Doug A. Lauffenburger - Publications

Affiliations: 
1979-1990 University of Pennsylvania, Philadelphia, PA, United States 
 1990-1994 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 1995- Bioengineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Molecular Cell Bioengineering
Website:
http://web.mit.edu/dallab/people/index.html

223/232 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Yoneyama T, Gorry M, Sobo-Vujanovic A, Lin Y, Vujanovic L, Gaither-Davis A, Moss ML, Miller MA, Griffith LG, Lauffenburger DA, Stabile LP, Herman J, Vujanovic NL. ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker. Journal of Cancer. 9: 2559-2570. PMID 30026855 DOI: 10.7150/jca.24601  1
2018 Edington CD, Chen WLK, Geishecker E, Kassis T, Soenksen LR, Bhushan BM, Freake D, Kirschner J, Maass C, Tsamandouras N, Valdez J, Cook CD, Parent T, Snyder S, Yu J, ... ... Lauffenburger DA, et al. Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Scientific Reports. 8: 4530. PMID 29540740 DOI: 10.1038/s41598-018-22749-0  1
2018 Clark AM, Kumar M, Wheeler S, Young C, Venkataramanan R, Stolz D, Griffith L, Lauffenburger DA, Wells A. A model of dormant-emergent metastatic breast cancer progression enabling exploration of biomarker signatures. Molecular & Cellular Proteomics : McP. PMID 29353230 DOI: 10.1074/mcp.RA117.000370  0.48
2017 Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL. Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates. Journal of Cancer. 8: 3916-3932. PMID 29187866 DOI: 10.7150/jca.20779  1
2017 Chen WLK, Edington C, Suter E, Yu J, Velazquez JJ, Velazquez JG, Shockley M, Large EM, Venkataramanan R, Hughes DJ, Stokes CL, Trumper DL, Carrier RL, Cirit M, Griffith LG, ... Lauffenburger DA, et al. Integrated Gut/Liver Microphysiological Systems Elucidates Inflammatory Inter-Tissue Crosstalk. Biotechnology and Bioengineering. PMID 28667746 DOI: 10.1002/bit.26370  1
2017 Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR. Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a 3D human liver-immunocompetent co-culture system. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28450578 DOI: 10.1124/dmd.116.074005  1
2017 Jørgensen H, Hill AS, Beste MT, Kumar MP, Chiswick E, Fedorcsak P, Isaacson KB, Lauffenburger DA, Griffith LG, Qvigstad E. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility. Fertility and Sterility. PMID 28433374 DOI: 10.1016/j.fertnstert.2017.03.013  1
2017 Cook CD, Hill AS, Guo M, Stockdale L, Papps JP, Isaacson KB, Lauffenburger DA, Griffith LG. Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28317948 DOI: 10.1039/c6ib00245e  1
2016 Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA. TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Science Signaling. 9: ra59. PMID 27273097 DOI: 10.1126/scisignal.aad3373  0.8
2016 Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA. Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance. Cancer Discovery. PMID 26984351 DOI: 10.1158/2159-8290.CD-15-0933  1
2015 Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Science Signaling. 8: ra129. PMID 26671150 DOI: 10.1126/scisignal.aac7235  0.8
2015 Gordonov S, Hwang MK, Wells A, Gertler FB, Lauffenburger DA, Bathe M. Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 26658688 DOI: 10.1039/c5ib00283d  1
2015 Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Scientific Reports. 5: 16622. PMID 26564777 DOI: 10.1038/srep16622  0.8
2015 Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, ... ... Lauffenburger DA, et al. Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology. Cell. 163: 988-98. PMID 26544943 DOI: 10.1016/j.cell.2015.10.027  1
2015 Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M. Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration. Cpt: Pharmacometrics & Systems Pharmacology. 4: 585-94. PMID 26535159 DOI: 10.1002/psp4.12010  1
2015 Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA. Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain. Scientific Reports. 5: 15150. PMID 26477568 DOI: 10.1038/srep15150  1
2015 Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, ... Lauffenburger DA, et al. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Molecular Biology of the Cell. PMID 26337385 DOI: 10.1091/mbc.E15-06-0442  1
2015 Meyer AS, Zweemer AJ, Lauffenburger DA. The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity. Cell Systems. 1: 25-36. PMID 26236777 DOI: 10.1016/j.cels.2015.06.002  1
2015 Birse K, Arnold KB, Novak RM, McCorrister S, Shaw S, Westmacott GR, Ball TB, Lauffenburger DA, Burgener A. Molecular signatures of immune activation and epithelial barrier remodeling are enhanced during the luteal phase of the menstrual cycle: implications for HIV susceptibility. Journal of Virology. PMID 26085144 DOI: 10.1128/JVI.00756-15  0.8
2015 Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ. Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. Science Signaling. 8: ra51. PMID 26012634 DOI: 10.1126/scisignal.aaa1977  1
2015 Melas IN, Sakellaropoulos T, Iorio F, Alexopoulos LG, Loh WY, Lauffenburger DA, Saez-Rodriguez J, Bai JP. Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25932872 DOI: 10.1039/c4ib00294f  0.8
2015 Masson L, Passmore JA, Liebenberg LJ, Werner L, Baxter C, Arnold KB, Williamson C, Little F, Mansoor LE, Naranbhai V, Lauffenburger DA, Ronacher K, Walzl G, Garrett NJ, Williams BL, et al. Genital Inflammation and the Risk of HIV Acquisition in Women. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 61: 260-9. PMID 25900168 DOI: 10.1093/cid/civ298  1
2015 Wu L, Claas AM, Sarkar A, Lauffenburger DA, Han J. High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 513-24. PMID 25832727 DOI: 10.1039/c5ib00019j  0.8
2015 Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, ... ... Lauffenburger DA, et al. ADAM8 as a drug target in pancreatic cancer. Nature Communications. 6: 6175. PMID 25629724 DOI: 10.1038/ncomms7175  0.8
2015 Ng EX, Miller MA, Jing T, Lauffenburger DA, Chen CH. Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array. Lab On a Chip. 15: 1153-9. PMID 25553996 DOI: 10.1039/c4lc01162g  1
