Jeanne A. Hardy, Ph.D. - Publications

Affiliations: 
1994-2000 Chemistry University of California, Berkeley, Berkeley, CA 
 2005- Chemistry University of Massachusetts, Amherst, Amherst, MA 
Area:
structural biology, with a major emphasis on electron microscopy
Website:
https://hardylab.chem.umass.edu/people/

154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. Acs Chemical Biology. PMID 34553588 DOI: 10.1021/acschembio.1c00456  1
2021 Soni IV, Hardy JA. Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry. PMID 34472839 DOI: 10.1021/acs.biochem.1c00459  1
2021 Anson F, Thayumanavan S, Hardy JA. Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes. Jacs Au. 1: 1240-1256. PMID 34467362 DOI: 10.1021/jacsau.1c00261  1
2021 Anson F, Liu B, Kanjilal P, Wu P, Hardy JA, Thayumanavan S. Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP. Biomacromolecules. PMID 33591168 DOI: 10.1021/acs.biomac.0c01767  1
2020 Anson F, Kanjilal P, Thayumanavan S, Hardy JA. Tracking Exogenous Intracellular Casp-3 Using Split GFP. Protein Science : a Publication of the Protein Society. PMID 33165988 DOI: 10.1002/pro.3992  1
2020 Arias-Arias JL, MacPherson DJ, Hill ME, Hardy JA, Mora-Rodríguez R. A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. The Journal of Biological Chemistry. PMID 31919100 DOI: 10.1074/Jbc.Ra119.011319  1
2020 Hardy J. The role of mobility in flavivirus protease substrate selection The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07113  0.01
2020 Hardy J. Targeting Rare Conformational States to Achieve Selective Caspase Protease Inhibition Biophysical Journal. 118: 160a-161a. DOI: 10.1016/J.Bpj.2019.11.993  0.01
2019 Pham B, Eron SJ, Hill ME, Li X, Fahie MA, Hardy JA, Chen M. A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates. Biophysical Journal. PMID 31427065 DOI: 10.1016/J.Bpj.2019.07.045  1
2019 Okerberg ES, Dagbay KB, Green JL, Soni I, Aban A, Nomanbhoy TK, Savinov SN, Hardy JA, Kozarich JW. Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP-Binding Site at the Dimer Interface of Procaspase-6. Biochemistry. PMID 31095371 DOI: 10.1021/Acs.Biochem.9B00290  1
2018 Hill ME, Yildiz M, Hardy JA. Cysteine Disulfide Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS2B-NS3 Protease. Biochemistry. PMID 30472839 DOI: 10.1021/Acs.Biochem.8B00978  1
2018 MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. The Journal of Biological Chemistry. PMID 30420425 DOI: 10.1074/Jbc.Ra118.005914  1
2018 Hardy JA. Fighting Kinase Drug Resistance with Caspase Activators. Cell Chemical Biology. 25: 927-928. PMID 30118670 DOI: 10.1016/J.Chembiol.2018.08.001  0.01
2018 Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. The unique cofactor region of Zika virus NS2B-NS3 protease facilitates cleavage of key host proteins. Acs Chemical Biology. PMID 30080377 DOI: 10.1021/Acschembio.8B00508  1
2018 Tubeleviciute-Aydin A, Zhou L, Sharma G, Soni IV, Savinov SN, Hardy JA, LeBlanc AC. Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity. Scientific Reports. 8: 4428. PMID 29535332 DOI: 10.1038/S41598-018-22283-Z  1
2018 Huber KL, Serrano BP, Hardy JA. Caspase-9 CARD: core domain interactions require a properly formed active site. The Biochemical Journal. PMID 29500231 DOI: 10.1042/Bcj20170913  1
2018 Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA. Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases -3, -6, -7, & -8. Acs Chemical Biology. PMID 29364645 DOI: 10.1021/Acschembio.8B00064  1
2018 Serrano BP, Hardy JA. Phosphorylation by protein kinase A disassembles the caspase-9 core. Cell Death and Differentiation. PMID 29352269 DOI: 10.1038/S41418-017-0052-9  1
2017 Homyak CC, Fernandez A, Touve MA, Zhao B, Anson F, Hardy JA, Vachet RW, Gianneschi NC, Ross JL, Thayumanavan S. Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules. Biomacromolecules. PMID 29141403 DOI: 10.1021/Acs.Biomac.7B01300  1
2017 Serrano BP, Szydlo HS, Alfandari DR, Hardy JA. Active-site adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9. The Journal of Biological Chemistry. PMID 29066624 DOI: 10.1074/Jbc.M117.811976  1
2017 Raghupathi K, Eron SJ, Anson F, Hardy JA, Thayumanavan S. Utilizing Inverse Emulsion Polymerization to Generate Responsive Nanogels for Cytosolic Protein Delivery. Molecular Pharmaceutics. PMID 29053277 DOI: 10.1021/Acs.Molpharmaceut.7B00643  1
