Liping H. Pettus - Publications

Affiliations: 
1990-1995 University of Rochester, Rochester, NY 
 1995-1998 Rensselaer Polytechnic Institute, Troy, NY, United States 
 1998-1999 University of California, Santa Barbara, Santa Barbara, CA, United States 

31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Pettus LH, Andrews KL, Booker SK, Chen J, Cee VJ, Chavez F, Chen Y, Eastwood H, Guerrero N, Herberich BJ, Hickman D, Lanman BA, Laszlo Iii J, Lee MR, Lipford JR, et al. Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable pan-Pim Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 27285051 DOI: 10.1021/acs.jmedchem.6b00610  1
2016 Cee VJ, Chavez F, Herberich B, Lanman BA, Pettus LH, Reed AB, Wu B, Wurz RP, Andrews KL, Chen J, Hickman D, Laszlo J, Lee MR, Guerrero N, Mattson BK, et al. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. Acs Medicinal Chemistry Letters. 7: 408-12. PMID 27096050 DOI: 10.1021/acsmedchemlett.5b00403  1
2015 Wurz RP, Pettus LH, Ashton K, Brown J, Chen JJ, Herberich B, Hong FT, Hu-Harrington E, Nguyen T, St Jean DJ, Tadesse S, Bauer D, Kubryk M, Zhan J, Cooke K, et al. Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors. Acs Medicinal Chemistry Letters. 6: 987-92. PMID 26396685 DOI: 10.1021/acsmedchemlett.5b00193  1
2015 Wu B, Wang HL, Cee VJ, Lanman BA, Nixey T, Pettus L, Reed AB, Wurz RP, Guerrero N, Sastri C, Winston J, Lipford JR, Lee MR, Mohr C, Andrews KL, et al. Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 775-80. PMID 25616902 DOI: 10.1016/j.bmcl.2014.12.091  1
2015 Wurz RP, Pettus LH, Jackson C, Wu B, Wang HL, Herberich B, Cee V, Lanman BA, Reed AB, Chavez F, Nixey T, Laszlo J, Wang P, Nguyen Y, Sastri C, et al. The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 847-55. PMID 25599837 DOI: 10.1016/j.bmcl.2014.12.067  1
2015 Cushing TD, Hao X, Shin Y, Andrews K, Brown M, Cardozo M, Chen Y, Duquette J, Fisher B, Gonzalez-Lopez de Turiso F, He X, Henne KR, Hu YL, Hungate R, Johnson MG, ... ... Pettus LH, et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. Journal of Medicinal Chemistry. 58: 480-511. PMID 25469863 DOI: 10.1021/jm501624r  1
2014 Lanman BA, Reed AB, Cee VJ, Hong FT, Pettus LH, Wurz RP, Andrews KL, Jiang J, McCarter JD, Mullady EL, San Miguel T, Subramanian R, Wang L, Whittington DA, Wu T, et al. Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511. Bioorganic & Medicinal Chemistry Letters. 24: 5630-4. PMID 25466188 DOI: 10.1016/j.bmcl.2014.10.085  1
2012 Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, ... ... Pettus LH, et al. Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511. Journal of Medicinal Chemistry. 55: 7796-816. PMID 22897589 DOI: 10.1021/jm300846z  1
2012 Wurz RP, Liu L, Yang K, Nishimura N, Bo Y, Pettus LH, Caenepeel S, Freeman DJ, McCarter JD, Mullady EL, Miguel TS, Wang L, Zhang N, Andrews KL, Whittington DA, et al. Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold. Bioorganic & Medicinal Chemistry Letters. 22: 5714-20. PMID 22832322 DOI: 10.1016/j.bmcl.2012.06.078  1
2012 Smith AL, D'Angelo ND, Bo YY, Booker SK, Cee VJ, Herberich B, Hong FT, Jackson CL, Lanman BA, Liu L, Nishimura N, Pettus LH, Reed AB, Tadesse S, Tamayo NA, et al. Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases. Journal of Medicinal Chemistry. 55: 5188-219. PMID 22548365 DOI: 10.1021/jm300184s  1
2012 Herberich B, Jackson C, Wurz RP, Pettus LH, Sherman L, Liu Q, Henkle B, Saris CJ, Wong LM, Chmait S, Lee MR, Mohr C, Hsieh F, Tasker AS. Identification of triazolopyridazinones as potent p38α inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1226-9. PMID 22196117 DOI: 10.1016/j.bmcl.2011.11.067  1
2010 Wu B, Wang HL, Pettus L, Wurz RP, Doherty EM, Henkle B, McBride HJ, Saris CJ, Wong LM, Plant MH, Sherman L, Lee MR, Hsieh F, Tasker AS. Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors. Journal of Medicinal Chemistry. 53: 6398-411. PMID 20712346 DOI: 10.1021/jm100567y  1
2010 Pettus LH, Wurz RP, Xu S, Herberich B, Henkle B, Liu Q, McBride HJ, Mu S, Plant MH, Saris CJ, Sherman L, Wong LM, Chmait S, Lee MR, Mohr C, et al. Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. Journal of Medicinal Chemistry. 53: 2973-85. PMID 20218619 DOI: 10.1021/jm100095x  1
2010 Wurz RP, Pettus LH, Henkle B, Sherman L, Plant M, Miner K, McBride HJ, Wong LM, Saris CJ, Lee MR, Chmait S, Mohr C, Hsieh F, Tasker AS. Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorganic & Medicinal Chemistry Letters. 20: 1680-4. PMID 20138761 DOI: 10.1016/j.bmcl.2010.01.059  1
