Steven Douglas Bruner - Publications

Affiliations: 
2000 Harvard University, Cambridge, MA, United States 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Joshi J, Li Q, García-García JD, Leong BJ, Hu Y, Bruner SD, Hanson AD. Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases. The Biochemical Journal. PMID 34409984 DOI: 10.1042/BCJ20210565  1
2021 Patel KP, Silsby LM, Li G, Bruner SD. Structure-Based Engineering of Peptide Macrocyclases for the Chemoenzymatic Synthesis of Microviridins. The Journal of Organic Chemistry. PMID 34263606 DOI: 10.1021/acs.joc.1c00785  1
2021 Pastore AJ, Teo RD, Montoya A, Burg MJ, Twahir UT, Bruner SD, Beratan DN, Angerhofer A. Oxalate Decarboxylase uses Electron Hole Hopping for Catalysis. The Journal of Biological Chemistry. 100857. PMID 34097877 DOI: 10.1016/j.jbc.2021.100857  0.04
2021 Tripathi P, Bruner SD. Structural Basis for the Interactions of the Colibactin Resistance Gene Product ClbS with DNA. Biochemistry. PMID 33945270 DOI: 10.1021/acs.biochem.1c00201  1
2020 Zhang P, MacTavish BS, Yang G, Chen M, Roh J, Newsome KR, Bruner SD, Ding Y. Cyanobacterial Dihydroxyacid Dehydratases Are a Promising Growth Inhibition Target. Acs Chemical Biology. PMID 32786290 DOI: 10.1021/Acschembio.0C00507  1
2020 Patterson JA, He H, Folz JS, Li Q, Wilson MA, Fiehn O, Bruner SD, Bar-Even A, Hanson AD. Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli. The Biochemical Journal. PMID 32301498 DOI: 10.1042/Bcj20200198  1
2019 Niehaus TD, Patterson JA, Alexander DC, Folz JS, Pyc M, MacTavish BS, Bruner SD, Mullen RT, Fiehn O, Hanson AD. The metabolite repair enzyme Nit1 is a dual-targeted amidase that disposes of damaged glutathione in . The Biochemical Journal. PMID 30692244 DOI: 10.1042/Bcj20180931  1
2018 Zhang Y, Chen M, Bruner SD, Ding Y. Heterologous Production of Microbial Ribosomally Synthesized and Post-translationally Modified Peptides. Frontiers in Microbiology. 9: 1801. PMID 30135682 DOI: 10.3389/Fmicb.2018.01801  1
2018 Beaudoin GAW, Li Q, Folz J, Fiehn O, Goodsell JL, Angerhofer A, Bruner SD, Hanson AD. Salvage of the 5-deoxyribose byproduct of radical SAM enzymes. Nature Communications. 9: 3105. PMID 30082730 DOI: 10.1038/S41467-018-05589-4  1
2018 Hanson AD, Amthor JS, Sun J, Niehaus TD, Gregory JF, Bruner SD, Ding Y. Redesigning thiamin synthesis: Prospects and potential payoffs. Plant Science : An International Journal of Experimental Plant Biology. 273: 92-99. PMID 29907313 DOI: 10.1016/J.Plantsci.2018.01.019  1
2018 Zhang Y, Li K, Yang G, McBride JL, Bruner SD, Ding Y. A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate. Nature Communications. 9: 1780. PMID 29725007 DOI: 10.1038/S41467-018-04154-3  1
2018 Sun X, Winglee K, Gharaibeh RZ, Gauthier J, He Z, Tripathi P, Avram D, Bruner S, Fodor A, Jobin C. Microbiota-derived Metabolic Factors Reduce Campylobacteriosis in Mice. Gastroenterology. PMID 29408609 DOI: 10.1053/J.Gastro.2018.01.042  1
2017 Beaudoin GA, Li Q, Bruner SD, Hanson AD. An Unusual Diphosphatase from the PhnP Family Cleaves Reactive FAD Photoproducts. The Biochemical Journal. PMID 29229761 DOI: 10.1042/Bcj20170817  1
2017 Tripathi P, Shine EE, Healy AR, Kim CS, Herzon SB, Bruner SD, Crawford JM. ClbS is a cyclopropane hydrolase that confers colibactin resistance. Journal of the American Chemical Society. PMID 29112397 DOI: 10.1021/Jacs.7B09971  1
2017 Sun J, Jeffryes JG, Henry CS, Bruner SD, Hanson AD. Metabolite damage and repair in metabolic engineering design. Metabolic Engineering. PMID 29030275 DOI: 10.1016/J.Ymben.2017.10.006  1
2017 Guntaka NS, Healy AR, Crawford JM, Herzon SB, Bruner SD. Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway. Acs Chemical Biology. PMID 28846367 DOI: 10.1021/Acschembio.7B00479  1
2017 Zhang P, Li K, Yang G, Xia C, Polston JE, Li G, Li S, Lin Z, Yang LJ, Bruner SD, Ding Y. Cytotoxic protein from the mushroom Coprinus comatus possesses a unique mode for glycan binding and specificity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28784797 DOI: 10.1073/Pnas.1706894114  1
