Christopher W. Cunningham, Ph.D. - Related publications

2003-2008 Pharmaceutical Sciences University of Maryland School of Medicine, Baltimore, MD, United States 
Medicinal Chemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Degrandmaison J, Grisé O, Parent JL, Gendron L. Differential barcoding of opioid receptors trafficking. Journal of Neuroscience Research. PMID 34559903 DOI: 10.1002/jnr.24949   
2021 Zhang M, Xu B, Li N, Zhang R, Zhang Q, Shi X, Xu K, Xiao J, Chen D, Niu J, Shi Y, Fang Q. Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. Journal of Medicinal Chemistry. PMID 34465090 DOI: 10.1021/acs.jmedchem.1c00694   
2021 Dodu JC, Moncayo RK, Damaj MI, Schlosburg JE, Akbarali HI, O'Brien LD, Kendall DA, Lu D, Lichtman AH. The CB Receptor Positive Allosteric Modulator, ZCZ011, Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 34625464 DOI: 10.1124/jpet.121.000723   
2021 Aldrich JV, McLaughlin JP. Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development. Handbook of Experimental Pharmacology. PMID 34463847 DOI: 10.1007/164_2021_519   
2021 Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, et al. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of Medicinal Chemistry. PMID 34505767 DOI: 10.1021/acs.jmedchem.1c01273   
2021 Fan BW, Liu YL, Zhu GX, Wu B, Zhang MM, Deng Q, Wang JL, Chen JX, Han RW, Wei J. The active fragments of ghrelin cross the blood-brain barrier and enter the brain to produce antinociceptive effects after systemic administration. Canadian Journal of Physiology and Pharmacology. 1-12. PMID 34492212 DOI: 10.1139/cjpp-2020-0668   
2021 Zamarripa CA, Pareek T, Schrock HM, Prisinzano TE, Blough BE, Sufka KJ, Freeman KB. The kappa-opioid receptor agonist, triazole 1.1, reduces oxycodone self-administration and enhances oxycodone-induced thermal antinociception in male rats. Psychopharmacology. PMID 34430992 DOI: 10.1007/s00213-021-05965-x   
2021 Stahl EL, Bohn LM. Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists. Biochemistry. PMID 34468132 DOI: 10.1021/acs.biochem.1c00466   
2021 Gifford C, McGahan B, Miracle S, Minnema A, Murphy C, Vazquez D, Weaver T, Farhadi H. Perioperative Subcutaneous Methylnaltrexone Does Not Enhance Gastrointestinal Recovery after Posterior Short-Segment Spinal Arthrodesis Surgery: A Randomized Controlled Trial. The Spine Journal : Official Journal of the North American Spine Society. PMID 34419626 DOI: 10.1016/j.spinee.2021.08.004   
2021 Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, et al. Positive allosteric mechanisms of adenosine A receptor-mediated analgesia. Nature. PMID 34497422 DOI: 10.1038/s41586-021-03897-2   
2021 Li T, Wang L, Zhang L, Li B, Wang D, Zhang L, Wang T, Fu F. Rotigotine-loaded microspheres exerts the antinociceptive effect via central dopaminergic system. European Journal of Pharmacology. 174443. PMID 34464604 DOI: 10.1016/j.ejphar.2021.174443   
2021 Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R. Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. PMID 34433090 DOI: 10.1016/j.molcel.2021.07.033   
2021 Bailey AMJ, Li HO, Burns K, Cheng W, Collister D, Westby EP, Purdy KS, Walsh M, Tennankore KK. Targeting the Opioid Pathway for the Treatment of Chronic Kidney Disease Associated Pruritus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The British Journal of Dermatology. PMID 34582571 DOI: 10.1111/bjd.20769   
2021 Zhao Y, Joshi AA, Aldrich JV, Murray TF. Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 143: 112173. PMID 34536757 DOI: 10.1016/j.biopha.2021.112173   
2021 Faúndez-Parraguez M, Alarcón-Miranda C, Cho YH, Pessoa-Mahana H, Gallardo-Garrido C, Chung H, Faúndez M, Pessoa-Mahana D. New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists. International Journal of Molecular Sciences. 22. PMID 34681877 DOI: 10.3390/ijms222011212   
