Byron Caughey - Publications

Affiliations: 
NIH RML 

193 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kraus A, Hoyt F, Schwartz CL, Hansen B, Artikis E, Hughson AG, Raymond GJ, Race B, Baron GS, Caughey B. High-resolution structure and strain comparison of infectious mammalian prions. Molecular Cell. PMID 34433091 DOI: 10.1016/j.molcel.2021.08.011  1
2021 Luk CC, Mathiason CK, Orrù CD, Jansen GH, Thiele A, Caughey B, Sim VL. Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues. Prion. 15: 107-111. PMID 34132175 DOI: 10.1080/19336896.2021.1933872  1
2021 Ferreira NC, Charco JM, Plagenz J, Orru CD, Denkers ND, Metrick MA, Hughson AG, Griffin KA, Race B, Hoover EA, Castilla J, Nichols TA, Miller MW, Caughey B. Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear. Scientific Reports. 11: 7702. PMID 33833330 DOI: 10.1038/s41598-021-87295-8  1
2021 Nahass GR, Sun Y, Xu Y, Batchelor M, Reilly M, Benilova I, Kedia N, Spehar K, Sobott F, Sessions RB, Caughey BW, Radford SE, Jat P, Collinge J, Bieschke J. Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium. Journal of Molecular Biology. 166878. PMID 33610557 DOI: 10.1016/j.jmb.2021.166878  1
2021 Hermann P, Appleby B, Brandel JP, Caughey B, Collins S, Geschwind MD, Green A, Haïk S, Kovacs GG, Ladogana A, Llorens F, Mead S, Nishida N, Pal S, Parchi P, et al. Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease. The Lancet. Neurology. 20: 235-246. PMID 33609480 DOI: 10.1016/S1474-4422(20)30477-4  1
2020 Orrù CD, Ma TC, Hughson AG, Groveman BR, Srivastava A, Galasko D, Angers R, Downey P, Crawford K, Hutten SJ, Kang UJ, Caughey B. A rapid α-synuclein seed assay of Parkinson's disease CSF panel shows high diagnostic accuracy. Annals of Clinical and Translational Neurology. PMID 33373501 DOI: 10.1002/acn3.51280  1
2020 Orrú CD, Groveman BR, Foutz A, Bongianni M, Cardone F, McKenzie N, Culeux A, Poleggi A, Grznarova K, Perra D, Fiorini M, Liu X, Ladogana A, Sbriccoli M, Hughson AG, ... ... Caughey B, et al. Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD. Annals of Clinical and Translational Neurology. 7: 2262-2271. PMID 33185334 DOI: 10.1002/acn3.51219  1
2020 Artikis E, Roy A, Verli H, Cordeiro Y, Caughey B. Accommodation of In-Register N-Linked Glycans on Prion Protein Amyloid Cores. Acs Chemical Neuroscience. PMID 33180459 DOI: 10.1021/acschemneuro.0c00635  1
2020 Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B. Correction to: Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC. Acta Neuropathologica Communications. 8: 180. PMID 33153488 DOI: 10.1186/s40478-020-01052-y  1
2020 Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, et al. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology. PMID 33000167 DOI: 10.1093/jnen/nlaa109  0.01
2020 Wang Z, Becker K, Donadio V, Siedlak S, Yuan J, Rezaee M, Incensi A, Kuzkina A, Orrú CD, Tatsuoka C, Liguori R, Gunzler SA, Caughey B, Jimenez-Capdeville ME, Zhu X, et al. Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease. Jama Neurology. PMID 32986090 DOI: 10.1001/jamaneurol.2020.3311  1
2020 Ferreira NDC, Caughey B. Proteopathic Seed Amplification Assays for Neurodegenerative Disorders. Clinics in Laboratory Medicine. 40: 257-270. PMID 32718498 DOI: 10.1016/j.cll.2020.04.002  0.01
2020 Rossi M, Candelise N, Baiardi S, Capellari S, Giannini G, Orrù CD, Antelmi E, Mammana A, Hughson AG, Calandra-Buonaura G, Ladogana A, Plazzi G, Cortelli P, Caughey B, Parchi P. Correction to: Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies. Acta Neuropathologica. PMID 32556961 DOI: 10.1007/S00401-020-02170-6  1
2020 Raymond GJ, Race B, Orrú CD, Raymond LD, Bongianni M, Fiorini M, Groveman BR, Ferrari S, Sacchetto L, Hughson AG, Monaco S, Pocchiari M, Zanusso G, Caughey B. Transmission of CJD from nasal brushings but not spinal fluid or RT-QuIC product. Annals of Clinical and Translational Neurology. 7: 932-944. PMID 32538552 DOI: 10.1002/Acn3.51057  1
2020 Rossi M, Candelise N, Baiardi S, Capellari S, Giannini G, Orrù CD, Antelmi E, Mammana A, Hughson AG, Calandra-Buonaura G, Ladogana A, Plazzi G, Cortelli P, Caughey B, Parchi P. Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies. Acta Neuropathologica. PMID 32342188 DOI: 10.1007/S00401-020-02160-8  1
2020 Mammana A, Baiardi S, Rossi M, Franceschini A, Donadio V, Capellari S, Caughey B, Parchi P. Detection of prions in skin punch biopsies of Creutzfeldt-Jakob disease patients. Annals of Clinical and Translational Neurology. PMID 32141717 DOI: 10.1002/Acn3.51000  0.01
2020 Metrick MA, Ferreira NDC, Saijo E, Kraus A, Newell K, Zanusso G, Vendruscolo M, Ghetti B, Caughey B. A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases. Acta Neuropathologica Communications. 8: 22. PMID 32087764 DOI: 10.1186/S40478-020-0887-Z  1
2019 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, ... ... Caughey B, et al. Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. Acta Neuropathologica. PMID 31748840 DOI: 10.1007/S00401-019-02092-Y  1
2019 Caughey B, Kraus A. Transmissibility versus Pathogenicity of Self-Propagating Protein Aggregates. Viruses. 11. PMID 31717531 DOI: 10.3390/v11111044  1
2019 Metrick MA, do Carmo Ferreira N, Saijo E, Hughson AG, Kraus A, Orrú C, Miller MW, Zanusso G, Ghetti B, Vendruscolo M, Caughey B. Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons. Proceedings of the National Academy of Sciences of the United States of America. PMID 31641070 DOI: 10.1073/Pnas.1909322116  1
2019 Saijo E, Metrick MA, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, ... ... Caughey B, et al. 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. Acta Neuropathologica. PMID 31616982 DOI: 10.1007/S00401-019-02080-2  1
