Xiaoxiang Liu - Publications

2002 Chemistry University of Wisconsin-Milwaukee, Milwaukee, WI 

13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Mandal M, Wu Y, Misiaszek J, Li G, Buevich AV, Caldwell JP, Liu X, Mazzola RD, Orth P, Strickland C, Voigt JH, Wang H, Zhu Z, Chen X, Grzelak M, et al. Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in non-Human Primates. Journal of Medicinal Chemistry. PMID 26937601 DOI: 10.1021/acs.jmedchem.5b01995  0.44
2012 Huang X, Zhou W, Liu X, Li H, Sun G, Mandal M, Vicarel M, Zhu X, Bennett C, McCraken T, Pissarnitski D, Zhao Z, Cole D, Gallo G, Zhu Z, et al. Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease. Acs Medicinal Chemistry Letters. 3: 931-5. PMID 24900409 DOI: 10.1021/ml300209g  0.44
2012 Mandal M, Zhu Z, Cumming JN, Liu X, Strickland C, Mazzola RD, Caldwell JP, Leach P, Grzelak M, Hyde L, Zhang Q, Terracina G, Zhang L, Chen X, Kuvelkar R, et al. Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation. Journal of Medicinal Chemistry. 55: 9331-45. PMID 22989333 DOI: 10.1021/jm301039c  0.44
2012 Sun ZY, Asberom T, Bara T, Bennett C, Burnett D, Chu I, Clader J, Cohen-Williams M, Cole D, Czarniecki M, Durkin J, Gallo G, Greenlee W, Josien H, Huang X, ... ... Liu X, et al. Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo. Journal of Medicinal Chemistry. 55: 489-502. PMID 22098494 DOI: 10.1021/jm201407j  0.44
2009 Tsou HR, Liu X, Birnberg G, Kaplan J, Otteng M, Tran T, Kutterer K, Tang Z, Suayan R, Zask A, Ravi M, Bretz A, Grillo M, McGinnis JP, Rabindran SK, et al. Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4. Journal of Medicinal Chemistry. 52: 2289-310. PMID 19317452 DOI: 10.1021/jm801026e  0.44
2008 Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorganic & Medicinal Chemistry. 16: 4626-51. PMID 18321710 DOI: 10.1016/j.bmc.2008.02.050  0.44
2007 Han D, Försterling FH, Deschamps JR, Parrish D, Liu X, Yin W, Huang S, Cook JM. Conformational analysis of the cis- and trans-adducts of the Pictet - Spengler reaction. Evidence for the structural basis for the C(1) - N(2) scission process in the cis- to trans-isomerization. Journal of Natural Products. 70: 75-82. PMID 17253853 DOI: 10.1021/np060391g  0.44
2004 Liu X, Hartwig JF. Palladium-catalyzed arylation of trimethylsilyl enolates of esters and imides. High functional group tolerance and stereoselective synthesis of alpha-aryl carboxylic acid derivatives. Journal of the American Chemical Society. 126: 5182-91. PMID 15099101 DOI: 10.1021/ja031544e  0.44
2003 Hama T, Liu X, Culkin DA, Hartwig JF. Palladium-catalyzed alpha-arylation of esters and amides under more neutral conditions. Journal of the American Chemical Society. 125: 11176-7. PMID 16220921 DOI: 10.1021/ja036792p  0.44
2003 Yu J, Wang T, Liu X, Deschamps J, Flippen-Anderson J, Liao X, Cook JM. General approach for the synthesis of sarpagine indole alkaloids. Enantiospecific total synthesis of (+)-vellosimine, (+)-normacusine B, (-)-alkaloid Q3, (-)-panarine, (+)-Na-methylvellosimine, and (+)-Na-methyl-16-epipericyclivine. The Journal of Organic Chemistry. 68: 7565-81. PMID 14510528 DOI: 10.1021/jo030006h  0.44
2003 Liu X, Hartwig JF. Palladium-catalyzed alpha-arylation of azlactones to form quaternary amino acid derivatives. Organic Letters. 5: 1915-8. PMID 12762685 DOI: 10.1021/ol034570q  0.44
2002 Jørgensen M, Lee S, Liu X, Wolkowski JP, Hartwig JF. Efficient synthesis of alpha-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates. Journal of the American Chemical Society. 124: 12557-65. PMID 12381200 DOI: 10.1021/ja027643u  0.44
2002 Liu X, Deschamp JR, Cook JM. Regiospecific, enantiospecific total synthesis of the alkoxy-substituted indole bases, 16-epi-N(a)-methylgardneral, 11-methoxyaffinisine, and 11-methoxymacroline as well as the indole alkaloids alstophylline and macralstonine. Organic Letters. 4: 3339-42. PMID 12323013 DOI: 10.1021/ol020101x  0.44
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