Kent S. Gates, Ph.D. - Publications

Affiliations: 
1993- Chemistry University of Missouri, Columbia, MO 
Area:
Medicinal Chemistry
Website:
http://faculty.missouri.edu/~gatesk/index.html

129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Laciak AR, Korasick DA, Gates KS, Tanner JJ. Structural Analysis of Pathogenic Mutations Targeting Glu427 of ALDH7A1, the Hot Spot Residue of Pyridoxine-Dependent Epilepsy. Journal of Inherited Metabolic Disease. PMID 31652343 DOI: 10.1002/jimd.12184  0.36
2019 Laciak AR, Korasick DA, Wyatt JW, Gates KS, Tanner JJ. Structural and Biochemical Consequences of Pyridoxine-Dependent Epilepsy Mutations That Target the Aldehyde Binding Site of Aldehyde Dehydrogenase ALDH7A1. The Febs Journal. PMID 31302938 DOI: 10.1111/febs.14997  0.36
2019 Nejad MI, Price NE, Haldar T, Lewis C, Wang Y, Gates KS. Interstrand DNA Cross-Links Derived from Reaction of a 2-Aminopurine Residue with an Abasic Site. Acs Chemical Biology. PMID 31259519 DOI: 10.1021/acschembio.9b00208  0.44
2019 Nejad MI, Guo X, Housh K, Nel C, Yang Z, Price NE, Wang Y, Gates KS. Preparation and Purification of Oligodeoxynucleotide Duplexes Containing a Site-Specific, Reduced, Chemically Stable Covalent Interstrand Cross-Link Between a Guanine Residue and an Abasic Site. Methods in Molecular Biology (Clifton, N.J.). 1973: 163-175. PMID 31016701 DOI: 10.1007/978-1-4939-9216-4_10  0.44
2018 Shen X, Laber CH, Sarkar U, Gallazzi F, Johnson KM, Mahieu NG, Hillebrand R, Fuchs-Knotts T, Barnes CL, Baker GA, Gates KS. Exploiting the inherent photophysical properties of the major tirapazamine metabolite in the development of profluorescent substrates for enzymes that catalyze the bioreductive activation of hypoxia-selective anticancer prodrugs. The Journal of Organic Chemistry. PMID 29461834 DOI: 10.1021/acs.joc.7b03035  0.96
2017 Korasick D, Wyatt J, Luo M, Laciak AR, Ruddraraju K, Gates KS, Henzl MT, Tanner JJ. Importance of the C-terminus of ALDH7A1 for Oligomerization and Catalytic Activity. Biochemistry. PMID 29045138 DOI: 10.1021/acs.biochem.7b00803  0.36
2017 Wang Y, Tian K, Shi R, Gu A, Pennella M, Alberts L, Gates KS, Li G, Fan H, Wang MX, Gu LQ. Nanolock-Nanopore Facilitated Digital Diagnostics of Cancer Driver Mutation in Tumor Tissue. Acs Sensors. 2: 975-981. PMID 28750524 DOI: 10.1021/acssensors.7b00235  0.44
2017 Yang Z, Price NE, Johnson KM, Wang Y, Gates KS. Interstrand cross-links arising from strand breaks at true abasic sites in duplex DNA. Nucleic Acids Research. PMID 28531327 DOI: 10.1093/nar/gkx394  0.44
2017 Sarkar U, Hillebrand R, Johnson KM, Cummings AH, Phung NL, Rajapakse A, Zhou H, Willis JR, Barnes CL, Gates KS. Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine. Journal of Heterocyclic Chemistry. 54: 155-160. PMID 28439141 DOI: 10.1002/jhet.2559  0.96
2017 Price NE, Li L, Gates KS, Wang Y. Replication and repair of a reduced 2΄-deoxyguanosine-abasic site interstrand cross-link in human cells. Nucleic Acids Research. PMID 28431012 DOI: 10.1093/nar/gkx266  0.44
2017 Punthasee P, Laciak AR, Cummings AH, Ruddraraju KV, Lewis SM, Hillebrand R, Singh H, Tanner JJ, Gates KS. Covalent allosteric inactivation of PTP1B by an inhibitor-electrophile conjugate. Biochemistry. PMID 28345882 DOI: 10.1021/acs.biochem.7b00151  0.8
2017 Yang Z, Nejad MI, Varela JG, Price NE, Wang Y, Gates KS. A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites. Dna Repair. PMID 28262582 DOI: 10.1016/j.dnarep.2017.02.011  0.44
2017 Ruddraraju KV, Parsons ZD, Lewis CD, Gates KS. Correction to "Allylation and Alkylation of Biologically Relevant Nucleophiles by Diallyl Sulfides". The Journal of Organic Chemistry. PMID 28170252 DOI: 10.1021/acs.joc.7b00246  0.36