2017 Thamm AM, Li G, Taja-Moreno M, Gerdes SY, de Crécy-Lagard V, Bruner SD, Hanson AD. A strictly monofunctional bacterial hydroxymethylpyrimidine phosphate kinase precludes damaging errors in thiamin biosynthesis. The Biochemical Journal. PMID 28729425 DOI: 10.1042/Bcj20170437  1
2017 Li K, Fielding EN, Condurso HL, Bruner SD. Probing the structural basis of oxygen binding in a cofactor-independent dioxygenase. Acta Crystallographica. Section D, Structural Biology. 73: 573-580. PMID 28695857 DOI: 10.1107/S2059798317007045  1
2017 Zuo R, Zhang Y, Jiang C, Hackett JC, Loria R, Bruner SD, Ding Y. Engineered P450 biocatalysts show improved activity and regio-promiscuity in aromatic nitration. Scientific Reports. 7: 842. PMID 28405004 DOI: 10.1038/S41598-017-00897-Z  1
2017 Zallot R, Ross R, Chen WH, Bruner SD, Limbach PA, De Crecy-Lagard V. Identification of a novel epoxyqueuosine reductase family by comparative genomics. Acs Chemical Biology. PMID 28128549 DOI: 10.1021/Acschembio.6B01100  1
2017 Luo Z, Ren H, Mousa JJ, Rangel D, Zhang Y, Bruner SD, Keyhani NO. The PacC transcription factor regulates secondary metabolite production, stress response, but has only minor effects on virulence in the insect pathogenic fungus Beauveria bassiana. Environmental Microbiology. PMID 28083986 DOI: 10.1111/1462-2920.13648  1
2016 Mousa JJ, Newsome RC, Yang Y, Jobin C, Bruner SD. ClbM is a versatile, cation-promiscuous MATE multi-drug transporter found in the colibactin biosynthetic gene cluster. Biochemical and Biophysical Research Communications. PMID 27939886 DOI: 10.1016/J.Bbrc.2016.12.018  1
2016 Li K, Condurso HL, Li G, Ding Y, Bruner SD. Structural basis for precursor protein-directed ribosomal peptide macrocyclization. Nature Chemical Biology. PMID 27669417 DOI: 10.1038/Nchembio.2200  1
2016 Mousa JJ, Yang Y, Tomkovich S, Shima A, Newsome RC, Tripathi P, Oswald E, Bruner SD, Jobin C. MATE transport of the E. coli-derived genotoxin colibactin. Nature Microbiology. 1: 15009. PMID 27571755 DOI: 10.1038/Nmicrobiol.2015.9  1
2016 Zhang X, Li K, Jones RA, Bruner SD, Butcher RA. Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. PMID 27551084 DOI: 10.1073/Pnas.1608262113  1
2016 Mousa JJ, Bruner SD. Structural and mechanistic diversity of multidrug transporters. Natural Product Reports. PMID 27472662 DOI: 10.1039/C6Np00006A  1
2016 Chen WH, Li K, Guntaka NS, Bruner SD. Interdomain and intermodule organization in epimerization domain containing nonribosomal peptide synthetases. Acs Chemical Biology. PMID 27294598 DOI: 10.1021/Acschembio.6B00332  1
2016 Li K, Chen WH, Bruner SD. Microbial siderophore-based iron assimilation and therapeutic applications. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. PMID 27146331 DOI: 10.1007/S10534-016-9935-3  1
2016 Bruner SD, Jobin C. Intestinal microbiota in inflammatory bowel disease and carcinogenesis: Implication for therapeutics. Clinical Pharmacology and Therapeutics. PMID 26850686 DOI: 10.1002/Cpt.348  1
2016 Zuo R, Zhang Y, Huguet-Tapia JC, Mehta M, Dedic E, Bruner SD, Loria R, Ding Y. An artificial self-sufficient cytochrome P450 directly nitrates fluorinated tryptophan analogs with a different regio-selectivity. Biotechnology Journal. PMID 26743860 DOI: 10.1002/Biot.201500416  1
2015 Li K, Li G, Bradbury LM, Hanson AD, Bruner SD. Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli. The Biochemical Journal. PMID 26564203 DOI: 10.1042/Bj20150980  1
2015 Li K, Bruner SD. Structure and functional analysis of the siderophore periplasmic binding protein from the fuscachelin gene cluster of Thermobifida fusca. Proteins. PMID 26537767 DOI: 10.1002/Prot.24959  1
2015 Di Russo NV, Condurso HL, Li K, Bruner SD, Roitberg AE. Oxygen diffusion pathways in a cofactor-independent dioxygenase. Chemical Science (Royal Society of Chemistry : 2010). 6: 6341-6348. PMID 26508997 DOI: 10.1039/C5Sc01638J  1
