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James M. Cook, Ph.D. - Publications

Affiliations: 
1973- Chemistry University of Wisconsin-Milwaukee, Milwaukee, WI 
Area:
Alkaloid total synthesis
Website:
http://alchemy.chem.uwm.edu/research/cook/

303 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Meng Z, Berro LF, Sawyer EK, Rüedi-Bettschen D, Cook JE, Li G, Platt DM, Cook JM, Rowlett JK. Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for α3 subunit-containing GABA receptors. Journal of Psychopharmacology (Oxford, England). 269881119882803. PMID 31670615 DOI: 10.1177/0269881119882803  0.8
2019 Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Roni MSR, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, ... ... Cook JM, et al. Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABA Receptors in the Lung". Molecular Pharmaceutics. PMID 31633359 DOI: 10.1021/acs.molpharmaceut.9b01053  0.76
2019 Witkin JM, Ping X, Cerne R, Mouser C, Jin X, Hobbs J, Tiruveedhula VVNPB, Li G, Jahan R, Rashid F, Kumar Golani L, Cook JM, Smith JL. The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs:The example of CERC-611 and KRM-II-81. Brain Research. 146356. PMID 31369732 DOI: 10.1016/j.brainres.2019.146356  0.76
2019 Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Marković BD, Banasr M, ... Cook JM, et al. Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. Molecular Neuropsychiatry. 5: 84-97. PMID 31192221 DOI: 10.1159/000496086  0.76
2019 Prevot TD, Li G, Cook JM, Sibille E. Insight into Novel Treatment for Cognitive Dysfunctions across Disorders. Acs Chemical Neuroscience. PMID 30920790 DOI: 10.1021/acschemneuro.9b00148  0.6
2019 Berro LF, Rüedi-Bettschen D, Cook JE, Golani LK, Li G, Jahan R, Rashid F, Cook JM, Rowlett JK, Platt DM. GABA receptor subtypes and the abuse-related effects of ethanol in rhesus monkeys: Experiments with selective positive allosteric modulators. Alcoholism, Clinical and Experimental Research. PMID 30861153 DOI: 10.1111/acer.14000  0.8
2019 Kallay L, Keskin H, Ross A, Rupji M, Moody OA, Wang X, Li G, Ahmed T, Rashid F, Stephen MR, Cottrill KA, Nuckols TA, Xu M, Martinson DE, Tranghese F, ... ... Cook JM, et al. Modulating native GABA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death. Journal of Neuro-Oncology. PMID 30725256 DOI: 10.1007/s11060-019-03115-0  0.76
2019 Chandler CM, Reeves-Darby J, Jones SA, McDonald JA, Li G, Rahman MT, Cook JM, Platt DM. α5GABA subunit-containing receptors and sweetened alcohol cue-induced reinstatement and active sweetened alcohol self-administration in male rats. Psychopharmacology. PMID 30637435 DOI: 10.1007/s00213-018-5163-6  0.72
2019 Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM. Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA receptors. European Journal of Pain (London, England). PMID 30633839 DOI: 10.1002/ejp.1365  0.72
2018 Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B. Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons. Frontiers in Pharmacology. 9: 1523. PMID 30687091 DOI: 10.3389/fphar.2018.01523  0.6
2018 Yocum GT, Perez-Zoghbi JF, Danielsson J, Kuforiji AS, Zhang Y, Li G, Roni MSR, Kodali R, Stafford DC, Arnold LA, Cook JM, Emala CW. A Novel GABA Receptor Ligand MIDD0301 with Limited Blood-Brain Barrier Penetration Relaxes Airway Smooth Muscle Ex Vivo and In Vivo. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30489155 DOI: 10.1152/ajplung.00356.2018  0.76
2018 Batinić B, Stanković T, Stephen MR, Kodali R, Tiruveedhula VV, Li G, Scholze P, Marković BD, Obradović AL, Ernst M, Cook JM, Savić MM. Attaining in vivo selectivity of positive modulation of α3βγ2 GABA receptors in rats: A hard task! European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 29891214 DOI: 10.1016/j.euroneuro.2018.05.014  0.76
2018 Elgarf AA, Siebert DCB, Steudle F, Draxler A, Li G, Huang S, Cook JM, Ernst M, Scholze P. Different Benzodiazepines Bind with Distinct Binding Modes to GABA Receptors. Acs Chemical Biology. PMID 29767950 DOI: 10.1021/acschembio.8b00144  0.8
2018 Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK. Evidence that Sedative Effects of Benzodiazepines Involve Unexpected GABA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys. The Journal of Pharmacology and Experimental Therapeutics. PMID 29720564 DOI: 10.1124/jpet.118.249250  0.96
2018 Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni S, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, ... ... Cook JM, et al. A novel orally available asthma drug candidate that reduces smooth muscle constriction and inflammation by targeting GABA(A) receptors in the lung. Molecular Pharmaceutics. PMID 29578347 DOI: 10.1021/acs.molpharmaceut.7b01013  0.76
2018 Knutson DE, Kodali R, Divovic B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, ... ... Cook JM, et al. Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. Journal of Medicinal Chemistry. PMID 29481759 DOI: 10.1021/acs.jmedchem.7b01664  0.76
2018 Wang B, Lu M, Cook JM, Yang DR, Dunn DW, Wang RW. Chemical camouflage: a key process in shaping an ant-treehopper and fig-fig wasp mutualistic network. Scientific Reports. 8: 1833. PMID 29382931 DOI: 10.1038/s41598-018-20310-7  0.76
2018 Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM. Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. Psychopharmacology. PMID 29374303 DOI: 10.1007/s00213-018-4832-9  0.96
2017 Rahman MT, Deschamps JR, Imler GH, Cook JM. Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29244896 DOI: 10.1002/chem.201705575  0.8
2017 Schwan WR, Polanowski R, Dunman PM, Medina-Bielski S, Lane M, Rott M, Lipker L, Wescott A, Monte A, Cook JM, Baumann DD, Tiruveedhula VVNPB, Witzigmann CM, Mikel C, Rahman MT. Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray. Antibiotics (Basel, Switzerland). 6. PMID 28892020 DOI: 10.3390/antibiotics6030017  0.72
2017 Stephen MR, Rahman MT, Tiruveedhula VVNPB, Fonseca GO, Deschamps JR, Cook JM. Concise Total Synthesis of (-)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (-)-Macrogentine, (+)-Na-Demethylalstonisine, (-)-Alstonoxine A and (+)-Alstonisine. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28875520 DOI: 10.1002/chem.201703572  0.8
2017 Meyer MAA, Corcoran KA, Chen HJ, Gallego S, Li G, Tiruveedhula VV, Cook JM, Radulovic J. Neurobiological correlates of state-dependent context fear. Learning & Memory (Cold Spring Harbor, N.Y.). 24: 385-391. PMID 28814463 DOI: 10.1101/lm.045542.117  0.72
2017 Batinić B, Santrač A, Jančić I, Li G, Vidojević A, Marković B, Cook JM, Savić MM. Positive modulation of α5 GABAA receptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 61: 31-39. PMID 28610974 DOI: 10.1016/j.ijdevneu.2017.06.001  0.72
2017 Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, ... ... Cook JM, et al. Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators. Molecular Pharmaceutics. PMID 28440659 DOI: 10.1021/acs.molpharmaceut.7b00183  0.76
2017 Schwienteck KL, Li G, Poe MM, Cook JM, Banks ML, Stevens Negus S. Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats. Psychopharmacology. PMID 28365836 DOI: 10.1007/s00213-017-4615-8  0.64
2017 Fischer BD, Schlitt RJ, Hamade BZ, Rehman S, Ernst M, Poe MM, Li G, Kodali R, Arnold LA, Cook JM. Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024. Brain Research Bulletin. PMID 28267561 DOI: 10.1016/j.brainresbull.2017.03.001  0.76
2017 Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX. Antinociceptive effects of a novel α2/α3-subtype selective GABAA receptor positive allosteric modulator. Acs Chemical Neuroscience. PMID 28150939 DOI: 10.1021/acschemneuro.6b00447  0.6
2016 Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, ... Cook JM, et al. Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy. Journal of Medicinal Chemistry. 59: 10800-10806. PMID 27933953 DOI: 10.1021/acs.jmedchem.6b01332  0.76
2016 Piantadosi SC, French BJ, Poe MM, Timić T, Marković BD, Pabba M, Seney ML, Oh H, Orser BA, Savić MM, Cook JM, Sibille E. Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator. Frontiers in Pharmacology. 7: 446. PMID 27920723 DOI: 10.3389/fphar.2016.00446  0.72
2016 Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, et al. Optimization of substituted imidazobenzodiazepines as novel asthma treatments. European Journal of Medicinal Chemistry. 126: 550-560. PMID 27915170 DOI: 10.1016/j.ejmech.2016.11.045  0.76
2016 Holtyn AF, Tiruveedhula VV, Stephen MR, Cook JM, Weerts EM. Effects of the benzodiazepine GABAA α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons. Drug and Alcohol Dependence. 170: 25-31. PMID 27865151 DOI: 10.1016/j.drugalcdep.2016.10.036  0.72
2016 Rahman MT, Tiruveedhula VV, Cook JM. Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review. Molecules (Basel, Switzerland). 21. PMID 27854259 DOI: 10.3390/molecules21111525  0.72
2016 Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM. Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit. European Journal of Pharmacology. PMID 27639297 DOI: 10.1016/j.ejphar.2016.09.016  0.72
2016 Yuan NY, Poe MM, Witzigmann C, Cook JM, Stafford D, Arnold LA. Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells. Journal of Pharmacological and Toxicological Methods. PMID 27544543 DOI: 10.1016/j.vascn.2016.08.006  0.64