2019 Raymond GJ, Zhao HT, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O'Keefe R, Lubke LL, Reidenbach AG, Kraus A, Schreiber SL, ... ... Caughey B, et al. Antisense oligonucleotides extend survival of prion-infected mice. Jci Insight. 5. PMID 31361599 DOI: 10.1172/Jci.Insight.131175  1
2019 Staffaroni AM, Kramer AO, Casey M, Kang H, Rojas JC, Orrú CD, Caughey B, Allen IE, Kramer JH, Rosen HJ, Blennow K, Zetterberg H, Geschwind MD. Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease. Jama Neurology. PMID 31058916 DOI: 10.1001/Jamaneurol.2019.1071  1
2019 Favole A, Mazza M, Vallino Costassa E, D'Angelo A, Lombardi G, Marconi P, Crociara P, Berrone E, Gallo M, Palmitessa C, Orrù CD, Caughey B, Acutis PL, Caramelli M, Casalone C, et al. Early and Pre-Clinical Detection of Prion Seeding Activity in Cerebrospinal Fluid of Goats using Real-Time Quaking-Induced Conversion Assay. Scientific Reports. 9: 6173. PMID 30992522 DOI: 10.1038/s41598-019-42449-7  1
2019 Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, ... ... Caughey B, et al. Publisher Correction: Early preclinical detection of prions in the skin of prion-infected animals. Nature Communications. 10: 640. PMID 30718499 DOI: 10.1038/S41467-019-08648-6  1
2019 Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, ... ... Caughey B, et al. Early preclinical detection of prions in the skin of prion-infected animals. Nature Communications. 10: 247. PMID 30651538 DOI: 10.1038/S41467-018-08130-9  1
2019 Baskakov IV, Caughey B, Requena JR, Sevillano AM, Surewicz WK, Wille H. The Prion 2018 round tables (I): The structure of PrP. Prion. PMID 30646817 DOI: 10.1080/19336896.2019.1569450  1
2019 Saijo E, Groveman BR, Kraus A, Metrick M, Orrù CD, Hughson AG, Caughey B. Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates. Methods in Molecular Biology (Clifton, N.J.). 1873: 19-37. PMID 30341601 DOI: 10.1007/978-1-4939-8820-4_2  1
2018 Kraus A, Saijo E, Metrick MA, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B. Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease. Acta Neuropathologica. PMID 30570675 DOI: 10.1007/S00401-018-1947-3  1
2018 Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ. Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients. Mbio. 9. PMID 30459197 DOI: 10.1128/Mbio.02095-18  1
2018 Ferreira NDC, Caughey B. Cell-free prion protein conversion assays in screening for anti-prion drug candidates. Current Opinion in Pharmacology. 44: 1-7. PMID 30412823 DOI: 10.1016/j.coph.2018.10.001  0.01
2018 Baiardi S, Redaelli V, Ripellino P, Rossi M, Franceschini A, Moggio M, Sola P, Ladogana A, Fociani P, Magherini A, Capellari S, Giese A, Caughey B, Caroppo P, Parchi P. Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30355606 DOI: 10.1136/Jnnp-2018-319221  0.01
2018 Haley NJ, Richt JA, Davenport KA, Henderson DM, Hoover EA, Manca M, Caughey B, Marthaler D, Bartz J, Gilch S. Design, implementation, and interpretation of amplification studies for prion detection. Prion. 1-25. PMID 29468946 DOI: 10.1080/19336896.2018.1443000  1
2018 Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B. Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC. Acta Neuropathologica Communications. 6: 7. PMID 29422107 DOI: 10.1186/s40478-018-0508-2  1
2017 Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, ... ... Caughey B, et al. Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease. Science Translational Medicine. 9. PMID 29167394 DOI: 10.1126/Scitranslmed.Aam7785  1
2017 Groveman BR, Raymond GJ, Campbell KJ, Race B, Raymond LD, Hughson AG, Orrú CD, Kraus A, Phillips K, Caughey B. Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates. Plos Pathogens. 13: e1006623. PMID 28910420 DOI: 10.1371/Journal.Ppat.1006623  1
2017 Franceschini A, Baiardi S, Hughson AG, McKenzie N, Moda F, Rossi M, Capellari S, Green A, Giaccone G, Caughey B, Parchi P. High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions. Scientific Reports. 7: 10655. PMID 28878311 DOI: 10.1038/S41598-017-10922-W  1
2017 Orrù CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Campbell KJ, Anson KJ, Kraus A, Caughey B. RT-QuIC Assays for Prion Disease Detection and Diagnostics. Methods in Molecular Biology (Clifton, N.J.). 1658: 185-203. PMID 28861791 DOI: 10.1007/978-1-4939-7244-9_14  1
2017 Caughey B, Orru CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Race B, Saijo E, Kraus A. Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants. Progress in Molecular Biology and Translational Science. 150: 375-388. PMID 28838670 DOI: 10.1016/Bs.Pmbts.2017.06.003  1
2017 Kraus A, Raymond GJ, Race B, Campbell KJ, Hughson AG, Anson KJ, Raymond LD, Caughey B. PrP P102L and nearby lysine mutations promote spontaneous in vitro formation of transmissible prions. Journal of Virology. PMID 28835493 DOI: 10.1128/Jvi.01276-17  1
2017 Wang F, Wang X, Orrú CD, Groveman BR, Surewicz K, Abskharon R, Imamura M, Yokoyama T, Kim YS, Vander Stel KJ, Sinniah K, Priola SA, Surewicz WK, Caughey B, Ma J. Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity. Plos Pathogens. 13: e1006491. PMID 28704563 DOI: 10.1371/Journal.Ppat.1006491  1
2017 Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathologica Communications. 5: 32. PMID 28431576 DOI: 10.1186/S40478-017-0430-Z  1
2017 Saijo E, Ghetti B, Zanusso G, Oblak A, Furman JL, Diamond MI, Kraus A, Caughey B. Ultrasensitive and selective detection of 3-repeat tau seeding activity in Pick disease brain and cerebrospinal fluid. Acta Neuropathologica. PMID 28293793 DOI: 10.1007/S00401-017-1692-Z  1
