| Year |
Citation |
Score |
| 2009 |
Pettus T, Pettus L. Intermolecular Applications of o-Quinone Methides (o-QMs) Anionically Generated at Low Temperatures: Kinetic Conditions Quinone Methides. 89-117. DOI: 10.1002/9780470452882.ch4 |
0.653 |
|
| 2004 |
Khim SK, Dai M, Zhang X, Chen L, Pettus L, Thakkar K, Schultz AG. Novel fragmentation reaction of 2-alkyl- and 2,4-dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones. The Journal of Organic Chemistry. 69: 7728-33. PMID 15498003 DOI: 10.1021/Jo0490853 |
0.635 |
|
| 2004 |
Wang J, Pettus LH, Pettus TRR. Cycloadditions of o-quinone dimethides with p-quinol derivatives: Regiocontrolled formation of anthracyclic ring systems Tetrahedron Letters. 45: 1793-1796. DOI: 10.1016/J.Tetlet.2003.12.114 |
0.585 |
|
| 2002 |
Zhang X, Guzi T, Pettus L, Schultz AG. A 6-exo-trig radical cyclization approach to the hydrochrysene skeleton Tetrahedron Letters. 43: 7605-7608. DOI: 10.1016/S0040-4039(02)01728-8 |
0.632 |
|
| 2001 |
Pettus LH, Van De Water RW, Pettus TR. Synthesis of (+/-)-epoxysorbicillinol using a novel cyclohexa-2,5-dienone with synthetic applications to other sorbicillin derivatives. Organic Letters. 3: 905-8. PMID 11263912 DOI: 10.1021/Ol0155438 |
0.722 |
|
| 2001 |
Magdziak D, Pettus LH, Pettus TR. Enantioselective hydride abstraction in organic substrates: a novel use for chiral carbenium ions. Organic Letters. 3: 557-9. PMID 11178824 DOI: 10.1021/Ol006963K |
0.568 |
|
| 1998 |
Schlessinger RH, Pettus LH. Asymmetric syn-selective aldol reactions of χ-oxygenated vinylogous urethane with a second generation chiral auxiliary: Application in construction of (+)-3-deoxy-d-manno-2-octulosonic acid Journal of Organic Chemistry. 63: 9089-9094. DOI: 10.1021/jo981916f |
0.679 |
|
| 1998 |
Schultz AG, Dai M, Khim SK, Pettus L, Thakkar K. Asymmetric synthesis fragmentation reactions of 2-alkyl- and 2,4- dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones. Single enantiomer preparation of Δ(α,β)-butenolides, 2-alkyl-4-hydroxy-2-cyclohexen-1-ones and butyrolactones Tetrahedron Letters. 39: 4203-4206. DOI: 10.1016/S0040-4039(98)00785-0 |
0.659 |
|
| 1997 |
Schultz AG, Pettus L. Desymmetrization of benzoic acid in the context of the asymmetric Birch reduction-alkylation protocol. Asymmetric total syntheses of (-)-eburnamonine and (-)-aspidospermidine Journal of Organic Chemistry. 62: 6855-6861. DOI: 10.1021/Jo9707592 |
0.7 |
|
| 1997 |
Schultz AG, Pettus L. Asymmetric synthesis of 4,4-disubstituted-2-cyclohexen-1-ones from a chiral 2-(trimethylsilyl)benzamide Tetrahedron Letters. 38: 5433-5436. DOI: 10.1016/S0040-4039(97)01215-X |
0.642 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2003 |
Tempest P, Pettus L, Gore V, Hulme C. MCC/SNAr methodology. Part 2: Novel three-step solution phase access to libraries of benzodiazepines Tetrahedron Letters. 44: 1947-1950. DOI: 10.1016/S0040-4039(03)00084-4 |
0.222 |
|
| 2007 |
Doherty EM, Fotsch C, Bannon AW, Bo Y, Chen N, Dominguez C, Falsey J, Gavva NR, Katon J, Nixey T, Ognyanov VI, Pettus L, Rzasa RM, Stec M, Surapaneni S, et al. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. Journal of Medicinal Chemistry. 50: 3515-27. PMID 17585750 DOI: 10.1021/jm070190p |
0.117 |
|
| 2008 |
Herberich B, Cao GQ, Chakrabarti PP, Falsey JR, Pettus L, Rzasa RM, Reed AB, Reichelt A, Sham K, Thaman M, Wurz RP, Xu S, Zhang D, Hsieh F, Lee MR, et al. Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. Journal of Medicinal Chemistry. 51: 6271-9. PMID 18817365 DOI: 10.1021/Jm8005417 |