2016 Nejad MI, Johnson KM, Price NE, Gates KS. A New Cross-Link for an Old Cross-Linking Drug: The Nitrogen Mustard Anticancer Agent Mechlorethamine Generates Cross-Links Derived from Abasic Sites in Addition to the Expected Drug-Bridged Cross-Links. Biochemistry. 55: 7033-7041. PMID 27992994 DOI: 10.1021/acs.biochem.6b01080  0.44
2016 Viswanatharaju Ruddraraju K, Parsons ZD, Lewis CD, Gates KS. Allylation and Alkylation of Biologically Relevant Nucleophiles by Diallyl Sulfides. The Journal of Organic Chemistry. PMID 27973787 DOI: 10.1021/acs.joc.6b02517  0.36
2016 Catalano MJ, Ruddraraju KV, Barnes CL, Gates KS. Crystal structure of a nucleoside model for the inter-strand cross-link formed by the reaction of 2'-de-oxy-guanosine and an abasic site in duplex DNA. Acta Crystallographica. Section E, Crystallographic Communications. 72: 624-7. PMID 27308004 DOI: 10.1107/S205698901600517X  0.56
2016 Parsons ZD, Ruddraraju KV, Santo N, Gates KS. Sulfone-stabilized carbanions for the reversible covalent capture of a posttranslationally-generated cysteine oxoform found in protein tyrosine phosphatase 1B (PTP1B). Bioorganic & Medicinal Chemistry. PMID 27132865 DOI: 10.1016/j.bmc.2016.03.054  1
2016 Catalano MJ, Price NE, Gates KS. Effective molarity in a nucleic acid-controlled reaction. Bioorganic & Medicinal Chemistry Letters. PMID 27117430 DOI: 10.1016/j.bmcl.2016.04.022  1
2015 Zhang X, Xu X, Yang Z, Burcke AJ, Gates KS, Chen SJ, Gu LQ. Vectorial unfolding of RNA pseudoknot in a protein channel. Journal of the American Chemical Society. PMID 26595106 DOI: 10.1021/jacs.5b07910  1
2015 Zhang X, Price NE, Fang X, Yang Z, Gu LQ, Gates KS. Characterization of Interstrand DNA-DNA Cross-Links Using the α-Hemolysin Protein Nanopore. Acs Nano. PMID 26563913 DOI: 10.1021/acsnano.5b03923  1
2015 Ruddraraju KV, Parsons ZD, Llufrio EM, Frost NL, Gates KS. Reactions of 1,3-Diketones with a Dipeptide Isothiazolidin-3-one: Toward Agents That Covalently Capture Oxidized Protein Tyrosine Phosphatase 1B (PTP1B). The Journal of Organic Chemistry. PMID 26517018 DOI: 10.1021/acs.joc.5b01949  1
2015 Lewis SM, Li Y, Catalano MJ, Laciak AR, Singh H, Seiner DR, Reilly TJ, Tanner JJ, Gates KS. Inactivation of protein tyrosine phosphatases by dietary isothiocyanates. Bioorganic & Medicinal Chemistry Letters. PMID 26338358 DOI: 10.1016/j.bmcl.2015.08.065  1
2015 Ruddraraju KV, Hillebrand R, Barnes CL, Gates KS. Crystal structure of methyl (S)-2-{(R)-4-[(tert-but-oxy-carbon-yl)amino]-3-oxo-1,2-thia-zolidin-2-yl}-3-methyl-butano-ate: a chemical model for oxidized protein tyrosine phosphatase 1B (PTP1B). Acta Crystallographica. Section E, Crystallographic Communications. 71: 741-3. PMID 26279856 DOI: 10.1107/S2056989015010051  0.56
2015 Yang Z, Price NE, Johnson KM, Gates KS. Characterization of interstrand DNA-DNA cross-links derived from abasic sites using bacteriophage φ29 DNA polymerase. Biochemistry. PMID 26103998 DOI: 10.1021/acs.biochem.5b00482  1
2015 Ruddraraju KV, Hillebrand R, Barnes CL, Gates KS. Crystal structure of 5-{4'-[(2-{2-[2-(2-ammonio-eth-oxy)eth-oxy]eth-oxy}eth-yl)carbamo-yl]-4-meth-oxy-[1,1'-biphen-yl]-3-yl}-3-oxo-1,2,5-thia-diazo-lidin-2-ide 1,1-dioxide: a potential inhibitor of the enzyme protein tyrosine phosphatase 1B (PTP1B). Acta Crystallographica. Section E, Crystallographic Communications. 71: 336-8. PMID 26029383 DOI: 10.1107/S2056989015003850  1
2015 Gamboa Varela J, Gates KS. A simple, high-yield synthesis of DNA duplexes containing a covalent, thermally cleavable interstrand cross-link at a defined location. Angewandte Chemie (International Ed. in English). 54: 7666-9. PMID 25967397 DOI: 10.1002/anie.201502566  1
2015 Glaser R, Hillebrand R, Wycoff W, Camasta C, Gates KS. Near-silence of isothiocyanate carbon in (13)C NMR spectra: a case study of allyl isothiocyanate. The Journal of Organic Chemistry. 80: 4360-9. PMID 25882372 DOI: 10.1021/acs.joc.5b00080  1