2016 Rahman MT, Deschamps JR, Imler GH, Schwabacher AW, Cook JM. Total Synthesis of Macrocarpines D and E via an Enolate-Driven Copper-Mediated Cross-Coupling Process: Replacement of Catalytic Palladium with Copper Iodide. Organic Letters. PMID 27526647 DOI: 10.1021/acs.orglett.6b01526  0.8
2016 Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, et al. First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. Journal of Biomedical Nanotechnology. 12: 1297-302. PMID 27319222 DOI: 10.1166/jbn.2016.2262  0.56
2016 Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Yocum GT, Treven M, Stephen MR, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, ... ... Cook JM, et al. Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma treatments. Molecular Pharmaceutics. PMID 27120014 DOI: 10.1021/acs.molpharmaceut.6b00159  0.56
2016 Namjoshi OA, Cook JM. Sarpagine and Related Alkaloids. The Alkaloids. Chemistry and Biology. 76: 63-169. PMID 26827883 DOI: 10.1016/bs.alkal.2015.08.002  0.92
2016 Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. European Journal of Medicinal Chemistry. 109: 238-246. PMID 26774929 DOI: 10.1016/j.ejmech.2016.01.002  0.76
2015 Schwan WR, Kolesar JM, Kabir MS, Elder EJ, Williams JB, Minerath R, Cook JM, Witzigmann CM, Monte A, Flaherty T. Pharmacokinetic/Toxicity Properties of the New Anti-Staphylococcal Lead Compound SK-03-92. Antibiotics (Basel, Switzerland). 4: 617-626. PMID 26877886 DOI: 10.3390/antibiotics4040617  0.96
2015 McMurray KM, Sidhu PS, Cook JM, Arnold LA, Palmer AA. Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice. Addiction Biology. PMID 26691867 DOI: 10.1111/adb.12333  0.6
2015 Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM. A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model. International Journal of Medicinal Chemistry. 2015: 430248. PMID 26682068 DOI: 10.1155/2015/430248  0.84
2015 Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A. Corrigendum: Regulating anxiety with extrasynaptic inhibition. Nature Neuroscience. 18: 1862. PMID 26605888 DOI: 10.1038/nn1215-1862a  0.6
2015 Fischer BD, Platt DM, Rallapalli SK, Namjoshi OA, Cook JM, Rowlett JK. Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis. Drug and Alcohol Dependence. PMID 26596587 DOI: 10.1016/j.drugalcdep.2015.10.026  0.52
2015 Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, et al. Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. Anticancer Research. 35: 6001-7. PMID 26504023  0.4
2015 Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW. Targeting the GABAA Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction. American Journal of Respiratory Cell and Molecular Biology. PMID 26405827 DOI: 10.1165/rcmb.2015-0176OC  0.76
2015 Phani Babu Tiruveedhula VV, Methuku KR, Deschamps JR, Cook JM. Synthesis of aza and carbocyclic β-carbolines for the treatment of alcohol abuse. Regiospecific solution to the problem of 3,6-disubstituted β- and aza-β-carboline specificity. Organic & Biomolecular Chemistry. 13: 10705-15. PMID 26349488 DOI: 10.1039/c5ob01572c  1
2015 Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A. Regulating anxiety with extrasynaptic inhibition. Nature Neuroscience. PMID 26322928 DOI: 10.1038/nn.4102  0.52
2015 Berendse K, Engelen M, Ferdinandusse S, Majoie CB, Waterham HR, Vaz FM, Koelman JH, Barth PG, Wanders RJ, Poll-The BT. Zellweger spectrum disorders: clinical manifestations in patients surviving into adulthood. Journal of Inherited Metabolic Disease. PMID 26287655 DOI: 10.1007/s10545-015-9880-2  0.76
2015 Timić Stamenić T, Joksimović S, Biawat P, Stanković T, Marković B, Cook JM, Savić MM. Negative modulation of α5 GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion. Journal of Psychopharmacology (Oxford, England). PMID 26105958 DOI: 10.1177/0269881115590601  0.72
2015 Gallos G, Yocum GT, Siviski ME, Yim PD, Fu XW, Poe MM, Cook JM, Harrison N, Perez-Zoghbi J, Emala CW. Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling. American Journal of Physiology. Lung Cellular and Molecular Physiology. 308: L931-42. PMID 25659897 DOI: 10.1152/ajplung.00107.2014  1
2015 Richetto J, Labouesse MA, Poe MM, Cook JM, Grace AA, Riva MA, Meyer U. Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25636893 DOI: 10.1093/ijnp/pyu055  0.56
2015 Cook JM, Reuter C, Moore JC, West SA. Fighting in fig wasps: Do males avoid killing brothers or do they never meet them? Ecological Entomology. 40: 741-747. DOI: 10.1111/een.12250  0.88
2015 Hall AAG, Gherlenda AN, Hasegawa S, Johnson SN, Cook JM, Riegler M. Anatomy of an outbreak: The biology and population dynamics of a Cardiaspina psyllid species in an endangered woodland ecosystem Agricultural and Forest Entomology. 17: 292-301. DOI: 10.1111/afe.12106  0.88
2015 Sutton TL, Reuter C, Riegler M, Cook JM. Characterisation of microsatellite markers for fig-pollinating wasps in the Pleistodontes imperialis species complex Australian Journal of Zoology. 63: 122-126. DOI: 10.1071/ZO15011  0.88
2015 Fonseca GO, Wang ZJ, Namjoshi OA, Deschamps JR, Cook JM. First stereospecific total synthesis of (-)-affinisine oxindole as well as facile entry into the C(7)-diastereomeric chitosenine stereochemistry Tetrahedron Letters. 56: 3052-3056. DOI: 10.1016/j.tetlet.2014.11.036  1
2014 Darwell CT, al-Beidh S, Cook JM. Molecular species delimitation of a symbiotic fig-pollinating wasp species complex reveals extreme deviation from reciprocal partner specificity. Bmc Evolutionary Biology. 14: 189. PMID 25927719 DOI: 10.1186/s12862-014-0189-9  0.88
2014 Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, et al. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Reports. 9: 1034-46. PMID 25437558 DOI: 10.1016/j.celrep.2014.09.046  1
2014 Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle DD, Cook JM, Arnold LA. IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING. Nuclear Receptor Research. 1. PMID 25419525 DOI: 10.11131/2014/101076  0.6
2014 Igbinoba SI, Onyeji CO, Akanmu MA, Soyinka JO, Pullela SS, Cook JM, Nathaniel TI. Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers. Journal of Clinical Pharmacology. PMID 25328082 DOI: 10.1002/jcph.414  1
2014 Edwankar RV, Edwankar CR, Deschamps JR, Cook JM. General strategy for synthesis of C-19 methyl-substituted sarpagine/macroline/ajmaline indole alkaloids including total synthesis of 19(S),20(R)-dihydroperaksine, 19(S),20(R)-dihydroperaksine-17-al, and peraksine. The Journal of Organic Chemistry. 79: 10030-48. PMID 25247616 DOI: 10.1021/jo5016163  1
2014 Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemotherapy and Pharmacology. 74: 787-98. PMID 25107568 DOI: 10.1007/s00280-014-2549-y  1
2014 Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA. Development of novel Vitamin D Receptor-Coactivator Inhibitors. Acs Medicinal Chemistry Letters. 5: 199-204. PMID 24799995 DOI: 10.1021/ml400462j  1
2014 Rallapalli SK, Namjoshi OA, Tiruveedhula VV, Deschamps JR, Cook JM. Stereospecific total synthesis of the indole alkaloid ervincidine. Establishment of the C-6 hydroxyl stereochemistry. The Journal of Organic Chemistry. 79: 3776-80. PMID 24697213 DOI: 10.1021/jo402692u  1
2014 Kovačević J, Timić T, Tiruveedhula VV, Batinić B, Namjoshi OA, Milić M, Joksimović S, Cook JM, Savić MM. Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats. Brain Research Bulletin. 104: 1-6. PMID 24695241 DOI: 10.1016/j.brainresbull.2014.03.002  1
2014 Wang B, Geng XZ, Ma LB, Cook JM, Wang RW. A trophic cascade induced by predatory ants in a fig-fig wasp mutualism. The Journal of Animal Ecology. 83: 1149-57. PMID 24666375 DOI: 10.1111/1365-2656.12219  0.88
2014 McMurray KM, Distler MG, Sidhu PS, Cook JM, Arnold LA, Palmer AA, Plant LD. Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development. Biochemical Society Transactions. 42: 461-7. PMID 24646261 DOI: 10.1042/BST20140027  1
2014 Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM. Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. Brain Research. 1554: 36-48. PMID 24472579 DOI: 10.1016/j.brainres.2014.01.036  1
2014 Gill KM, Cook JM, Poe MM, Grace AA. Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia. Schizophrenia Bulletin. 40: 341-50. PMID 24464874 DOI: 10.1093/schbul/sbt236  1
2014 Sawyer EK, Moran C, Sirbu MH, Szafir M, Van Linn M, Namjoshi O, Phani Babu Tiruveedhula VV, Cook JM, Platt DM. Little evidence of a role for the α1GABAA subunit-containing receptor in a rhesus monkey model of alcohol drinking. Alcoholism, Clinical and Experimental Research. 38: 1108-17. PMID 24330519 DOI: 10.1111/acer.12320  1
2014 Rae CD, Davidson JE, Maher AD, Rowlands BD, Kashem MA, Nasrallah FA, Rallapalli SK, Cook JM, Balcar VJ. Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations. Journal of Neurochemistry. 129: 304-14. PMID 24313287 DOI: 10.1111/jnc.12634  1
2014 Sengupta S, Weeraratne SD, Sun H, Phallen J, Rallapalli SK, Teider N, Kosaras B, Amani V, Pierre-Francois J, Tang Y, Nguyen B, Yu F, Schubert S, Balansay B, Mathios D, ... ... Cook JM, et al. α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. Acta Neuropathologica. 127: 593-603. PMID 24196163 DOI: 10.1007/s00401-013-1205-7  1
2014 Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU. Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 477-87. PMID 24045508 DOI: 10.1038/npp.2013.221  1
