Jason C. Rech, Ph.D. - Related publications

University of Pittsburgh, Pittsburgh, PA, United States 
Reaction Design, Total Synthesis, Mechanistic Analysis, Diversity Oriented Synthesis
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 da Silva Moreira LK, Silva RR, da Silva DM, Mendes MAS, de Brito AF, de Carvalho FS, Sanz G, Rodrigues MF, da Silva ACG, Thomaz DV, de Oliveira V, Vaz BG, Lião LM, Valadares MC, de Souza Gil E, et al. Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice. Behavioural Brain Research. 113582. PMID 34536431 DOI: 10.1016/j.bbr.2021.113582   
2021 Myers SJ, Ruppa KP, Wilson LJ, Tahirovic YA, Lyuboslavsky P, Menaldino DS, Dentmon ZW, Koszalka GW, Zaczek R, Dingledine RJ, Traynelis SF, Liotta DC. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34493631 DOI: 10.1124/jpet.120.000370   
2021 Jin C, Yi C, Zhong W, Xue Y, Chen K, Deng K, Wang Z, Wang T. Design, synthesis and biological evaluation of pyridinylmethylenepiperidine derivatives as potent 5-HT receptor agonists for migraine therapy. European Journal of Medicinal Chemistry. 225: 113782. PMID 34419891 DOI: 10.1016/j.ejmech.2021.113782   
2021 Dutt Konar A, Jain AK, Gupta A, Karthikeyan C, Trivedi P. Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics. Chemistry & Biodiversity. PMID 34486216 DOI: 10.1002/cbdv.202100364   
2021 Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. European Journal of Medicinal Chemistry. 226: 113805. PMID 34536667 DOI: 10.1016/j.ejmech.2021.113805   
2021 Brockett AT, Deng C, Shuster M, Perera S, DiMaggio D, Cheng M, Murkli S, Briken V, Roesch MR, Isaacs L. In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34613641 DOI: 10.1002/chem.202102919   
2021 Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of Medicinal Chemistry. PMID 34435786 DOI: 10.1021/acs.jmedchem.1c00239   
2021 Avram S, Stan MS, Udrea AM, Buiu C, Boboc AA, Mernea M. 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds. Pharmaceutics. 13. PMID 34575524 DOI: 10.3390/pharmaceutics13091449   
2021 Shih TL, Lin KH, Chen RJ, Chen TY, Kao WT, Liu JW, Wang HH, Peng HY, Sun YY, Lu WJ. A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. Journal of Cellular and Molecular Medicine. PMID 34448532 DOI: 10.1111/jcmm.16886   
2021 Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, et al. Positive allosteric mechanisms of adenosine A receptor-mediated analgesia. Nature. PMID 34497422 DOI: 10.1038/s41586-021-03897-2   
2021 Zhang M, Xu B, Li N, Zhang R, Zhang Q, Shi X, Xu K, Xiao J, Chen D, Niu J, Shi Y, Fang Q. Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. Journal of Medicinal Chemistry. PMID 34465090 DOI: 10.1021/acs.jmedchem.1c00694   
2021 Ochiai K, Fujii S. Structure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 46: 128141. PMID 34048883 DOI: 10.1016/j.bmcl.2021.128141   
2021 Shah A, Shah AA, Nandakumar K, Kumar A, Pai A, Lobo R. In-silico and in-vivo evaluation of sesamol and its derivatives for benign prostatic hypertrophy. 3 Biotech. 11: 411. PMID 34466348 DOI: 10.1007/s13205-021-02952-z   
2021 Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T, Nie H, Cheng J. Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis. European Journal of Medicinal Chemistry. 226: 113878. PMID 34634742 DOI: 10.1016/j.ejmech.2021.113878   
