Paul R. Carlier, Ph.D. - Publications

Affiliations: 
1988-1991 Chemistry Polaroid, Sankt-Peterburg, Saint Petersburg, Russia 
 1991-2000 Chemistry Hong Kong Univ. of Sci. & Technology 
 2000- Chemistry Virginia Polytechnic and State University, United States 
Area:
Stereoselective synthesis, medicinal chemistry
Website:
http://www.carliergroup.chem.vt.edu

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Deora N, Carlier PR. A computational study of regioselectivity in aluminum hydride ring-opening of cis- and trans-4-t-butyl and 3-methylcyclohexene oxides. Organic & Biomolecular Chemistry. PMID 31528943 DOI: 10.1039/c9ob01675a  1
2019 Mutunga JM, Ma M, Chen QH, Hartsel JA, Wong DM, Ding S, Totrov M, Carlier PR, Bloomquist JR. Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates. International Journal of Environmental Research and Public Health. 16. PMID 31035318 DOI: 10.3390/ijerph16091500  0.44
2018 Taylor-Wells J, Gross AD, Jiang S, Demares F, Clements JS, Carlier PR, Bloomquist JR. Toxicity, mode of action, and synergist potential of flonicamid against mosquitoes. Pesticide Biochemistry and Physiology. 151: 3-9. PMID 30704710 DOI: 10.1016/j.pestbp.2018.06.004  0.44
2018 Carlier PR, Chen QH, Verma A, Wong DM, Mutunga JM, Müller J, Islam R, Shimozono AM, Tong F, Li J, Totrov M, Bloomquist JR. Select β- and γ-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of versus human acetylcholinesterase. Pesticide Biochemistry and Physiology. 151: 32-39. PMID 30524149 DOI: 10.1016/j.pestbp.2018.02.003  0.44
2018 Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak S, Carlier PR, Cui W, Han Y. Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice. Frontiers in Cellular Neuroscience. 12: 396. PMID 30483056 DOI: 10.3389/fncel.2018.00396  0.48
2017 Clements JS, Islam R, Sun B, Tong F, Gross AD, Bloomquist JR, Carlier PR. N'-mono- and N, N'-diacyl derivatives of benzyl and arylhydrazines as contact insecticides against adult Anopheles gambiae. Pesticide Biochemistry and Physiology. 143: 33-38. PMID 29183608 DOI: 10.1016/j.pestbp.2017.10.001  0.44
2017 Ghavami M, Merino EF, Yao Z, Elahi R, Simpson M, Fernandez-Murga M, Butler JH, Casasanta M, Krai P, Totrov M, Slade DJ, Carlier PR, Cassera MB. Biological studies and target-engagement of the 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD)-targeting antimalarial agent (1R,3S)-MMV008138 and analogs. Acs Infectious Diseases. PMID 29072835 DOI: 10.1021/acsinfecdis.7b00159  0.44
2017 Han Q, Wong DM, Robinson H, Ding H, Lam PC, Totrov MM, Carlier PR, Li J. Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae. Insect Science. PMID 28247978 DOI: 10.1111/1744-7917.12450  0.44
2017 Carlier PR, Bloomquist JR, Totrov M, Li J. Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito. Current Medicinal Chemistry. PMID 28176636 DOI: 10.2174/0929867324666170206130024  0.44
2016 Mutunga JM, Chen QH, Wong DM, Lam PC, Li J, Totrov MM, Gross AD, Carlier PR, Bloomquist JR. Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae. Chimia. 70: 704-708. PMID 27779928 DOI: 10.2533/chimia.2016.704  0.44
2016 Larson NR, Carlier PR, Gross AD, Islam RM, Ma M, Sun B, Totrov MM, Yadav R, Bloomquist JR. Toxicology of Potassium Channel-Directed Compounds in Mosquitoes. Neurotoxicology. PMID 27262624 DOI: 10.1016/j.neuro.2016.05.021  0.44
