-butyrolactone in rhesus monkeys. European Journal of Pharmacology. 466: 113-20. PMID 12679147 DOI: 10.1016/S0014-2999(03)01486-9  1
2003 Foster A, Wu H, Chen W, Williams W, Bowen WD, Matsumoto RR, Coop A. 1,4-dibenzylpiperazines possess anticocaine activity. Bioorganic & Medicinal Chemistry Letters. 13: 749-51. PMID 12639573 DOI: 10.1016/S0960-894X(02)01034-X  1
2003 Bernard D, Coop A, MacKerell AD. 2D conformationally sampled pharmacophore: a ligand-based pharmacophore to differentiate delta opioid agonists from antagonists. Journal of the American Chemical Society. 125: 3101-7. PMID 12617677 DOI: 10.1021/ja027644m  1
2003 Chen W, Wu H, Bernard D, Metcalf MD, Deschamps JR, Flippen-Anderson JL, MacKerell AD, Coop A. Rearrangement of 5-trimethylsilylthebaine on treatment with L-selectride: an efficient synthesis of (+)-bractazonine. The Journal of Organic Chemistry. 68: 1929-32. PMID 12608812 DOI: 10.1021/jo020704m  1
2003 Carter LP, Flores LR, Wu H, Chen W, Unzeitig AW, Coop A, France CP. The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies. The Journal of Pharmacology and Experimental Therapeutics. 305: 668-74. PMID 12606639 DOI: 10.1124/jpet.102.047860  1
2003 Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb R, France CP, Coop A. A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand. The Journal of Pharmacology and Experimental Therapeutics. 305: 675-9. PMID 12606613 DOI: 10.1124/jpet.102.046797  1
2003 May EL, Coop A, Woods JH, Aceto MD, Bowman ER, Harris LS, Traynor JR. N-(trifluoromethyl)benzyl substituted N-normetazocines and N-norketobemidones. Bioorganic & Medicinal Chemistry. 11: 31-3. PMID 12467704 DOI: 10.1016/S0968-0896(02)00435-2  1
2003 Chen W, Metcalf MD, Coop A, Flippen-Anderson JL, Deschamps JR. 5-Butylthevinone: Stereochemistry of the Diels-Alder reaction of 5-butylthebaine with 3-buten-2-one Acta Crystallographica Section E: Structure Reports Online. 59: o114-i116. DOI: 10.1107/S1600536802023413  1
2003 Van Well RM, Overkleeft HS, Van Boom JH, Coop A, Wang JB, Wang H, Van der Marel GA, Overhand M. Synthesis of novel sugar amino acids by Curtius rearrangement European Journal of Organic Chemistry. 1704-1710.  1
2002 Crawford KW, Coop A, Bowen WD. sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells. European Journal of Pharmacology. 443: 207-9. PMID 12044812 DOI: 10.1016/S0014-2999(02)01581-9  1
2002 Cook CD, Aceto MD, Coop A, Beardsley PM. Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice. Psychopharmacology. 160: 99-106. PMID 11862379 DOI: 10.1007/s00213-001-0951-8  1
2002 Maeda DY, Williams W, Kim WE, Thatcher LN, Bowen WD, Coop A. N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents. Bioorganic & Medicinal Chemistry Letters. 12: 497-500. PMID 11814827 DOI: 10.1016/S0960-894X(01)00788-0  1
2002 Hsin LW, Tian X, Webster EL, Coop A, Caldwell TM, Jacobson AE, Chrousos GP, Gold PW, Habib KE, Ayala A, Eckelman WC, Contoreggi C, Rice KC. CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists. Bioorganic & Medicinal Chemistry. 10: 175-83. PMID 11738619 DOI: 10.1016/S0968-0896(01)00261-9  1
2002 Coop A, MacKerell AD. The future of opioid analgesics American Journal of Pharmaceutical Education. 66: 153-156.  1