2021 Guo M, Bakhoda A, Gao ZG, Ramsey JM, Li Y, O'Conor KA, Kelleher AC, Eisenberg SM, Kang Y, Yan X, Javdan C, Fowler JS, Rice KC, Hooker JM, Jacobson KA, et al. Discovery of Highly Potent Adenosine A Receptor Agonists: Targeting Positron Emission Tomography Probes. Acs Chemical Neuroscience. PMID 34469110 DOI: 10.1021/acschemneuro.1c00397   
2021 Kumar S, Kumar N, Sharma CS, Mishra SS. Molecular Insights of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole as CRF-1 Receptor Antagonists: Combined QSAR, Glide Docking, Molecular Dynamics, and ADME Studies. Iranian Journal of Pharmaceutical Research : Ijpr. 20: 22-34. PMID 34567143 DOI: 10.22037/ijpr.2020.113746.14464   
2021 Gwak J, Cha J, Lee J, Kim Y, An SA, Lee S, Moon HB, Hur J, Giesy JP, Hong S, Khim JS. Effect-directed identification of novel aryl hydrocarbon receptor-active aromatic compounds in coastal sediments collected from a highly industrialized area. The Science of the Total Environment. 803: 149969. PMID 34481160 DOI: 10.1016/j.scitotenv.2021.149969   
2021 Kumar A, Gupta KB, Dhiman M, Arora S, Jaitak V. New pentacyclic triterpene from Lodd. as anticancer agent for breast cancer targeting estrogen receptor-. Natural Product Research. 1-6. PMID 34606404 DOI: 10.1080/14786419.2021.1986495   
2021 Krautmann M, Walters R, Cole P, Tena J, Bergeron LM, Messamore J, Mwangi D, Rai S, Dominowski P, Saad K, Zhu Y, Guillot M, Chouinard L. Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs. Veterinary Journal (London, England : 1997). 276: 105733. PMID 34391918 DOI: 10.1016/j.tvjl.2021.105733   
2021 Neumann WL, Sandoval KE, Mobayen S, Minaeian M, Kukielski SG, Srabony KN, Frare R, Slater O, Farr SA, Niehoff ML, Hospital A, Kontoyianni M, Crider AM, Witt KA. Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment. Rsc Medicinal Chemistry. 12: 1352-1365. PMID 34458738 DOI: 10.1039/d1md00044f   
2021 Sun J, Liu HY, Zhang YH, Fang ZY, Lv PC. Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ. Bioorganic Chemistry. 116: 105342. PMID 34536928 DOI: 10.1016/j.bioorg.2021.105342   
2021 Aly MW, Ludwig FA, Deuther-Conrad W, Brust P, Abadi AH, Moldovan RP, Osman NA. Development of fluorinated and methoxylated benzothiazole derivatives as highly potent and selective cannabinoid CB receptor ligands. Bioorganic Chemistry. 114: 105191. PMID 34375194 DOI: 10.1016/j.bioorg.2021.105191   
2021 Mach M, Bazydło-Guzenda K, Buda P, Matłoka M, Dzida R, Stelmach F, Gałązka K, Wąsińska-Kałwa M, Smuga D, Hołowińska D, Dawid U, Gurba-Bryśkiewicz L, Wiśniewski K, Dubiel K, Pieczykolan J, et al. Discovery and development of CPL207280 as new GPR40/FFA1 agonist. European Journal of Medicinal Chemistry. 226: 113810. PMID 34537444 DOI: 10.1016/j.ejmech.2021.113810   
2021 Chen Y, Lei H, Li T, Cui Y, Wang X, Cao Z, Wu H, Zhai X. Design, synthesis and anti-fibrosis evaluation of imidazo[1,2-a]pyridine derivatives as potent ATX inhibitors. Bioorganic & Medicinal Chemistry. 46: 116362. PMID 34428714 DOI: 10.1016/j.bmc.2021.116362   