2015 Lauffenburger DA. Innovation and insight in integrative biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 9. PMID 25500816 DOI: 10.1039/c4ib90047b  1
2014 Muraro D, Lauffenburger DA, Simmons A. Prioritisation and network analysis of Crohn's disease susceptibility genes. Plos One. 9: e108624. PMID 25268122 DOI: 10.1371/journal.pone.0108624  1
2014 Zhao B, Hemann MT, Lauffenburger DA. Reply to Azuaje: Predicting effective combined therapies for heterogeneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 111: E4288. PMID 25253893 DOI: 10.1073/pnas.1415737111  1
2014 Tape CJ, Worboys JD, Sinclair J, Gourlay R, Vogt J, McMahon KM, Trost M, Lauffenburger DA, Lamont DJ, Jørgensen C. Reproducible automated phosphopeptide enrichment using magnetic TiO2 and Ti-IMAC. Analytical Chemistry. 86: 10296-302. PMID 25233145 DOI: 10.1021/ac5025842  1
2014 Cheow LF, Sarkar A, Kolitz S, Lauffenburger D, Han J. Detecting kinase activities from single cell lysate using concentration-enhanced mobility shift assay. Analytical Chemistry. 86: 7455-62. PMID 25025773 DOI: 10.1021/ac502185v  0.8
2014 Palmer CD, Tomassilli J, Sirignano M, Romero-Tejeda M, Arnold KB, Che D, Lauffenburger DA, Jost S, Allen T, Mayer KH, Altfeld M. Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM. Aids (London, England). 28: 2162-6. PMID 25003719 DOI: 10.1097/QAD.0000000000000386  0.8
2014 Zhao B, Hemann MT, Lauffenburger DA. Intratumor heterogeneity alters most effective drugs in designed combinations. Proceedings of the National Academy of Sciences of the United States of America. 111: 10773-8. PMID 25002493 DOI: 10.1073/pnas.1323934111  1
2014 Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. A microphysiological system model of therapy for liver micrometastases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1170-9. PMID 24821820 DOI: 10.1177/1535370214532596  1
2014 Tape CJ, Norrie IC, Worboys JD, Lim L, Lauffenburger DA, Jørgensen C. Cell-specific labeling enzymes for analysis of cell-cell communication in continuous co-culture. Molecular & Cellular Proteomics : McP. 13: 1866-76. PMID 24820872 DOI: 10.1074/mcp.O113.037119  0.8
2014 Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT. Approaches to in vitro tissue regeneration with application for human disease modeling and drug development. Drug Discovery Today. 19: 754-62. PMID 24793141 DOI: 10.1016/j.drudis.2014.04.017  1
2014 Sarkar A, Kolitz S, Lauffenburger DA, Han J. Microfluidic probe for single-cell analysis in adherent tissue culture. Nature Communications. 5: 3421. PMID 24594667 DOI: 10.1038/ncomms4421  0.8
2014 Beste MT, Pfäffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG. Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Science Translational Medicine. 6: 222ra16. PMID 24500404 DOI: 10.1126/scitranslmed.3007988  1
2014 Zhao B, Pritchard JR, Lauffenburger DA, Hemann MT. Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Cancer Discovery. 4: 166-74. PMID 24318931 DOI: 10.1158/2159-8290.CD-13-0465  1
2014 Arneja A, Johnson H, Gabrovsek L, Lauffenburger DA, White FM. Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration. Journal of Immunology (Baltimore, Md. : 1950). 192: 123-35. PMID 24298013 DOI: 10.4049/jimmunol.1302291  1
2014 Young CL, Griffith LG, Lauffenburger DA. Evaluation of biomolecular metrics in microphysiological systems: Technical challenges associated with multiplex arrays Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972992  0.8
2014 Koppes AN, Carrier RL, Baranov PY, Young MJ, Oudin MJ, Gertler FB, Miller MA, Lauffenburger DA. High-throughput screening for directed chemotaxis of retinal progenitor cells in 3D hydrogels Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972844  0.4
2014 Lauffenburger DA. Evolution of a biological journal Integrative Biology (United Kingdom). 6: 8. DOI: 10.1039/c3ib90043f  1
2013 Melas IN, Lauffenburger DA, Alexopoulos LG. Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data. Proceedings / Annual Ieee International Symposium On Bioinformatics and Bioengineering (Bibe). Ieee International Symposium On Bioinformatics and Bioengineering. 2013. PMID 25729777 DOI: 10.1109/BIBE.2013.6701683  1
2013 Simmons RP, Scully EP, Groden EE, Arnold KB, Chang JJ, Lane K, Lifson J, Rosenberg E, Lauffenburger DA, Altfeld M. HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways. Aids (London, England). 27: 2505-17. PMID 24096630 DOI: 10.1097/01.aids.0000432455.06476.bc  1
2013 Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 1355-65. PMID 24084984 DOI: 10.1039/c3ib40062j  1
2013 Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD, Lauffenburger DA. Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context. Molecular & Cellular Proteomics : McP. 12: 3704-18. PMID 24023389 DOI: 10.1074/mcp.M113.030528  1
2013 Meyer AS, Miller MA, Gertler FB, Lauffenburger DA. The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Science Signaling. 6: ra66. PMID 23921085 DOI: 10.1126/scisignal.2004155  1
2013 Wagner JP, Wolf-Yadlin A, Sevecka M, Grenier JK, Root DE, Lauffenburger DA, MacBeath G. Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Science Signaling. 6: ra58. PMID 23861540 DOI: 10.1126/scisignal.2003994  1
2013 Wilson JL, Hemann MT, Fraenkel E, Lauffenburger DA. Integrated network analyses for functional genomic studies in cancer. Seminars in Cancer Biology. 23: 213-8. PMID 23811269 DOI: 10.1016/j.semcancer.2013.06.004  1
2013 Janes KA, Lauffenburger DA. Models of signalling networks - what cell biologists can gain from them and give to them. Journal of Cell Science. 126: 1913-21. PMID 23720376 DOI: 10.1242/jcs.112045  1
2013 Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A. Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways. Proceedings of the National Academy of Sciences of the United States of America. 110: 9776-81. PMID 23720309 DOI: 10.1073/pnas.1307478110  1
2013 Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, et al. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 940-63. PMID 23685806 DOI: 10.1039/c3ib40013a  0.8