2001 Mehta AK, Muschaweck NM, Maeda DY, Coop A, Ticku MK. Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 299: 1148-53. PMID 11714906  1
2001 Huang SM, Bisogno T, Petros TJ, Chang SY, Zavitsanos PA, Zipkin RE, Sivakumar R, Coop A, Maeda DY, De Petrocellis L, Burstein S, Di Marzo V, Walker JM. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. The Journal of Biological Chemistry. 276: 42639-44. PMID 11518719 DOI: 10.1074/jbc.M107351200  1
2001 McLamore S, Ullrich T, Rothman RB, Xu H, Dersch C, Coop A, Davis P, Porreca F, Jacobson AE, Rice KC. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. Journal of Medicinal Chemistry. 44: 1471-4. PMID 11311071 DOI: 10.1021/jm000511w  1
2001 Maeda DY, Coop A. An improved hydrolysis of 7α-chloro-7β-cyano-6,14-endoethenotetrahydrothebaine to its 7-oxo derivative Heterocycles. 55: 1147-1149.  1
2000 Coop A, Rice KC. Role of delta-opioid receptors in biological processes. Drug News & Perspectives. 13: 481-7. PMID 12937621  1
2000 Coop A, Jacobson AE, Aceto MD, Harris LS, Traynor JR, Woods JH, Rice KC. N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. Bioorganic & Medicinal Chemistry Letters. 10: 2449-51. PMID 11078198  1
2000 Furness MS, Zhang X, Coop A, Jacobson AE, Rothman RB, Dersch CM, Xu H, Porreca F, Rice KC. Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers. Journal of Medicinal Chemistry. 43: 3193-6. PMID 10956228 DOI: 10.1021/jm0001222  1
2000 Broom DC, Guo L, Coop A, Husbands SM, Lewis JW, Woods JH, Traynor JR. BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 294: 1195-200. PMID 10945877  1
2000 Coop A, Norton CL, Berzetei-Gurske I, Burnside J, Toll L, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures: ethers of orvinol and isoorvinol. Journal of Medicinal Chemistry. 43: 1852-7. PMID 10794701 DOI: 10.1021/jm990951r  1
2000 Maeda DY, Williams W, Bowen WD, Coop A. A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays. Bioorganic & Medicinal Chemistry Letters. 10: 17-8. PMID 10636233 DOI: 10.1016/S0960-894X(99)00590-9  1
2000 Coop A, Berzetei-Gurske I, Burnside J, Toll L, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures. Ethers of 7,8-cyclopenta-fused analogs of buprenorphine Helvetica Chimica Acta. 83: 687-693. DOI: 10.1002/(SICI)1522-2675(20000412)83:4<687::AID-HLCA687>3.0.CO;2-W  1
2000 Coop A, Rice KC. Role of δ-opioid receptors in biological processes Drug News and Perspectives. 13: 481-487.  1
2000 Derrick I, Coop A, Al-Mousawi SM, Husbands SM, Lewis JW. Perchloric acid induced epimerisation of the thevinones: An improved synthesis of 7β-dihydrothevinones Tetrahedron Letters. 41: 7571-7576.  1
2000 Maeda DY, Coop A. Studies into the direct conversion of indolomorphinans to their 4-phenolic derivatives Tetrahedron. 56: 7399-7402.  1
1999 Zhang X, Rice KC, Calderon SN, Kayakiri H, Smith L, Coop A, Jacobson AE, Rothman RB, Davis P, Dersch CM, Porreca F. Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands. Journal of Medicinal Chemistry. 42: 5455-63. PMID 10639287 DOI: 10.1021/jm9903895  1
1999 Coop A, Pinto J, Wang L, McCullough K, Rothman RB, Dersch C, Jacobson AE, Rice KC. Delta opioid binding selectivity of 3-ether analogs of naltrindole. Bioorganic & Medicinal Chemistry Letters. 9: 3435-8. PMID 10617086  1