2015 Camerino E, Wong DM, Tong F, Körber F, Gross AD, Islam R, Viayna E, Mutunga JM, Li J, Totrov MM, Bloomquist JR, Carlier PR. Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters. PMID 26386602 DOI: 10.1016/j.bmcl.2015.09.019  0.44
2015 Mutunga JM, Anderson TD, Craft DT, Gross AD, Swale DR, Tong F, Wong DM, Carlier PR, Bloomquist JR. Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae. Pesticide Biochemistry and Physiology. 121: 116-21. PMID 26047119 DOI: 10.1016/j.pestbp.2015.03.001  0.44
2015 Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD. Structural Genomics for Drug Design against the Pathogen Coxiella burnetii. Proteins. PMID 26033498 DOI: 10.1002/prot.24841  0.44
2015 Yao ZK, Krai PM, Merino EF, Simpson ME, Slebodnick C, Cassera MB, Carlier PR. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorganic & Medicinal Chemistry Letters. 25: 1515-9. PMID 25754494 DOI: 10.1016/j.bmcl.2015.02.020  0.44
2015 Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae. Bioorganic & Medicinal Chemistry. 23: 1321-40. PMID 25684426 DOI: 10.1016/j.bmc.2015.01.026  0.44
2015 Hu S, Wang R, Cui W, Zhang Z, Mak S, Xu D, Choi C, Tsim KW, Carlier PR, Lee M, Han Y. Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue. Journal of Molecular Neuroscience : Mn. 55: 1014-21. PMID 25407821 DOI: 10.1007/s12031-014-0458-5  0.44
2015 Swale DR, Carlier PR, Hartsel JA, Ma M, Bloomquist JR. Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management. Pest Management Science. 71: 1158-64. PMID 25185896 DOI: 10.1002/ps.3899  0.44
2014 Temeyer KB, Tong F, Totrov MM, Tuckow AP, Chen QH, Carlier PR, Pérez de León AA, Bloomquist JR. Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant. Parasites & Vectors. 7: 577. PMID 25491113 DOI: 10.1186/s13071-014-0577-4  0.44
2014 Antolak SA, Yao ZK, Richoux GM, Slebodnick C, Carlier PR. Enantioselective deprotonative ring contraction of N1-methyl-N4-Boc-benzo[e][1,4]diazepine-2,5-diones. Organic Letters. 16: 5204-7. PMID 25247475 DOI: 10.1021/ol502586n  0.44
2014 Bowman JD, Merino EF, Brooks CF, Striepen B, Carlier PR, Cassera MB. Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box. Antimicrobial Agents and Chemotherapy. 58: 811-9. PMID 24247137 DOI: 10.1128/AAC.01500-13  0.44
2014 Bloomquist JR, Mutunga JM, Islam RM, Verma A, Ma M, Totrov MM, Carlier PR. Voltage-sensitive potassium Kv2 channels as new targets for insecticides Acs Symposium Series. 1172: 71-81. DOI: 10.1021/bk-2014-1172.ch006  0.44
2013 Swale DR, Tong F, Temeyer KB, Li A, Lam PC, Totrov MM, Carlier PR, Pérez de León AA, Bloomquist JR. Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi. Pesticide Biochemistry and Physiology. 106. PMID 24187393 DOI: 10.1016/j.pestbp.2013.03.005  0.44
2013 Tong F, Islam RM, Carlier PR, Ma M, Ekström F, Bloomquist JR. Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase. Pesticide Biochemistry and Physiology. 106: 79-84. PMID 24003261 DOI: 10.1016/j.pestbp.2013.04.001  0.44
2013 Gao M, Patwardhan NN, Carlier PR. Stereochemical inversion of a cyano-stabilized grignard reagent: remarkable effects of the ethereal solvent structure and concentration. Journal of the American Chemical Society. 135: 14390-400. PMID 23978216 DOI: 10.1021/ja407348s  0.44
2013 Mutunga JM, Boina DR, Anderson TD, Bloomquist JR, Carlier PR, Wong DM, Lam PC, Totrov MM. Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase. Archives of Insect Biochemistry and Physiology. 83: 180-94. PMID 23740645 DOI: 10.1002/arch.21104  0.44