2013 Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA. ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 110: E2074-83. PMID 23674691 DOI: 10.1073/pnas.1222387110  1
2013 Huang SS, Clarke DC, Gosline SJ, Labadorf A, Chouinard CR, Gordon W, Lauffenburger DA, Fraenkel E. Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling. Plos Computational Biology. 9: e1002887. PMID 23408876 DOI: 10.1371/journal.pcbi.1002887  1
2013 Rimchala T, Kamm RD, Lauffenburger DA. Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 510-22. PMID 23303249 DOI: 10.1039/c2ib20090b  1
2013 Pritchard JR, Bruno PM, Hemann MT, Lauffenburger DA. Predicting cancer drug mechanisms of action using molecular network signatures. Molecular Biosystems. 9: 1604-19. PMID 23287973 DOI: 10.1039/c2mb25459j  1
2013 Pritchard JR, Bruno PM, Gilbert LA, Capron KL, Lauffenburger DA, Hemann MT. Defining principles of combination drug mechanisms of action. Proceedings of the National Academy of Sciences of the United States of America. 110: E170-9. PMID 23251029 DOI: 10.1073/pnas.1210419110  1
2013 Lauffenburger DA. Our new look at biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 15-6. PMID 23223812 DOI: 10.1039/c2ib90056d  1
2013 Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J. Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis. Journal of the American Chemical Society. 135: 1645-8. PMID 23157326 DOI: 10.1021/ja307866z  1
2013 Paradise RK, Whitfield MJ, Lauffenburger DA, Van Vliet KJ. Directional cell migration in an extracellular pH gradient: a model study with an engineered cell line and primary microvascular endothelial cells. Experimental Cell Research. 319: 487-97. PMID 23153553 DOI: 10.1016/j.yexcr.2012.11.006  1
2013 Clarke DC, Morris MK, Lauffenburger DA. Normalization and statistical analysis of multiplexed bead-based immunoassay data using mixed-effects modeling. Molecular & Cellular Proteomics : McP. 12: 245-62. PMID 23071098 DOI: 10.1074/mcp.M112.018655  1
2013 Benedict KF, Lauffenburger DA. Insights into proteomic immune cell signaling and communication via data-driven modeling. Current Topics in Microbiology and Immunology. 363: 201-33. PMID 22878785 DOI: 10.1007/82_2012_249  1
2013 Lauffenburger DA, VanHook AM. Science signaling podcast: 6 August 2013 Science Signaling. 6. DOI: 10.1126/scisignal.2004499  1
2012 Mitsos A, Melas IN, Morris MK, Saez-Rodriguez J, Lauffenburger DA, Alexopoulos LG. Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways. Plos One. 7: e50085. PMID 23226239 DOI: 10.1371/journal.pone.0050085  1
2012 Yamanaka YJ, Szeto GL, Gierahn TM, Forcier TL, Benedict KF, Brefo MS, Lauffenburger DA, Irvine DJ, Love JC. Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Analytical Chemistry. 84: 10531-6. PMID 23205933 DOI: 10.1021/ac302264q  1
2012 Pritchard JR, Lauffenburger DA, Hemann MT. Understanding resistance to combination chemotherapy. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 15: 249-57. PMID 23164555 DOI: 10.1016/j.drup.2012.10.003  1
2012 Terfve C, Cokelaer T, Henriques D, MacNamara A, Goncalves E, Morris MK, van Iersel M, Lauffenburger DA, Saez-Rodriguez J. CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms. Bmc Systems Biology. 6: 133. PMID 23079107 DOI: 10.1186/1752-0509-6-133  1
2012 Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. Plos Biology. 10: e1001393. PMID 23055830 DOI: 10.1371/journal.pbio.1001393  1
2012 Kolitz SE, Lauffenburger DA. Measurement and modeling of signaling at the single-cell level. Biochemistry. 51: 7433-43. PMID 22954137 DOI: 10.1021/bi300846p  1
2012 Noonan EM, Shah D, Yaffe MB, Lauffenburger DA, Samson LD. O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1237-55. PMID 22892544 DOI: 10.1039/c2ib20091k  1
2012 Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2574-83. PMID 22889908 DOI: 10.1098/rstb.2012.0010  1
2012 Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions. Molecular Biosystems. 8: 2771-82. PMID 22851037 DOI: 10.1039/c2mb25200g  1
2012 Meyer AS, Hughes-Alford SK, Kay JE, Castillo A, Wells A, Gertler FB, Lauffenburger DA. 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. The Journal of Cell Biology. 197: 721-9. PMID 22665521 DOI: 10.1083/jcb.201201003  1
2012 Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK. Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. Bmc Systems Biology. 6: 29. PMID 22548703 DOI: 10.1186/1752-0509-6-29  1
2012 Stains CI, Tedford NC, Walkup TC, Lukovi? E, Goguen BN, Griffith LG, Lauffenburger DA, Imperiali B. Interrogating signaling nodes involved in cellular transformations using kinase activity probes. Chemistry & Biology. 19: 210-7. PMID 22365604 DOI: 10.1016/j.chembiol.2011.11.012  1
2012 Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Molecular Systems Biology. 8: 568. PMID 22294094 DOI: 10.1038/msb.2012.1  1
2012 Hughes-Alford SK, Lauffenburger DA. Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer. Current Opinion in Cell Biology. 24: 284-91. PMID 22284347 DOI: 10.1016/j.ceb.2012.01.001  1
2012 Clarke DC, Lauffenburger DA. Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments. Biochemical Society Transactions. 40: 133-8. PMID 22260679 DOI: 10.1042/BST20110633  1
2012 Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proceedings of the National Academy of Sciences of the United States of America. 109: 1607-12. PMID 22160692 DOI: 10.1073/pnas.1117194109  1
2012 Morris MK, Shriver Z, Sasisekharan R, Lauffenburger DA. Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions. Biotechnology Journal. 7: 374-86. PMID 22125256 DOI: 10.1002/biot.201100222  1
2012 Hang TC, Lauffenburger DA, Griffith LG, Stolz DB. Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G375-88. PMID 22075778 DOI: 10.1152/ajpgi.00288.2011  1
2012 Sarkar A, Kolitz S, Lauffenburger DA, Han J. An integrated microfluidic probe for multiplexed single cell kinase kinase activity measurement Proceedings of the 16th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2012. 416-418.  0.8