2015 Price NE, Catalano MJ, Liu S, Wang Y, Gates KS. Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA. Nucleic Acids Research. 43: 3434-41. PMID 25779045 DOI: 10.1093/nar/gkv174  0.44
2015 Catalano MJ, Liu S, Andersen N, Yang Z, Johnson KM, Price NE, Wang Y, Gates KS. Chemical structure and properties of interstrand cross-links formed by reaction of guanine residues with abasic sites in duplex DNA. Journal of the American Chemical Society. 137: 3933-45. PMID 25710271 DOI: 10.1021/jacs.5b00669  1
2015 Sinha S, Shen X, Gallazzi F, Li Q, Zmijewski JW, Lancaster JR, Gates KS. Generation of Reactive Oxygen Species Mediated by 1-Hydroxyphenazine, a Virulence Factor of Pseudomonas aeruginosa. Chemical Research in Toxicology. PMID 25590513 DOI: 10.1021/tx500259s  1
2015 Luo M, Gates KS, Henzl MT, Tanner JJ. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. Acs Chemical Biology. 10: 693-7. PMID 25554827 DOI: 10.1021/cb500977q  0.36
2015 Price NE, Catalano MJ, Liu S, Wang Y, Gates KS. Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA Nucleic Acids Research. 43: 3434-3441. DOI: 10.1093/nar/gkv174  1
2014 Rajapakse A, Hillebrand R, Lewis SM, Parsons ZD, Barnes CL, Gates KS. Crystal structure of N-(quinolin-6-yl)hydroxyl-amine. Acta Crystallographica. Section E, Structure Reports Online. 70: 322-4. PMID 25484734 DOI: 10.1107/S160053681402193X  1
2014 Melton D, Lewis CD, Price NE, Gates KS. Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double- and single-stranded DNA. Chemical Research in Toxicology. 27: 2113-8. PMID 25405892 DOI: 10.1021/tx5003657  1
2014 Wang Y, Luan BQ, Yang Z, Zhang X, Ritzo B, Gates K, Gu LQ. Single molecule investigation of Ag+ interactions with single cytosine-, methylcytosine- and hydroxymethylcytosine-cytosine mismatches in a nanopore. Scientific Reports. 4: 5883. PMID 25103463 DOI: 10.1038/srep05883  1
2014 Johnson KM, Parsons ZD, Barnes CL, Gates KS. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). The Journal of Organic Chemistry. 79: 7520-31. PMID 25029663 DOI: 10.1021/jo501252p  1
2014 Gates KS. Natural products: DNA double whammy. Nature Chemistry. 6: 464-5. PMID 24848229 DOI: 10.1038/nchem.1965  1
2014 Price NE, Johnson KM, Wang J, Fekry MI, Wang Y, Gates KS. Interstrand DNA-DNA cross-link formation between adenine residues and abasic sites in duplex DNA. Journal of the American Chemical Society. 136: 3483-90. PMID 24506784 DOI: 10.1021/ja410969x  1
2014 Shen X, Rajapakse A, Gallazzi F, Junnotula V, Fuchs-Knotts T, Glaser R, Gates KS. Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide. Chemical Research in Toxicology. 27: 111-8. PMID 24328261 DOI: 10.1021/tx400356y  1
2013 Parsons ZD, Gates KS. Thiol-dependent recovery of catalytic activity from oxidized protein tyrosine phosphatases. Biochemistry. 52: 6412-23. PMID 23957891 DOI: 10.1021/bi400451m  1
2013 Parsons ZD, Gates KS. Redox regulation of protein tyrosine phosphatases: methods for kinetic analysis of covalent enzyme inactivation. Methods in Enzymology. 528: 129-54. PMID 23849863 DOI: 10.1016/B978-0-12-405881-1.00008-2  1
2013 Gates KS. Structural biology: FaPy lesions and DNA mutations. Nature Chemical Biology. 9: 412-4. PMID 23774871 DOI: 10.1038/nchembio.1274  1
2013 Rajapakse A, Linder C, Morrison RD, Sarkar U, Leigh ND, Barnes CL, Daniels JS, Gates KS. Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions. Chemical Research in Toxicology. 26: 555-63. PMID 23488987 DOI: 10.1021/tx300483z  1
2013 Johnson KM, Price NE, Wang J, Fekry MI, Dutta S, Seiner DR, Wang Y, Gates KS. On the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA. Journal of the American Chemical Society. 135: 1015-25. PMID 23215239 DOI: 10.1021/ja308119q  1
