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Lee D. Fader, Ph.D. - Publications

Affiliations: 
2002 Chemistry McGill University, Montreal, QC, Canada 
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dorich S, Cox JH, Burch JD, Chagnon F, Chen B, Léger S, St-Onge M, Fader LD. Novel pyridone EP agonists featuring allylic alcohol ω-chains. Bioorganic & Medicinal Chemistry Letters. 127104. PMID 32201020 DOI: 10.1016/J.Bmcl.2020.127104  0.307
2017 Meyers K, Cogan DA, Burke J, Arenas R, Balestra M, Brown NF, Cerny MA, Clifford HE, Colombo F, Fader L, Frederick KS, Guo X, Hornberger KR, Kugler S, Lord J, et al. Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity. Bioorganic & Medicinal Chemistry Letters. PMID 29254646 DOI: 10.1016/J.Bmcl.2017.12.015  0.368
2016 Fader LD, Bailey M, Beaulieu E, Bilodeau F, Bonneau P, Bousquet Y, Carson RJ, Chabot C, Coulombe R, Duan J, Fenwick C, Garneau M, Halmos T, Jakalian A, James C, et al. Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs. Acs Medicinal Chemistry Letters. 7: 797-801. PMID 27563405 DOI: 10.1021/Acsmedchemlett.6B00194  0.645
2016 Fader L, Brault M, Desjardins J, Dansereau N, Lamorte L, Tremblay S, Bilodeau F, Bordeleau J, Duplessis M, Gorys V, Gillard J, Gleason JL, James C, Joly MA, Kuhn C, et al. Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus. Acs Medicinal Chemistry Letters. 7: 525-30. PMID 27190604 DOI: 10.1021/Acsmedchemlett.6B00064  0.416
2014 Fader LD, Carson R, Morin S, Bilodeau F, Chabot C, Halmos T, Bailey MD, Kawai SH, Coulombe R, Laplante S, Mekhssian K, Jakalian A, Garneau M, Duan J, Mason SW, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. Acs Medicinal Chemistry Letters. 5: 711-6. PMID 24944749 DOI: 10.1021/Ml500110J  0.672
2014 Fader LD, Malenfant E, Parisien M, Carson R, Bilodeau F, Landry S, Pesant M, Brochu C, Morin S, Chabot C, Halmos T, Bousquet Y, Bailey MD, Kawai SH, Coulombe R, et al. Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1. Acs Medicinal Chemistry Letters. 5: 422-7. PMID 24900852 DOI: 10.1021/Ml500002N  0.63
2014 Fenwick C, Amad M, Bailey MD, Bethell R, Bös M, Bonneau P, Cordingley M, Coulombe R, Duan J, Edwards P, Fader LD, Faucher AM, Garneau M, Jakalian A, Kawai S, et al. Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor. Antimicrobial Agents and Chemotherapy. 58: 3233-44. PMID 24663024 DOI: 10.1128/Aac.02719-13  0.64
2013 Fader LD, Landry S, Goulet S, Morin S, Kawai SH, Bousquet Y, Dion I, Hucke O, Goudreau N, Lemke CT, Rancourt J, Bonneau P, Titolo S, Amad M, Garneau M, et al. Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety. Bioorganic & Medicinal Chemistry Letters. 23: 3401-5. PMID 23601710 DOI: 10.1016/J.Bmcl.2013.03.074  0.446
2013 Fader LD, Landry S, Morin S, Kawai SH, Bousquet Y, Hucke O, Goudreau N, Lemke CT, Bonneau P, Titolo S, Mason S, Simoneau B. Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification. Bioorganic & Medicinal Chemistry Letters. 23: 3396-400. PMID 23583513 DOI: 10.1016/J.Bmcl.2013.03.073  0.436
2013 Goudreau N, Coulombe R, Faucher AM, Grand-Maître C, Lacoste JE, Lemke CT, Malenfant E, Bousquet Y, Fader L, Simoneau B, Mercier JF, Titolo S, Mason SW. Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series. Chemmedchem. 8: 405-14. PMID 23401268 DOI: 10.1002/Cmdc.201200580  0.389
2013 Goudreau N, Coulombe R, Faucher A, Grand‐Maître C, Lacoste J, Lemke CT, Malenfant E, Bousquet Y, Fader L, Simoneau B, Mercier J, Titolo S, Mason SW. Inside Cover: Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series (ChemMedChem 3/2013) Chemmedchem. 8: 346-346. DOI: 10.1002/Cmdc.201390006  0.327
2012 Lemke CT, Titolo S, von Schwedler U, Goudreau N, Mercier JF, Wardrop E, Faucher AM, Coulombe R, Banik SS, Fader L, Gagnon A, Kawai SH, Rancourt J, Tremblay M, Yoakim C, et al. Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein. Journal of Virology. 86: 6643-55. PMID 22496222 DOI: 10.1128/Jvi.00493-12  0.407
2012 Kleinbeck F, Fettes GJ, Fader LD, Carreira EM. Total synthesis of bafilomycin A1. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 3598-610. PMID 22344969 DOI: 10.1002/Chem.201102797  0.378
2011 LaPlante SR, Edwards PJ, Fader LD, Jakalian A, Hucke O. Revealing atropisomer axial chirality in drug discovery. Chemmedchem. 6: 505-13. PMID 21360821 DOI: 10.1002/Cmdc.201000485  0.32
2011 Fader LD, Bethell R, Bonneau P, Bös M, Bousquet Y, Cordingley MG, Coulombe R, Deroy P, Faucher AM, Gagnon A, Goudreau N, Grand-Maître C, Guse I, Hucke O, Kawai SH, et al. Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly. Bioorganic & Medicinal Chemistry Letters. 21: 398-404. PMID 21087861 DOI: 10.1016/J.Bmcl.2010.10.131  0.438
2010 Gagnon A, Duplessis M, Fader L. Arylcyclopropanes: Properties, synthesis and use in medicinal chemistry Organic Preparations and Procedures International. 42: 1-69. DOI: 10.1080/00304940903507788  0.327
2005 Fader LD, Tsantrizos YS. Modifications of peptide nucleic acid (PNA) monomers as a strategy for modulating the physicochemical and pharmacokinetic properties of PNA oligomers Chimica Oggi. 23: 40-44.  0.6
2004 Fader LD, Carreira EM. Stereochemically rich pentaketides from bis(isoxazolines): a general strategy for efficient polyketide synthesis. Organic Letters. 6: 2485-8. PMID 15228310 DOI: 10.1021/Ol0490633  0.329
2004 Fader LD, Myers EL, Tsantrizos YS. Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties Tetrahedron. 60: 2235-2246. DOI: 10.1016/J.Tet.2004.01.026  0.646
2002 Fader LD, Tsantrizos YS. Hybridization properties of aromatic peptide nucleic acids: a novel class of oligonucleotide analogues. Organic Letters. 4: 63-6. PMID 11772091 DOI: 10.1021/ol010231q  0.599
2001 Fader LD, Boyd M, Tsantrizos YS. Backbone modifications of aromatic peptide nucleic acid (APNA ) monomers and their hybridization properties with DNA and RNA. The Journal of Organic Chemistry. 66: 3372-9. PMID 11348119 DOI: 10.1021/jo001650o  0.615
1997 Tsantrizos YS, Lunetta JF, Boyd M, Fader LD, Wilson MC. Stereoselective Synthesis of a Thymine Derivative of (S)-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers Journal of Organic Chemistry. 62: 5451-5457.  0.606
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