2013 Cui W, Hu S, Chan HH, Luo J, Li W, Mak S, Choi TC, Rong J, Carlier PR, Han Y. Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. Chemico-Biological Interactions. 203: 365-70. PMID 23085120 DOI: 10.1016/j.cbi.2012.10.003  0.44
2013 Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR. Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae. Chemico-Biological Interactions. 203: 314-8. PMID 22989775 DOI: 10.1016/j.cbi.2012.09.001  0.44
2013 Jiang Y, Swale D, Carlier PR, Hartsel JA, Ma M, Ekström F, Bloomquist JR. Evaluation of novel carbamate insecticides for neurotoxicity to non-target species Pesticide Biochemistry and Physiology. 106: 156-161. DOI: 10.1016/j.pestbp.2013.03.006  0.44
2012 Wong DM, Li J, Chen QH, Han Q, Mutunga JM, Wysinski A, Anderson TD, Ding H, Carpenetti TL, Verma A, Islam R, Paulson SL, Lam PC, Totrov M, Bloomquist JR, ... Carlier PR, et al. Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron). Plos One. 7: e46712. PMID 23049714 DOI: 10.1371/journal.pone.0046712  0.44
2012 Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR. Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 22: 4593-8. PMID 22738634 DOI: 10.1016/j.bmcl.2012.05.103  0.44
2012 Hartsel JA, Craft DT, Chen QH, Ma M, Carlier PR. Access to "Friedel-Crafts-restricted" tert-alkyl aromatics by activation/methylation of tertiary benzylic alcohols. The Journal of Organic Chemistry. 77: 3127-33. PMID 22394317 DOI: 10.1021/jo202371c  0.44
2011 Zhao Y, Dou J, Luo J, Li W, Chan HH, Cui W, Zhang H, Han R, Carlier PR, Zhang X, Han Y. Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets. Brain Research. 1421: 100-9. PMID 21978549 DOI: 10.1016/j.brainres.2011.09.014  0.44
2011 Patwardhan NN, Gao M, Carlier PR. Incremental solvation precedes ion-pair separation in enantiomerization of a cyano-stabilized Grignard reagent. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 12250-3. PMID 21938750 DOI: 10.1002/chem.201102253  0.44
2011 Cui W, Cui GZ, Li W, Zhang Z, Hu S, Mak S, Zhang H, Carlier PR, Choi CL, Wong YT, Lee SM, Han Y. Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR. Brain Research. 1401: 10-7. PMID 21665194 DOI: 10.1016/j.brainres.2011.05.042  0.44
2011 Monceaux CJ, Hirata-Fukae C, Lam PC, Totrov MM, Matsuoka Y, Carlier PR. Triazole-linked reduced amide isosteres: an approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 3992-6. PMID 21621412 DOI: 10.1016/j.bmcl.2011.05.007  0.44
2011 Cui W, Li W, Zhao Y, Mak S, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han Y. Preventing Hâ‚‚Oâ‚‚-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone. Brain Research. 1394: 14-23. PMID 21315693 DOI: 10.1016/j.brainres.2011.02.006  0.44
2011 Ma M, Mehta J, Williams LD, Carlier PR. Pd-catalyzed amination as an alternative to nucleophilic aromatic substitution for the synthesis of N-alkyltacrines and analogues. Tetrahedron Letters. 52: 916-919. PMID 21286231 DOI: 10.1016/j.tetlet.2010.12.073  0.44
2010 Carlier PR, Sun YS, Hsu DC, Chen QH. Axial-selective H/D exchange of glycine-derived 1H-benzo[e][1,4]diazepin-2(3H)-ones: kinetic and computational studies of enantiomerization. The Journal of Organic Chemistry. 75: 6588-94. PMID 20828175 DOI: 10.1021/jo1010608  0.44
2010 Deora N, Carlier PR. Computational studies of ion-pair separation of benzylic organolithium compounds in THF: importance of explicit and implicit solvation. The Journal of Organic Chemistry. 75: 1061-9. PMID 20102232 DOI: 10.1021/jo9016452  0.44