2015 Li K, Chen WH, Bruner SD. Structure and Mechanism of the Siderophore-Interacting Protein from the Fuscachelin Gene Cluster of Thermobifida fusca. Biochemistry. 54: 3989-4000. PMID 26043104 DOI: 10.1021/Acs.Biochem.5B00354  1
2015 Di Russo NV, Bruner SD, Roitberg AE. Applicability of fluorescence-based sensors to the determination of kinetic parameters for O₂ in oxygenases. Analytical Biochemistry. 475: 53-5. PMID 25637681 DOI: 10.1016/J.Ab.2015.01.009  1
2015 Luo Z, Li Y, Mousa J, Bruner S, Zhang Y, Pei Y, Keyhani NO. Bbmsn2 acts as a pH-dependent negative regulator of secondary metabolite production in the entomopathogenic fungus Beauveria bassiana. Environmental Microbiology. 17: 1189-202. PMID 24965521 DOI: 10.1111/1462-2920.12542  1
2012 Condurso HL, Bruner SD. Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery. Natural Product Reports. 29: 1099-110. PMID 22729219 DOI: 10.1039/C2Np20023F  1
2012 Dimise EJ, Condurso HL, Stoker GE, Bruner SD. Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca. Organic & Biomolecular Chemistry. 10: 5353-6. PMID 22688132 DOI: 10.1039/C2Ob26010G  1
2012 Condurso HL, Bruner SD. Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways. Current Opinion in Chemical Biology. 16: 162-9. PMID 22369855 DOI: 10.1016/J.Cbpa.2012.02.002  1
2011 Liu Y, Zheng T, Bruner SD. Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. Chemistry & Biology. 18: 1482-8. PMID 22118682 DOI: 10.1016/J.Chembiol.2011.09.018  1
2011 Bruner SD. Enzyme catalysis: C-H activation is a Reiske business. Nature Chemistry. 3: 342-3. PMID 21505488 DOI: 10.1038/Nchem.1038  1
2010 Cooke HA, Bruner SD. Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites. Biopolymers. 93: 802-10. PMID 20577998 DOI: 10.1002/Bip.21500  1
2010 Dimise EJ, Bruner SD. Biosynthesis: unmasking morphine. Nature Chemical Biology. 6: 251-2. PMID 20300094 DOI: 10.1038/Nchembio.334  1
2010 Montavon TJ, Bruner SD. Nonribosomal peptide synthetases Comprehensive Natural Products Ii: Chemistry and Biology. 5: 619-655.  1
2009 Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry. 48: 9590-8. PMID 19702337 DOI: 10.1021/Bi901257Q  1
2009 Cooke HA, Christianson CV, Bruner SD. Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes. Current Opinion in Chemical Biology. 13: 460-8. PMID 19620019 DOI: 10.1016/J.Cbpa.2009.06.013  1
2009 Widboom PF, Bruner SD. Complex oxidation chemistry in the biosynthetic pathways to vancomycin/teicoplanin antibiotics. Chembiochem : a European Journal of Chemical Biology. 10: 1757-64. PMID 19533699 DOI: 10.1002/Cbic.200900117  1
2008 Dimise EJ, Widboom PF, Bruner SD. Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca. Proceedings of the National Academy of Sciences of the United States of America. 105: 15311-6. PMID 18832174 DOI: 10.1073/Pnas.0805451105  1
2008 Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B. Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. The Journal of Biological Chemistry. 283: 14694-702. PMID 18387946 DOI: 10.1074/Jbc.M802206200  1
2008 Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD. Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. Bioorganic & Medicinal Chemistry Letters. 18: 3099-102. PMID 18078753 DOI: 10.1016/J.Bmcl.2007.11.046  1
2007 Christianson CV, Montavon TJ, Festin GM, Cooke HA, Shen B, Bruner SD. The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis. Journal of the American Chemical Society. 129: 15744-5. PMID 18052279 DOI: 10.1021/Ja0762689  1
2007 Fielding EN, Widboom PF, Bruner SD. Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC. Biochemistry. 46: 13994-4000. PMID 18004875 DOI: 10.1021/Bi701148B  1
2007 Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD. Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Journal of the American Chemical Society. 129: 7728-9. PMID 17539640 DOI: 10.1021/Ja071886A  1