2012 Chen CH, Miller MA, Sarkar A, Beste MT, Lauffenburger DA, Griffith LG, Han J. High-throughput mutiplexed protease activity measurement using a droplet based microfluidic platform with picoinjector Proceedings of the 16th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2012. 1504-1506.  0.8
2011 Lauffenburger DA. ROCK in a stiff place. Science Translational Medicine. 3: 112fs12. PMID 22158859 DOI: 10.1126/scitranslmed.3003389  1
2011 Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK. Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Molecular Systems Biology. 7: 553. PMID 22108795 DOI: 10.1038/msb.2011.85  1
2011 Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, ... ... Lauffenburger DA, et al. ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 40443-51. PMID 21956108 DOI: 10.1074/jbc.M111.280495  1
2011 Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK. Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Molecular Cell. 43: 723-37. PMID 21884975 DOI: 10.1016/j.molcel.2011.07.014  1
2011 Kim HD, Meyer AS, Wagner JP, Alford SK, Wells A, Gertler FB, Lauffenburger DA. Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts. Molecular & Cellular Proteomics : McP. 10: M111.008433. PMID 21832255 DOI: 10.1074/mcp.M111.008433  1
2011 Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA. MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets. Plos Computational Biology. 7: e1002119. PMID 21799663 DOI: 10.1371/journal.pcbi.1002119  1
2011 Pritchard JR, Gilbert LA, Meacham CE, Ricks JL, Jiang H, Lauffenburger DA, Hemann MT. Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response. Cancer Research. 71: 5850-8. PMID 21784872 DOI: 10.1158/0008-5472.CAN-11-1014  1
2011 Wu S, Wells A, Griffith LG, Lauffenburger DA. Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. Biomaterials. 32: 7524-31. PMID 21782235 DOI: 10.1016/j.biomaterials.2011.06.050  1
2011 Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Research. 71: 5400-11. PMID 21742771 DOI: 10.1158/0008-5472.CAN-10-4453  1
2011 Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator. Journal of the American Chemical Society. 133: 10368-71. PMID 21671557 DOI: 10.1021/ja2036628  1
2011 Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y, Pozzuto M, Stobezki R, Goswami S, Segall JE, Lauffenburger DA, Bresnick AR, Gertler FB, Condeelis JS. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. Journal of Cell Science. 124: 2120-31. PMID 21670198 DOI: 10.1242/jcs.086231  1
2011 Peyton SR, Kalcioglu ZI, Cohen JC, Runkle AP, Van Vliet KJ, Lauffenburger DA, Griffith LG. Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. Biotechnology and Bioengineering. 108: 1181-93. PMID 21449030 DOI: 10.1002/bit.23027  1
2011 Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs. Science Signaling. 4: ra16. PMID 21427409 DOI: 10.1126/scisignal.2001338  1
2011 Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA. Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli. Plos Computational Biology. 7: e1001099. PMID 21408212 DOI: 10.1371/journal.pcbi.1001099  1
2011 Bagheri N, Shiina M, Lauffenburger DA, Korn WM. A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition. Plos Computational Biology. 7: e1001085. PMID 21379332 DOI: 10.1371/journal.pcbi.1001085  1
2011 Palmer MJ, Mahajan VS, Chen J, Irvine DJ, Lauffenburger DA. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunology and Cell Biology. 89: 581-94. PMID 21339767 DOI: 10.1038/icb.2011.5  1
2011 Paradise RK, Lauffenburger DA, Van Vliet KJ. Acidic extracellular pH promotes activation of integrin α(v)β(3). Plos One. 6: e15746. PMID 21283814 DOI: 10.1371/journal.pone.0015746  1
2011 Wells A, Chao YL, Grahovac J, Wu Q, Lauffenburger DA. Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Frontiers in Bioscience (Landmark Edition). 16: 815-37. PMID 21196205 DOI: 10.2741/3722  1
2011 Jiang H, Pritchard JR, Williams RT, Lauffenburger DA, Hemann MT. A mammalian functional-genetic approach to characterizing cancer therapeutics. Nature Chemical Biology. 7: 92-100. PMID 21186347 DOI: 10.1038/nchembio.503  1
2011 Miller MA, Barkal L, Jeng K, Herrlich A, Moss M, Griffith LG, Lauffenburger DA. Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 422-38. PMID 21180771 DOI: 10.1039/c0ib00083c  1
2011 Wu R, Goldsipe A, Schauer DB, Lauffenburger DA. Cellular defense processes regulated by pathogen-elicited receptor signaling Proceedings of Spie - the International Society For Optical Engineering. 8058. DOI: 10.1117/12.889123  1
2011 Sarkar A, Kolitz S, Cheow LF, Lauffenburger DA, Han J. An integrated microfluidic probe for concentration-enhanced selective single cell kinase activity measurement 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 2: 1394-1396.  0.8
2011 Chen CH, Sarkar A, Song YA, Miller MA, Kim SJ, Griffith LG, Lauffenburger DA, Han J. Enhancing/multiplexing protease assay with droplet based microfluidics using biomolecule concentrator 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 3: 2080-2082.  0.8
2011 Cheow LF, Sarkar A, Kolitz S, Lauffenburger D, Han J. Concentration enhanced mobility shift assay with applications to aptamer-based biomarker detection and kinase profiling 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 2: 1023-1025.  0.8
2010 Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Molecular & Cellular Proteomics : McP. 9: 2558-70. PMID 20631208 DOI: 10.1074/mcp.M110.001206  1
2010 Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS. Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line. Molecular Biosystems. 6: 1956-72. PMID 20617251 DOI: 10.1039/c002848g  1
2010 Spangler JB, Neil JR, Abramovitch S, Yarden Y, White FM, Lauffenburger DA, Wittrup KD. Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling. Proceedings of the National Academy of Sciences of the United States of America. 107: 13252-7. PMID 20616078 DOI: 10.1073/pnas.0913476107  1
2010 Prince RN, Schreiter ER, Zou P, Wiley HS, Ting AY, Lee RT, Lauffenburger DA. The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release. Journal of Cell Science. 123: 2308-18. PMID 20530570 DOI: 10.1242/jcs.058321  1