2021 Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of Medicinal Chemistry. PMID 34435786 DOI: 10.1021/acs.jmedchem.1c00239   
2021 Gerak LR, France CP. Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeys. Drug and Alcohol Dependence. 227: 108991. PMID 34482043 DOI: 10.1016/j.drugalcdep.2021.108991   
2021 Cappoli N, Aceto P, Tabolacci E, Mezzogori D, Sollazzi L, Navarra P, Dello Russo C. Effects of remifentanil on human C20 microglial pro-inflammatory activation. European Review For Medical and Pharmacological Sciences. 25: 5268-5274. PMID 34486703 DOI: 10.26355/eurrev_202108_26547   
2021 Lee JC, Janda KD. Immunopharmacotherapeutic advancements in addressing methamphetamine abuse. Rsc Chemical Biology. 2: 77-93. PMID 34458776 DOI: 10.1039/d0cb00165a   
2021 Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118   
2021 Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T, Nie H, Cheng J. Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis. European Journal of Medicinal Chemistry. 226: 113878. PMID 34634742 DOI: 10.1016/j.ejmech.2021.113878   
2021 Leo LM, Abood ME. CB1 Cannabinoid Receptor Signaling and Biased Signaling. Molecules (Basel, Switzerland). 26. PMID 34500853 DOI: 10.3390/molecules26175413   
2021 Elvir-Lazo OL, White PF, Cruz Eng H, Yumul F, Chua R, Yumul R. Impact of chronic medications in the perioperative period -mechanisms of action and adverse drug effects (part i). Postgraduate Medicine. PMID 34551662 DOI: 10.1080/00325481.2021.1982297   
2021 Guo M, Bakhoda A, Gao ZG, Ramsey JM, Li Y, O'Conor KA, Kelleher AC, Eisenberg SM, Kang Y, Yan X, Javdan C, Fowler JS, Rice KC, Hooker JM, Jacobson KA, et al. Discovery of Highly Potent Adenosine A Receptor Agonists: Targeting Positron Emission Tomography Probes. Acs Chemical Neuroscience. PMID 34469110 DOI: 10.1021/acschemneuro.1c00397   
2021 Ding G, Li D, Sun Y, Chen K, Song D. -Opioid Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca/CaMKII/CREB Pathway. Journal of Healthcare Engineering. 2021: 3401654. PMID 34608407 DOI: 10.1155/2021/3401654   
2021 Misery L, Brenaut E, Pierre O, Le Garrec R, Gouin O, Lebonvallet N, Abasq-Thomas C, Talagas M, Le Gall-Ianotto C, Besner-Morin C, Fluhr JW, Leven C. CHRONIC ITCH: EMERGING TREATMENTS FOLLOWING NEW RESEARCH CONCEPTS. British Journal of Pharmacology. PMID 34463358 DOI: 10.1111/bph.15672   
2021 Ochiai K, Fujii S. Structure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 46: 128141. PMID 34048883 DOI: 10.1016/j.bmcl.2021.128141   
2021 Neumann WL, Sandoval KE, Mobayen S, Minaeian M, Kukielski SG, Srabony KN, Frare R, Slater O, Farr SA, Niehoff ML, Hospital A, Kontoyianni M, Crider AM, Witt KA. Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment. Rsc Medicinal Chemistry. 12: 1352-1365. PMID 34458738 DOI: 10.1039/d1md00044f   
2021 Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. European Journal of Medicinal Chemistry. 226: 113805. PMID 34536667 DOI: 10.1016/j.ejmech.2021.113805   
2021 Mitra A, Sarkar A, Borics A. Universal Properties and Specificities of the β-Adrenergic Receptor-G Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations. International Journal of Molecular Sciences. 22. PMID 34638767 DOI: 10.3390/ijms221910423   
2021 Elvir-Lazo OL, White PF, Cruz Eng H, Yumul F, Chua R, Yumul R. Impact of chronic medications in the perioperative period -anesthetic implications (part ii). Postgraduate Medicine. PMID 34551658 DOI: 10.1080/00325481.2021.1982298   
2021 Sun J, Liu HY, Zhang YH, Fang ZY, Lv PC. Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ. Bioorganic Chemistry. 116: 105342. PMID 34536928 DOI: 10.1016/j.bioorg.2021.105342   