2013 Keerthi K, Rajapakse A, Sun D, Gates KS. Synthesis and characterization of a small analogue of the anticancer natural product leinamycin. Bioorganic & Medicinal Chemistry. 21: 235-41. PMID 23168080 DOI: 10.1016/j.bmc.2012.10.021  1
2013 Sinha P, Shin Y, Hays AM, Gates K, Sun D. Cellular responses to the DNA damaging natural compound leinamycin Journal of Cancer Science and Therapy. 5. DOI: 10.4172/1948-5956.S8-003  1
2012 Viswesh V, Hays AM, Gates K, Sun D. DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences Bioorganic and Medicinal Chemistry. 20: 4413-4421. PMID 22682923 DOI: 10.1016/j.bmc.2012.05.033  1
2012 Hoffman M, Rajapakse A, Shen X, Gates KS. Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions: chemistry relevant to both the genotoxic and cell signaling properties of H(2)S. Chemical Research in Toxicology. 25: 1609-15. PMID 22621314 DOI: 10.1021/tx300066z  1
2012 Sivaramakrishnan S, Breydo L, Sun D, Gates KS. The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product. Bioorganic & Medicinal Chemistry Letters. 22: 3791-4. PMID 22560586 DOI: 10.1016/j.bmcl.2012.04.003  1
2012 Rajapakse A, Gates KS. Hypoxia-selective, enzymatic conversion of 6-nitroquinoline into a fluorescent helicene: pyrido[3,2-f]quinolino[6,5-c]cinnoline 3-oxide. The Journal of Organic Chemistry. 77: 3531-7. PMID 22417220 DOI: 10.1021/jo3004748  1
2012 Yin J, Glaser R, Gates KS. Electron and spin-density analysis of tirapazamine reduction chemistry. Chemical Research in Toxicology. 25: 620-33. PMID 22390194 DOI: 10.1021/tx2005458  1
2012 Yin J, Glaser R, Gates KS. On the reaction mechanism of tirapazamine reduction chemistry: unimolecular N-OH homolysis, stepwise dehydration, or triazene ring-opening. Chemical Research in Toxicology. 25: 634-45. PMID 22390168 DOI: 10.1021/tx200546u  1
2012 Chowdhury G, Sarkar U, Pullen S, Wilson WR, Rajapakse A, Fuchs-Knotts T, Gates KS. DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions. Chemical Research in Toxicology. 25: 197-206. PMID 22084973 DOI: 10.1021/tx2004213  1
2012 Gatenyo J, Johnson K, Rajapakse A, Gates KS, Rozen S. Transferring oxygen isotopes to 1,2,4-benzotriazine 1-oxides forming the corresponding 1,4-dioxides by using the HOF·CH 3CN complex Tetrahedron. 68: 8942-8944. DOI: 10.1016/j.tet.2012.08.017  1
2011 Rajapakse A, Barnes CL, Gates KS. Synthesis and Crystal Structure of the Azoxydichinyl Helicene, Pyrido[3,2-f]quinolino[6,5-c]cinnoline 5-Oxide Monohydrate. Journal of Chemical Crystallography. 41: 1712-1716. PMID 22303091 DOI: 10.1007/s10870-011-0162-z  0.56
2011 Fekry MI, Szekely J, Dutta S, Breydo L, Zang H, Gates KS. Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator. Journal of the American Chemical Society. 133: 17641-51. PMID 21954957 DOI: 10.1021/ja2046149  1
2011 Zhou H, Singh H, Parsons ZD, Lewis SM, Bhattacharya S, Seiner DR, LaButti JN, Reilly TJ, Tanner JJ, Gates KS. The biological buffer bicarbonate/CO2 potentiates H2O2-mediated inactivation of protein tyrosine phosphatases. Journal of the American Chemical Society. 133: 15803-5. PMID 21913686 DOI: 10.1021/ja2077137  1
2011 Fekry MI, Tipton PA, Gates KS. Kinetic consequences of replacing the internucleotide phosphorus atoms in DNA with arsenic. Acs Chemical Biology. 6: 127-30. PMID 21268588 DOI: 10.1021/cb2000023  1
2011 Fekry MI, Price NE, Zang H, Huang C, Harmata M, Brown P, Daniels JS, Gates KS. Thiol-activated DNA damage by α-bromo-2-cyclopentenone Chemical Research in Toxicology. 24: 217-228. PMID 21250671 DOI: 10.1021/tx100282b  1
2011 Tanner JJ, Parsons ZD, Cummings AH, Zhou H, Gates KS. Redox regulation of protein tyrosine phosphatases: structural and chemical aspects. Antioxidants & Redox Signaling. 15: 77-97. PMID 20919935 DOI: 10.1089/ars.2010.3611  1