2017 Groveman BR, Orrú CD, Hughson AG, Bongianni M, Fiorini M, Imperiale D, Ladogana A, Pocchiari M, Zanusso G, Caughey B. Extended and direct evaluation of RT-QuIC assays for Creutzfeldt-Jakob disease diagnosis. Annals of Clinical and Translational Neurology. 4: 139-144. PMID 28168213 DOI: 10.1002/acn3.378  1
2017 Cracco L, Notari S, Cali I, Sy MS, Chen SG, Cohen ML, Ghetti B, Appleby BS, Zou WQ, Caughey B, Safar JG, Gambetti P. Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type. Scientific Reports. 7: 38280. PMID 28091514 DOI: 10.1038/Srep38280  1
2016 Bongianni M, Orrù C, Groveman BR, Sacchetto L, Fiorini M, Tonoli G, Triva G, Capaldi S, Testi S, Ferrari S, Cagnin A, Ladogana A, Poleggi A, Colaizzo E, Tiple D, ... ... Caughey B, et al. Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples. Jama Neurology. PMID 27942718 DOI: 10.1001/Jamaneurol.2016.4614  1
2016 Foutz A, Appleby BS, Hamlin C, Liu X, Yang S, Cohen Y, Chen W, Blevins J, Fausett C, Wang H, Gambetti P, Zhang S, Hughson A, Tatsuoka C, Schonberger LB, ... ... Caughey B, et al. Diagnostic and Prognostic Value of Human Prion Detection in Cerebrospinal Fluid. Annals of Neurology. PMID 27893164 DOI: 10.1002/Ana.24833  1
2016 Alibhai J, Blanco RA, Barria MA, Piccardo P, Caughey B, Perry VH, Freeman TC, Manson JC. Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration. Plos Biology. 14: e1002579. PMID 27880767 DOI: 10.1371/journal.pbio.1002579  0.01
2016 Schmitz M, Cramm M, Llorens F, Müller-Cramm D, Collins S, Atarashi R, Satoh K, Orrù CD, Groveman BR, Zafar S, Schulz-Schaeffer WJ, Caughey B, Zerr I. The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases. Nature Protocols. 11: 2233-2242. PMID 27735933 DOI: 10.1038/nprot.2016.120  1
2016 Hughson AG, Race B, Kraus A, Sangaré LR, Robins L, Groveman BR, Saijo E, Phillips K, Contreras L, Dhaliwal V, Manca M, Zanusso G, Terry D, Williams JF, Caughey B. Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid. Plos Pathogens. 12: e1005914. PMID 27685252 DOI: 10.1371/Journal.Ppat.1005914  1
2016 Kraus A, Race B, Phillips K, Winkler C, Saturday G, Kurnellas M, Rothbard JB, Groveman BR, Steinman L, Caughey B. Genetic background modulates outcome of therapeutic amyloid peptides in treatment of neuroinflammation. Journal of Neuroimmunology. 298: 42-50. PMID 27609274 DOI: 10.1016/J.Jneuroim.2016.06.010  1
2016 Zanusso G, Monaco S, Pocchiari M, Caughey B. Advanced tests for early and accurate diagnosis of Creutzfeldt-Jakob disease. Nature Reviews. Neurology. PMID 27313104 DOI: 10.1038/nrneurol.2016.92  1
2016 Orrú CD, Hughson AG, Groveman BR, Campbell KJ, Anson KJ, Manca M, Kraus A, Caughey B. Factors That Improve RT-QuIC Detection of Prion Seeding Activity. Viruses. 8. PMID 27223300 DOI: 10.3390/V8050140  1
2016 Zanusso G, Monaco S, Pocchiari M, Caughey B. Advanced tests for early and accurate diagnosis of Creutzfeldt-Jakob disease. Nature Reviews. Neurology. PMID 27174240 DOI: 10.1038/Nrneurol.2016.65  1
2016 Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B. Correction for Masujin et al., Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion. Journal of Clinical Microbiology. 54: 1407. PMID 27114566 DOI: 10.1128/JCM.00472-16  1
2016 Kellock J, Hopping G, Caughey B, Daggett V. Peptides comprised of alternating L- and D- Amino acids inhibit amyloidogenesis in Three Distinct Amyloid Systems independent of sequence. Journal of Molecular Biology. PMID 27012425 DOI: 10.1016/J.Jmb.2016.03.013  1
2016 Saijo E, Hughson AG, Raymond GJ, Suzuki A, Horiuchi M, Caughey B. PrPSc-Specific Antibody Reveals C-terminal Conformational Differences between Prion Strains. Journal of Virology. PMID 26937029 DOI: 10.1128/JVI.00088-16  1
2016 Haley NJ, Siepker C, Hoon-Hanks LL, Mitchell G, Walter WD, Manca M, Monello RJ, Powers JG, Wild MA, Hoover EA, Caughey B, Richt JA. Seeded amplification of chronic wasting disease prions in nasal brushings and recto-anal mucosa associated lymphoid tissues from elk by real time quaking-induced conversion. Journal of Clinical Microbiology. PMID 26888899 DOI: 10.1128/Jcm.02700-15  1
2016 Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson A, Caughey B. Detection of atypical H-type bovine spongiform encephalopathy and the discrimination of bovine prion strains by RT-QuIC. Journal of Clinical Microbiology. PMID 26739160 DOI: 10.1128/JCM.02731-15  1
2015 Dassanayake RP, Orru CD, Hughson AG, Caughey B, Graça T, Zhuang D, Madsen-Bouterse SA, Knowles DP, Schneider DA. Sensitive and Specific Detection of Classical Scrapie Prions in the Brains of Goats by Real-Time Quaking-Induced Conversion. The Journal of General Virology. PMID 26653410 DOI: 10.1099/Jgv.0.000367  1
2015 Dai Z, Cai W, Hu F, Lan Y, Li L, Chung C, Caughey B, Zhang K, Tang X. Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART). Current Molecular Medicine. PMID 26592244 DOI: 10.2174/1566524016666151123114401  0.01
2015 Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, et al. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 26554006 DOI: 10.1073/pnas.1518151112  0.01
2015 Chesebro B, Striebel J, Rangel A, Phillips K, Hughson A, Caughey B, Race B. Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice. Mbio. 6: e01419-15. PMID 26396245 DOI: 10.1128/Mbio.01419-15  1
2015 Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B. Correction: Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains. Plos Pathogens. 11: e1005117. PMID 26284358 DOI: 10.1371/Journal.Ppat.1005117  1
2015 Crowell J, Hughson A, Caughey B, Bessen RA. Host determinants of prion strain diversity independent of prion protein genotype. Journal of Virology. PMID 26246570 DOI: 10.1128/JVI.01586-15  1
2015 Kraus A, Anson KJ, Raymond LD, Martens C, Groveman BR, Dorward DW, Caughey B. Prion protein prolines 102 and 105 and the surrounding lysine cluster impede amyloid formation. The Journal of Biological Chemistry. PMID 26175152 DOI: 10.1074/Jbc.M115.665844  1
