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Prafull S. Gandhi, Ph.D. - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Biophysics) Washington University, Saint Louis, St. Louis, MO 
Area:
protein folding, protein structure/function relationships, protein-protein interactions and the mechanisms of enzymatic reactions
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19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ruben EA, Gandhi PS, Chen Z, Koester SK, DeKoster GT, Frieden C, Di Cera E. 19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2. The Journal of Biological Chemistry. PMID 32358061 DOI: 10.1074/Jbc.Ra120.013419  0.536
2020 Petersen M, Gandhi PS, Buchardt J, Alanentalo T, Fels JJ, Johansen NL, Helding-Kvist P, Vad K, Thygesen P. Tissue Distribution and Receptor Activation by Somapacitan, a Long Acting Growth Hormone Derivative. International Journal of Molecular Sciences. 21. PMID 32053994 DOI: 10.3390/Ijms21041181  0.334
2019 Sorensen AB, Tuneew I, Svensson LA, Persson E, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS. Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa. The Journal of Biological Chemistry. PMID 31801825 DOI: 10.1074/Jbc.Ra119.009183  0.451
2019 Sorensen AB, Madsen JJ, Frimurer TM, Overgaard MT, Gandhi PS, Persson E, Olsen OH. Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures. Biophysical Journal. PMID 31003762 DOI: 10.1016/J.Bpj.2019.03.024  0.477
2017 Nielsen AL, Sorensen AB, Holmberg HL, Gandhi PS, Karlsson J, Buchardt J, Lamberth K, Kjelgaard-Hansen M, Ley CD, Sørensen BB, Ruf W, Olsen OH, Østergaard H. Engineering of a membrane-triggered activity switch in coagulation factor VIIa. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109275 DOI: 10.1073/Pnas.1618713114  0.346
2016 Hennen S, Kodra JT, Soroka V, Krogh BO, Wu X, Kaastrup P, Ørskov C, Rønn SG, Schluckebier G, Barbateskovic S, Gandhi PS, Reedtz-Runge S. Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor. Scientific Reports. 6: 26236. PMID 27196125 DOI: 10.1038/Srep26236  0.35
2015 Sorensen AB, Madsen JJ, Svensson LA, Pedersen AA, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS. Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-Mediated Allosteric Regulation of Factor VIIa Activity. The Journal of Biological Chemistry. PMID 26694616 DOI: 10.1074/Jbc.M115.698613  0.455
2014 Østergaard H, Hansen L, Pelzer H, Agersø H, Pedersen AA, Glue TH, Johnsen LB, Andersen G, Bjelke JR, Breinholt J, Stennicke H, Gandhi PS, Olsen OH, Hermit MB. Modulating the Antithrombin-Mediated in Vivo Clearance of Coagulation Factor VIIa Blood. 124: 4233-4233. DOI: 10.1182/Blood.V124.21.4233.4233  0.329
2014 Gandhi PS, Grøn H, Petersen HH, Reedtz-Runge SL, Olsen OH, Østergaard H. Protein Engineering and in Vitro Characterization of a Factor VIIa Analog with Selective Abrogation of Tissue Factor Binding Blood. 124: 4230-4230. DOI: 10.1182/Blood.V124.21.4230.4230  0.428
2011 Niu W, Chen Z, Gandhi PS, Vogt AD, Pozzi N, Pelc LA, Zapata F, Di Cera E. Crystallographic and kinetic evidence of allostery in a trypsin-like protease. Biochemistry. 50: 6301-7. PMID 21707111 DOI: 10.1021/Bi200878C  0.473
2011 Gandhi PS, Chen Z, Appelbaum E, Zapata F, Di Cera E. Structural basis of thrombin-protease-activated receptor interactions. Iubmb Life. 63: 375-82. PMID 21698746 DOI: 10.1002/Iub.461  0.446
2011 Gandhi PS, Chen Z, Appelbaum E, Zapata F, Cera ED. Structural basis of thrombin-protease-receptor interactions Iubmb Life. 63: 375-382. DOI: 10.2210/Pdb3Qdz/Pdb  0.319
2010 Marino F, Pelc LA, Vogt A, Gandhi PS, Di Cera E. Engineering thrombin for selective specificity toward protein C and PAR1. The Journal of Biological Chemistry. 285: 19145-52. PMID 20404340 DOI: 10.1074/Jbc.M110.119875  0.347
2010 Gandhi PS, Chen Z, Di Cera E. Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1. The Journal of Biological Chemistry. 285: 15393-8. PMID 20236938 DOI: 10.1074/Jbc.M110.115337  0.468
2009 Niu W, Chen Z, Bush-Pelc LA, Bah A, Gandhi PS, Di Cera E. Mutant N143P reveals how Na+ activates thrombin. The Journal of Biological Chemistry. 284: 36175-85. PMID 19846563 DOI: 10.1074/Jbc.M109.069500  0.385
2009 Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. The Journal of Biological Chemistry. 284: 24098-105. PMID 19586901 DOI: 10.1074/Jbc.M109.025403  0.491
2009 Bah A, Carrell CJ, Chen Z, Gandhi PS, Di Cera E. Stabilization of the E* form turns thrombin into an anticoagulant. The Journal of Biological Chemistry. 284: 20034-40. PMID 19473969 DOI: 10.1074/Jbc.M109.012344  0.474
2008 Papaconstantinou ME, Gandhi PS, Chen Z, Bah A, Di Cera E. Na+ binding to meizothrombin desF1. Cellular and Molecular Life Sciences : Cmls. 65: 3688-97. PMID 18854941 DOI: 10.1007/S00018-008-8502-7  0.449
2008 Gandhi PS, Chen Z, Mathews FS, Di Cera E. Structural identification of the pathway of long-range communication in an allosteric enzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 1832-7. PMID 18250335 DOI: 10.1073/Pnas.0710894105  0.418
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