2014 Segar ST, Dunn DW, Darwell CT, Cook JM. How to be a fig wasp down under: The diversity and structure of anAustralian fig wasp community Acta Oecologica. 57: 17-27. DOI: 10.1016/j.actao.2013.03.014  0.88
2013 Xiao JH, Yue Z, Jia LY, Yang XH, Niu LH, Wang Z, Zhang P, Sun BF, He SM, Li Z, Xiong TL, Xin W, Gu HF, Wang B, Werren JH, ... ... Cook JM, et al. Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology. 14: R141. PMID 24359812 DOI: 10.1186/gb-2013-14-12-r141  0.88
2013 Huang CC, Monte A, Cook JM, Kabir MS, Peterson KP. Zebrafish heart failure models for the evaluation of chemical probes and drugs. Assay and Drug Development Technologies. 11: 561-72. PMID 24351044 DOI: 10.1089/adt.2013.548  1
2013 Tiruveedhula VV, Witzigmann CM, Verma R, Kabir MS, Rott M, Schwan WR, Medina-Bielski S, Lane M, Close W, Polanowski RL, Sherman D, Monte A, Deschamps JR, Cook JM. Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis. Bioorganic & Medicinal Chemistry. 21: 7830-40. PMID 24200931 DOI: 10.1016/j.bmc.2013.10.011  1
2013 Segar ST, Pereira RA, Compton SG, Cook JM. Convergent structure of multitrophic communities over three continents. Ecology Letters. 16: 1436-45. PMID 24134201 DOI: 10.1111/ele.12183  0.88
2013 Ishikawa M, Otaka M, Neumann PA, Wang Z, Cook JM, Schlüter OM, Dong Y, Huang YH. Exposure to cocaine regulates inhibitory synaptic transmission from the ventral tegmental area to the nucleus accumbens. The Journal of Physiology. 591: 4827-41. PMID 23918773 DOI: 10.1113/jphysiol.2013.262915  0.72
2013 Soto PL, Ator NA, Rallapalli SK, Biawat P, Clayton T, Cook JM, Weed MR. Allosteric modulation of GABA(A) receptor subtypes:effects on visual recognition and visuospatial working memory in rhesus monkeys [corrected]. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2315-25. PMID 23722241 DOI: 10.1038/npp.2013.137  1
2013 Edwankar CR, Edwankar RV, Namjoshi OA, Liao X, Cook JM. Stereospecific approach to the synthesis of ring-A oxygenated sarpagine indole alkaloids. Total synthesis of the dimeric indole alkaloid P-(+)-dispegatrine and six other monomeric indole alkaloids. The Journal of Organic Chemistry. 78: 6471-87. PMID 23721107 DOI: 10.1021/jo400469t  1
2013 Joksimović S, Varagic Z, Kovačević J, Van Linn M, Milić M, Rallapalli S, Timić T, Sieghart W, Cook JM, Savić MM. Insights into functional pharmacology of α₁ GABA(A) receptors: how much does partial activation at the benzodiazepine site matter? Psychopharmacology. 230: 113-23. PMID 23685860 DOI: 10.1007/s00213-013-3143-4  1
2013 Varagic Z, Wimmer L, Schnürch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. British Journal of Pharmacology. 169: 371-83. PMID 23472852 DOI: 10.1111/bph.12151  1
2013 Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. European Journal of Pharmacology. 703: 18-24. PMID 23380687 DOI: 10.1016/j.ejphar.2013.01.034  1
2013 Fischer BD, Teixeira LP, van Linn ML, Namjoshi OA, Cook JM, Rowlett JK. Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation. Psychopharmacology. 227: 347-54. PMID 23354533 DOI: 10.1007/s00213-013-2975-2  1
2013 Makaron L, Moran CA, Namjoshi O, Rallapalli S, Cook JM, Rowlett JK. Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys. Pharmacology, Biochemistry, and Behavior. 104: 62-8. PMID 23290931 DOI: 10.1016/j.pbb.2012.12.018  1
2013 Kaminski BJ, Van Linn ML, Cook JM, Yin W, Weerts EM. Effects of the benzodiazepine GABAA α1-preferring ligand, 3-propoxy-β-carboline hydrochloride (3-PBC), on alcohol seeking and self-administration in baboons. Psychopharmacology. 227: 127-36. PMID 23271191 DOI: 10.1007/s00213-012-2946-z  1
2013 Milić M, Timić T, Joksimović S, Biawat P, Rallapalli S, Divljaković J, Radulović T, Cook JM, Savić MM. PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats. Behavioural Brain Research. 241: 206-13. PMID 23261875 DOI: 10.1016/j.bbr.2012.12.016  1
2013 Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes. Bioorganic & Medicinal Chemistry. 21: 93-101. PMID 23218469 DOI: 10.1016/j.bmc.2012.10.057  1
2013 Divljaković J, Milić M, Namjoshi OA, Tiruveedhula VV, Timić T, Cook JM, Savić MM. βCCT, an antagonist selective for α(1)GABA(A) receptors, reverses diazepam withdrawal-induced anxiety in rats. Brain Research Bulletin. 91: 1-7. PMID 23149168 DOI: 10.1016/j.brainresbull.2012.10.011  1
2013 Rüedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM. Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys. Alcoholism, Clinical and Experimental Research. 37: 624-34. PMID 23126673 DOI: 10.1111/acer.12018  1
2013 Joksimović S, Divljaković J, Van Linn ML, Varagic Z, Brajković G, Milinković MM, Yin W, Timić T, Sieghart W, Cook JM, Savić MM. Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABA(A) receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 390-9. PMID 22633616 DOI: 10.1016/j.euroneuro.2012.05.003  1
2013 Wang H, Ridley J, Dunn DW, Wang R, Cook JM, Yu DW. Biased oviposition and biased survival together help resolve a fig-wasp conflict Oikos. 122: 533-540. DOI: 10.1111/j.1600-0706.2012.20463.x  0.88
2013 Campbell H, Townsend IR, Fellowes MDE, Cook JM. Thorn-dwelling ants provide antiherbivore defence for camelthorn trees, Vachellia erioloba, in Namibia African Journal of Ecology. 51: 590-598. DOI: 10.1111/aje.12070  0.88
2013 Campbell H, Fellowes MDE, Cook JM. Arboreal thorn-dwelling ants coexisting on the savannah ant-plant, Vachellia erioloba, use domatia morphology to select nest sites Insectes Sociaux. 60: 373-382. DOI: 10.1007/s00040-013-0307-5  0.88
2012 Oliver TH, Leather SR, Cook JM. Ant Larval Demand Reduces Aphid Colony Growth Rates in an Ant-Aphid Interaction. Insects. 3: 120-30. PMID 26467951 DOI: 10.3390/insects3010120  0.88
2012 Yang CY, Xiao JH, Niu LM, Ma GC, Cook JM, Bian SN, Fu YG, Huang DW. Chaos of Wolbachia sequences inside the compact fig syconia of Ficus benjamina (Ficus: moraceae). Plos One. 7: e48882. PMID 23145008 DOI: 10.1371/journal.pone.0048882  0.96
2012 Edwankar CR, Edwankar RV, Deschamps JR, Cook JM. Nature-inspired stereospecific total synthesis of P-(+)-dispegatrine and four other monomeric sarpagine indole alkaloids. Angewandte Chemie (International Ed. in English). 51: 11762-5. PMID 23073985 DOI: 10.1002/anie.201206015  1
2012 Vinkers CH, van Oorschot R, Nielsen EØ, Cook JM, Hansen HH, Groenink L, Olivier B, Mirza NR. GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment. Plos One. 7: e43054. PMID 22912786 DOI: 10.1371/journal.pone.0043054  1
2012 Cruaud A, Rønsted N, Chantarasuwan B, Chou LS, Clement WL, Couloux A, Cousins B, Genson G, Harrison RD, Hanson PE, Hossaert-McKey M, Jabbour-Zahab R, Jousselin E, Kerdelhué C, Kjellberg F, ... ... Cook JM, et al. An extreme case of plant-insect codiversification: figs and fig-pollinating wasps. Systematic Biology. 61: 1029-47. PMID 22848088 DOI: 10.1093/sysbio/sys068  0.88
2012 Chen Q, Yim PD, Yuan N, Johnson J, Cook JM, Smith S, Ionescu-Zanetti C, Wang ZJ, Arnold LA, Emala CW. Comparison of cell expression formats for the characterization of GABA(A) channels using a microfluidic patch clamp system. Assay and Drug Development Technologies. 10: 325-35. PMID 22574655 DOI: 10.1089/adt.2011.415  0.8
2012 Song X, Fanelli MG, Cook JM, Bai F, Parish CA. Mechanisms for the reaction of thiophene and methylthiophene with singlet and triplet molecular oxygen. The Journal of Physical Chemistry. A. 116: 4934-46. PMID 22515263 DOI: 10.1021/jp301919g  0.48
2012 Milić M, Divljaković J, Rallapalli S, van Linn ML, Timić T, Cook JM, Savić MM. The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats. Behavioural Pharmacology. 23: 191-7. PMID 22327019 DOI: 10.1097/FBP.0b013e3283512c85  1
2012 Edwankar RV, Edwankar CR, Namjoshi OA, Deschamps JR, Cook JM. Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids. Journal of Natural Products. 75: 181-8. PMID 22257244 DOI: 10.1021/np200759h  1
2012 Kabir MS, Namjoshi OA, Verma R, Lorenz M, Tiruveedhula VV, Monte A, Bertz SH, Schwabacher AW, Cook JM. Base-mediated stereospecific synthesis of aryloxy and amino substituted ethyl acrylates. The Journal of Organic Chemistry. 77: 300-10. PMID 22073965 DOI: 10.1021/jo201948e  1
2012 Gallos G, Yim P, Chang S, Zhang Y, Xu D, Cook JM, Gerthoffer WT, Emala CW. Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 302: L248-56. PMID 21949156 DOI: 10.1152/ajplung.00131.2011  0.72
2012 Vinkers CH, Hendriksen H, van Oorschot R, Cook JM, Rallipalli S, Huang S, Millan MJ, Olivier B, Groenink L. Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes. Psychopharmacology. 219: 897-908. PMID 21833506 DOI: 10.1007/s00213-011-2423-0  1
2012 Schwan WR, Kabir MS, Kallaus M, Krueger S, Monte A, Cook JM. Synthesis and minimum inhibitory concentrations of SK-03-92 against Staphylococcus aureus and other gram-positive bacteria. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy. 18: 124-6. PMID 21739106 DOI: 10.1007/s10156-011-0273-7  1
2011 Edwankar RV, Edwankar CR, Deschamps J, Cook JM. Regiospecific, enantiospecific total synthesis of C-19 methyl substituted sarpagine alkaloids dihydroperaksine-17-al and dihydroperaksine. Organic Letters. 13: 5216-9. PMID 21877687 DOI: 10.1021/ol202101p  1