2010 Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 202-8. PMID 20473400 DOI: 10.1039/b925935j  1
2010 Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Molecular & Cellular Proteomics : McP. 9: 1849-65. PMID 20460255 DOI: 10.1074/mcp.M110.000406  1
2010 Joslin EJ, Shankaran H, Opresko LK, Bollinger N, Lauffenburger DA, Wiley HS. Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context. Molecular Biosystems. 6: 1293-306. PMID 20458382 DOI: 10.1039/c003921g  1
2010 Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Research. 70: 3843-50. PMID 20406974 DOI: 10.1158/0008-5472.CAN-09-3421  1
2010 Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Molecular Biosystems. 6: 1195-206. PMID 20361094 DOI: 10.1039/b926287c  1
2010 Morris MK, Saez-Rodriguez J, Sorger PK, Lauffenburger DA. Logic-based models for the analysis of cell signaling networks. Biochemistry. 49: 3216-24. PMID 20225868 DOI: 10.1021/bi902202q  1
2010 Ciaccio MF, Wagner JP, Chuu CP, Lauffenburger DA, Jones RB. Systems analysis of EGF receptor signaling dynamics with microwestern arrays. Nature Methods. 7: 148-55. PMID 20101245 DOI: 10.1038/nmeth.1418  1
2010 Kreeger PK, Lauffenburger DA. Cancer systems biology: a network modeling perspective. Carcinogenesis. 31: 2-8. PMID 19861649 DOI: 10.1093/carcin/bgp261  1
2010 Joughin BA, Cheung E, Karuturi RKM, Saez-Rodriguez J, Lauffenburger DA, Liu ET. Cellular Regulatory Networks Systems Biomedicine. 57-108. DOI: 10.1016/B978-0-12-372550-9.00004-3  0.8
2010 Liu ET, Lauffenburger DA. Systems Biomedicine Systems Biomedicine 0.8
2009 Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA. A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5452-5. PMID 19964679 DOI: 10.1109/IEMBS.2009.5334019  1
2009 Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Molecular Systems Biology. 5: 331. PMID 19953085 DOI: 10.1038/msb.2009.87  1
2009 Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA. RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Research. 69: 8191-9. PMID 19789336 DOI: 10.1158/0008-5472.CAN-09-1921  1
2009 Wittmann DM, Krumsiek J, Saez-Rodriguez J, Lauffenburger DA, Klamt S, Theis FJ. Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling. Bmc Systems Biology. 3: 98. PMID 19785753 DOI: 10.1186/1752-0509-3-98  1
2009 Platt MO, Wilder CL, Wells A, Griffith LG, Lauffenburger DA. Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells (Dayton, Ohio). 27: 2804-14. PMID 19750537 DOI: 10.1002/stem.215  1
2009 Lee JH, Cosgrove BD, Lauffenburger DA, Han J. Microfluidic concentration-enhanced cellular kinase activity assay. Journal of the American Chemical Society. 131: 10340-1. PMID 19722608 DOI: 10.1021/ja902594f  1
2009 Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA. Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death. Molecular Cancer Therapeutics. 8: 2183-92. PMID 19671754 DOI: 10.1158/1535-7163.MCT-08-1203  1
2009 Platt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. Journal of Cellular Physiology. 221: 306-17. PMID 19544388 DOI: 10.1002/jcp.21854  1
2009 Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicology and Applied Pharmacology. 237: 317-30. PMID 19362101 DOI: 10.1016/j.taap.2009.04.002  1
2009 Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA. Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. Plos Computational Biology. 5: e1000340. PMID 19343194 DOI: 10.1371/journal.pcbi.1000340  1
2009 Sachs K, Itani S, Carlisle J, Nolan GP, Pe'er D, Lauffenburger DA. Learning signaling network structures with sparsely distributed data. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 16: 201-12. PMID 19193145 DOI: 10.1089/cmb.2008.07TT  1
2009 Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Molecular Systems Biology. 5: 239. PMID 19156131 DOI: 10.1038/msb.2008.74  1
2009 Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, White FM. An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells. Molecular Biosystems. 5: 59-67. PMID 19081932 DOI: 10.1039/b815075c  1
2009 Lazzara MJ, Lauffenburger DA. Quantitative modeling perspectives on the erbb system of cell regulatory processes Experimental Cell Research. 315: 717-725. PMID 19022246 DOI: 10.1016/j.yexcr.2008.10.033  1
2009 Lee JH, Cosgrove BD, Lauffenburger DA, Han J. In-vitro concentration-enhanced cellular kinase activity assays directly from cell lysates Proceedings of Conference, Microtas 2009 - the 13th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 1341-1343.  0.8
2008 Macdonald A, Horwitz AR, Lauffenburger DA. Kinetic model for lamellipodal actin-integrin 'clutch' dynamics. Cell Adhesion & Migration. 2: 95-105. PMID 19262096  1
2008 Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, Gertler FB. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Developmental Cell. 15: 813-28. PMID 19081071 DOI: 10.1016/j.devcel.2008.09.003  1
2008 Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. Plos Biology. 6: 2831-52. PMID 19053173 DOI: 10.1371/journal.pbio.0060299  0.44
2008 Kim HD, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA. Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Molecular Biology of the Cell. 19: 4249-59. PMID 18632979 DOI: 10.1091/mbc.E08-05-0501  1
2008 Harley BA, Kim HD, Zaman MH, Yannas IV, Lauffenburger DA, Gibson LJ. Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions. Biophysical Journal. 95: 4013-24. PMID 18621811 DOI: 10.1529/biophysj.107.122598  1
2008 Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG. An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha. Hepatology (Baltimore, Md.). 48: 276-88. PMID 18536058 DOI: 10.1002/hep.22335  1
2008 Palmer MJ, Mahajan VS, Trajman LC, Irvine DJ, Lauffenburger DA, Chen J. Interleukin-7 receptor signaling network: an integrated systems perspective. Cellular & Molecular Immunology. 5: 79-89. PMID 18445337 DOI: 10.1038/cmi.2008.10  1
2008 Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Molecular Cell. 30: 11-25. PMID 18406323 DOI: 10.1016/j.molcel.2008.02.012  1