2021 Bachurin SO, Makhaeva GF, Shevtsova EF, Aksinenko AY, Grigoriev VV, Shevtsov PN, Goreva TV, Epishina TA, Kovaleva NV, Pushkareva EA, Boltneva NP, Lushchekina SV, Gabrelyan AV, Zamoyski VL, Dubova LG, et al. Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. Molecules (Basel, Switzerland). 26. PMID 34576998 DOI: 10.3390/molecules26185527   
2021 Hu HC, Tsai YH, Chuang YC, Lai KH, Hsu YM, Hwang TL, Lin CC, Fülöp F, Wu YC, Yu SY, Kuo YT, Chang FR. Estrogenic and anti-neutrophilic inflammatory phenanthrenes from L. Natural Product Research. 1-11. PMID 34498976 DOI: 10.1080/14786419.2021.1954644   
2021 Müller CE, Namasivayam V. Recommended tool compounds and drugs for blocking P2X and P2Y receptors. Purinergic Signalling. PMID 34476721 DOI: 10.1007/s11302-021-09813-7   
2021 Shan L, Martens GJM, Swaab DF. Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases. Current Topics in Behavioral Neurosciences. PMID 34432256 DOI: 10.1007/7854_2021_237   
2021 Pankiewicz P, Szybiński M, Kisielewska K, Gołębiowski F, Krzemiński P, Rutkowska-Włodarczyk I, Moszczyński-Pętkowski R, Gurba-Bryśkiewicz L, Delis M, Mulewski K, Smuga D, Dominowski J, Janusz A, Górka M, Abramski K, et al. Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists. Pharmaceuticals (Basel, Switzerland). 14. PMID 34451801 DOI: 10.3390/ph14080704   
2021 Sarkar A, Galasiti Kankanamalage AC, Zhang Q, Cheng H, Sivaprakasam P, Naglich J, Xie C, Gangwar S, Boger DL. Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 30: 1377-1385. PMID 34421287 DOI: 10.1007/s00044-021-02736-3   
2021 Moehle MS, Bender AM, Dickerson JW, Foster DJ, Qi A, Cho HP, Donsante Y, Peng W, Bryant Z, Stillwell KJ, Bridges TM, Chang S, Watson KJ, O'Neill JC, Engers JL, et al. Discovery of the First Selective M Muscarinic Acetylcholine Receptor Antagonists with Antiparkinsonian and Antidystonic Efficacy. Acs Pharmacology & Translational Science. 4: 1306-1321. PMID 34423268 DOI: 10.1021/acsptsci.0c00162   
2021 Wang X, Zhou H, Wang X, Lei K, Wang S. Design, Synthesis, and In Vivo and In Silico Evaluation of Coumarin Derivatives with Potential Antidepressant Effects. Molecules (Basel, Switzerland). 26. PMID 34577028 DOI: 10.3390/molecules26185556   
2021 Berthier A, Staels B, Lefebvre P. An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells. Star Protocols. 2: 100658. PMID 34286290 DOI: 10.1016/j.xpro.2021.100658   
2021 Ben David A, Barnea A, Diamant E, Dor E, Schwartz A, Torgeman A, Zichel R. Small Molecule Receptor Binding Inhibitors with In Vivo Efficacy against Botulinum Neurotoxin Serotypes A and E. International Journal of Molecular Sciences. 22. PMID 34445283 DOI: 10.3390/ijms22168577   
2021 Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118   
2021 Lee JC, Janda KD. Immunopharmacotherapeutic advancements in addressing methamphetamine abuse. Rsc Chemical Biology. 2: 77-93. PMID 34458776 DOI: 10.1039/d0cb00165a   
2021 Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 226: 113838. PMID 34571173 DOI: 10.1016/j.ejmech.2021.113838   
2021 Kirstgen M, Müller SF, Lowjaga KAAT, Goldmann N, Lehmann F, Alakurtti S, Yli-Kauhaluoma J, Baringhaus KH, Krieg R, Glebe D, Geyer J. Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening. Viruses. 13. PMID 34452354 DOI: 10.3390/v13081489   