2011 Iyer SV, Benavides RA, Chandra D, Cook JM, Rallapalli S, June HL, Homanics GE. α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513. Frontiers in Pharmacology. 2: 18. PMID 21779248 DOI: 10.3389/fphar.2011.00018  1
2011 Ghosh K, Sen T, Patra A, Mancini JS, Cook JM, Parish CA. (rac)-1,1'-binaphthyl-based simple receptors designed for fluorometric discrimination of maleic and fumaric acids. The Journal of Physical Chemistry. B. 115: 8597-608. PMID 21661730 DOI: 10.1021/jp202304k  0.48
2011 Gill KM, Lodge DJ, Cook JM, Aras S, Grace AA. A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1903-11. PMID 21562483 DOI: 10.1038/npp.2011.76  1
2011 Namjoshi OA, Gryboski A, Fonseca GO, Van Linn ML, Wang ZJ, Deschamps JR, Cook JM. Development of a two-step route to 3-PBC and βCCt, two agents active against alcohol self-administration in rodent and primate models. The Journal of Organic Chemistry. 76: 4721-7. PMID 21495660 DOI: 10.1021/jo200425m  1
2011 Sun XJ, Xiao JH, Cook JM, Feng G, Huang DW. Comparisons of host mitochondrial, nuclear and endosymbiont bacterial genes reveal cryptic fig wasp species and the effects of Wolbachia on host mtDNA evolution and diversity. Bmc Evolutionary Biology. 11: 86. PMID 21457543 DOI: 10.1186/1471-2148-11-86  0.96
2011 Wang Y, Chandra R, Samsa LA, Gooch B, Fee BE, Cook JM, Vigna SR, Grant AO, Liddle RA. Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G528-37. PMID 21183662 DOI: 10.1152/ajpgi.00387.2010  0.44
2011 Di Lio A, Benke D, Besson M, Desmeules J, Daali Y, Wang ZJ, Edwankar R, Cook JM, Zeilhofer HU. HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain. Neuropharmacology. 60: 626-32. PMID 21145329 DOI: 10.1016/j.neuropharm.2010.11.026  1
2010 Yin W, Majumder S, Clayton T, Petrou S, VanLinn ML, Namjoshi OA, Ma C, Cromer BA, Roth BL, Platt DM, Cook JM. Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. Bioorganic & Medicinal Chemistry. 18: 7548-64. PMID 20888240 DOI: 10.1016/j.bmc.2010.08.049  1
2010 Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, et al. Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure. Neuropharmacology. 59: 612-8. PMID 20727364 DOI: 10.1016/j.neuropharm.2010.08.011  1
2010 Kabir MS, Namjoshi OA, Verma R, Polanowski R, Krueger SM, Sherman D, Rott MA, Schwan WR, Monte A, Cook JM. A new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives. Bioorganic & Medicinal Chemistry. 18: 4178-86. PMID 20537903 DOI: 10.1016/j.bmc.2010.05.016  1
2010 Kabir MS, Lorenz M, Van Linn ML, Namjoshi OA, Ara S, Cook JM. A very active cu-catalytic system for the synthesis of aryl, heteroaryl, and vinyl sulfides. The Journal of Organic Chemistry. 75: 3626-43. PMID 20429581 DOI: 10.1021/jo1004179  1
2010 Van Linn ML, Cook JM. Mechanistic studies on the cis to trans epimerization of trisubstituted 1,2,3,4-tetrahydro-beta-carbolines. The Journal of Organic Chemistry. 75: 3587-99. PMID 20429580 DOI: 10.1021/jo1003778  1
2010 Yin W, Kabir MS, Wang Z, Rallapalli SK, Ma J, Cook JM. Enantiospecific total synthesis of the important biogenetic intermediates along the ajmaline pathway, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epivellosimine and macusine A. The Journal of Organic Chemistry. 75: 3339-49. PMID 20392128 DOI: 10.1021/jo100279w  1
2010 Soyinka JO, Onyeji CO, Omoruyi SI, Owolabi AR, Sarma PV, Cook JM. Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration. British Journal of Clinical Pharmacology. 69: 262-70. PMID 20233197 DOI: 10.1111/j.1365-2125.2009.03566.x  0.36
2010 Lorenz M, Kabir MS, Cook JM. A two step synthesis of BzR/GABAergic active flavones via a Wacker-related oxidation. Tetrahedron Letters. 51: 1095. PMID 20161661 DOI: 10.1016/j.tetlet.2009.12.107  1
2010 Savić MM, Kukić JM, Grayer RJ, Milinković MM, Marin PD, Divljaković J, Van Linn M, Cook JM, Petrović SD. Behavioural characterization of four endemic Stachys taxa. Phytotherapy Research : Ptr. 24: 1309-16. PMID 20127664 DOI: 10.1002/ptr.3106  1
2010 Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM. Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 34: 376-86. PMID 20074611 DOI: 10.1016/j.pnpbp.2010.01.004  1
2010 Kabir MS, Lorenz M, Namjoshi OA, Cook JM. First application of an efficient and versatile ligand for copper-catalyzed cross-coupling reactions of vinyl halides with N-heterocycles and phenols. Organic Letters. 12: 464-7. PMID 20039699 DOI: 10.1021/ol9026446  1
2010 Grant JA, Bonnick T, Gossell-Williams M, Clayton T, Cook JM, Jackson YA. Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides. Bioorganic & Medicinal Chemistry. 18: 909-21. PMID 19962901 DOI: 10.1016/j.bmc.2009.11.032  1
2010 Licata SC, Platt DM, Rüedi-Bettschen D, Atack JR, Dawson GR, Van Linn ML, Cook JM, Rowlett JK. Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes. Neuropharmacology. 58: 357-64. PMID 19853619 DOI: 10.1016/j.neuropharm.2009.10.004  1
2010 Lorenz M, van Linn ML, Cook JM. The asymmetric pictet-spengler reaction Current Organic Synthesis. 7: 189-223. DOI: 10.2174/157017910791163011  1
2010 Yang J, Rallapalli SK, Cook JM. The first enantiospecific total synthesis of the 3-oxygenated sarpagine indole alkaloids affinine and 16-epiaffinine, as well as vobasinediol and 16-epivobasinediol Tetrahedron Letters. 51: 815-817. DOI: 10.1016/j.tetlet.2009.12.002  1
2009 Bouteiller-Reuter C, Hale ML, Cook JM. Characterization of microsatellite markers for Sycoscapter nonpollinating fig wasps. Molecular Ecology Resources. 9: 832-5. PMID 21564760 DOI: 10.1111/j.1755-0998.2008.02284.x  0.88
2009 Yang J, Teng Y, Ara S, Rallapalli S, Cook JM. An Improved Process for the Synthesis of 4H-Imidazo[1,5-a][1,4]benzodiazepines. Synthesis. 40: nihpa145687. PMID 19936036 DOI: 10.1002/chin.200932173  0.96
2009 Edwankar CR, Edwankar RV, Namjoshi OA, Rallapalli SK, Yang J, Cook JM. Recent progress in the total synthesis of indole alkaloids. Current Opinion in Drug Discovery & Development. 12: 752-71. PMID 19894188  1
2009 Wiltgen BJ, Godsil BP, Peng Z, Saab F, June HL, Linn ML, Cook JM, Houser CR, O'Dell TJ, Homanics GE, Fanselow MS. The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. Frontiers in Behavioral Neuroscience. 3: 37. PMID 19876409 DOI: 10.3389/neuro.08.037.2009  1
2009 Bailey R, Schönrogge K, Cook JM, Melika G, Csóka G, Thuróczy C, Stone GN. Host niches and defensive extended phenotypes structure parasitoid wasp communities. Plos Biology. 7: e1000179. PMID 19707266 DOI: 10.1371/journal.pbio.1000179  0.88
2009 Lopez-Vaamonde C, Wikström N, Kjer KM, Weiblen GD, Rasplus JY, Machado CA, Cook JM. Molecular dating and biogeography of fig-pollinating wasps. Molecular Phylogenetics and Evolution. 52: 715-26. PMID 19500682 DOI: 10.1016/j.ympev.2009.05.028  0.88
2009 Soyinka JO, Onyeji CO, Omoruyi SI, Owolabi AR, Sarma PV, Cook JM. Effects of concurrent administration of nevirapine on the disposition of quinine in healthy volunteers. The Journal of Pharmacy and Pharmacology. 61: 439-43. PMID 19298689 DOI: 10.1211/jpp/61.04.0004  0.36
2009 Stone GN, Hernandez-Lopez A, Nicholls JA, di Pierro E, Pujade-Villar J, Melika G, Cook JM. Extreme host plant conservatism during at least 20 million years of host plant pursuit by oak gallwasps. Evolution; International Journal of Organic Evolution. 63: 854-69. PMID 19292826 DOI: 10.1111/j.1558-5646.2008.00604.x  0.88
2009 Rivas FM, Stables JP, Murphree L, Edwankar RV, Edwankar CR, Huang S, Jain HD, Zhou H, Majumder S, Sankar S, Roth BL, Ramerstorfer J, Furtmüller R, Sieghart W, Cook JM. Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Journal of Medicinal Chemistry. 52: 1795-8. PMID 19275170 DOI: 10.1021/jm801652d  1
2009 Kumpaty HJ, Van Linn ML, Kabir MS, Försterling FH, Deschamps JR, Cook JM. Study of the cis to trans isomerization of 1-phenyl-2,3-disubstituted tetrahydro-beta-carbolines at C(1). Evidence for the carbocation-mediated mechanism. The Journal of Organic Chemistry. 74: 2771-9. PMID 19275130 DOI: 10.1021/jo8028168  1
2009 Savić MM, Milinković MM, Rallapalli S, Clayton T, Joksimović S, Van Linn M, Cook JM. The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 1179-93. PMID 19265570 DOI: 10.1017/S1461145709000108  1
2009 Vinkers CH, Klanker M, Groenink L, Korte SM, Cook JM, Van Linn ML, Hopkins SC, Olivier B. Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress. Psychopharmacology. 204: 299-311. PMID 19169673 DOI: 10.1007/s00213-009-1460-4  1
2009 Takahashi A, Yap JJ, Bohager DZ, Faccidomo S, Clayton T, Cook JM, Miczek KA. Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology. 204: 61-71. PMID 19099296 DOI: 10.1007/s00213-008-1437-8  1
2009 Ma J, Yin W, Zhou H, Liao X, Cook JM. General approach to the total synthesis of 9-methoxy-substituted indole alkaloids: synthesis of mitragynine, as well as 9-methoxygeissoschizol and 9-methoxy-N(b)-methylgeissoschizol. The Journal of Organic Chemistry. 74: 264-73. PMID 19046119 DOI: 10.1021/jo801839t  1
2009 Licata SC, Platt DM, Cook JM, Van Linn ML, Rowlett JK. Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys. Psychopharmacology. 203: 539-46. PMID 19031072 DOI: 10.1007/s00213-008-1401-7  1
2009 Yang J, Teng Y, Ara S, Rallapalli S, Cook JM. An improved process for the synthesis of 4H-imidazo[1,5-a][1,4] benzodiazepines Synthesis. 1036-1040. DOI: 10.1055/s-0028-1083358  1