2015 Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B. Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains. Plos Pathogens. 11: e1004983. PMID 26086786 DOI: 10.1371/Journal.Ppat.1004983  1
2015 Orrú CD, Favole A, Corona C, Mazza M, Manca M, Groveman BR, Hughson AG, Acutis PL, Caramelli M, Zanusso G, Casalone C, Caughey B. Detection and discrimination of classical and atypical L-type bovine spongiform encephalopathy by real-time quaking-induced conversion. Journal of Clinical Microbiology. 53: 1115-20. PMID 25609728 DOI: 10.1128/JCM.02906-14  1
2015 Orrú CD, Groveman BR, Hughson AG, Zanusso G, Coulthart MB, Caughey B. Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal fluid. Mbio. 6. PMID 25604790 DOI: 10.1128/mBio.02451-14  1
2015 Groveman BR, Kraus A, Raymond LD, Dolan MA, Anson KJ, Dorward DW, Caughey B. Charge neutralization of the central lysine cluster in prion protein (PrP) promotes PrP(Sc)-like folding of recombinant PrP amyloids. The Journal of Biological Chemistry. 290: 1119-28. PMID 25416779 DOI: 10.1074/Jbc.M114.619627  1
2015 Dai Z, Cai W, Hu F, Lan Y, Li L, Chung C, Caughey B, Zhang K, Tang X. Plasma mitochondrial DNA levels as a biomarker of lipodystrophy among HIV-infected patients treated with highly active a ntiretroviral therapy (HAART) Current Molecular Medicine. 15: 975-979.  1
2014 Zanusso G, Bongianni M, Caughey B. A test for Creutzfeldt-Jakob disease using nasal brushings. The New England Journal of Medicine. 371: 1842-3. PMID 25372096 DOI: 10.1056/NEJMc1410732  1
2014 Bejar R, Lord A, Stevenson K, Bar-Natan M, Pérez-Ladaga A, Zaneveld J, Wang H, Caughey B, Stojanov P, Getz G, Garcia-Manero G, Kantarjian H, Chen R, Stone RM, Neuberg D, et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood. 124: 2705-12. PMID 25224413 DOI: 10.1182/Blood-2014-06-582809  1
2014 Orrú CD, Bongianni M, Tonoli G, Ferrari S, Hughson AG, Groveman BR, Fiorini M, Pocchiari M, Monaco S, Caughey B, Zanusso G. A test for Creutzfeldt-Jakob disease using nasal brushings. The New England Journal of Medicine. 371: 519-29. PMID 25099576 DOI: 10.1056/Nejmoa1315200  1
2014 Bejar R, Stevenson KE, Caughey B, Lindsley RC, Mar BG, Stojanov P, Getz G, Steensma DP, Ritz J, Soiffer R, Antin JH, Alyea E, Armand P, Ho V, Koreth J, et al. Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 2691-8. PMID 25092778 DOI: 10.1200/Jco.2013.52.3381  1
2014 Groveman BR, Dolan MA, Taubner LM, Kraus A, Wickner RB, Caughey B. Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids Journal of Biological Chemistry. 289: 24129-24142. PMID 25028516 DOI: 10.1074/Jbc.M114.578344  1
2014 Hopping G, Kellock J, Barnwal RP, Law P, Bryers J, Varani G, Caughey B, Daggett V. Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers. Elife. 3: e01681. PMID 25027691 DOI: 10.7554/Elife.01681  1
2014 Christensen LB, Woods TA, Carmody AB, Caughey B, Peterson KE. Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia. Journal of Neuroinflammation. 11: 70. PMID 24708744 DOI: 10.1186/1742-2094-11-70  1
2014 Vieira TC, Cordeiro Y, Caughey B, Silva JL. Heparin binding confers prion stability and impairs its aggregation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2667-76. PMID 24648544 DOI: 10.1096/Fj.13-246777  1
2014 Ferreira NC, Marques IA, Conceição WA, Macedo B, Machado CS, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, Nunes RJ, Hughson AG, Raymond LD, Pascutti PG, Caughey B, Cordeiro Y. Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches. Plos One. 9: e84531. PMID 24400098 DOI: 10.1371/Journal.Pone.0084531  1
2013 Hopping G, Kellock J, Caughey B, Daggett V. Designed Trpzip-3 β-Hairpin Inhibits Amyloid Formation in Two Different Amyloid Systems. Acs Medicinal Chemistry Letters. 4: 824-8. PMID 24900756 DOI: 10.1021/Ml300478W  1
2013 Elder AM, Henderson DM, Nalls AV, Wilham JM, Caughey BW, Hoover EA, Kincaid AE, Bartz JC, Mathiason CK. In vitro detection of prionemia in TSE-infected cervids and hamsters. Plos One. 8: e80203. PMID 24224043 DOI: 10.1371/Journal.Pone.0080203  1
2013 Henderson DM, Manca M, Haley NJ, Denkers ND, Nalls AV, Mathiason CK, Caughey B, Hoover EA. Rapid antemortem detection of CWD prions in deer saliva. Plos One. 8: e74377. PMID 24040235 DOI: 10.1371/Journal.Pone.0074377  1
2013 Kraus A, Groveman BR, Caughey B. Prions and the potential transmissibility of protein misfolding diseases. Annual Review of Microbiology. 67: 543-64. PMID 23808331 DOI: 10.1146/Annurev-Micro-092412-155735  1
2013 Wilham JM, Orrù CD, Vascellari S, Hughson AG, Caughey B. Quaking-induced conversion assays for the detection and diagnosis of prion diseases Prions and Diseases. 2: 223-232. DOI: 10.1007/978-1-4614-5338-3_14  1
2012 Vascellari S, Orrù CD, Hughson AG, King D, Barron R, Wilham JM, Baron GS, Race B, Pani A, Caughey B. Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC. Plos One. 7: e48969. PMID 23139828 DOI: 10.1371/journal.pone.0048969  1
2012 McGuire LI, Peden AH, Orrú CD, Wilham JM, Appleford NE, Mallinson G, Andrews M, Head MW, Caughey B, Will RG, Knight RS, Green AJ. Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease. Annals of Neurology. 72: 278-85. PMID 22926858 DOI: 10.1002/ana.23589  1
2012 Bejar R, Stevenson KE, Caughey BA, Abdel-Wahab O, Steensma DP, Galili N, Raza A, Kantarjian H, Levine RL, Neuberg D, Garcia-Manero G, Ebert BL. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 3376-82. PMID 22869879 DOI: 10.1200/Jco.2011.40.7379  1
2012 Wolfe LL, Kocisko DA, Caughey B, Miller MW. Assessment of prospective preventive therapies for chronic wasting disease in mule deer. Journal of Wildlife Diseases. 48: 530-3. PMID 22493139 DOI: 10.7589/0090-3558-48.2.530  1