2011 Rajapakse A, Barnes CL, Gates KS. Synthesis and crystal structure of the azoxydichinyl helicene, pyrido[3,2-f]quinolino[6,5-c]cinnoline 5-oxide monohydrate Journal of Chemical Crystallography. 41: 1712-1716. DOI: 10.1007/s10870-011-0162-z  1
2010 Sarkar U, Glaser R, Parsons ZD, Barnes CL, Gates KS. Synthesis, Crystal Structure, and Rotational Energy Profile of 3-Cyclopropyl-1,2,4-benzotriazine 1,4-Di-N-oxide. Journal of Chemical Crystallography. 40: 624-629. PMID 22294856 DOI: 10.1007/s10870-010-9707-9  0.96
2010 Bhattacharyya S, Zhou H, Seiner DR, Gates KS. Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones. Bioorganic & Medicinal Chemistry. 18: 5945-9. PMID 20655236 DOI: 10.1016/j.bmc.2010.06.084  1
2010 Junnotula V, Rajapakse A, Arbillaga L, de Cerain AL, Solano B, Villar R, Monge A, Gates KS. DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide. Bioorganic & Medicinal Chemistry. 18: 3125-32. PMID 20371184 DOI: 10.1016/j.bmc.2010.03.042  1
2010 Viswesh V, Gates K, Sun D. Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells Chemical Research in Toxicology. 23: 99-107. PMID 20017514 DOI: 10.1021/tx900301r  1
2010 Sivaramakrishnan S, Cummings AH, Gates KS. Protection of a single-cysteine redox switch from oxidative destruction: On the functional role of sulfenyl amide formation in the redox-regulated enzyme PTP1B. Bioorganic & Medicinal Chemistry Letters. 20: 444-7. PMID 20015650 DOI: 10.1016/j.bmcl.2009.12.001  1
2010 Sarkar U, Glaser R, Parsons ZD, Barnes CL, Gates KS. Synthesis, crystal structure, and rotational energy profile of 3-cyclopropyl-1,2,4-benzotriazine 1,4-di-n-oxide Journal of Chemical Crystallography. 40: 624-629. DOI: 10.1007/s10870-010-9707-9  1
2009 Fekry MI, Gates KS. DNA-catalyzed hydrolysis of DNA phosphodiesters. Nature Chemical Biology. 5: 710-1. PMID 19763101 DOI: 10.1038/nchembio.224  1
2009 Gates KS. An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals. Chemical Research in Toxicology. 22: 1747-60. PMID 19757819 DOI: 10.1021/tx900242k  1
2009 Junnotula V, Sarkar U, Sinha S, Gates KS. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide. Journal of the American Chemical Society. 131: 1015-24. PMID 19117394 DOI: 10.1021/ja8049645  1
2009 LaButti JN, Gates KS. Biologically relevant chemical properties of peroxymonophosphate (=O3POOH). Bioorganic & Medicinal Chemistry Letters. 19: 218-21. PMID 19022671 DOI: 10.1016/j.bmcl.2008.10.133  1
2008 Bhattacharya S, Labutti JN, Seiner DR, Gates KS. Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides. Bioorganic & Medicinal Chemistry Letters. 18: 5856-9. PMID 18595691 DOI: 10.1016/j.bmcl.2008.06.029  1
2008 Keerthi K, Sivaramakrishnan S, Gates KS. Evidence for a Morin type intramolecular cyclization of an alkene with a phenylsulfenic acid group in neutral aqueous solution. Chemical Research in Toxicology. 21: 1368-74. PMID 18500784 DOI: 10.1021/tx8000187  1
2008 Glaser R, Sui Y, Sarkar U, Gates KS. Electronic structures and spin topologies of gamma-picoliniumyl radicals. A study of the homolysis of N-methyl-gamma-picolinium and of benzo-, dibenzo-, and naphthoannulated analogs. The Journal of Physical Chemistry. A. 112: 4800-14. PMID 18494451 DOI: 10.1021/jp8011987  1
2008 Sivaramakrishnan S, Gates KS. Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin. Bioorganic & Medicinal Chemistry Letters. 18: 3076-80. PMID 18068362 DOI: 10.1016/j.bmcl.2007.11.092  1
2007 Solano B, Junnotula V, Marín A, Villar R, Burguete A, Vicente E, Pérez-Silanes S, Aldana I, Monge A, Dutta S, Sarkar U, Gates KS. Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues. Journal of Medicinal Chemistry. 50: 5485-92. PMID 17910426 DOI: 10.1021/jm0703993  1