2008 Shahjahan Kabir M, Engelbrecht K, Polanowski R, Krueger SM, Ignasiak R, Rott M, Schwan WR, Stemper ME, Reed KD, Sherman D, Cook JM, Monte A. New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis. Bioorganic & Medicinal Chemistry Letters. 18: 5745-9. PMID 18849164 DOI: 10.1016/j.bmcl.2008.09.085  1
2008 Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, ... ... Cook JM, et al. A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry. 16: 8853-62. PMID 18790643 DOI: 10.1016/j.bmc.2008.08.072  1
2008 Dunn DW, Yu DW, Ridley J, Cook JM. Longevity, early emergence and body size in a pollinating fig wasp--implications for stability in a fig-pollinator mutualism. The Journal of Animal Ecology. 77: 927-35. PMID 18624736 DOI: 10.1111/j.1365-2656.2008.01416.x  0.76
2008 Yang J, Wearing XZ, Le Quesne PW, Deschamps JR, Cook JM. Enantiospecific synthesis of (+)-alstonisine via a stereospecific osmylation process. Journal of Natural Products. 71: 1431-40. PMID 18611051 DOI: 10.1021/np800269k  1
2008 Kabir MS, Van Linn ML, Monte A, Cook JM. Stereo- and regiospecific cu-catalyzed cross-coupling reaction of vinyl iodides and thiols: a very mild and general route for the synthesis of vinyl sulfides. Organic Letters. 10: 3363-6. PMID 18611035 DOI: 10.1021/ol801149n  1
2008 Rønsted N, Weiblen GD, Savolainen V, Cook JM. Phylogeny, biogeography, and ecology of Ficus section Malvanthera (Moraceae). Molecular Phylogenetics and Evolution. 48: 12-22. PMID 18490180 DOI: 10.1016/j.ympev.2008.04.005  0.88
2008 Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM. PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain Research. 1208: 150-9. PMID 18394590 DOI: 10.1016/j.brainres.2008.02.020  1
2008 Dunn DW, Segar ST, Ridley J, Chan R, Crozier RH, Yu DW, Cook JM. A role for parasites in stabilising the fig-pollinator mutualism. Plos Biology. 6: e59. PMID 18336072 DOI: 10.1371/journal.pbio.0060059  0.76
2008 Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry. 16: 4626-51. PMID 18321710 DOI: 10.1016/j.bmc.2008.02.050  1
2008 Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM. Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 332-9. PMID 17392731 DOI: 10.1038/sj.npp.1301403  1
2008 Edwankar CR, Edwankar RV, Rallapalli S, Cook JM. General approach to the total synthesis of macroline-related sarpagine and ajmaline alkaloids Natural Product Communications. 3: 1839-1870.  1
2007 Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models. Current Medicinal Chemistry. 14: 2755-75. PMID 18045122 DOI: 10.2174/092986707782360097  1
2007 Oliver TH, Mashanova A, Leather SR, Cook JM, Jansen VA. Ant semiochemicals limit apterous aphid dispersal. Proceedings. Biological Sciences / the Royal Society. 274: 3127-31. PMID 17925280 DOI: 10.1098/rspb.2007.1251  0.88
2007 Ma J, Yin W, Zhou H, Cook JM. Total synthesis of the opioid agonistic indole alkaloid mitragynine and the first total syntheses of 9-methoxygeissoschizol and 9-methoxy-Nb-methylgeissoschizol. Organic Letters. 9: 3491-4. PMID 17685530 DOI: 10.1021/ol071220l  1
2007 Liao X, Huang S, Zhou H, Parrish D, Cook JM. Cascade approach toward the core structure of neosarpagine. Organic Letters. 9: 1469-71. PMID 17358071 DOI: 10.1021/ol070148o  1
2007 Han D, Försterling FH, Deschamps JR, Parrish D, Liu X, Yin W, Huang S, Cook JM. Conformational analysis of the cis- and trans-adducts of the Pictet - Spengler reaction. Evidence for the structural basis for the C(1) - N(2) scission process in the cis- to trans-isomerization. Journal of Natural Products. 70: 75-82. PMID 17253853 DOI: 10.1021/np060391g  1
2007 Yin W, Ma J, Rivas FM, Cook JM. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. Organic Letters. 9: 295-8. PMID 17217288 DOI: 10.1021/ol062762q  1
2007 June HL, Foster KL, Eiler WJ, Goergen J, Cook JB, Johnson N, Mensah-Zoe B, Simmons JO, June HL, Yin W, Cook JM, Homanics GE. Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 137-52. PMID 16710315 DOI: 10.1038/sj.npp.1301097  1
2007 Kabir MS, Monte A, Cook JM. An efficient palladium-catalyzed Negishi cross-coupling reaction with arylvinyl iodides: facile regioselective synthesis of E-stilbenes and their analogues Tetrahedron Letters. 48: 7269-7273. DOI: 10.1016/j.tetlet.2007.08.047  1
2006 Liao X, Zhou H, Yu J, Cook JM. An improved total synthesis of (+)-macroline and alstonerine as well as the formal total synthesis of (-)-talcarpine and (-)-anhydromacrosalhine-methine. The Journal of Organic Chemistry. 71: 8884-90. PMID 17081019 DOI: 10.1021/jo061652u  1
2006 Turner JG, Gump JL, Zhang C, Cook JM, Marchion D, Hazlehurst L, Munster P, Schell MJ, Dalton WS, Sullivan DM. ABCG2 expression, function, and promoter methylation in human multiple myeloma. Blood. 108: 3881-9. PMID 16917002 DOI: 10.1182/blood-2005-10-009084  0.48
2006 Duke AN, Platt DM, Cook JM, Huang S, Yin W, Mattingly BA, Rowlett JK. Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes. Psychopharmacology. 187: 321-30. PMID 16783540 DOI: 10.1007/s00213-006-0431-2  1
2006 Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Van Linn M, Bokonjić DR. Benzodiazepine site inverse agonists and locomotor activity in rats: bimodal and biphasic influence. Pharmacology, Biochemistry, and Behavior. 84: 35-42. PMID 16725185 DOI: 10.1016/j.pbb.2006.04.001  1
2006 Srirama Sarma PV, Cook JM. Enantiospecific synthesis of (+)-N(a)-methylpericyclivine and (-)-N(a)-methylakuammidine as well as the ring-A oxygenated natural products, (+)-10-methoxy N(a)-methylpericyclivine and 10-hydroxy N(a)-methylpericyclivine. Organic Letters. 8: 1017-20. PMID 16524257 DOI: 10.1021/ol0526266  1
2006 Zhou H, Liao X, Yin W, Ma J, Cook JM. General approach for the synthesis of 12-methoxy-substituted sarpagine indole alkaloids including (-)-12-methoxy-N(b)-methylvoachalotine, (+)-12-methoxy-N(a)-methylvellosimine, (+)-12-methoxyaffinisine, and (-)-fuchsiaefoline. The Journal of Organic Chemistry. 71: 251-9. PMID 16388644 DOI: 10.1021/jo052081t  1
2005 Cook JM, West SA. Figs and fig wasps. Current Biology : Cb. 15: R978-80. PMID 16360672 DOI: 10.1016/j.cub.2005.11.057  0.88
2005 Rønsted N, Weiblen GD, Cook JM, Salamin N, Machado CA, Savolainen V. 60 million years of co-divergence in the fig-wasp symbiosis. Proceedings. Biological Sciences / the Royal Society. 272: 2593-9. PMID 16321781 DOI: 10.1098/rspb.2005.3249  0.88
2005 Cook JB, Foster KL, Eiler WJ, McKay PF, Woods J, Harvey SC, Garcia M, Grey C, McCane S, Mason D, Cummings R, Li X, Cook JM, June HL. Selective GABAA alpha5 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol. Alcoholism, Clinical and Experimental Research. 29: 1390-401. PMID 16131846 DOI: 10.1097/01.alc.0000175073.94575.86  1
2005 Liao X, Zhou H, Wearing XZ, Ma J, Cook JM. The first regiospecific, enantiospecific total synthesis of 6-oxoalstophylline and an improved total synthesis of alstonerine and alstophylline as well as the bisindole alkaloid macralstonine. Organic Letters. 7: 3501-4. PMID 16048327 DOI: 10.1021/ol051208y  1
2005 Srirama Sarma PV, Han D, Deschamps JR, Cook JM. Confirmation of the structure of (3S)-3-hydroxyquinine: synthesis and X-ray crystal structure of its 9-aceto analogue. Journal of Natural Products. 68: 942-4. PMID 15974625 DOI: 10.1021/np050015g  1
2005 Yu J, Wearing XZ, Cook JM. A general strategy for the synthesis of vincamajine-related indole alkaloids: stereocontrolled total synthesis of (+)-dehydrovoachalotine, (-)-vincamajinine, and (-)-11-methoxy-17-epivincamajine as well as the related quebrachidine diol, vincamajine diol, and vincarinol. The Journal of Organic Chemistry. 70: 3963-79. PMID 15876085 DOI: 10.1021/jo040282b  1
2005 Savić MM, Obradović DI, Ugresić ND, Cook JM, Sarma PV, Bokonjić DR. Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt. Psychopharmacology. 180: 455-65. PMID 15719222 DOI: 10.1007/s00213-005-2170-1  0.72
2005 Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Bokonjić DR. Bidirectional effects of benzodiazepine binding site ligands in the passive avoidance task: differential antagonism by flumazenil and beta-CCt. Behavioural Brain Research. 158: 293-300. PMID 15698896 DOI: 10.1016/j.bbr.2004.09.011  1
2005 Licata SC, Platt DM, Cook JM, Sarma PV, Griebel G, Rowlett JK. Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one]. The Journal of Pharmacology and Experimental Therapeutics. 313: 1118-25. PMID 15687371 DOI: 10.1124/jpet.104.081612  1
2005 Cao H, Van Ornum SG, Deschamps J, Flippen-Anderson J, Laib F, Cook JM. Synthesis of dicyclopenta[a,e]pentalenes via a molybdenum carbonyl mediated tandem allenic Pauson-Khand reaction and the X-ray crystal structure of a planar dicyclopenta[a,e]pentalene. Journal of the American Chemical Society. 127: 933-43. PMID 15656632 DOI: 10.1021/ja040120x  1
2005 Platt DM, Duggan A, Spealman RD, Cook JM, Li X, Yin W, Rowlett JK. Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 313: 658-67. PMID 15650112 DOI: 10.1124/jpet.104.080275  1
2005 Rowlett JK, Cook JM, Duke AN, Platt DM. Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs. Cns Spectrums. 10: 40-8. PMID 15618946  1
2005 Yin W, Sarma PVVS, Ma J, Han D, Chen JL, Cook JM. Synthesis of bivalent ligands of β-carboline-3-carboxylates via a palladium-catalyzed homocoupling process Tetrahedron Letters. 46: 6363-6368. DOI: 10.1016/j.tetlet.2005.07.022  1