2012 Orrù CD, Wilham JM, Vascellari S, Hughson AG, Caughey B. New generation QuIC assays for prion seeding activity. Prion. 6: 147-52. PMID 22421206 DOI: 10.4161/pri.19430  1
2012 Orrù CD, Hughson AG, Race B, Raymond GJ, Caughey B. Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations. Journal of Clinical Microbiology. 50: 1464-6. PMID 22238438 DOI: 10.1128/JCM.06099-11  1
2012 Hasebe R, Raymond GJ, Horiuchi M, Caughey B. Reaction of complement factors varies with prion strains in vitro and in vivo. Virology. 423: 205-13. PMID 22222213 DOI: 10.1016/j.virol.2011.11.017  1
2012 Bessen RA, Wilham JM, Lowe D, Watschke CP, Shearin H, Martinka S, Caughey B, Wiley JA. Accelerated shedding of prions following damage to the olfactory epithelium. Journal of Virology. 86: 1777-88. PMID 22130543 DOI: 10.1128/JVI.06626-11  1
2012 Peden AH, McGuire LI, Appleford NE, Mallinson G, Wilham JM, Orrú CD, Caughey B, Ironside JW, Knight RS, Will RG, Green AJ, Head MW. Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion. The Journal of General Virology. 93: 438-49. PMID 22031526 DOI: 10.1099/vir.0.033365-0  1
2012 Barton KA, Sim VL, Hughson AG, Caughey B. Analysis of prions by field-flow fractionation Field-Flow Fractionation in Biopolymer Analysis. 139-150. DOI: 10.1007/978-3-7091-0154-4_10  1
2011 Orrú CD, Caughey B. Prion seeded conversion and amplification assays. Topics in Current Chemistry. 305: 121-33. PMID 21678135 DOI: 10.1007/128_2011_184  1
2011 Barton KA, Caughey B. Is PrP the road to ruin? The Embo Journal. 30: 1882-4. PMID 21593729 DOI: 10.1038/emboj.2011.129  1
2011 Orrú CD, Wilham JM, Raymond LD, Kuhn F, Schroeder B, Raeber AJ, Caughey B. Prion disease blood test using immunoprecipitation and improved quaking-induced conversion. Mbio. 2: e00078-11. PMID 21558432 DOI: 10.1128/mBio.00078-11  1
2011 Baron GS, Hughson AG, Raymond GJ, Offerdahl DK, Barton KA, Raymond LD, Dorward DW, Caughey B. Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra. Biochemistry. 50: 4479-90. PMID 21539311 DOI: 10.1021/Bi2003907  1
2011 Smirnovas V, Baron GS, Offerdahl DK, Raymond GJ, Caughey B, Surewicz WK. Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nature Structural & Molecular Biology. 18: 504-6. PMID 21441913 DOI: 10.1038/Nsmb.2035  1
2010 Wilham JM, Orrú CD, Bessen RA, Atarashi R, Sano K, Race B, Meade-White KD, Taubner LM, Timmes A, Caughey B. Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. Plos Pathogens. 6: e1001217. PMID 21152012 DOI: 10.1371/Journal.Ppat.1001217  1
2010 Bessen RA, Shearin H, Martinka S, Boharski R, Lowe D, Wilham JM, Caughey B, Wiley JA. Prion shedding from olfactory neurons into nasal secretions. Plos Pathogens. 6: e1000837. PMID 20419120 DOI: 10.1371/journal.ppat.1000837  1
2010 Kim JI, Cali I, Surewicz K, Kong Q, Raymond GJ, Atarashi R, Race B, Qing L, Gambetti P, Caughey B, Surewicz WK. Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors. The Journal of Biological Chemistry. 285: 14083-7. PMID 20304915 DOI: 10.1074/Jbc.C110.113464  1
2010 Taubner LM, Bienkiewicz EA, Copié V, Caughey B. Structure of the flexible amino-terminal domain of prion protein bound to a sulfated glycan. Journal of Molecular Biology. 395: 475-90. PMID 19913031 DOI: 10.1016/J.Jmb.2009.10.075  1
2010 Sim VL, Caughey B. Prion Disease Therapy: Trials and Tribulations Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 259-303. DOI: 10.1002/9780470572702.ch13  1
2009 Smirnovas V, Kim JI, Lu X, Atarashi R, Caughey B, Surewicz WK. Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange. The Journal of Biological Chemistry. 284: 24233-41. PMID 19596861 DOI: 10.1074/Jbc.M109.036558  1
2009 Orrú CD, Wilham JM, Hughson AG, Raymond LD, McNally KL, Bossers A, Ligios C, Caughey B. Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein. Protein Engineering, Design & Selection : Peds. 22: 515-21. PMID 19570812 DOI: 10.1093/protein/gzp031  1
2009 Caughey B, Baron GS, Chesebro B, Jeffrey M. Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annual Review of Biochemistry. 78: 177-204. PMID 19231987 DOI: 10.1146/Annurev.Biochem.78.082907.145410  1
2009 Sim VL, Caughey B. Recent advances in prion chemotherapeutics. Infectious Disorders Drug Targets. 9: 81-91. PMID 19200018  1
2009 Sim VL, Caughey B. Ultrastructures and strain comparison of under-glycosylated scrapie prion fibrils. Neurobiology of Aging. 30: 2031-42. PMID 18394757 DOI: 10.1016/j.neurobiolaging.2008.02.016  1
2008 Caughey B, Baron GS. Are cheetahs on the run from prion-like amyloidosis? Proceedings of the National Academy of Sciences of the United States of America. 105: 7113-4. PMID 18487456 DOI: 10.1073/pnas.0803438105  1
2008 Liberski PP, Brown DR, Sikorska B, Caughey B, Brown P. Cell death and autophagy in prion diseases (transmissible spongiform encephalopathies). Folia Neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. 46: 1-25. PMID 18368623  1
2008 Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, Johnson LM, Onwubiko HA, Priola SA, Caughey B. Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nature Methods. 5: 211-2. PMID 18309304 DOI: 10.1038/Nmeth0308-211  1
2007 Lee KS, Raymond LD, Schoen B, Raymond GJ, Kett L, Moore RA, Johnson LM, Taubner L, Speare JO, Onwubiko HA, Baron GS, Caughey WS, Caughey B. Hemin interactions and alterations of the subcellular localization of prion protein. The Journal of Biological Chemistry. 282: 36525-33. PMID 17925394 DOI: 10.1074/Jbc.M705620200  1
2007 Caughey WS, Priola SA, Kocisko DA, Raymond LD, Ward A, Caughey B. Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity. Antimicrobial Agents and Chemotherapy. 51: 3887-94. PMID 17709470 DOI: 10.1128/Aac.01599-06  1