2010 Monceaux CJ, Carlier PR. Regioselective synthesis of aniline-derived 1,3- and Ci-symmetric 1,4-diols from trans-1,4-cyclohexadiene dioxide. Organic Letters. 12: 620-3. PMID 20067254 DOI: 10.1021/ol902856b  0.44
2010 Carlier PR, Hsu DC, Bryson SA. Self-regeneration of stereocenters (SRS) via stereolabile axially chiral intermediates Topics in Stereochemistry. 26: 53-91.  0.44
2009 Hsu DC, Lam PC, Slebodnick C, Carlier PR. Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones. Journal of the American Chemical Society. 131: 18168-76. PMID 19921816 DOI: 10.1021/ja907507j  0.44
2009 Yu H, Li WM, Cheung MC, Zuo Z, Carlier PR, Gu ZM, Chan K, Huang M, Wang YT, Han YF. Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 49: 410-4. PMID 19124214 DOI: 10.1016/j.jpba.2008.11.013  0.44
2009 Mutunga JM, Anderson TD, Wong DM, Carlier PR, Bloomquist JR. Inhibition of Blattella germanica acetylcholinesterase by Bis(n)-tacrines: Prospects for the molecular design of a selective insecticide for a household pest Acs Symposium Series. 1015: 41-51. DOI: 10.1021/bk-2009-1015.ch004  0.44
2009 Anderson TD, Paulson SL, Wong DM, Carlier PR, Bloomquist JR. Pharmacological mapping of the acetylcholinesterase catalytic gorge in mosquitoes with bis(n)-tacrines Acs Symposium Series. 1014: 143-151. DOI: 10.1021/bk-2009-1014.ch010  0.44
2008 Liang Y, Shaw AM, Boules M, Briody S, Robinson J, Oliveros A, Blazar E, Williams K, Zhang Y, Carlier PR, Richelson E. Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS). The Journal of Pharmacology and Experimental Therapeutics. 327: 573-83. PMID 18689611 DOI: 10.1124/jpet.108.143610  0.44
2008 Carlier PR, Anderson TD, Wong DM, Hsu DC, Hartsel J, Ma M, Wong EA, Choudhury R, Lam PC, Totrov MM, Bloomquist JR. Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae. Chemico-Biological Interactions. 175: 368-75. PMID 18554580 DOI: 10.1016/j.cbi.2008.04.037  0.44
2008 Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF. The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine. Journal of Pharmaceutical and Biomedical Analysis. 46: 75-81. PMID 17931815 DOI: 10.1016/j.jpba.2007.08.027  0.44
2008 Bloomquist JR, Boina DR, Chow E, Carlier PR, Reina M, Gonzalez-Coloma A. Mode of action of the plant-derived silphinenes on insect and mammalian GABAA receptor/chloride channel complex Pesticide Biochemistry and Physiology. 91: 17-23. DOI: 10.1016/j.pestbp.2007.12.002  0.44
2007 Li WM, Kan KK, Carlier PR, Pang YP, Han YF. East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. Current Alzheimer Research. 4: 386-96. PMID 17908041 DOI: 10.2174/156720507781788918  0.44
2007 Carlier PR, Zhang Y. The first enantioenriched metalated nitrile possessing macroscopic configurational stability. Organic Letters. 9: 1319-22. PMID 17348666 DOI: 10.1021/ol070149g  0.44
2007 Shaw AM, Boules M, Zhang Y, Williams K, Robinson J, Carlier PR, Richelson E. Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050. European Journal of Pharmacology. 555: 30-6. PMID 17109850 DOI: 10.1016/j.ejphar.2006.10.004  0.44
2007 Li C, Carlier PR, Ren H, Kan KK, Hui K, Wang H, Li W, Li Z, Xiong K, Clement EC, Xue H, Liu X, Li M, Pang Y, Han Y. Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers. Neuropharmacology. 52: 436-43. PMID 17056074 DOI: 10.1016/j.neuropharm.2006.07.039  0.44