2005 Zhou H, Han D, Liao X, Cook JM. First regiospecific, enantiospecific total synthesis of gardnerine and gardnutine Tetrahedron Letters. 46: 4219-4224. DOI: 10.1016/j.tetlet.2005.04.051  1
2004 Savić MM, Obradović DI, Ugresić ND, Cook JM, Yin W, Bokonjić DR. Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt. Pharmacology, Biochemistry, and Behavior. 79: 279-90. PMID 15501303 DOI: 10.1016/j.pbb.2004.07.013  1
2004 Yu DW, Ridley J, Jousselin E, Herre EA, Compton SG, Cook JM, Moore JC, Weiblen GD. Oviposition strategies, host coercion and the stable exploitation of figs by wasps. Proceedings. Biological Sciences / the Royal Society. 271: 1185-95. PMID 15306369 DOI: 10.1098/rspb.2003.2630  0.88
2004 Han D, Försterling FH, Li X, Deschamps JR, Cao H, Cook JM. Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. Bioorganic & Medicinal Chemistry Letters. 14: 1465-9. PMID 15006383 DOI: 10.1016/j.bmcl.2004.01.018  1
2004 Yu J, Wearing XZ, Cook JM. Stereocontrolled total synthesis of (-)-vincamajinine and (-)-11-methoxy-17-epivincamajine. Journal of the American Chemical Society. 126: 1358-9. PMID 14759191 DOI: 10.1021/ja039798n  1
2004 Zhou H, Liao X, Cook JM. Regiospecific, enantiospecific total synthesis of the 12-alkoxy-substituted indole alkaloids, (+)-12-methoxy-Na-methylvellosimine, (+)-12-methoxyaffinisine, and (-)-fuchsiaefoline. Organic Letters. 6: 249-52. PMID 14723540 DOI: 10.1021/ol0362212  1
2004 McKay PF, Foster KL, Mason D, Cummings R, Garcia M, Williams LS, Grey C, McCane S, He X, Cook JM, June HL. A high affinity ligand for GABAA-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats. Psychopharmacology. 172: 455-62. PMID 14666398 DOI: 10.1007/s00213-003-1671-z  1
2004 Foster KL, McKay PF, Seyoum R, Milbourne D, Yin W, Sarma PV, Cook JM, June HL. GABA(A) and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 269-84. PMID 14666116 DOI: 10.1038/sj.npp.1300306  1
2004 de Almeida RM, Rowlett JK, Cook JM, Yin W, Miczek KA. GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice. Psychopharmacology. 172: 255-63. PMID 14647970 DOI: 10.1007/s00213-003-1661-1  1
2004 Li X, Yin W, Sarma PVVS, Zhou H, Jun Ma, Cook JM. Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors Tetrahedron Letters. 45: 8569-8573. DOI: 10.1016/j.tetlet.2004.09.113  1
2004 Li X, Yu J, Atack JR, Cook JM. Development of selective ligands for benzodiazepine receptor subtypes by manipulating the substituents at positions 3- and 7- of optically active BzR ligands Medicinal Chemistry Research. 13: 259-281. DOI: 10.1007/s00044-004-0033-7  1
2003 Li X, Cao H, Zhang C, Furtmueller R, Fuchs K, Huck S, Sieghart W, Deschamps J, Cook JM. Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. Journal of Medicinal Chemistry. 46: 5567-70. PMID 14667209 DOI: 10.1021/jm034164c  1
2003 Yu J, Wang T, Liu X, Deschamps J, Flippen-Anderson J, Liao X, Cook JM. General approach for the synthesis of sarpagine indole alkaloids. Enantiospecific total synthesis of (+)-vellosimine, (+)-normacusine B, (-)-alkaloid Q3, (-)-panarine, (+)-Na-methylvellosimine, and (+)-Na-methyl-16-epipericyclivine. The Journal of Organic Chemistry. 68: 7565-81. PMID 14510528 DOI: 10.1021/jo030006h  1
2003 June HL, Foster KL, McKay PF, Seyoum R, Woods JE, Harvey SC, Eiler WJ, Grey C, Carroll MR, McCane S, Jones CM, Yin W, Mason D, Cummings R, Garcia M, ... ... Cook JM, et al. The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2124-37. PMID 12968126 DOI: 10.1038/sj.npp.1300239  1
2003 Zhao S, Liao X, Wang T, Flippen-Anderson J, Cook JM. The enantiospecific, stereospecific total synthesis of the ring-A oxygenated sarpagine indole alkaloids (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine, as well as the total synthesis of the alstonia bisindole alkaloid macralstonidine. The Journal of Organic Chemistry. 68: 6279-95. PMID 12895062 DOI: 10.1021/jo030055u  1
2003 Yu J, Wang T, Wearing XZ, Ma J, Cook JM. Enantiospecific total synthesis of (-)-(E)16-epiaffinisine, (+)-(E)16-epinormacusine B, and (+)-dehydro-16-epiaffinisine as well as the stereocontrolled total synthesis of alkaloid G. The Journal of Organic Chemistry. 68: 5852-9. PMID 12868917 DOI: 10.1021/jo030116o  1
2003 Cao H, Flippen-Anderson J, Cook JM. The synthesis of a dicyclopenta[a,e]pentalene via a molybdenum hexacarbonyl-mediated tandem allenic Pauson-Khand reaction. Journal of the American Chemical Society. 125: 3230-1. PMID 12630875 DOI: 10.1021/ja021159+  1
2003 Rokas A, Melika G, Abe Y, Nieves-Aldrey JL, Cook JM, Stone GN. Lifecycle closure, lineage sorting, and hybridization revealed in a phylogenetic analysis of European oak gallwasps (Hymenoptera: Cynipidae: Cynipini) using mitochondrial sequence data. Molecular Phylogenetics and Evolution. 26: 36-45. PMID 12470936 DOI: 10.1016/S1055-7903(02)00329-9  0.88
2003 Rowlett JK, Spealman RD, Lelas S, Cook JM, Yin W. Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors. Psychopharmacology. 165: 209-15. PMID 12420154 DOI: 10.1007/s00213-002-1275-z  1
2003 Cao H, Mundla SR, Cook JM. Studies on the Rh and Ir mediated tandem Pauson-Khand reaction. A new entry into the dicyclopenta[a,d]cyclooctene ring system Tetrahedron Letters. 44: 6165-6168. DOI: 10.1016/S0040-4039(03)01418-7  1
2002 Yu J, Liao X, Cook JM. Stereospecific, enantiospecific total synthesis of the sarpagine indole alkaloids (E)16-epiaffinisine, (E)16-epinormacusine B, and dehydro-16-epiaffinisine. Organic Letters. 4: 4681-4. PMID 12489960 DOI: 10.1021/ol020209c  1
2002 Wearing XZ, Cook JM. Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine. Organic Letters. 4: 4237-40. PMID 12443067 DOI: 10.1021/ol020170b  1
2002 Cook JM, Rokas A, Pagel M, Stone GN. Evolutionary shifts between host oak sections and host-plant organs in Andricus gallwasps. Evolution; International Journal of Organic Evolution. 56: 1821-30. PMID 12389727  0.88
2002 Liu X, Deschamp JR, Cook JM. Regiospecific, enantiospecific total synthesis of the alkoxy-substituted indole bases, 16-epi-N(a)-methylgardneral, 11-methoxyaffinisine, and 11-methoxymacroline as well as the indole alkaloids alstophylline and macralstonine. Organic Letters. 4: 3339-42. PMID 12323013 DOI: 10.1021/ol020101x  1
2002 Bailey DJ, Tetzlaff JE, Cook JM, He X, Helmstetter FJ. Effects of hippocampal injections of a novel ligand selective for the alpha 5 beta 2 gamma 2 subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning. Neurobiology of Learning and Memory. 78: 1-10. PMID 12071663 DOI: 10.1006/nlme.2001.4050  1
2002 Lelas S, Rowlett JK, Spealman RD, Cook JM, Ma C, Li X, Yin W. Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys. Psychopharmacology. 161: 180-8. PMID 11981598 DOI: 10.1007/s00213-002-1037-y  1
2002 Harvey SC, Foster KL, McKay PF, Carroll MR, Seyoum R, Woods JE, Grey C, Jones CM, McCane S, Cummings R, Mason D, Ma C, Cook JM, June HL. The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3765-75. PMID 11978852  1
2002 Zhao S, Smith KS, Deveau AM, Dieckhaus CM, Johnson MA, Macdonald TL, Cook JM. Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines. Journal of Medicinal Chemistry. 45: 1559-62. PMID 11931609 DOI: 10.1021/jm0155953  1
2002 Zhao S, Liao X, Cook JM. Enantiospecific, stereospecific total synthesis of (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine as well as the total synthesis of the Alstonia bisindole macralstonidine. Organic Letters. 4: 687-90. PMID 11869102  1
2002 McMahon LR, Gerak LR, Carter L, Ma C, Cook JM, France CP. Discriminative stimulus effects of benzodiazepine (BZ)(1) receptor-selective ligands in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 300: 505-12. PMID 11805210 DOI: 10.1124/jpet.300.2.505  1
2002 Li X, Ma C, He X, Yu J, Han D, Zhang C, Atack JR, Cook JM. Studies in search of diazepam-insensitive subtype selective agents for GABA/Bz receptors Medicinal Chemistry Research. 11: 504-537.  1
2001 Liu X, Cook JM. General approach for the synthesis of sarpagine/macroline indole alkaloids. Enantiospecific total synthesis of the indole alkaloid trinervine. Organic Letters. 3: 4023-6. PMID 11735575 DOI: 10.1021/ol0101990  1
2001 DeLorey TM, Lin RC, McBrady B, He X, Cook JM, Lameh J, Loew GH. Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory. European Journal of Pharmacology. 426: 45-54. PMID 11525770 DOI: 10.1016/S0014-2999(01)01199-2  1
2001 Paronis CA, Cox ED, Cook JM, Bergman J. Different types of GABA(A) receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys. Psychopharmacology. 156: 461-8. PMID 11498724 DOI: 10.1007/s002130100754  0.32
2001 Wang T, Xu Q, Yu P, Liu X, Cook JM. Stereocontrolled total synthesis of alkaloid G via the oxy-anion Cope rearrangement and improved total synthesis of (+)-ajmaline. Organic Letters. 3: 345-8. PMID 11428010 DOI: 10.1021/ol000331g  1
2001 Ma C, Liu X, Li X, Flippen-Anderson J, Yu S, Cook JM. Efficient asymmetric synthesis of biologically important tryptophan analogues via a palladium-mediated heteroannulation reaction. The Journal of Organic Chemistry. 66: 4525-42. PMID 11421771 DOI: 10.1021/jo001679s  1
2001 Rowlett JK, Tornatzky W, Cook JM, Ma C, Miczek KA. Zolpidem, triazolam, and diazepam decrease distress vocalizations in mouse pups: differential antagonism by flumazenil and beta-Carboline-3-carboxylate-t-butyl ester (beta-CCt). The Journal of Pharmacology and Experimental Therapeutics. 297: 247-53. PMID 11259551  1