2007 Chowdhury G, Junnotula V, Daniels JS, Greenberg MM, Gates KS. DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2). Journal of the American Chemical Society. 129: 12870-7. PMID 17900117 DOI: 10.1021/ja074432m  1
2007 Seiner DR, LaButti JN, Gates KS. Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein. Chemical Research in Toxicology. 20: 1315-20. PMID 17655273 DOI: 10.1021/tx700213s  1
2007 Keerthi K, Gates KS. Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides. Organic & Biomolecular Chemistry. 5: 1595-600. PMID 17571189 DOI: 10.1039/b701179b  1
2007 LaButti JN, Chowdhury G, Reilly TJ, Gates KS. Redox regulation of protein tyrosine phosphatase 1B by peroxymonophosphate (=O3POOH). Journal of the American Chemical Society. 129: 5320-1. PMID 17411049 DOI: 10.1021/ja070194j  1
2007 Dutta S, Chowdhury G, Gates KS. Interstrand cross-links generated by abasic sites in duplex DNA. Journal of the American Chemical Society. 129: 1852-3. PMID 17253689 DOI: 10.1021/ja067294u  1
2007 Sut Y, Glaser R, Sarkar U, Gates K. Stabilities and spin distributions of benzannulated benzyl radicals Journal of Chemical Theory and Computation. 3: 1091-1099. DOI: 10.1021/ct700051j  1
2006 Gates KS. Getting under wraps: alkylating DNA in the nucleosome. Nature Chemical Biology. 2: 64-6. PMID 16421582 DOI: 10.1038/nchembio0206-64  1
2006 Szekely J, Gates KS. Noncovalent DNA binding and the mechanism of oxidative DNA damage by fecapentaene-12. Chemical Research in Toxicology. 19: 117-21. PMID 16411664 DOI: 10.1021/tx050197e  1
2006 Junnotula V, Sarkar U, Barnes CL, Thallapally PK, Gates KS. Crystal structures of 3-methyl-1,2,4-benzotriazine 1-oxide and 2-oxide Journal of Chemical Crystallography. 36: 557-561. DOI: 10.1007/s10870-006-9099-z  1
2006 Gates KS. The Chemical Reactions of DNA Damage and Degradation Reviews of Reactive Intermediate Chemistry. 333-378. DOI: 10.1002/9780470120828.ch8  1
2005 Dutta S, Abe H, Aoyagi S, Kibayashi C, Gates KS. DNA damage by fasicularin. Journal of the American Chemical Society. 127: 15004-5. PMID 16248621 DOI: 10.1021/ja053735i  1
2005 Sivaramakrishnan S, Keerthi K, Gates KS. A chemical model for redox regulation of protein tyrosine phosphatase 1B (PTP1B) activity. Journal of the American Chemical Society. 127: 10830-1. PMID 16076179 DOI: 10.1021/ja052599e  1
2005 Chatterji T, Keerthi K, Gates KS. Generation of reactive oxygen species by a persulfide (BnSSH). Bioorganic & Medicinal Chemistry Letters. 15: 3921-4. PMID 16005218 DOI: 10.1016/j.bmcl.2005.05.110  1
2005 Shipova E, Gates KS. A fluorimetric assay for the spontaneous release of an N7-alkylguanine residue from duplex DNA. Bioorganic & Medicinal Chemistry Letters. 15: 2111-3. PMID 15808479 DOI: 10.1016/j.bmcl.2005.02.058  1
2004 Chowdhury G, Kotandeniya D, Daniels JS, Barnes CL, Gates KS. Enzyme-activated, hypoxia-selective DNA damage by 3-amino-2-quinoxalinecarbonitrile 1,4-di-N-oxide. Chemical Research in Toxicology. 17: 1399-405. PMID 15540937 DOI: 10.1021/tx049836w  1
2004 Nooner T, Dutta S, Gates KS. Chemical properties of the leinamycin-guanine adduct in DNA. Chemical Research in Toxicology. 17: 942-9. PMID 15257620 DOI: 10.1021/tx049964k  1
2004 Gates KS, Nooner T, Dutta S. Biologically relevant chemical reactions of N7-alkylguanine residues in DNA. Chemical Research in Toxicology. 17: 839-56. PMID 15257608 DOI: 10.1021/tx049965c  1
2004 Breydo L, Zang H, Gates KS. Synthesis and noncovalent DNA-binding properties of thiazole derivatives related to leinamycin Tetrahedron Letters. 45: 5711-5716. DOI: 10.1016/j.tetlet.2004.05.093  1
2003 Zang H, Gates KS. Sequence specificity of DNA alkylation by the antitumor natural product leinamycin. Chemical Research in Toxicology. 16: 1539-46. PMID 14680367 DOI: 10.1021/tx0341658  1