2007 Atarashi R, Moore RA, Sim VL, Hughson AG, Dorward DW, Onwubiko HA, Priola SA, Caughey B. Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nature Methods. 4: 645-50. PMID 17643109 DOI: 10.1038/Nmeth1066  1
2007 Lee KS, Caughey B. A simplified recipe for prions. Proceedings of the National Academy of Sciences of the United States of America. 104: 9551-2. PMID 17535888 DOI: 10.1073/pnas.0703910104  1
2007 Raymond GJ, Raymond LD, Meade-White KD, Hughson AG, Favara C, Gardner D, Williams ES, Miller MW, Race RE, Caughey B. Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains. Journal of Virology. 81: 4305-14. PMID 17287284 DOI: 10.1128/JVI.02474-06  1
2007 Kocisko DA, Bertholet N, Moore RA, Caughey B, Vaillant A. Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay. Analytical Biochemistry. 363: 154-6. PMID 17276383 DOI: 10.1016/j.ab.2006.11.007  1
2006 DeMarco ML, Silveira J, Caughey B, Daggett V. Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models. Biochemistry. 45: 15573-82. PMID 17176078 DOI: 10.1021/Bi0612723  1
2006 Caughey B, Baron GS. Prions and their partners in crime. Nature. 443: 803-10. PMID 17051207 DOI: 10.1038/nature05294  1
2006 Kocisko DA, Caughey B. Searching for anti-prion compounds: cell-based high-throughput in vitro assays and animal testing strategies. Methods in Enzymology. 412: 223-34. PMID 17046661 DOI: 10.1016/S0076-6879(06)12014-5  1
2006 Silveira JR, Hughson AG, Caughey B. Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation. Methods in Enzymology. 412: 21-33. PMID 17046649 DOI: 10.1016/S0076-6879(06)12002-9  1
2006 Kocisko DA, Caughey B, Morrey JD, Race RE. Enhanced antiscrapie effect using combination drug treatment. Antimicrobial Agents and Chemotherapy. 50: 3447-9. PMID 17005828 DOI: 10.1128/Aac.00715-06  1
2006 Caughey B, Caughey WS, Kocisko DA, Lee KS, Silveira JR, Morrey JD. Prions and Transmissible Spongiform Encephalopathy (TSE) chemotherapeutics: A common mechanism for anti-TSE compounds? Accounts of Chemical Research. 39: 646-653. PMID 16981681 DOI: 10.1021/ar050068p  1
2006 Tahiri-Alaoui A, Sim VL, Caughey B, James W. Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease. The Journal of Biological Chemistry. 281: 34171-8. PMID 16980300 DOI: 10.1074/Jbc.M606606200  1
2006 Atarashi R, Sim VL, Nishida N, Caughey B, Katamine S. Prion strain-dependent differences in conversion of mutant prion proteins in cell culture. Journal of Virology. 80: 7854-62. PMID 16873242 DOI: 10.1128/JVI.00424-06  1
2006 Lima LM, Cordeiro Y, Tinoco LW, Marques AF, Oliveira CL, Sampath S, Kodali R, Choi G, Foguel D, Torriani I, Caughey B, Silva JL. Structural insights into the interaction between prion protein and nucleic acid. Biochemistry. 45: 9180-7. PMID 16866364 DOI: 10.1021/Bi060532D  1
2006 Kocisko DA, Vaillant A, Lee KS, Arnold KM, Bertholet N, Race RE, Olsen EA, Juteau JM, Caughey B. Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides. Antimicrobial Agents and Chemotherapy. 50: 1034-44. PMID 16495266 DOI: 10.1128/AAC.50.3.1034-1044.2006  1
2006 Baron GS, Magalhães AC, Prado MA, Caughey B. Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res. Journal of Virology. 80: 2106-17. PMID 16474119 DOI: 10.1128/JVI.80.5.2106-2117.2006  1
2006 Kocisko DA, Caughey WS, Race RE, Roper G, Caughey B, Morrey JD. A porphyrin increases survival time of mice after intracerebral prion infection Antimicrobial Agents and Chemotherapy. 50: 759-761. PMID 16436739 DOI: 10.1128/Aac.50.2.759-761.2006  1
2006 Kocisko DA, Caughey B. Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo. Journal of Virology. 80: 1044-6. PMID 16379006 DOI: 10.1128/JVI.80.2.1044-1046.2006  1
2006 Raymond GJ, Olsen EA, Lee KS, Raymond LD, Bryant PK, Baron GS, Caughey WS, Kocisko DA, McHolland LE, Favara C, Langeveld JP, van Zijderveld FG, Mayer RT, Miller MW, Williams ES, ... Caughey B, et al. Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. Journal of Virology. 80: 596-604. PMID 16378962 DOI: 10.1128/JVI.80.2.596-604.2006  1
2005 Silveira JR, Raymond GJ, Hughson AG, Race RE, Sim VL, Hayes SF, Caughey B. The most infectious prion protein particles. Nature. 437: 257-61. PMID 16148934 DOI: 10.1038/nature03989  1
2005 Kocisko DA, Engel AL, Harbuck K, Arnold KM, Olsen EA, Raymond LD, Vilette D, Caughey B. Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie. Neuroscience Letters. 388: 106-11. PMID 16039063 DOI: 10.1016/j.neulet.2005.06.053  1
2005 Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, Raymond L, Favara C, Baron G, Priola S, Caughey B, Masliah E, Oldstone M. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science (New York, N.Y.). 308: 1435-9. PMID 15933194 DOI: 10.1126/Science.1110837  1
2005 Magalhães AC, Baron GS, Lee KS, Steele-Mortimer O, Dorward D, Prado MA, Caughey B. Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5207-16. PMID 15917460 DOI: 10.1523/JNEUROSCI.0653-05.2005  1
2004 Cashman NR, Caughey B. Prion diseases--close to effective therapy? Nature Reviews. Drug Discovery. 3: 874-84. PMID 15459678 DOI: 10.1038/Nrd1525  1
2004 Kocisko DA, Morrey JD, Race RE, Chen J, Caughey B. Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice. The Journal of General Virology. 85: 2479-83. PMID 15269390 DOI: 10.1099/Vir.0.80082-0  1
2004 Silveira JR, Caughey B, Baron GS. Prion protein and the molecular features of transmissible spongiform encephalopathy agents. Current Topics in Microbiology and Immunology. 284: 1-50. PMID 15148986  1
2003 Maxson L, Wong C, Herrmann LM, Caughey B, Baron GS. A solid-phase assay for identification of modulators of prion protein interactions. Analytical Biochemistry. 323: 54-64. PMID 14622959 DOI: 10.1016/j.ab.2003.07.028  1