2001 June HL, Harvey SC, Foster KL, McKay PF, Cummings R, Garcia M, Mason D, Grey C, McCane S, Williams LS, Johnson TB, He X, Rock S, Cook JM. GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2166-77. PMID 11245701  1
2000 He X, Huang Q, Ma C, Yu S, McKernan R, Cook JM. Pharmacophore/receptor models for GABA(A)/BzR alpha2beta3gamma2, alpha3beta3gamma2 and alpha4beta3gamma2 recombinant subtypes. Included volume analysis and comparison to alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2 subtypes. Drug Design and Discovery. 17: 131-71. PMID 11045902  0.96
2000 Harris DL, DeLorey TM, He X, Cook JM, Loew GH. Determinants of recognition of ligands binding to benzodiazepine receptor/GABA(A) receptors initiating sedation. European Journal of Pharmacology. 401: 271-87. PMID 10936485 DOI: 10.1016/S0014-2999(00)00462-3  1
2000 Van Ornum SG, Bruendl MM, Cao H, Reddy M, Grubisha DS, Bennett DW, Cook JM. Utility of the tandem Pauson-Khand reaction in the construction of tetracycles The Journal of Organic Chemistry. 65: 1957-71. PMID 10774014  0.96
2000 Huang Q, He X, Ma C, Liu R, Yu S, Dayer CA, Wenger GR, McKernan R, Cook JM. Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. Journal of Medicinal Chemistry. 43: 71-95. PMID 10633039 DOI: 10.1021/jm990341r  1
1999 He X, Huang Q, Yu S, Ma C, McKernan R, Cook JM. Studies of molecular pharmacophore/receptor models for GABAA/BzR subtypes: binding affinities of symmetrically substituted pyrazolo[4,3-c]quinolin-3-ones at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis. Drug Design and Discovery. 16: 77-91. PMID 10466058  0.96
1999 Huang Q, Cox ED, Gan T, Ma C, Bennett DW, McKernan RM, Cook JM. Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis. Drug Design and Discovery. 16: 55-76. PMID 10466057  1
1998 Huang Q, Liu R, Zhang P, He X, McKernan R, Gan T, Bennett DW, Cook JM. Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis. Journal of Medicinal Chemistry. 41: 4130-42. PMID 9767648 DOI: 10.1021/jm980317y  0.96
1998 Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM. Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors. Journal of Medicinal Chemistry. 41: 2537-52. PMID 9651158 DOI: 10.1021/jm970460b  1
1997 Liu R, Zhang P, Gan T, Cook JM. Regiospecific Bromination of 3-Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides(1). The Journal of Organic Chemistry. 62: 7447-7456. PMID 11671863  0.84
1997 Cox ED, Hamaker LK, Li J, Yu P, Czerwinski KM, Deng L, Bennett DW, Cook JM, Watson WH, Krawiec M. Enantiospecific Formation of Trans 1,3-Disubstituted Tetrahydro-beta-carbolines by the Pictet-Spengler Reaction and Conversion of Cis Diastereomers into Their Trans Counterparts by Scission of the C-1/N-2 Bond. The Journal of Organic Chemistry. 62: 44-61. PMID 11671363  1
1997 Greenberg HE, Scharf M, Mendelson W, Cook JM, Cox E, Scharf SM. Effect of beta-carboline-3-carboxoylate-t-butyl ester on ventilatory control. Life Sciences. 60: 485-92. PMID 9042377 DOI: 10.1016/S0024-3205(96)00679-0  1
1997 Van Ornum SG, Li J, Kubiak GG, Cook JM. Steric and electronic effects on the Weiss reaction. Isolation of 1:1 adducts Journal of the Chemical Society - Perkin Transactions 1. 3471-3478.  1
1997 Williams RV, Gadgil VR, Vij A, Cook JM, Kubiak G, Huang Q. Unexpected stereoselectivity in the Weiss-Cook condensation of dimethyl 1,3-acetonedicarboxylate with pentane-2,3-dione Journal of the Chemical Society - Perkin Transactions 1. 1425-1428.  1
1995 Zhang P, Zhang W, Liu R, Harris B, Skolnick P, Cook JM. Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors. Journal of Medicinal Chemistry. 38: 1679-88. PMID 7752192  1
1995 Zhang W, Koehler KF, Zhang P, Cook JM. Development of a comprehensive pharmacophore model for the benzodiazepine receptor. Drug Design and Discovery. 12: 193-248. PMID 7662830  0.84
1995 Cox ED, Cook JM. The pictet-spengler condensation: A new direction for an old reaction Chemical Reviews. 95: 1797-1842.  1
1994 Ator NA, Cook JM, Allen MS, Griffiths RR. Discriminative-stimulus effects of azaspirodecanedione anxiolytics in baboons trained to discriminate beta-carboline-3-carboxylic acid ethyl ester or pentylenetetrazole. Behavioural Pharmacology. 5: 176-188. PMID 11224266  0.88
1994 Zhang W, Koehler KF, Harris B, Skolnick P, Cook JM. Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors. Journal of Medicinal Chemistry. 37: 745-57. PMID 8145224  1
1994 Wigler PW, Lyon KL, Patterson FK, La Loggia AJ, Diaz-Araúzo H, Reddy MS, Cook JM. Epoxide metabolite of quinine and inhibition of the multidrug resistance pump in human leukemic lymphoblasts. Molecular Pharmacology. 46: 562-7. PMID 7935339  0.32
1994 Bi Y, Zhang LH, Hamaker LK, Cook JM. Enantiospecific synthesis of (-)-alstonerine and (+)-macroline as well as a partial synthesis of (+)-villalstonine Journal of the American Chemical Society. 116: 9027-9041. DOI: 10.1021/ja00099a021  1
1994 Bi Y, Cook JM, LeQuesne PW. A partial synthesis of the Alstonia bisindole alkaloid villalstonine Tetrahedron Letters. 35: 3877-3878. DOI: 10.1016/S0040-4039(00)76690-1  1
1993 Wong G, Koehler KF, Skolnick P, Gu ZQ, Ananthan S, Schönholzer P, Hunkeler W, Zhang W, Cook JM. Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors. Journal of Medicinal Chemistry. 36: 1820-30. PMID 8390574  1
1993 Fu X, Kubiak G, Zhang W, Han W, Gupta AK, Cook JM. General approach for the synthesis of polyquinenes via the Weiss reaction XV. Synthesis of the [5.5.5.5]fenestrane system via the aldol approach and studies directed toward the [5.5.6.6]fenestranes Tetrahedron. 49: 1511-1524. DOI: 10.1016/S0040-4020(01)80338-0  1
1993 Bi Y, Cook JM. General approach for the synthesis of macroline/sarpagine alkaloids. The total synthesis of (+)-macroline Tetrahedron Letters. 34: 4501-4504. DOI: 10.1016/0040-4039(93)88069-U  1
1993 Fu X, Cook JM. General approach for the synthesis of ajmaline-related alkaloids. Enantiospecific total synthesis of (-)-suaveoline, (-)-raumacline, and (-)-Nb-methylraumacline Journal of Organic Chemistry. 58: 661-672.  1
1992 Takada K, Barrett JE, Allen MS, Cook JM, Katz JL. Punishment of schedule-controlled behavior with beta-carboline injections: antagonism and comparisons with other compounds. The Journal of Pharmacology and Experimental Therapeutics. 261: 138-45. PMID 1560359  1
1992 Allen MS, LaLoggia AJ, Dorn LJ, Martin MJ, Costantino G, Hagen TJ, Koehler KF, Skolnick P, Cook JM. Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. Journal of Medicinal Chemistry. 35: 4001-10. PMID 1331452  1
1992 Allen MS, Skolnick P, Cook JM. Synthesis of novel 2-phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: topological comparisons with analogues of 2-phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-ones at benzodiazepine receptors. Journal of Medicinal Chemistry. 35: 368-74. PMID 1310121  1
1992 Fu X, Cook JM. The synthesis of polyquinanes and polyquinenes via the weiss reaction Aldrichimica Acta. 25: 43-54.  1
1992 Fu X, Cook JM. General approach for the synthesis of polyquinenes via the Weiss reaction. 14. Synthesis of ellacene (1,10-decanotriquinacene) and studies of the proposed dimerization to a substituted dodecahedrane Journal of Organic Chemistry. 57: 5121-5128.  1
1992 Zhang LH, Bi YZ, Yu FX, Menzia G, Cook JM. Stereospecificity in the Pictet-Spengler reaction. Enantiospecific synthesis of (6s, 10s)-(-)-5-methyl-9-oxo-12-benzyl-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooct[b]indole, a template for preparation of macroline/sarpagine alkaloids Heterocycles. 34: 517-547.  1
1992 Fu X, Cook JM. Enantiospecific total synthesis of the ajmaline related alkaloids (-)-suaveoline, (-)-raumacline, and (-)-N(b)-methylraumacline Journal of the American Chemical Society. 114: 6910-6912.  1
1991 Diaz-Arauzo H, Evoniuk GE, Skolnick P, Cook JM. The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic. Journal of Medicinal Chemistry. 34: 1754-6. PMID 1674542  1
1991 Sannerud CA, Allen M, Cook JM, Griffiths RR. Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons. European Journal of Pharmacology. 202: 159-69. PMID 1666365  0.36
1991 Diaz-Arauzo H, Koehler KF, Hagen TJ, Cook JM. Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors. Life Sciences. 49: 207-16. PMID 1648158 DOI: 10.1016/0024-3205(91)90005-V  1
1991 Narayanan K, Cook JM. Carboxyl-mediated Pictet-Spengler reaction. Improved synthesis of 2,3,5,6,11,11b-hexahydro-3-oxo-1H-indolizino[8,7-b]indoles from tryptamine-2-carboxylic acids Journal of Organic Chemistry. 56: 5733-5736.  1
1991 Narayanan K, Schindler L, Cook JM. Carboxyl-mediated Pictet-Spengler reaction. Direct synthesis of 1,2,3,4-tetrahydro-β-carbolines from Tryptamine-2-Carboxylic acids Journal of Organic Chemistry. 56: 359-365.  1
1990 Díaz-Araúzo H, Cook JM, Christie DJ. Synthesis of 10,11-dihydroxydihydroquinidine N-oxide, a new metabolite of quinidine. Preparation and 1H-nmr spectroscopy of the metabolites of quinine and quinidine and conformational analysis via 2D COSY nmr spectroscopy. Journal of Natural Products. 53: 112-24. PMID 2348197  0.48
1990 Trudell ML, Lifer SL, Tan YC, Martin MJ, Deng L, Skolnick P, Cook JM. Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties. Journal of Medicinal Chemistry. 33: 2412-20. PMID 2167978  1