2003 Birincioglu M, Jaruga P, Chowdhury G, Rodriguez H, Dizdaroglu M, Gates KS. DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). Journal of the American Chemical Society. 125: 11607-15. PMID 13129365 DOI: 10.1021/ja0352146  1
2003 Zagorevskii D, Song M, Breneman C, Yuan Y, Fuchs T, Gates KS, Greenlief CM. A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates. Journal of the American Society For Mass Spectrometry. 14: 881-92. PMID 12892912 DOI: 10.1016/S1044-0305(03)00334-9  1
2003 Chatterji T, Kizil M, Keerthi K, Chowdhury G, Pospísil T, Gates KS. Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin. Journal of the American Chemical Society. 125: 4996-7. PMID 12708847 DOI: 10.1021/ja029169y  1
2003 Chatterji T, Gates KS. Reaction of thiols with 7-methylbenzopentathiepin. Bioorganic & Medicinal Chemistry Letters. 13: 1349-52. PMID 12657280 DOI: 10.1016/S0960-894X(03)00103-3  1
2002 Breydo L, Gates KS. Activation of leinamycin by thiols: a theoretical study. The Journal of Organic Chemistry. 67: 9054-60. PMID 12467428 DOI: 10.1021/jo020568l  1
2002 Kotandeniya D, Ganley B, Gates KS. Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). Bioorganic & Medicinal Chemistry Letters. 12: 2325-9. PMID 12161126 DOI: 10.1016/S0960-894X(02)00468-7  1
2002 Breydo L, Barnes CL, Gates KS. Two (E,E)- and (Z,E)-thiazol-5-ylpenta-2,4-dienones. Acta Crystallographica. Section C, Crystal Structure Communications. 58: o447-9. PMID 12154296 DOI: 10.1107/S0108270102007503  1
2002 Poole JS, Hadad CM, Platz MS, Fredin ZP, Pickard L, Guerrero EL, Kessler M, Chowdhury G, Kotandeniya D, Gates KS. Photochemical electron transfer reactions of tirapazamine. Photochemistry and Photobiology. 75: 339-45. PMID 12003122 DOI: 10.1562/0031-8655(2002)075<0339:PETROT>2.0.CO;2  1
2001 Ganley B, Chowdhury G, Bhansali J, Daniels JS, Gates KS. Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxide. Bioorganic & Medicinal Chemistry. 9: 2395-401. PMID 11553481 DOI: 10.1016/S0968-0896(01)00163-8  1
2001 Breydo L, Zang H, Mitra K, Gates KS. Thiol-independent DNA alkylation by leinamycin. Journal of the American Chemical Society. 123: 2060-1. PMID 11456831 DOI: 10.1021/ja003309r  1
2001 Fuchs T, Chowdhury G, Barnes CL, Gates KS. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). The Journal of Organic Chemistry. 66: 107-14. PMID 11429885 DOI: 10.1021/jo001232j  1
2001 Zang H, Breydo L, Mitra K, Dannaldson J, Gates KS. DNA alkylation by leinamycin can be triggered by cyanide and phosphines. Bioorganic & Medicinal Chemistry Letters. 11: 1511-5. PMID 11412971 DOI: 10.1016/S0960-894X(01)00196-2  1
2001 Fuchs T, Barnes CL, Gates KS. Crystal structure of 3-amino-5-methyl-1,2,4-benzotriazine 1-oxide: Evidence for formation of a covalent attachment between a carbon-centered radical and the antitumor agent tirapazamine Journal of Chemical Crystallography. 31: 387-391. DOI: 10.1023/A:1015655507952  1
2000 Zang H, Gates KS. DNA binding and alkylation by the "left half" of azinomycin B. Biochemistry. 39: 14968-75. PMID 11101313 DOI: 10.1021/bi001998d  1
2000 Gates KS. Mechanisms of DNA damage by leinamycin. Chemical Research in Toxicology. 13: 953-6. PMID 11080040 DOI: 10.1021/tx000089m  1
2000 Breydo L, Gates KS. Thiol-dependent DNA cleavage by 3H-1,2-benzodithiol-3-one 1,1-dioxide. Bioorganic & Medicinal Chemistry Letters. 10: 885-9. PMID 10853652 DOI: 10.1016/S0960-894X(00)00125-6  1
1999 Fuchs T, Gates KS, Hwang JT, Greenberg MM. Photosensitization of guanine-specific DNA damage by a cyano-substituted quinoxaline di-N-oxide. Chemical Research in Toxicology. 12: 1190-4. PMID 10604868 DOI: 10.1021/tx990149s  1
1999 Hwang JT, Greenberg MM, Fuchs T, Gates KS. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions. Biochemistry. 38: 14248-55. PMID 10571998 DOI: 10.1021/bi991488n  1