2006 Carlier PR, Zhao H, MacQuarrie-Hunter SL, DeGuzman JC, Hsu DC. Enantioselective synthesis of diversely substituted quaternary 1,4-benzodiazepin-2-ones and 1,4-benzodiazepine-2,5-diones. Journal of the American Chemical Society. 128: 15215-20. PMID 17117873 DOI: 10.1021/ja0640142  0.44
2006 Carlier PR, Zhang Y, Slebodnick C, Lo MM, Williams ID. Effect of 2,6-disubstituted aryl groups on acyclic conformation: preference for an antiperiplanar orientation of the geminal and vicinal hydrogens. The Journal of Organic Chemistry. 71: 8835-41. PMID 17081013 DOI: 10.1021/jo061495z  0.44
2006 Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL. Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. Journal of Medicinal Chemistry. 49: 5491-500. PMID 16942022 DOI: 10.1021/jm060164b  0.44
2006 Carlier PR, Deora N, Crawford TD. Protonated 2-methyl-1,2-epoxypropane: A challenging problem for density functional theory Journal of Organic Chemistry. 71: 1592-1597. PMID 16468811 DOI: 10.1021/jo052303n  0.44
2005 MacQuarrie-Hunter S, Carlier PR. Highly enantioselective synthesis of rigid, quaternary 1,4-benzodiazepine-2,5-diones derived from proline. Organic Letters. 7: 5305-8. PMID 16268564 DOI: 10.1021/ol052182d  0.44
2005 Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL. Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase Journal of the American Chemical Society. 127: 11029-11036. PMID 16076210 DOI: 10.1021/ja051765f  0.44
2005 Lam PC, Carlier PR. Experimental and computational studies of ring inversion of 1,4-benzodiazepin-2-ones: implications for memory of chirality transformations. The Journal of Organic Chemistry. 70: 1530-8. PMID 15730270 DOI: 10.1021/jo048450n  0.44
2005 Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, et al. Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 280: 18179-88. PMID 15710623 DOI: 10.1074/jbc.M411085200  0.44
2005 Zhao H, Hsu DC, Carlier PR. Memory of chirality: An emerging strategy for asymmetric synthesis Synthesis. 1-16. DOI: 10.1055/s-2004-834931  0.44
2005 Clement EC, Carlier PR. A simple route to tetrahydro-1,4-benzodiazepin-3-ones bearing diverse N1, N4, and C10 functionalization Tetrahedron Letters. 46: 3633-3635. DOI: 10.1016/j.tetlet.2005.03.171  0.44
2005 Carlier PR, Lam PCH, DeGuzman JC, Zhao H. Memory of chirality trapping of low inversion barrier 1,4-benzodiazepin-2- one enolates Tetrahedron Asymmetry. 16: 2998-3002. DOI: 10.1016/j.tetasy.2005.08.017  0.44
2004 Carlier PR. Threading the needle: mimicking natural toroidal catalysts. Angewandte Chemie (International Ed. in English). 43: 2602-5. PMID 18629975 DOI: 10.1002/anie.200301731  0.44
2004 Du DM, Carlier PR. Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease. Current Pharmaceutical Design. 10: 3141-56. PMID 15544504 DOI: 10.2174/1381612043383412  0.44
2003 Carlier PR, Zhao H, DeGuzman J, Lam PC. Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality. Journal of the American Chemical Society. 125: 11482-3. PMID 13129335 DOI: 10.1021/ja0365781  0.44
2003 Carlier PR. Configurational stability of chiral lithiated cyclopropylnitriles: a density functional study. Chirality. 15: 340-7. PMID 12666242 DOI: 10.1002/chir.10222  0.44
2003 Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. Journal of the American Chemical Society. 125: 363-73. PMID 12517147 DOI: 10.1021/ja021111w  0.44