2009 Wurz RP, Pettus LH, Xu S, Henkle B, Sherman L, Plant M, Miner K, McBride H, Wong LM, Saris CJ, Lee MR, Chmait S, Mohr C, Hsieh F, Tasker AS. Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorganic & Medicinal Chemistry Letters. 19: 4724-8. PMID 19574047 DOI: 10.1016/j.bmcl.2009.06.058  1
2009 Pettus T, Pettus L. Intermolecular Applications of o-Quinone Methides (o-QMs) Anionically Generated at Low Temperatures: Kinetic Conditions Quinone Methides. 89-117. DOI: 10.1002/9780470452882.ch4  1
2008 Pettus LH, Wurz RP. Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008. Current Topics in Medicinal Chemistry. 8: 1452-67. PMID 18991731 DOI: 10.2174/156802608786264245  1
2008 Herberich B, Cao GQ, Chakrabarti PP, Falsey JR, Pettus L, Rzasa RM, Reed AB, Reichelt A, Sham K, Thaman M, Wurz RP, Xu S, Zhang D, Hsieh F, Lee MR, et al. Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. Journal of Medicinal Chemistry. 51: 6271-9. PMID 18817365 DOI: 10.1021/jm8005417  1
2008 Pettus LH, Xu S, Cao GQ, Chakrabarti PP, Rzasa RM, Sham K, Wurz RP, Zhang D, Middleton S, Henkle B, Plant MH, Saris CJ, Sherman L, Wong LM, Powers DA, et al. 3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase. Journal of Medicinal Chemistry. 51: 6280-92. PMID 18817364 DOI: 10.1021/jm8005405  1
2007 Wang X, Chakrabarti PP, Ognyanov VI, Pettus LH, Tamir R, Tan H, Tang P, Treanor JJ, Gavva NR, Norman MH. Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility. Bioorganic & Medicinal Chemistry Letters. 17: 6539-45. PMID 17937985 DOI: 10.1016/j.bmcl.2007.09.080  1
2007 Doherty EM, Fotsch C, Bannon AW, Bo Y, Chen N, Dominguez C, Falsey J, Gavva NR, Katon J, Nixey T, Ognyanov VI, Pettus L, Rzasa RM, Stec M, Surapaneni S, et al. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. Journal of Medicinal Chemistry. 50: 3515-27. PMID 17585750 DOI: 10.1021/jm070190p  1
2004 Khim SK, Dai M, Zhang X, Chen L, Pettus L, Thakkar K, Schultz AG. Novel fragmentation reaction of 2-alkyl- and 2,4-dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones. The Journal of Organic Chemistry. 69: 7728-33. PMID 15498003 DOI: 10.1021/jo0490853  1
2004 Wang J, Pettus LH, Pettus TRR. Cycloadditions of o-quinone dimethides with p-quinol derivatives: Regiocontrolled formation of anthracyclic ring systems Tetrahedron Letters. 45: 1793-1796. DOI: 10.1016/j.tetlet.2003.12.114  1
2003 Tempest P, Pettus L, Gore V, Hulme C. MCC/SNAr methodology. Part 2: Novel three-step solution phase access to libraries of benzodiazepines Tetrahedron Letters. 44: 1947-1950. DOI: 10.1016/S0040-4039(03)00084-4  1
2002 Zhang X, Guzi T, Pettus L, Schultz AG. A 6-exo-trig radical cyclization approach to the hydrochrysene skeleton Tetrahedron Letters. 43: 7605-7608. DOI: 10.1016/S0040-4039(02)01728-8  1
2001 Pettus LH, Van De Water RW, Pettus TR. Synthesis of (+/-)-epoxysorbicillinol using a novel cyclohexa-2,5-dienone with synthetic applications to other sorbicillin derivatives. Organic Letters. 3: 905-8. PMID 11263912 DOI: 10.1021/ol0155438  1
2001 Magdziak D, Pettus LH, Pettus TR. Enantioselective hydride abstraction in organic substrates: a novel use for chiral carbenium ions. Organic Letters. 3: 557-9. PMID 11178824 DOI: 10.1021/ol006963k  1
1998 Schlessinger RH, Pettus LH. Asymmetric syn-selective aldol reactions of χ-oxygenated vinylogous urethane with a second generation chiral auxiliary: Application in construction of (+)-3-deoxy-d-manno-2-octulosonic acid Journal of Organic Chemistry. 63: 9089-9094. DOI: 10.1021/jo981916f  1
1998 Schultz AG, Dai M, Khim SK, Pettus L, Thakkar K. Asymmetric synthesis fragmentation reactions of 2-alkyl- and 2,4- dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones. Single enantiomer preparation of Δ(α,β)-butenolides, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones and butyrolactones Tetrahedron Letters. 39: 4203-4206. DOI: 10.1016/S0040-4039(98)00785-0  1
1997 Schultz AG, Pettus L. Desymmetrization of benzoic acid in the context of the asymmetric Birch reduction-alkylation protocol. Asymmetric total syntheses of (-)-eburnamonine and (-)-aspidospermidine Journal of Organic Chemistry. 62: 6855-6861. DOI: 10.1021/jo9707592  1
1997 Schultz AG, Pettus L. Asymmetric synthesis of 4,4-disubstituted-2-cyclohexen-1-ones from a chiral 2-(trimethylsilyl)benzamide Tetrahedron Letters. 38: 5433-5436. DOI: 10.1016/S0040-4039(97)01215-X  1
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