1990 Hollinshead SP, Trudell ML, Skolnick P, Cook JM. Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester. Journal of Medicinal Chemistry. 33: 1062-9. PMID 1968513  1
1990 Cook JM, Diaz-Arauzo H, Allen MS. Inverse agonists, probes to study the structure, topology and function of the benzodiazepine receptor. Nida Research Monograph. 105: 133-9. PMID 1652068  1
1990 Kubiak O, Fu X, Gupta AK, Cook JM. General approach for the synthesis of polyquinenes via the weiss reaction XIII. Aldol approach to fenestranes Tetrahedron Letters. 31: 4285-4288. DOI: 10.1016/S0040-4039(00)97602-0  1
1990 Fu X, Cook JM. General approach for the synthesis of polyquinenes via the weiss reaction XII. The chugaev approach to ellacene (1,10-cyclododecanotriquinancene) Tetrahedron Letters. 31: 3409-3412. DOI: 10.1016/S0040-4039(00)97409-4  1
1990 Narayanan K, Cook JM. Carboxyl-mediated pictet-spengler reaction. Direct synthesis of 1,2,3,4-tetrahydro β-carbolines from tryptamine-2-carboxylic acids Tetrahedron Letters. 31: 3397-3400. DOI: 10.1016/S0040-4039(00)97406-9  1
1990 Gupta AK, Sambasivarao K, Opansky B, Cook JM. A general approach to the synthesis of polyquinenes via the weiss reaction. 10. Transient formation of cis-tetracyclo[7.2.1.04,11.06,10]dodeca-3,5,7,9-tetraene and an approach toward 10,11-dimethyl-cis-tetracyclo[7.2.1.04,11.0 6,10]dodeca-3,5,7,9-tetraene Journal of Organic Chemistry. 55: 4480-4483.  1
1990 Sambasivarao K, Hollinshead S, Grubisha D, Laib F, Bennett D, Cook JM. Synthetic approach to pentaleno[2,1-b:5,4-b′]diindoles Journal of Organic Chemistry. 55: 3858-3866.  1
1990 Zhang LH, Cook JM. General approach to the synthesis of macroline-related alkaloids. Stereospecific total synthesis of (-)-alstonerine Journal of the American Chemical Society. 112: 4088-4090.  1
1990 Narayanan K, Cook JM. Molecular yardsticks: Synthesis of higher homologs of 7,12-dihydropyrido[3,4-b: 5,4-b′]diindole. Probing the dimensions of the benzodiazepine receptor inverse agonist site Heterocycles. 31: 203-209.  1
1989 Martin JV, Cook JM, Hagen TJ, Mendelson WB. Inhibition of sleep and benzodiazepine receptor binding by a beta-carboline derivative. Pharmacology, Biochemistry, and Behavior. 34: 37-42. PMID 2560549 DOI: 10.1016/0091-3057(89)90349-3  1
1989 Sandrin J, Hollinshead SP, Cook JM. Pictet-Spengler reactions in aprotic media. Stereospecificity in the Pictet-Spengler reaction Journal of Organic Chemistry. 54: 5636-5640.  1
1989 Trudell ML, Cook JM. Total synthesis of (±)-suaveoline Journal of the American Chemical Society. 111: 7504-7507.  1
1989 Hagen TJ, Narayanan K, Names J, Cook JM. DDQ oxidations in the indole area. Synthesis of 4-alkoxy-β-carbolines including the natural products crenatine and 1-methoxycanthin-6-one Journal of Organic Chemistry. 54: 2170-2178.  1
1989 Zhang LH, Gupta AK, Cook JM. Reinvestigation of the mechanism of the acid-catalyzed epimerization of reserpine to isoreserpine Journal of Organic Chemistry. 54: 4708-4712.  1
1989 Gupta AK, Lannoye GS, Kubiak G, Schkeryantz J, Wehrli S, Cook JM. General approach to the synthesis of polyquinenes. 8. Synthesis of triquinacene, 1,10-dimethyltriquinacene, and 1,10-cyclohexanotriquinacene Journal of the American Chemical Society. 111: 2169-2179.  1
1989 Hollinshead SP, Grubisha DS, Bennett DW, Cook JM. Studies in the formation of oxindoles from their indoloazabicyclo[3.3.1]nonane counterparts and implications for the biogenesis of alstonisine Heterocycles. 29: 529-537.  1
1988 Christie DJ, Diaz-Arauzo H, Cook JM. Antibody-mediated platelet destruction by quinine, quinidine, and their metabolites. The Journal of Laboratory and Clinical Medicine. 112: 92-8. PMID 3392460  1
1988 Takada K, Hagen TJ, Cook JM, Goldberg SR, Katz JL. Discriminative stimulus effects of intravenous nicotine in squirrel monkeys. Pharmacology, Biochemistry, and Behavior. 30: 243-7. PMID 3174749 DOI: 10.1016/0091-3057(88)90452-2  1
1988 Trullas R, Ginter H, Jackson B, Skolnick P, Allen MS, Hagen TJ, Cook JM. 3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties. Life Sciences. 43: 1189-97. PMID 2845211 DOI: 10.1016/0024-3205(88)90208-1  1
1988 Allen MS, Hagen TJ, Trudell ML, Codding PW, Skolnick P, Cook JM. Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. Journal of Medicinal Chemistry. 31: 1854-61. PMID 2842507  1
1988 Gupta AK, Cook JM, Weiss U. General approach to the synthesis of polyquinenes VII. Synthesis of a centro-substituted triquinacene Tetrahedron Letters. 29: 2535-2538. DOI: 10.1016/S0040-4039(00)86105-5  1
1988 Lannoye G, Cook JM. General approach to the synthesis of polyquinenes via the weiss reaction. V. Progress toward the synthesis of dicyclopentapentalenes Tetrahedron Letters. 29: 171-174. DOI: 10.1016/S0040-4039(00)80044-1  1
1988 Lannoye G, Sambasivarao K, Wehrli S, Cook JM, Weiss U. General approach to the synthesis of polyquinenes via the weiss reaction. 6. Progress toward the synthesis of dicyclopentapentalenes Journal of Organic Chemistry. 53: 2327-2340.  1
1988 Zhang Lh, Cook JM. Pictet-Spengler reactions in aprotic media. Nb-benzyl promoted retention of optical activity in the synthesis of an indolo substituted azabicyclo[3.3.1]nonane, a key template for the synthesis of macroline alkaloids Heterocycles. 27: 2795-2802.  1
1988 Sambasivarao K, Kubiak G, Lannoye G, Cook JM. General approach to the synthesis of polyquinenes. 9. The monofunctionalization and alteration of the symmetry of the cis-bicyclo[3.3.0]octane-3,7-dione unit Journal of Organic Chemistry. 53: 5173-5175.  1
1988 Zhang LH, Cook JM. Pictet-spengler reactions in aprotic media. Stereospecific conversion of optically active cis-1,3-disubstituted 1,2,3,4-tetrahydro-β-carbolines into their corresponding trans diastereomers Heterocycles. 27: 1357-1363.  1
1987 Hagen TJ, Skolnick P, Cook JM. Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. Journal of Medicinal Chemistry. 30: 750-3. PMID 3031296  1
1987 Trudell ML, Basile AS, Shannon HE, Skolnick P, Cook JM. Synthesis of 7,12-dihydropyrido[3,4-b:5,4-b']diindoles. A novel class of rigid, planar benzodiazepine receptor ligands. Journal of Medicinal Chemistry. 30: 456-8. PMID 3029372  1
1987 Lannoye G, Cook JM. General approach to the synthesis of polyquinenes. IV. Studies directed toward the preparation of dicyclopenta[cd,gh]pentalene. Tetrahedron Letters. 28: 4821-4824. DOI: 10.1016/S0040-4039(00)96634-6  1
1987 Trudell ML, Fukada N, Cook JM. Hydrazine-mediated one-pot amination-oxidation reaction: Facile synthesis of 4-amino-β-carbolines and 4-aminoisoquinolines Journal of Organic Chemistry. 52: 4293-4296.  1
1987 Venkatachalam M, Wehrli S, Kubiak G, Cook JM, Weiss U. General approach to the synthesis of polyquinanes. Preparation of trans,trans -4,8-diacetoxytetracyclo[9.3.0.01,5 .07,11]-tetradecan-6-one Journal of Organic Chemistry. 52: 4110-4115.  1
1986 Hoffman WE, Albrecht RF, Miletich DJ, Hagen TJ, Cook JM. Cerebrovascular and cerebral metabolic effects of physostigmine, midazolam, and a benzodiazepine antagonist. Anesthesia and Analgesia. 65: 639-44. PMID 2939779  1
1986 Deshpande MN, Wehrli S, Jawdosiuk M, Guy JT, Bennett DW, Cook JM, Depp MR, Weiss U. Formation of the tetracyclo[5.4.2.02,6.02,9]tridecane ring system by a novel transannular aldolization reaction Journal of Organic Chemistry. 51: 2436-2444.  1
1985 Van Gorder PN, Hoffman WE, Baughman V, Albrecht RF, Miletich DJ, Guzman F, Cook JM. Midazolam-ethanol interactions and reversal with a benzodiazepine antagonist. Anesthesia and Analgesia. 64: 129-35. PMID 2857540  0.44
1984 Christie DJ, Weber RW, Mullen PC, Cook JM, Aster RH. Structural features of the quinidine and quinine molecules necessary for binding of drug-induced antibodies to human platelets. The Journal of Laboratory and Clinical Medicine. 104: 730-40. PMID 6491470  0.48
1984 Guzman F, Cain M, Larscheid P, Hagen T, Cook JM, Schweri M, Skolnick P, Paul SM. Biomimetic approach to potential benzodiazepine receptor agonists and antagonists. Journal of Medicinal Chemistry. 27: 564-70. PMID 6325688  1
1984 Shannon HE, Guzman F, Cook JM. beta-Carboline-3-carboxylate-t-butyl ester: a selective BZ1 benzodiazepine receptor antagonist. Life Sciences. 35: 2227-36. PMID 6094935 DOI: 10.1016/0024-3205(84)90464-8  1
1983 Mendelson WB, Cain M, Cook JM, Paul SM, Skolnick P. A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam. Science (New York, N.Y.). 219: 414-6. PMID 6294835  0.84
1982 Mendelson WB, Cain M, Cook JM, Paul SM, Skolnick P. Do benzodiazepine receptors play a role in sleep regulation? Studies with the benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline (3-HMC). Progress in Clinical and Biological Research. 90: 253-61. PMID 6287492  0.84
1982 Skolnick P, Williams EF, Cook JM, Cain M, Rice KC, Mendelson WB, Crawley JN, Paul SM. beta-Carbolines and benzodiazepine receptors: structure-activity relationships and pharmacologic activity. Progress in Clinical and Biological Research. 90: 233-52. PMID 6287491  1
1982 Cain M, Weber RW, Guzman F, Cook JM, Barker SA, Rice KC, Crawley JN, Paul SM, Skolnick P. Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors. Journal of Medicinal Chemistry. 25: 1081-91. PMID 6127411  1
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