2003 Caughey B, Kocisko DA. Prion diseases: a nucleic-acid accomplice? Nature. 425: 673-4. PMID 14562085 DOI: 10.1038/425673a  1
2003 Caughey B. Prion protein conversions: insight into mechanisms, TSE transmission barriers and strains. British Medical Bulletin. 66: 109-20. PMID 14522853 DOI: 10.1093/bmb/66.1.109  1
2003 Kocisko DA, Baron GS, Rubenstein R, Chen J, Kuizon S, Caughey B. New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. Journal of Virology. 77: 10288-94. PMID 12970413 DOI: 10.1128/JVI.77.19.10288-10294.2003  1
2003 Dimcheff DE, Portis JL, Caughey B. Prion proteins meet protein quality control. Trends in Cell Biology. 13: 337-40. PMID 12837603 DOI: 10.1016/S0962-8924(03)00125-9  1
2003 Caughey B. Probing for prions: recognizing misfolded PrP. Nature Medicine. 9: 819-20. PMID 12835691 DOI: 10.1038/nm0703-819  1
2003 Priola SA, Chesebro B, Caughey B. Biomedicine. A view from the top--prion diseases from 10,000 feet. Science (New York, N.Y.). 300: 917-9. PMID 12738843 DOI: 10.1126/Science.1085920  1
2003 Caughey B, Lansbury PT. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annual Review of Neuroscience. 26: 267-98. PMID 12704221 DOI: 10.1146/Annurev.Neuro.26.010302.081142  1
2003 Caughey B, Raymond LD, Raymond GJ, Maxson L, Silveira J, Baron GS. Inhibition of protease-resistant prion protein accumulation in vitro by curcumin. Journal of Virology. 77: 5499-502. PMID 12692251 DOI: 10.1128/JVI.77.9.5499-5502.2003  1
2003 Baron GS, Caughey B. Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform. The Journal of Biological Chemistry. 278: 14883-92. PMID 12594216 DOI: 10.1074/jbc.M210840200  1
2003 Speare JO, Rush TS, Bloom ME, Caughey B. The role of helix 1 aspartates and salt bridges in the stability and conversion of prion protein. The Journal of Biological Chemistry. 278: 12522-9. PMID 12551897 DOI: 10.1074/Jbc.M211599200  1
2003 Leblanc AC, Roucou X, Priola SA, Caughey B, Chesebro B. Toxicity and protection in prions [3] (multiple letters) Science. 301: 168-169. DOI: 10.1126/science.301.5630.168  1
2002 Race R, Meade-White K, Raines A, Raymond GJ, Caughey B, Chesebro B. Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages. The Journal of Infectious Diseases. 186: S166-70. PMID 12424693 DOI: 10.1086/344267  1
2002 Caughey B, Baron GS. Factors affecting interactions between prion protein isoforms. Biochemical Society Transactions. 30: 565-9. PMID 12196138 DOI: 10.1042/  1
2002 Welker E, Raymond LD, Scheraga HA, Caughey B. Intramolecular versus intermolecular disulfide bonds in prion proteins. The Journal of Biological Chemistry. 277: 33477-81. PMID 12082114 DOI: 10.1074/jbc.M204273200  1
2002 Baron GS, Wehrly K, Dorward DW, Chesebro B, Caughey B. Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. The Embo Journal. 21: 1031-40. PMID 11867531 DOI: 10.1093/Emboj/21.5.1031  1
2001 Uptain SM, Sawicki GJ, Caughey B, Lindquist S. Strains of [PSI(+)] are distinguished by their efficiencies of prion-mediated conformational conversion. The Embo Journal. 20: 6236-45. PMID 11707395 DOI: 10.1093/emboj/20.22.6236  1
2001 Xiong LW, Raymond LD, Hayes SF, Raymond GJ, Caughey B. Conformational change, aggregation and fibril formation induced by detergent treatments of cellular prion protein. Journal of Neurochemistry. 79: 669-78. PMID 11701770 DOI: 10.1046/j.1471-4159.2001.00606.x  1
2001 Race R, Raines A, Raymond GJ, Caughey B, Chesebro B. Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans. Journal of Virology. 75: 10106-12. PMID 11581378 DOI: 10.1128/Jvi.75.21.10106-10112.2001  1
2001 Caughey B, Chesebro B. Transmissible spongiform encephalopathies and prion protein interconversions. Advances in Virus Research. 56: 277-311. PMID 11450303 DOI: 10.1016/S0065-3527(01)56031-5  1
2001 Caughey B, Raymond GJ, Callahan MA, Wong C, Baron GS, Xiong LW. Interactions and conversions of prion protein isoforms. Advances in Protein Chemistry. 57: 139-69. PMID 11447689  1
2001 Callahan MA, Xiong L, Caughey B. Reversibility of scrapie-associated prion protein aggregation. The Journal of Biological Chemistry. 276: 28022-8. PMID 11375994 DOI: 10.1074/jbc.M103629200  1
2001 Caughey B. Interactions between prion protein isoforms: the kiss of death? Trends in Biochemical Sciences. 26: 235-42. PMID 11295556  0.01
2001 Horiuchi M, Baron GS, Xiong LW, Caughey B. Inhibition of interactions and interconversions of prion protein isoforms by peptide fragments from the C-terminal folded domain. The Journal of Biological Chemistry. 276: 15489-97. PMID 11279046 DOI: 10.1074/jbc.M100288200  1
2001 Caughey B, Pepys MB, Kelly JW, Ellis RJ, Collinge J, Perutz MF, Masel J. Prion protein interconversions Philosophical Transactions of the Royal Society B: Biological Sciences. 356: 197-202. PMID 11260800 DOI: 10.1098/rstb.2000.0765  1
2001 Wong C, Xiong LW, Horiuchi M, Raymond L, Wehrly K, Chesebro B, Caughey B. Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein. The Embo Journal. 20: 377-86. PMID 11157745 DOI: 10.1093/Emboj/20.3.377  1
2000 Caughey B. Formation of protease-resistant prion protein in cell-free systems. Current Issues in Molecular Biology. 2: 95-101. PMID 11471561  0.01
2000 Demaimay R, Chesebro B, Caughey B. Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs. Archives of Virology. Supplementum. 277-83. PMID 11214931 DOI: 10.1007/978-3-7091-6308-5_26  1
2000 Raymond GJ, Bossers A, Raymond LD, O'Rourke KI, McHolland LE, Bryant PK, Miller MW, Williams ES, Smits M, Caughey B. Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease. The Embo Journal. 19: 4425-30. PMID 10970836 DOI: 10.1093/emboj/19.17.4425  1