2002 Lewis WG, Green LG, Grynszpan F, Radi? Z, Carlier PR, Taylor P, Finn MG, Sharpless KB. Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angewandte Chemie (International Ed. in English). 41: 1053-7. PMID 12491310 DOI: 10.1002/1521-3773(20020315)41:6<1053::AID-ANIE1053>3.0.CO;2-4  0.44
2002 Jang CH, Stevens BD, Carlier PR, Calter MA, Ducker WA. Immobilized enzymes as catalytically-active tools for nanofabrication. Journal of the American Chemical Society. 124: 12114-5. PMID 12371849 DOI: 10.1021/ja017686v  0.44
2002 Carlier PR, Lam PC, Wong DM. Catalytic asymmetric synthesis of protected tryptophan regioisomers. The Journal of Organic Chemistry. 67: 6256-9. PMID 12182675 DOI: 10.1021/jo025964i  0.44
2002 Carlier PR, Chow ES, Barlow RL, Bloomquist JR. Discovery of non-zwitterionic GABA(A) receptor full agonists and a superagonist. Bioorganic & Medicinal Chemistry Letters. 12: 1985-8. PMID 12113824 DOI: 10.1016/S0960-894X(02)00299-8  0.44
2002 Carlier PR, Madura JD. Effective computational modeling of constitutional isomerism and aggregation states of explicit solvates of lithiated phenylacetonitrile. The Journal of Organic Chemistry. 67: 3832-40. PMID 12027700 DOI: 10.1021/jo0255633  0.44
2002 Pan SY, Han YF, Carlier PR, Pang YP, Mak DH, Lam BY, Ko KM. Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice. Planta Medica. 68: 217-20. PMID 11914957 DOI: 10.1055/s-2002-23145  0.44
2000 Lenigk R, Lam E, Lai A, Wang H, Han Y, Carlier P, Renneberg R. Enzyme biosensor for studying therapeutics of Alzheimer's disease Biosensors and Bioelectronics. 15: 541-547. PMID 11419651 DOI: 10.1016/S0956-5663(00)00078-6  0.44
2000 Xiao XQ, Lee NT, Carlier PR, Pang Y, Han YF. Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine. Neuroscience Letters. 290: 197-200. PMID 10963897 DOI: 10.1016/S0304-3940(00)01357-4  0.44
2000 Carlier PR, Lo CW, Lo MM, Wan NC, Williams ID. HMPA promotes retro-aldol reaction, resulting in syn-selective addition of lithiated 1-naphthylacetonitrile to aromatic aldehydes Organic Letters. 2: 2443-5. PMID 10956517  0.44
2000 Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP. Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1. Angewandte Chemie (International Ed. in English). 39: 1775-1777. PMID 10934357 DOI: 10.1002/(SICI)1521-3773(20000515)39:10<1775::AID-ANIE1775>3.0.CO;2-Q  0.44
2000 Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF, Wu D, Xiao X, Pang Y, Han Y. Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]. Neuroscience Letters. 288: 95-8. PMID 10876069 DOI: 10.1016/S0304-3940(00)01198-8  0.44
2000 Liu J, Ho W, Lee NT, Carlier PR, Pang Y, Han Y. Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats. Neuroscience Letters. 282: 165-8. PMID 10717417 DOI: 10.1016/S0304-3940(00)00905-8  0.44
2000 Carlier PR, Lo CWS. 7Li/31P NMR studies of lithiated arylacetonitriles in THF-HMPA solution: Characterization of HMPA-solvated monomers, dimers, and separated ion pairs Journal of the American Chemical Society. 122: 12819-12823. DOI: 10.1021/ja002318x  0.44
1999 Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR. Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities. Bioorganic & Medicinal Chemistry. 7: 2569-75. PMID 10632067 DOI: 10.1016/S0968-0896(99)00178-9  0.44
1999 Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP. Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions. Journal of Medicinal Chemistry. 42: 4225-31. PMID 10514292 DOI: 10.1021/jm990224w  0.44