0.108 |
|
| 2012 |
Wurz RP, Liu L, Yang K, Nishimura N, Bo Y, Pettus LH, Caenepeel S, Freeman DJ, McCarter JD, Mullady EL, Miguel TS, Wang L, Zhang N, Andrews KL, Whittington DA, et al. Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold. Bioorganic & Medicinal Chemistry Letters. 22: 5714-20. PMID 22832322 DOI: 10.1016/j.bmcl.2012.06.078 |
0.102 |
|
| 2015 |
Cushing TD, Hao X, Shin Y, Andrews K, Brown M, Cardozo M, Chen Y, Duquette J, Fisher B, Gonzalez-Lopez de Turiso F, He X, Henne KR, Hu YL, Hungate R, Johnson MG, ... ... Pettus LH, et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. Journal of Medicinal Chemistry. 58: 480-511. PMID 25469863 DOI: 10.1021/Jm501624R |
0.098 |
|
| 2012 |
Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, ... ... Pettus LH, et al. Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511. Journal of Medicinal Chemistry. 55: 7796-816. PMID 22897589 DOI: 10.1021/Jm300846Z |
0.091 |
|
| 2015 |
Wu B, Wang HL, Cee VJ, Lanman BA, Nixey T, Pettus L, Reed AB, Wurz RP, Guerrero N, Sastri C, Winston J, Lipford JR, Lee MR, Mohr C, Andrews KL, et al. Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 775-80. PMID 25616902 DOI: 10.1016/J.Bmcl.2014.12.091 |
0.083 |
|
| 2014 |
Lanman BA, Reed AB, Cee VJ, Hong FT, Pettus LH, Wurz RP, Andrews KL, Jiang J, McCarter JD, Mullady EL, San Miguel T, Subramanian R, Wang L, Whittington DA, Wu T, et al. Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511. Bioorganic & Medicinal Chemistry Letters. 24: 5630-4. PMID 25466188 DOI: 10.1016/J.Bmcl.2014.10.085 |
0.083 |
|
| 2010 |
Pettus LH, Wurz RP, Xu S, Herberich B, Henkle B, Liu Q, McBride HJ, Mu S, Plant MH, Saris CJ, Sherman L, Wong LM, Chmait S, Lee MR, Mohr C, et al. Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. Journal of Medicinal Chemistry. 53: 2973-85. PMID 20218619 DOI: 10.1021/jm100095x |
0.078 |
|
| 2010 |
Wu B, Wang HL, Pettus L, Wurz RP, Doherty EM, Henkle B, McBride HJ, Saris CJ, Wong LM, Plant MH, Sherman L, Lee MR, Hsieh F, Tasker AS. Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors. Journal of Medicinal Chemistry. 53: 6398-411. PMID 20712346 DOI: 10.1021/jm100567y |
0.072 |
|
| 2019 |
Wang HL, Andrews K, Booker SK, Canon J, Cee VJ, Chavez F, Chen Y, Eastwood H, Guerrero N, Herberich B, Hickman D, Lanman BA, Laszlo Iii J, Lee MR, Lipford JR, ... ... Pettus LH, et al. Discovery of (R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)-one, a Potent and Selective Pim- 1/2 Kinase Inhibitor for Hematological Malignancies. Journal of Medicinal Chemistry. PMID 30624936 DOI: 10.1021/acs.jmedchem.8b01733 |
0.065 |
|
| 2019 |
Pettus LH, Bourbeau MP, Bradley J, Bartberger MD, Chen K, Hickman D, Johnson M, Liu Q, Manning JR, Nanez A, Siegmund A, Wen PH, Whittington DA, Allen JR, Wood S. The Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in vivo Selectivity over BACE2. Journal of Medicinal Chemistry. PMID 31589043 DOI: 10.1021/Acs.Jmedchem.9B01034 |
0.061 |
|
| 2016 |
Cee VJ, Chavez F, Herberich B, Lanman BA, Pettus LH, Reed AB, Wu B, Wurz RP, Andrews KL, Chen J, Hickman D, Laszlo J, Lee MR, Guerrero N, Mattson BK, et al. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. Acs Medicinal Chemistry Letters. 7: 408-12. PMID 27096050 DOI: 10.1021/Acsmedchemlett.5B00403 |
0.06 |
|
| 2012 |
Smith AL, D'Angelo ND, Bo YY, Booker SK, Cee VJ, Herberich B, Hong FT, Jackson CL, Lanman BA, Liu L, Nishimura N, Pettus LH, Reed AB, Tadesse S, Tamayo NA, et al. Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases. Journal of Medicinal Chemistry. 55: 5188-219. PMID 22548365 DOI: 10.1021/Jm300184S |