2008 Kumar N, Afeyan R, Kim HD, Lauffenburger DA. Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells Molecular Pharmacology. 73: 1668-1678. PMID 18349105 DOI: 10.1124/mol.107.043794  1
2008 Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK. Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics (Oxford, England). 24: 840-7. PMID 18218655 DOI: 10.1093/bioinformatics/btn018  1
2008 Alexopoulos LG, Lauffenburger DA, Sorger PK. Modeling pro-death signaling pathways in cancer hepatocytes using multi-combinatorial treatments of inhibitors and stimuli 8th Ieee International Conference On Bioinformatics and Bioengineering, Bibe 2008. DOI: 10.1109/BIBE.2008.4696732  1
2008 Lazzara MJ, Lauffenburger DA. Altered EGFR trafficking and signaling in lung cancers with kinase-inhibitor-sensitizing mutations Aiche Annual Meeting, Conference Proceedings 1
2008 Miller-Jensen K, Lauffenburger DA, Schaffer DV. Systems biology approaches to studying intracellular signaling interactions between virus and host Aiche Annual Meeting, Conference Proceedings 1
2008 R. Peyton S, Lee HI, Kalcioglu ZI, Kuhlman WA, Lauffenburger DA, Van Vliet KJ, Hammond PT, Griffith LG. 3-D biomaterial design to direct mesenchymal stem cell migration 8th World Biomaterials Congress 2008. 2: 562.  1
2007 Zugates GT, Tedford NC, Zumbuehl A, Jhunjhunwala S, Kang CS, Griffith LG, Lauffenburger DA, Langer R, Anderson DG. Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjugate Chemistry. 18: 1887-96. PMID 17929884 DOI: 10.1021/bc7002082  1
2007 Joslin EJ, Opresko LK, Wells A, Wiley HS, Lauffenburger DA. EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. Journal of Cell Science. 120: 3688-99. PMID 17895366 DOI: 10.1242/jcs.010488  1
2007 Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature. 448: 604-8. PMID 17637676 DOI: 10.1038/nature06001  1
2007 Wille L, Kemp ML, Sandy P, Lewis CL, Lauffenburger DA. Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production. Molecular Immunology. 44: 3085-91. PMID 17418417 DOI: 10.1016/j.molimm.2007.02.008  1
2007 Kharait S, Hautaniemi S, Wu S, Iwabu A, Lauffenburger DA, Wells A. Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. Bmc Systems Biology. 1: 9. PMID 17408516 DOI: 10.1186/1752-0509-1-9  1
2007 Kemp ML, Wille L, Lewis CL, Nicholson LB, Lauffenburger DA. Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response. Journal of Immunology (Baltimore, Md. : 1950). 178: 4984-92. PMID 17404280  1
2007 Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proceedings of the National Academy of Sciences of the United States of America. 104: 5860-5. PMID 17389395 DOI: 10.1073/pnas.0608638104  1
2007 Kumar N, Afeyan R, Sheppard S, Harms B, Lauffenburger DA. Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment Biochemical and Biophysical Research Communications. 354: 14-20. PMID 17214972 DOI: 10.1016/j.bbrc.2006.12.188  1
2007 Kumar N, Wolf-Yadlin A, White FM, Lauffenburger DA. Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data. Plos Computational Biology. 3: e4. PMID 17206861 DOI: 10.1371/journal.pcbi.0030004  1
2007 Zaman MH, Matsudaira P, Lauffenburger DA. Understanding effects of matrix protease and matrix organization on directional persistence and translational speed in three-dimensional cell migration. Annals of Biomedical Engineering. 35: 91-100. PMID 17080315 DOI: 10.1007/s10439-006-9205-6  1
2007 Grodzinsky AJ, Kamm RD, Lauffenburger DA. Quantitative aspects Principles of Tissue Engineering. 251-261. DOI: 10.1016/B978-012370615-7/50022-6  1
2007 Cassman M, Arkin A, Doyle F, Katagiri F, Lauffenburger D, Stokes C. Systems biology: International research and development Systems Biology: International Research and Development. 1-262. DOI: 10.1007/978-1-4020-5468-6  0.8
2007 Green JJ, Zugates GT, Tedford NC, Huang YH, Griffith LG, Lauffenburger DA, Sawicki JA, Langer R, Anderson DG. Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus Advanced Materials. 19: 2836-2842. DOI: 10.1002/adma.200700371  1
2006 Aldridge BB, Haller G, Sorger PK, Lauffenburger DA. Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Systems Biology. 153: 425-32. PMID 17186704 DOI: 10.1049/ip-syb:20050065  1
2006 Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK. Physicochemical modelling of cell signalling pathways. Nature Cell Biology. 8: 1195-203. PMID 17060902 DOI: 10.1038/ncb1497  1
2006 Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nature Reviews. Molecular Cell Biology. 7: 803-12. PMID 17057751 DOI: 10.1038/nrm2042  1
2006 Lauffenburger DA. Right on cue Nature Chemical Biology. 2: 569-570. PMID 17051228 DOI: 10.1038/nchembio1106-569  1
2006 Wolf-Yadlin A, Kumar N, Zhang Y, Hautaniemi S, Zaman M, Kim HD, Grantcharova V, Lauffenburger DA, White FM. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Molecular Systems Biology. 2: 54. PMID 17016520 DOI: 10.1038/msb4100094  1
2006 Hendriks BS, Cook J, Burke JM, Beusmans JM, Lauffenburger DA, de Graaf D. Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity Iee Proceedings Systems Biology. 153: 22-33. PMID 16983832 DOI: 10.1049/ip-syb:20050057  1
2006 Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of Cell Science. 119: 3788-98. PMID 16940353 DOI: 10.1242/jcs.03102  1
2006 Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Applying computational modeling to drug discovery and development. Drug Discovery Today. 11: 806-11. PMID 16935748 DOI: 10.1016/j.drudis.2006.07.010  1
2006 Hua F, Hautaniemi S, Yokoo R, Lauffenburger DA. Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways Journal of the Royal Society Interface. 3: 515-526. PMID 16849248 DOI: 10.1098/rsif.2005.0109  1
2006 Zaman MH, Trapani LM, Sieminski AL, Siemeski A, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 103: 10889-94. PMID 16832052 DOI: 10.1073/pnas.0604460103  1
2006 Kumar N, Zaman MH, Kim HD, Lauffenburger DA. A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence. Biophysical Journal. 91: L32-4. PMID 16782798 DOI: 10.1529/biophysj.106.088898  1