1999 Carlier PR, Du DM, Han Y, Liu J, Pang YP. Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors. Bioorganic & Medicinal Chemistry Letters. 9: 2335-8. PMID 10476864 DOI: 10.1016/S0960-894X(99)00396-0  0.44
1999 Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF. Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica. 20: 211-7. PMID 10452094  0.44
1999 Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP. Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis. Bioorganic & Medicinal Chemistry. 7: 351-7. PMID 10218828 DOI: 10.1016/S0968-0896(98)00213-2  0.44
1999 Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. Neuroreport. 10: 795-800. PMID 10208550  0.44
1999 Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF. Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE. Neuroreport. 10: 789-93. PMID 10208549  0.44
1998 Carlier PR, Lo MM, Lo PC, Richelson E, Tatsumi M, Reynolds IJ, Sharma TA. Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. Bioorganic & Medicinal Chemistry Letters. 8: 487-92. PMID 9871604 DOI: 10.1016/S0960-894X(98)00062-6  0.44
1998 Carlier PR, Lam WWF, Wan NC, Williams ID. Lithium ephedrinate mediated aldol reaction of arylacetonitriles: Thermodynamic control of enantioselectivity Angewandte Chemie - International Edition. 37: 2252-2254.  0.44
1997 Carlier PR, Lo KM, Lo MMC, Lo PCK, Lo CWS. Synthetic Optimization and Structural Limitations of the Nitrile Aldol Reaction Journal of Organic Chemistry. 62: 6316-6321.  0.44
1997 Carlier PR, Lo KM, Lo MMC, Lam WWF. Development and applicaption of the nitrile aldol reaction Chinese Journal of Organic Chemistry. 17: 57-61.  0.44
1997 Carlier PR, Liu G, Lam HYP. Diastereoselective oxidation of 2,3-epoxy alcohol-derived thiiranes, and 1H NMR analysis of the corresponding thiirane s-oxides Phosphorus, Sulfur and Silicon and Related Elements. 126: 223-234.  0.44
1996 Lockshin MP, Filosa MP, Zuraw MJ, Carlier PR. Formation of a novel sulfonated enedione Journal of Organic Chemistry. 61: 2556-2558.  0.44
1995 Carlier PR, Lo KM, Lo MMC, Williams ID. Anti-selective aldol reaction of benzylic nitrites and synthesis of γ-amino alcohols The Journal of Organic Chemistry. 60: 7511-7517.  0.44
1994 Carlier PR, Lucht BL, Collum DB. 6Li/15N NMR-based solution structural determination of Et2O- and TMEDA-solvated lithiophenylacetonitrile and a LiHMDS mixed aggregate Journal of the American Chemical Society. 116: 11602-11603.  0.44
1994 Carlier PR, Lo KM. 2,3-Anti selective aldol reaction of phenylacetonitrile Journal of Organic Chemistry. 59: 4053-4055.  0.44
1994 Carlier PR, Lockshin MP, Filosa MP. Unexpected regioselectivity in the sulfonation of leuco xanthene dyes Journal of Organic Chemistry. 59: 3232-3236.  0.44
1989 Carlier PR, Sharpless KB. Studies on the mechanism of the asymmetric epoxidation: A ligand variation approach Journal of Organic Chemistry. 54: 4016-4018.  0.44
1988 Carlier PR, Mungall WS, Schröder G, Sharpless KB. Enhanced kinetic resolution and enzyme-like shape selectivity Journal of the American Chemical Society. 110: 2978-2979.  0.44
1988 Caron M, Carlier PR, Sharpless KB. Regioselective azide opening of 2,3-epoxy alcohols by [Ti(O-i-Pr)2(N3)2]: Synthesis of α-amino acids Journal of Organic Chemistry. 53: 5185-5187.  0.44
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