1999 Traynor JR, Guo L, Coop A, Lewis JW, Woods JH. Ring-constrained orvinols as analogs of buprenorphine: differences in opioid activity related to configuration of C(20) hydroxyl group. The Journal of Pharmacology and Experimental Therapeutics. 291: 1093-9. PMID 10565829  1
1999 Coop A, Rothman RB, Dersch C, Partilla J, Porreca F, Davis P, Jacobson AE, Rice KC. delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole. Journal of Medicinal Chemistry. 42: 1673-9. PMID 10229636 DOI: 10.1021/jm9807003  1
1999 Coop A, Jacobson AE. The LMC delta opioid recognition pharmacophore: comparison of SNC80 and oxymorphindole. Bioorganic & Medicinal Chemistry Letters. 9: 357-62. PMID 10091684 DOI: 10.1016/S0960-894X(98)00745-8  1
1999 Coop A, Rice KC. Studies into the direct oxidation of codeinone to 14-hydroxycodeinone Tetrahedron. 55: 11429-11436. DOI: 10.1016/S0040-4020(99)00665-1  1
1999 Breeden SW, Coop A, Husbands SM, Lewis JW. 6-O-demethylation of the thevinols with lithium aluminium hydride: Selective demethylation of a tertiary alkyl methyl ether in the presence of an aryl methyl ether Helvetica Chimica Acta. 82: 1978-1980. DOI: 10.1002/(SICI)1522-2675(19991110)82:11<1978::AID-HLCA1978>3.0.CO;2-Q  1
1999 Yu H, Wang L, Flippen-Anderson JL, Tian X, Coop A, Rice KC. Synthesis of a novel 7,14β-ethano-bridged opiate Heterocycles. 51: 2343-2347.  1
1999 Coop A, Rice KC. Direct and simple conversion of codeine to thebainone-A and dihydrothebainone Heterocycles. 50: 39-42.  1
1998 Coop A, Rice KC. A novel synthesis of thebaine from codeine Heterocycles. 49: 43-47.  1
1998 Coop A, Rice KC. L-selectride as a convenient reagent for the selective cleavage of carbamates Tetrahedron Letters. 39: 8933-8934.  1
1998 May EL, Jacobson AE, Mattson MV, Coop A, Aceto MD, Bowman ER, Traynor JR, Woods JH, Harris LS. Synthesis, in vitro, and in vivo activity of N-p-substituted-benzyl- (- )- and (+)-N-normetazocines, (-)- and (+)-N-normorphinans, N- norketobemidones, and (-)-N-nor-4,5-epoxymorphinans Medicinal Chemistry Research. 8: 311-321.  1
1998 Coop A, Janetka JW, Lewis JW, Rice KC. L-Selectride as a General Reagent for the O-Demethylation and N-Decarbomethoxylation of Opium Alkaloids and Derivatives Journal of Organic Chemistry. 63: 4392-4396.  1
1996 Coop A, Lewis JW, Rice KC. Direct and Simple O-Demethylation of Thebaine to Oripavine. The Journal of Organic Chemistry. 61: 6774. PMID 11667567 DOI: 10.1021/jo961473k  1
1995 Coop A, Grivas K, Husbands S, Lewis JW, Porter J. Ring constrained analogues of the thevinones; Diels-Alder reactions of thebaines with 1-indenone and methylene cycloalkanones Tetrahedron Letters. 36: 1689-1692. DOI: 10.1016/0040-4039(95)00046-F  1
1995 Coop A, Grivas K, Husbands S, Lewis JW. Methylation of the enolates of thevinone and some analogues Tetrahedron. 51: 9681-9698. DOI: 10.1016/0040-4020(95)00553-K  1
1993 Barton JW, Coop A, Lewis JW. Diels-Alder reactions of thebaines with cycloalkenones; Lithium tetrafluoroborate as a novel diels-alder catalyst Tetrahedron Letters. 34: 6777-6778. DOI: 10.1016/S0040-4039(00)61699-4  1
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