2006 Wells A, Harms B, Iwabu A, Koo L, Smith K, Griffith L, Lauffenburger DA. Motility signaled from the EGF receptor and related systems Methods in Molecular Biology (Clifton, N.J.). 327: 159-177. PMID 16780220  1
2006 Smith KD, Wells A, Lauffenburger DA. Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts Experimental Cell Research. 312: 1970-1982. PMID 16595133 DOI: 10.1016/j.yexcr.2006.02.022  1
2006 Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 124: 1225-39. PMID 16564013 DOI: 10.1016/j.cell.2006.01.041  1
2006 Janes KA, Lauffenburger DA. A biological approach to computational models of proteomic networks. Current Opinion in Chemical Biology. 10: 73-80. PMID 16406679 DOI: 10.1016/j.cbpa.2005.12.016  1
2006 Semino CE, Kamm RD, Lauffenburger DA. Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow Experimental Cell Research. 312: 289-298. PMID 16337626 DOI: 10.1016/j.yexcr.2005.10.029  1
2005 Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (New York, N.Y.). 310: 1646-53. PMID 16339439 DOI: 10.1126/science.1116598  1
2005 Kamei DT, Lao BJ, Ricci MS, Deshpande R, Xu H, Tidor B, Lauffenburger DA. Quantitative methods for developing Fc mutants with extended half-lives Biotechnology and Bioengineering. 92: 748-760. PMID 16136591 DOI: 10.1002/bit.20624  1
2005 Wells A, Huttenlocher A, Lauffenburger DA. Calpain proteases in cell adhesion and motility International Review of Cytology. 245: 1-16. PMID 16125543 DOI: 10.1016/S0074-7696(05)45001-9  1
2005 Rao BM, Driver I, Lauffenburger DA, Wittrup KD. High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth. Biochemistry. 44: 10696-701. PMID 16060678 DOI: 10.1021/bi050436x  1
2005 Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Molecular & Cellular Proteomics : McP. 4: 1569-90. PMID 16030008 DOI: 10.1074/mcp.M500158-MCP200  1
2005 Yoshioka J, Prince RN, Huang H, Perkins SB, Cruz FU, MacGillivray C, Lauffenburger DA, Lee RT. Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF. Proceedings of the National Academy of Sciences of the United States of America. 102: 10622-7. PMID 16020536 DOI: 10.1073/pnas.0501198102  1
2005 Hua F, Cornejo MG, Cardone MH, Stokes CL, Lauffenburger DA. Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions. Journal of Immunology (Baltimore, Md. : 1950). 175: 985-95. PMID 16002698  1
2005 Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Molecular & Cellular Proteomics : McP. 4: 1240-50. PMID 15951569 DOI: 10.1074/mcp.M500089-MCP200  1
2005 Zaman MH, Kamm RD, Matsudaira P, Lauffenburger DA. Computational model for cell migration in three-dimensional matrices. Biophysical Journal. 89: 1389-97. PMID 15908579 DOI: 10.1529/biophysj.105.060723  1
2005 Viswanathan S, Davey RE, Cheng D, Raghu RC, Lauffenburger DA, Zandstra PW. Clonal evolution of stem and differentiated cells can be predicted by integrating cell-intrinsic and -extrinsic parameters. Biotechnology and Applied Biochemistry. 42: 119-31. PMID 15882145 DOI: 10.1042/BA20040207  1
2005 Sachs K, Perez O, Pe'er D, Lauffenburger DA, Nolan GP. Causal protein-signaling networks derived from multiparameter single-cell data. Science (New York, N.Y.). 308: 523-9. PMID 15845847 DOI: 10.1126/science.1105809  1
2005 Dong J, Opresko LK, Chrisler W, Orr G, Quesenberry RD, Lauffenburger DA, Wiley HS. The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode. Molecular Biology of the Cell. 16: 2984-98. PMID 15829568 DOI: 10.1091/mbc.E04-11-0994  1
2005 Varga CM, Tedford NC, Thomas M, Klibanov AM, Griffith LG, Lauffenburger DA. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Therapy. 12: 1023-32. PMID 15815703 DOI: 10.1038/sj.gt.3302495  1
2005 Shults MD, Janes KA, Lauffenburger DA, Imperiali B. A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates. Nature Methods. 2: 277-83. PMID 15782220 DOI: 10.1038/nmeth747  1
2005 Hautaniemi S, Kharait S, Iwabu A, Wells A, Lauffenburger DA. Modeling of signal-response cascades using decision tree analysis Bioinformatics. 21: 2027-2035. PMID 15657095 DOI: 10.1093/bioinformatics/bti278  1
2005 Monine MI, Berezhkovskii AM, Joslin EJ, Wiley HS, Lauffenburger DA, Shvartsman SY. Ligand accumulation in autocrine cell cultures. Biophysical Journal. 88: 2384-90. PMID 15653719 DOI: 10.1529/biophysj.104.051425  1
2005 Woolf PJ, Prudhomme W, Daheron L, Daley GQ, Lauffenburger DA. Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. Bioinformatics (Oxford, England). 21: 741-53. PMID 15479714 DOI: 10.1093/bioinformatics/bti056  1
2005 Lazzara MJ, Jasper P, Sorger P, Lauffenburger DA. Altered Egfr trafficking and signaling in iressa-sensitive human cell lines Aiche Annual Meeting, Conference Proceedings. 9238.  1
2004 Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 11: 544-61. PMID 15579231 DOI: 10.1089/1066527041887258  1
2004 Lu H, Koo LY, Wang WM, Lauffenburger DA, Griffith LG, Jensen KF. Microfluidic shear devices for quantitative analysis of cell adhesion. Analytical Chemistry. 76: 5257-64. PMID 15362881 DOI: 10.1021/ac049837t  1
2003 Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & Cellular Proteomics : McP. 2: 463-73. PMID 12832460 DOI: 10.1074/mcp.M300045-MCP200  1
2003 Wiley HS, Shvartsman SY, Lauffenburger DA. Computational modeling of the EGF-receptor system: a paradigm for systems biology. Trends in Cell Biology. 13: 43-50. PMID 12480339 DOI: 10.1016/S0962-8924(02)00009-0  1
2002 Shvartsman SY, Muratov CB, Lauffenburger DA. Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. Development (Cambridge, England). 129: 2577-89. PMID 12015287  1
2002 Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW. Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem Cells (Dayton, Ohio). 20: 119-38. PMID 11897869 DOI: 10.1634/stemcells.20-2-119  1
2002 Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG. Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. Journal of Cell Science. 115: 1423-33. PMID 11896190  1
2002 Shvartsman SY, Hagan MP, Yacoub A, Dent P, Wiley HS, Lauffenburger DA. Autocrine loops with positive feedback enable context-dependent cell signaling. American Journal of Physiology. Cell Physiology. 282: C545-59. PMID 11832340 DOI: 10.1152/ajpcell.00260.2001  1