1999 Mitra K, Barnes CL, Gates KS. Crystal structure of methyl trans-3-[(2-(methoxycarbonyl) phenyl)sulfinyl]acrylate: A product resulting from trapping of a sulfenic acid by methyl propiolate Journal of Chemical Crystallography. 29: 1133-1136.  1
1998 Chatterji T, Gates KS. DNA cleavage by 7-methylbenzopentathiepin: a simple analog of the antitumor antibiotic varacin. Bioorganic & Medicinal Chemistry Letters. 8: 535-8. PMID 9871613 DOI: 10.1016/S0960-894X(98)00066-3  1
1998 Daniels JS, Gates KS, Tronche C, Greenberg MM. Direct evidence for bimodal DNA damage induced by tirapazamine. Chemical Research in Toxicology. 11: 1254-7. PMID 9815184 DOI: 10.1021/tx980184j  1
1998 Wang Y, Koreeda M, Chatterji T, Gates KS. Total synthesis and DNA-cleaving properties of thiarubrine C Journal of Organic Chemistry. 63: 8644-8645. DOI: 10.1021/jo981849p  1
1998 Daniels JS, Chatterji T, MacGillivray LR, Gates KS. Photochemical DNA cleavage by the antitumor agent 3-amino-1,2,4- benzotriazine 1,4-dioxide (tirapazamine, WIN 59075, SR4233) Journal of Organic Chemistry. 63: 10027-10030. DOI: 10.1021/jo981314w  1
1998 Behroozi SJ, Barnes CL, Gates KS. Crystal structure of 3H-1,2-benzodithiol-3-one 1-oxide Journal of Chemical Crystallography. 28: 689-691.  1
1997 Kim W, Gates KS. Evidence for thiol-dependent production of oxygen radicals by 4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) and 3H-1,2-dithiole-3-thione: possible relevance to the anticarcinogenic properties of 1,2-dithiole-3-thiones. Chemical Research in Toxicology. 10: 296-301. PMID 9084909 DOI: 10.1021/tx9601667  1
1997 Mitra K, Kim W, Daniels JS, Gates KS. Oxidative DNA cleavage by the antitumor antibiotic leinamycin and simple 1,2-dithiolan-3-one 1-oxides: Evidence for thiol-dependent conversion of molecular oxygen to DNA-cleaving oxygen radicals mediated by polysulfides Journal of the American Chemical Society. 119: 11691-11692. DOI: 10.1021/ja971359z  1
1996 Behroozi SJ, Kim W, Dannaldson J, Gates KS. 1,2-Dithiolan-3-one 1-oxides: a class of thiol-activated DNA-cleaving agents that are structurally related to the natural product leinamycin. Biochemistry. 35: 1768-74. PMID 8639657 DOI: 10.1021/bi952257t  1
1996 Daniels JS, Gates KS. DNA cleavage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (SR4233): Evidence for involvement of hydroxyl radical Journal of the American Chemical Society. 118: 3380-3385. DOI: 10.1021/ja9510774  1
1996 Kim W, Dannaldson J, Barnes CL, Gates KS. Reactions of 3H-1,2-benzodithiol-3-one 1-oxide with amines and anilines (Tetrahedron Letters, 1996, 37, 5337-5340 Tetrahedron Letters. 37: 6425. DOI: 10.1016/0040-4039(96)01506-7  1
1996 Kim W, Dannaldson J, Gates KS. Reactions of 3H-1,2-benzodithiol-3-one 1-oxide with amines and anilines Tetrahedron Letters. 37: 5337-5340. DOI: 10.1016/0040-4039(96)01124-0  1
1995 Behroozi SJ, Kim W, Gates KS. Reaction of n-propanethiol with 3H-1,2-benzodithiol-3-one 1-oxide and 5,5-dimethyl-1,2-dithiolan-3-one 1-oxide: Studies related to the reaction of antitumor antibiotic leinamycin with DNA Journal of Organic Chemistry. 60: 3964-3966. DOI: 10.1021/jo00118a010  1
1995 Mitra K, Gates KS. Novel syntheses of dithiosalicylide Tetrahedron Letters. 36: 1391-1394. DOI: 10.1016/0040-4039(95)00007-Y  1
1990 Gates KS, Silverman RB. 5-(Aminomethyl)-3-aryl-2-oxazolidinones. A novel class of mechanism-sased inactivators of monoamine oxidase B Journal of the American Chemical Society. 112: 9364-9372.  1
1989 Gates KS, Silverman RB. Model studies for the mechanism of inactivation of monoamine oxidase by 5-(aminomethyl)-3-aryl-2-oxazolidinones Journal of the American Chemical Society. 111: 8891-8895.  1
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