2021 Powell WS. Eicosanoid receptors as therapeutic targets for asthma. Clinical Science (London, England : 1979). 135: 1945-1980. PMID 34401905 DOI: 10.1042/CS20190657   
2021 Facchini FA, Minotti A, Luraghi A, Romerio A, Gotri N, Matamoros-Recio A, Iannucci A, Palmer C, Wang G, Ingram R, Martin-Santamaria S, Pirianov G, De Andrea M, Valvano MA, Peri F. Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity. Journal of Medicinal Chemistry. 64: 12261-12272. PMID 34382796 DOI: 10.1021/acs.jmedchem.1c00896   
2021 Li L, Lu JJ, Wang WT, Wang N, Wang LX, Ma YM, Liu S. [Potential targets of Euodiae Fructus in treatment of insomnia based on network pharmacology]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 46: 3016-3023. PMID 34467691 DOI: 10.19540/j.cnki.cjcmm.20210419.401   
2021 Zhao WY, Luan ZL, Sun CP, Zhang BJ, Jin LL, Deng S, Zhang HL, Yu ZL, Wang C, Ma XC. Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR. Phytochemistry. 193: 112974. PMID 34653908 DOI: 10.1016/j.phytochem.2021.112974   
2021 Rishton GM, Look GC, Ni ZJ, Zhang J, Wang Y, Huang Y, Wu X, Izzo NJ, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Catalano SM. Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease. Acs Medicinal Chemistry Letters. 12: 1389-1395. PMID 34531947 DOI: 10.1021/acsmedchemlett.1c00048   
2021 Aparicio-Prat E, Yan D, Mariotti M, Bassik M, Hess G, Fortin JP, Weston A, Xi HS, Stanton R. Roadmap for the use of base editors to decipher drug mechanism of action. Plos One. 16: e0257537. PMID 34547052 DOI: 10.1371/journal.pone.0257537   
2021 Elvir-Lazo OL, White PF, Cruz Eng H, Yumul F, Chua R, Yumul R. Impact of chronic medications in the perioperative period -anesthetic implications (part ii). Postgraduate Medicine. PMID 34551658 DOI: 10.1080/00325481.2021.1982298   
2021 Emon NU, Alam S, Rudra S, Haidar IKA, Farhad M, Rana MEH, Ganguly A. Antipyretic activity of (Rottl.) leaves extract along with phytoconstituent's binding affinity to COX-1, COX-2, and mPGES-1 receptors: and approaches. Saudi Journal of Biological Sciences. 28: 5302-5309. PMID 34466108 DOI: 10.1016/j.sjbs.2021.05.050   
2021 Van J, Frias JP, Bonora E, Raha S, Meyer J, Jung H, Cox D, Konig M, Peleshok J, Bethel MA. Gastrointestinal Tolerability of Once-Weekly Dulaglutide 3.0 mg and 4.5 mg: A Post Hoc Analysis of the Incidence and Prevalence of Nausea, Vomiting, and Diarrhea in AWARD-11. Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders. PMID 34514554 DOI: 10.1007/s13300-021-01140-9   
2021 Cao AM, Quast RB, Fatemi F, Rondard P, Pin JP, Margeat E. Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state. Nature Communications. 12: 5426. PMID 34521824 DOI: 10.1038/s41467-021-25620-5   
2021 Elvir-Lazo OL, White PF, Cruz Eng H, Yumul F, Chua R, Yumul R. Impact of chronic medications in the perioperative period -mechanisms of action and adverse drug effects (part i). Postgraduate Medicine. PMID 34551662 DOI: 10.1080/00325481.2021.1982297   
2021 Matsumoto R, Takahashi D, Watanabe M, Nakatani S, Takamura Y, Kurosaki Y, Kakuta H, Hase K. A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice. Frontiers in Pharmacology. 12: 715752. PMID 34475823 DOI: 10.3389/fphar.2021.715752