0.059 |
|
| 2015 |
Wurz RP, Pettus LH, Jackson C, Wu B, Wang HL, Herberich B, Cee V, Lanman BA, Reed AB, Chavez F, Nixey T, Laszlo J, Wang P, Nguyen Y, Sastri C, et al. The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 847-55. PMID 25599837 DOI: 10.1016/J.Bmcl.2014.12.067 |
0.05 |
|
| 2008 |
Pettus LH, Xu S, Cao GQ, Chakrabarti PP, Rzasa RM, Sham K, Wurz RP, Zhang D, Middleton S, Henkle B, Plant MH, Saris CJ, Sherman L, Wong LM, Powers DA, et al. 3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase. Journal of Medicinal Chemistry. 51: 6280-92. PMID 18817364 DOI: 10.1021/jm8005405 |
0.05 |
|
| 2012 |
Herberich B, Jackson C, Wurz RP, Pettus LH, Sherman L, Liu Q, Henkle B, Saris CJ, Wong LM, Chmait S, Lee MR, Mohr C, Hsieh F, Tasker AS. Identification of triazolopyridazinones as potent p38α inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1226-9. PMID 22196117 DOI: 10.1016/j.bmcl.2011.11.067 |
0.049 |
|
| 2010 |
Wurz RP, Pettus LH, Henkle B, Sherman L, Plant M, Miner K, McBride HJ, Wong LM, Saris CJ, Lee MR, Chmait S, Mohr C, Hsieh F, Tasker AS. Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorganic & Medicinal Chemistry Letters. 20: 1680-4. PMID 20138761 DOI: 10.1016/j.bmcl.2010.01.059 |
0.044 |
|
| 2016 |
Pettus LH, Andrews KL, Booker SK, Chen J, Cee VJ, Chavez F, Chen Y, Eastwood H, Guerrero N, Herberich BJ, Hickman D, Lanman BA, Laszlo Iii J, Lee MR, Lipford JR, et al. Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable pan-Pim Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 27285051 DOI: 10.1021/Acs.Jmedchem.6B00610 |
0.043 |
|
| 2008 |
Pettus LH, Wurz RP. Small molecule p38 MAP kinase inhibitors for the treatment of inflammatory diseases: novel structures and developments during 2006-2008. Current Topics in Medicinal Chemistry. 8: 1452-67. PMID 18991731 DOI: 10.2174/156802608786264245 |
0.036 |
|
| 2022 |
Tamayo NA, Bourbeau MP, Allen JR, Ashton KS, Chen JJ, Kaller MR, Nguyen TT, Nishimura N, Pettus LH, Walton M, Belmontes B, Moriguchi J, Chen K, McCarter JD, Hanestad K, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. Journal of Medicinal Chemistry. PMID 35286090 DOI: 10.1021/acs.jmedchem.1c02030 |
0.033 |
|
| 2009 |
Wurz RP, Pettus LH, Xu S, Henkle B, Sherman L, Plant M, Miner K, McBride H, Wong LM, Saris CJ, Lee MR, Chmait S, Mohr C, Hsieh F, Tasker AS. Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorganic & Medicinal Chemistry Letters. 19: 4724-8. PMID 19574047 DOI: 10.1016/j.bmcl.2009.06.058 |
0.033 |
|
| 2007 |
Wang X, Chakrabarti PP, Ognyanov VI, Pettus LH, Tamir R, Tan H, Tang P, Treanor JJ, Gavva NR, Norman MH. Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility. Bioorganic & Medicinal Chemistry Letters. 17: 6539-45. PMID 17937985 DOI: 10.1016/j.bmcl.2007.09.080 |
0.03 |
|
| 2016 |
Wurz RP, Sastri C, D'Amico DC, Herberich B, Jackson CL, Pettus LH, Tasker AS, Wu B, Guerrero N, Lipford JR, Winston JT, Yang Y, Wang P, Nguyen Y, Andrews KL, et al. Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27769621 DOI: 10.1016/j.bmcl.2016.09.067 |
0.025 |
|
| 2015 |
Wurz RP, Pettus LH, Ashton K, Brown J, Chen JJ, Herberich B, Hong FT, Hu-Harrington E, Nguyen T, St Jean DJ, Tadesse S, Bauer D, Kubryk M, Zhan J, Cooke K, et al. Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors. Acs Medicinal Chemistry Letters. 6: 987-92. PMID 26396685 DOI: 10.1021/acsmedchemlett.5b00193 |
0.018 |
|
| Hide low-probability matches. |