2001 Shvartsman SY, Wiley HS, Deen WM, Lauffenburger DA. Spatial range of autocrine signaling: modeling and computational analysis. Biophysical Journal. 81: 1854-67. PMID 11566760 DOI: 10.1016/S0006-3495(01)75837-7  1
2001 Orsello CE, Lauffenburger DA, Hammer DA. Molecular properties in cell adhesion: a physical and engineering perspective. Trends in Biotechnology. 19: 310-6. PMID 11451473  0.96
2001 Lauffenburger DA, Griffith LG. Who's got pull around here? Cell organization in development and tissue engineering. Proceedings of the National Academy of Sciences of the United States of America. 98: 4282-4. PMID 11296276 DOI: 10.1073/pnas.081083698  1
2000 Schaffer DV, Lauffenburger DA. Targeted synthetic gene delivery vectors. Current Opinion in Molecular Therapeutics. 2: 155-61. PMID 11249636  1
2000 Zandstra PW, Le HV, Daley GQ, Griffith LG, Lauffenburger DA. Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation. Biotechnology and Bioengineering. 69: 607-17. PMID 10918135 DOI: 10.1002/1097-0290(20000920)69:6<607::AID-BIT4>3.0.CO;2-F  1
2000 Maheshwari G, Brown G, Lauffenburger DA, Wells A, Griffith LG. Cell adhesion and motility depend on nanoscale RGD clustering. Journal of Cell Science. 113: 1677-86. PMID 10769199  1
2000 Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnology and Bioengineering. 67: 598-606. PMID 10649234 DOI: 10.1002/(SICI)1097-0290(20000305)67:5<598::AID-BIT10>3.0.CO;2-G  1
1999 Lauffenburger DA, Schaffer DV. The matrix delivers. Nature Medicine. 5: 733-4. PMID 10395312 DOI: 10.1038/10451  1
1999 Maheshwari G, Wells A, Griffith LG, Lauffenburger DA. Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration. Biophysical Journal. 76: 2814-23. PMID 10233097 DOI: 10.1016/S0006-3495(99)77435-7  1
1998 Schaffer DV, Lauffenburger DA. Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery. The Journal of Biological Chemistry. 273: 28004-9. PMID 9774415 DOI: 10.1074/jbc.273.43.28004  1
1997 Kuo SC, Hammer DA, Lauffenburger DA. Simulation of detachment of specifically bound particles from surfaces by shear flow. Biophysical Journal. 73: 517-31. PMID 9199814 DOI: 10.1016/S0006-3495(97)78090-1  0.96
1993 DiMilla PA, Stone JA, Quinn JA, Albelda SM, Lauffenburger DA. Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. The Journal of Cell Biology. 122: 729-37. PMID 8335696  1
1991 DiMilla PA, Barbee K, Lauffenburger DA. Mathematical model for the effects of adhesion and mechanics on cell migration speed. Biophysical Journal. 60: 15-37. PMID 1883934 DOI: 10.1016/S0006-3495(91)82027-6  1
1991 Wiley HS, Herbst JJ, Walsh BJ, Lauffenburger DA, Rosenfeld MG, Gill GN. The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. The Journal of Biological Chemistry. 266: 11083-94. PMID 1645724  0.8
1989 Hammer DA, Lauffenburger DA. A dynamical model for receptor-mediated cell adhesion to surfaces in viscous shear flow. Cell Biophysics. 14: 139-73. PMID 2472206 DOI: 10.1007/BF02797131  1
1988 Linderman JJ, Lauffenburger DA. Analysis of intracellular receptor/ligand sorting in endosomes. Journal of Theoretical Biology. 132: 203-45. PMID 2850411  1
1987 Hammer DA, Lauffenburger DA. A dynamical model for receptor-mediated cell adhesion to surfaces. Biophysical Journal. 52: 475-87. PMID 2820521 DOI: 10.1016/S0006-3495(87)83236-8  1
1986 Linderman JJ, Lauffenburger DA. Analysis of intracellular receptor/ligand sorting. Calculation of mean surface and bulk diffusion times within a sphere. Biophysical Journal. 50: 295-305. PMID 3741985  1
Low-probability matches
2015 Ip B, Cilfone NA, Belkina AC, DeFuria J, Jagannathan-Bogdan M, Zhu M, Kuchibhatla R, McDonnell ME, Xiao Q, Kepler TB, Apovian CM, Lauffenburger DA, Nikolajczyk BS. Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFα production. Obesity (Silver Spring, Md.). PMID 26576827 DOI: 10.1002/oby.21243  0.2
2015 Stokes CL, Cirit M, Lauffenburger DA. Physiome-on-a-Chip: The Challenge of "Scaling" in Design, Operation, and Translation of Microphysiological Systems. Cpt: Pharmacometrics & Systems Pharmacology. 4: 559-62. PMID 26535154 DOI: 10.1002/psp4.12042  0.2
2015 Arnold KB, Szeto GL, Alter G, Irvine DJ, Lauffenburger DA. CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Science Signaling. 8: ra104. PMID 26486173 DOI: 10.1126/scisignal.aab0808  0.16
2015 Oudin MJ, Hughes SK, Rohani N, Moufarrej MN, Jones JG, Condeelis JS, Lauffenburger DA, Gertler FB. Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression. Clinical & Experimental Metastasis. PMID 26680363 DOI: 10.1007/s10585-015-9775-5  0.08
2016 Zevin AS, Xie IY, Birse K, Arnold K, Romas L, Westmacott G, Novak RM, McCorrister S, McKinnon LR, Cohen CR, Mackelprang R, Lingappa J, Lauffenburger DA, Klatt NR, Burgener AD. Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract. Plos Pathogens. 12: e1005889. PMID 27656899 DOI: 10.1371/journal.ppat.1005889  0.01
2015 Masson L, Arnold KB, Little F, Mlisana K, Lewis DA, Mkhize N, Gamieldien H, Ngcapu S, Johnson L, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS. Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection. Sexually Transmitted Infections. PMID 26511781 DOI: 10.1136/sextrans-2015-052072  0.01
2015 Arnold KB, Burgener A, Birse K, Romas L, Dunphy LJ, Shahabi K, Abou M, Westmacott GR, McCorrister S, Kwatampora J, Nyanga B, Kimani J, Masson L, Liebenberg LJ, Abdool Karim SS, ... ... Lauffenburger DA, et al. Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells. Mucosal Immunology. PMID 26104913 DOI: 10.1038/mi.2015.51  0.01
2015 Li JZ, Arnold KB, Lo J, Dugast AS, Plants J, Ribaudo HJ, Cesa K, Heisey A, Kuritzkes DR, Lauffenburger DA, Alter G, Landay A, Grinspoon S, Pereyra F. Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics. Open Forum Infectious Diseases. 2: ofu117. PMID 25884005 DOI: 10.1093/ofid/ofu117  0.01
2012 Lauffenburger DA. The multiple dimensions of Integrative Biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 9. PMID 22158999 DOI: 10.1039/c1ib90041b  0.01
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