2021 Dvorácskó S, Lázár L, Fülöp F, Palkó M, Zalán Z, Penke B, Fülöp L, Tömböly C, Bogár F. Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening. International Journal of Molecular Sciences. 22. PMID 34360878 DOI: 10.3390/ijms22158112   
2021 León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, et al. Activity of ("Kratom") Alkaloids at Serotonin Receptors. Journal of Medicinal Chemistry. PMID 34467758 DOI: 10.1021/acs.jmedchem.1c00726   
2021 Han J, Andreu V, Langreck C, Pekarskaya EA, Grinnell SG, Allain F, Magalong V, Pintar J, Kieffer BL, Harris AZ, Javitch JA, Hen R, Nautiyal KM. Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34593976 DOI: 10.1038/s41386-021-01192-2   
2021 Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005   
2021 Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 226: 113838. PMID 34571173 DOI: 10.1016/j.ejmech.2021.113838   
2021 Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, et al. Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell Research. PMID 34561620 DOI: 10.1038/s41422-021-00569-8   
2021 Waters K. Pharmacologic Similarities and Differences Among Hallucinogens. Journal of Clinical Pharmacology. 61: S100-S113. PMID 34396556 DOI: 10.1002/jcph.1917   
2021 Magham SV, Thaggikuppe Krishnamurthy P, Shaji N, Mani L, Balasubramanian S. Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials. Journal of Neuroscience Research. PMID 34486749 DOI: 10.1002/jnr.24933   
2021 Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Research. PMID 34433901 DOI: 10.1038/s41422-021-00552-3   
2021 Dutt Konar A, Jain AK, Gupta A, Karthikeyan C, Trivedi P. Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics. Chemistry & Biodiversity. PMID 34486216 DOI: 10.1002/cbdv.202100364   
2021 Ishida A, Okabe Y, Matsushita T, Sekiguchi T, Nishio T, Komagata T, Iwaki M, Miyata H, Katagi J, Naganawa A, Maruyama T, Imagawa A. Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis. Bioorganic & Medicinal Chemistry. 49: 116424. PMID 34626901 DOI: 10.1016/j.bmc.2021.116424   
2021 Brockett AT, Deng C, Shuster M, Perera S, DiMaggio D, Cheng M, Murkli S, Briken V, Roesch MR, Isaacs L. In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34613641 DOI: 10.1002/chem.202102919   
2021 Duke AN, Tiruveedhula VVNPB, Sharmin D, Knutson DE, Cook JM, Platt DM, Rowlett JK. Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABA receptor subtypes. Drug and Alcohol Dependence. 228: 108985. PMID 34500240 DOI: 10.1016/j.drugalcdep.2021.108985   
2021 Matsumoto R, Takahashi D, Watanabe M, Nakatani S, Takamura Y, Kurosaki Y, Kakuta H, Hase K. A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice. Frontiers in Pharmacology. 12: 715752. PMID 34475823 DOI: 10.3389/fphar.2021.715752   
2021 Li Z, Ren Q, Zhou Z, Cai Z, Wang B, Han J, Zhang L. Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome. European Journal of Medicinal Chemistry. 225: 113807. PMID 34455359 DOI: 10.1016/j.ejmech.2021.113807   
2021 Jenkins L, Marsango S, Mancini S, Mahmud ZA, Morrison A, McElroy SP, Bennett KA, Barnes M, Tobin AB, Tikhonova IG, Milligan G. Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. Acs Pharmacology & Translational Science. 4: 1598-1613. PMID 34661077 DOI: 10.1021/acsptsci.1c00151   
2021 Ericson MD, Doering SR, Larson CM, Freeman KT, LaVoi TM, Donow HM, Santos RG, Cho RH, Koerperich ZM, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. Journal of Medicinal Chemistry. PMID 34592820 DOI: 10.1021/acs.jmedchem.1c01417   
2021 Kumar S, Kumar N, Sharma CS, Mishra SS. Molecular Insights of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole as CRF-1 Receptor Antagonists: Combined QSAR, Glide Docking, Molecular Dynamics, and ADME Studies. Iranian Journal of Pharmaceutical Research : Ijpr. 20: 22-34. PMID 34567143 DOI: 10.22037/ijpr.2020.113746.14464