2000 Caughey B. Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads? Nature Medicine. 6: 751-4. PMID 10888922 DOI: 10.1038/77476  0.01
1999 Caughey B, Raymond GJ, Priola SA, Kocisko DA, Race RE, Bessen RA, Lansbury PT, Chesebro B. Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. An update. Molecular Biotechnology. 13: 45-55. PMID 10934521 DOI: 10.1385/Mb:13:1:45  1
1999 Priola SA, Caughey B, Caughey WS. Novel therapeutic uses for porphyrins and phthalocyanines in the transmissible spongiform encephalopathies: Commentary Current Opinion in Microbiology. 2: 563-566. PMID 10617376 DOI: 10.1016/S1369-5274(99)00020-X  1
1998 Demaimay R, Harper J, Gordon H, Weaver D, Chesebro B, Caughey B. Structural aspects of Congo red as an inhibitor of protease-resistant prion protein formation. Journal of Neurochemistry. 71: 2534-41. PMID 9832153 DOI: 10.1046/J.1471-4159.1998.71062534.X  1
1998 Caughey WS, Raymond LD, Horiuchi M, Caughey B. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proceedings of the National Academy of Sciences of the United States of America. 95: 12117-22. PMID 9770449 DOI: 10.1073/pnas.95.21.12117  1
1998 Weber DJ, McFadden PN, Caughey B. Measurement of altered aspartyl residues in the scrapie associated form of prion protein Biochemical and Biophysical Research Communications. 246: 606-608. PMID 9618258 DOI: 10.1006/Bbrc.1998.8672  1
1998 Chabry J, Caughey B, Chesebro B. Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides. The Journal of Biological Chemistry. 273: 13203-7. PMID 9582363 DOI: 10.1074/Jbc.273.21.13203  1
1997 DebBurman SK, Raymond GJ, Caughey B, Lindquist S. Chaperone-supervised conversion of prion protein to its protease-resistant form. Proceedings of the National Academy of Sciences of the United States of America. 94: 13938-43. PMID 9391131 DOI: 10.1073/pnas.94.25.13938  1
1997 Raymond GJ, Hope J, Kocisko DA, Priola SA, Raymond LD, Bossers A, Ironside J, Will RG, Chen SG, Petersen RB, Gambetti P, Rubenstein R, Smits MA, Lansbury PT, Caughey B. Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature. 388: 285-8. PMID 9230438 DOI: 10.1038/40876  1
1996 Kocisko DA, Lansbury PT, Caughey B. Partial unfolding and refolding of scrapie-associated prion protein: evidence for a critical 16-kDa C-terminal domain. Biochemistry. 35: 13434-42. PMID 8873612 DOI: 10.1021/Bi9610562  1
1996 Lansbury PT, Caughey B. The double life of the prion protein. Current Biology : Cb. 6: 914-6. PMID 8805340 DOI: 10.1016/S0960-9822(02)00624-3  1
1995 Lansbury PT, Caughey B. The chemistry of scrapie infection: implications of the 'ice 9' metaphor. Chemistry & Biology. 2: 1-5. PMID 9383397 DOI: 10.1016/1074-5521(95)90074-8  1
1995 Dong A, Huang P, Caughey B, Caughey WS. Infrared analysis of ligand- and oxidation-induced conformational changes in hemoglobins and myoglobins Archives of Biochemistry and Biophysics. 316: 893-898. PMID 7864648 DOI: 10.1006/Abbi.1995.1120  1
1995 Priola SA, Caughey B, Wehrly K, Chesebro B. A 60-kDa prion protein (PrP) with properties of both the normal and scrapie-associated forms of PrP. The Journal of Biological Chemistry. 270: 3299-305. PMID 7852415 DOI: 10.1074/Jbc.270.7.3299  1
1995 Bessen RA, Kocisko DA, Raymond GJ, Nandan S, Lansbury PT, Caughey B. Non-genetic propagation of strain-specific properties of scrapie prion protein. Nature. 375: 698-700. PMID 7791905 DOI: 10.1038/375698A0  1
1995 Kocisko DA, Priola SA, Raymond GJ, Chesebro B, Lansbury PT, Caughey B. Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier. Proceedings of the National Academy of Sciences of the United States of America. 92: 3923-7. PMID 7732006 DOI: 10.1073/Pnas.92.9.3923  1
1994 Kocisko DA, Come JH, Priola SA, Chesebro B, Raymond GJ, Lansbury PT, Caughey B. Cell-free formation of protease-resistant prion protein. Nature. 370: 471-4. PMID 7913989 DOI: 10.1038/370471A0  1
1993 Chesebro B, Caughey B. Scrapie agent reflication without the prion protein? Current Biology : Cb. 3: 696-8. PMID 15335865 DOI: 10.1016/0960-9822(93)90072-V  1
1992 Dong A, Caughey B, Caughey WS, Bhat KS, Coe JE. Secondary structure of the pentraxin female protein in water determined by infrared spectroscopy: Effects of calcium and phosphorylcholine Biochemistry. 31: 9364-9370. PMID 1382589 DOI: 10.1021/bi00154a006  1
1991 Robertson MN, Miyazawa M, Mori S, Caughey B, Evans LH, Hayes SF, Chesebro B. Production of monoclonal antibodies reactive with a denatured form of the friend murine leukemia virus gp70 envelope protein: Use in a focal infectivity assay, immunohistochemical studies, electron microscopy and western blotting Journal of Virological Methods. 34: 255-271. PMID 1744218 DOI: 10.1016/0166-0934(91)90105-9  1
1987 Caughey B, Kirshner N. Effects of reserpine and tetrabenazine on catecholamine and ATP storage in cultured bovine adrenal medullary chromaffin cells. Journal of Neurochemistry. 49: 563-73. PMID 3598586 DOI: 10.1111/J.1471-4159.1987.Tb02901.X  0.01
1987 Kirshner N, Corcoran JJ, Caughey B, Korner M. Chromaffin vesicle function in intact cells. Annals of the New York Academy of Sciences. 493: 207-19. PMID 3473962 DOI: 10.1111/J.1749-6632.1987.Tb27202.X  0.01
1986 Corcoran JJ, Korner M, Caughey B, Kirshner N. Metabolic pools of ATP in cultured bovine adrenal medullary chromaffin cells. Journal of Neurochemistry. 47: 945-52. PMID 3734805 DOI: 10.1111/J.1471-4159.1986.Tb00702.X  0.01
1978 Hill GC, Shimer SP, Caughey B, Sauer LS. Growth of infective forms of Trypanosoma rhodesiense in vitro, the causative agent of African trypanosomiasis. Science (New York, N.Y.). 202: 763-5. PMID 715441 DOI: 10.1126/science.715441  0.01
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