2007 Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD. The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 46: 7205-14. PMID 17516659 DOI: 10.1021/Bi7003685  1
2007 Widboom PF, Fielding EN, Liu Y, Bruner SD. Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis. Nature. 447: 342-5. PMID 17507985 DOI: 10.1038/Nature05702  1
2007 Liu Y, Bruner SD. Rational manipulation of carrier-domain geometry in nonribosomal peptide synthetases. Chembiochem : a European Journal of Chemical Biology. 8: 617-21. PMID 17335097 DOI: 10.1002/Cbic.200700010  1
2004 Tseng CC, Vaillancourt FH, Bruner SD, Walsh CT. DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway. Chemistry & Biology. 11: 1195-203. PMID 15380180 DOI: 10.1016/J.Chembiol.2004.06.012  1
2004 Yeh E, Kohli RM, Bruner SD, Walsh CT. Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated. Chembiochem : a European Journal of Chemical Biology. 5: 1290-3. PMID 15368584 DOI: 10.1002/Cbic.200400077  1
2003 Fromme JC, Bruner SD, Yang W, Karplus M, Verdine GL. Product-assisted catalysis in base-excision DNA repair. Nature Structural Biology. 10: 204-11. PMID 12592398 DOI: 10.1038/Nsb902  1
2002 Tseng CC, Bruner SD, Kohli RM, Marahiel MA, Walsh CT, Sieber SA. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry. 41: 13350-9. PMID 12416979 DOI: 10.1021/Bi026592A  1
2002 Bruner SD, Weber T, Kohli RM, Schwarzer D, Marahiel MA, Walsh CT, Stubbs MT. Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure (London, England : 1993). 10: 301-10. PMID 12005429 DOI: 10.1016/S0969-2126(02)00716-5  1
2001 Norman DP, Bruner SD, Verdine GL. Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. Journal of the American Chemical Society. 123: 359-60. PMID 11456534 DOI: 10.1021/Ja003144M  1
2000 Bruner SD, Norman DP, Fromme JC, Verdine GL. Structural and mechanistic studies on repair of 8-oxoguanine in mammalian cells. Cold Spring Harbor Symposia On Quantitative Biology. 65: 103-11. PMID 12760025 DOI: 10.1101/Sqb.2000.65.103  1
2000 Sekino Y, Bruner SD, Verdine GL. Selective inhibition of herpes simplex virus type-1 uracil-DNA glycosylase by designed substrate analogs. The Journal of Biological Chemistry. 275: 36506-8. PMID 11084051 DOI: 10.1074/Jbc.C000585200  1
2000 Bruner SD, Norman DP, Verdine GL. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature. 403: 859-66. PMID 10706276 DOI: 10.1038/35002510  1
2000 Dobson JW, Harrison JC, Hale AH, Lau HC, Bernardi LA, Kielty JM, Albrecht MS, Bruner SD. Laboratory development and field application of a novel water-based drill-in fluid for geopressured horizontal wells Spe Drilling and Completion. 15: 105-111.  1
1998 Bruner SD, Nash HM, Lane WS, Verdine GL. Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway. Current Biology : Cb. 8: 393-403. PMID 9545197 DOI: 10.1016/S0960-9822(98)70158-7  1
1997 Radeke HS, Digits CA, Bruner SD, Snapper ML. New Tools for Studying Vesicular-Mediated Protein Trafficking: Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay. The Journal of Organic Chemistry. 62: 2823-2831. PMID 11671645 DOI: 10.1021/Jo962292L  1
1997 Verdine GL, Bruner SD. How do DNA repair proteins locate damaged bases in the genome? Chemistry & Biology. 4: 329-34. PMID 9195879 DOI: 10.1016/S1074-5521(97)90123-X  1
1997 Bruner SD, Lau HC, Morgenthaler LA, Bernardi LA, Kielty JM. Long-zone squeeze gravel packs in geopressured reservoirs in the Gulf of Mexico Spe Drilling and Completion. 12: 93-98.  1
1997 Bruner SD. Chemical biology of una repair Faseb Journal. 11: A1292.  1
1996 Nash HM, Bruner SD, Schärer OD, Kawate T, Addona TA, Spooner E, Lane WS, Verdine GL. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Current Biology : Cb. 6: 968-80. PMID 8805338 DOI: 10.1016/S0960-9822(02)00641-3  1
1995 Bruner SD, Radeke HS, Tallarico JA, Snapper ML. Total synthesis of (-)-ilimaquinone Journal of Organic Chemistry. 60: 1114-1115. DOI: 10.1021/Jo00110A010  1
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