2017 Dagbay KB, Hardy JA. Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proceedings of the National Academy of Sciences of the United States of America. PMID 28864531 DOI: 10.1073/Pnas.1704640114  1
2017 Dagbay KB, Hill ME, Barrett E, Hardy JA. Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency. Biochemistry. PMID 28726391 DOI: 10.1021/Acs.Biochem.7B00357  1
2017 Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase-6 Undergoes a Distinct Helix-Strand Interconversion Upon Substrate Binding. The Journal of Biological Chemistry. PMID 28154009 DOI: 10.1074/Jbc.M116.773499  1
2016 Eron SJ, Raghupathi K, Hardy JA. Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms. Structure (London, England : 1993). PMID 27889207 DOI: 10.1016/J.Str.2016.11.001  1
2016 Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chemical Biology. PMID 27032039 DOI: 10.1021/Acschembio.5B00971  1
2015 Wu Y, Lindblad JL, Garnett J, Kamber Kaya HE, Xu D, Zhao Y, Flores ER, Hardy J, Bergmann A. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila. Cell Death and Differentiation. PMID 26542461 DOI: 10.1038/Cdd.2015.144  1
2015 Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Artigas MS, Billington CK, Kheirallah AK, Allen R, Cook JP, Probert K, Obeidat M, Bossé Y, Hao K, Postma DS, et al. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. The Lancet. Respiratory Medicine. PMID 26423011 DOI: 10.1016/S2213-2600(15)00283-0  1
2015 Ventura J, Eron SJ, Gonzalez-Toro DC, Raghupathi K, Wang F, Hardy JA, Thayumanavan S. Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein. Biomacromolecules. PMID 26331939 DOI: 10.1021/Acs.Biomac.5B00779  1
2015 Jansen IE, Bras JM, Lesage S, Schulte C, Gibbs JR, Nalls MA, Brice A, Wood NW, Morris H, Hardy JA, Singleton AB, Gasser T, Heutink P, Sharma M. CHCHD2 and Parkinson's disease. The Lancet. Neurology. 14: 678-9. PMID 26067110 DOI: 10.1016/S1474-4422(15)00094-0  1
2015 Cummings DM, Liu W, Portelius E, Bayram S, Yasvoina M, Ho SH, Smits H, Ali SS, Steinberg R, Pegasiou CM, James OT, Matarin M, Richardson JC, Zetterberg H, Blennow K, ... Hardy JA, et al. First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression. Brain : a Journal of Neurology. 138: 1992-2004. PMID 25981962 DOI: 10.1093/Brain/Awv127  1
2015 Kim CS, Mout R, Zhao Y, Yeh YC, Tang R, Jeong Y, Duncan B, Hardy JA, Rotello VM. Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules. Bioconjugate Chemistry. 26: 950-4. PMID 25894332 DOI: 10.1021/Acs.Bioconjchem.5B00146  1
2015 Hardy JA. A Multi-Pronged Approach for Uncovering Allosteric Networks in Caspases Biophysical Journal. 108: 381a. DOI: 10.1016/J.Bpj.2014.11.2087  0.01
2014 Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, ... ... Hardy JA, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics. 46: 989-93. PMID 25064009 DOI: 10.1038/Ng.3043  1
2014 Dagbay K, Eron SJ, Serrano BP, Velázquez-Delgado EM, Zhao Y, Lin D, Vaidya S, Hardy JA. A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases. Methods in Enzymology. 544: 215-49. PMID 24974292 DOI: 10.1016/B978-0-12-417158-9.00009-1  1
2014 Casey MM, Bates SP, Galloway KW, Galloway RK, Hardy JA, Kay AE, Kirsop P, McQueen HA. Scaffolding student engagement via online peer learning European Journal of Physics. 35. DOI: 10.1088/0143-0807/35/4/045002  1
2013 Yildiz M, Ghosh S, Bell JA, Sherman W, Hardy JA. Allosteric inhibition of the NS2B-NS3 protease from dengue virus. Acs Chemical Biology. 8: 2744-52. PMID 24164286 DOI: 10.1021/Cb400612H  1
2013 Tang R, Kim CS, Solfiell DJ, Rana S, Mout R, Velázquez-Delgado EM, Chompoosor A, Jeong Y, Yan B, Zhu ZJ, Kim C, Hardy JA, Rotello VM. Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules. Acs Nano. 7: 6667-73. PMID 23815280 DOI: 10.1021/Nn402753Y  1
2013 Wu P, Nicholls SB, Hardy JA. A tunable, modular approach to fluorescent protease-activated reporters. Biophysical Journal. 104: 1605-14. PMID 23561537 DOI: 10.1016/J.Bpj.2013.01.058  1
2013 Nicholls SB, Hardy JA. Structural basis of fluorescence quenching in caspase activatable-GFP. Protein Science : a Publication of the Protein Society. 22: 247-57. PMID 23139158 DOI: 10.1002/Pro.2188  1
2013 Hardy JA, Römer U. Revealing disciplinary variation in student writing: A multi-dimensional analysis of the Michigan Corpus of Upper-level Student Papers (MICUSP) Corpora. 8: 183-207. DOI: 10.3366/cor.2013.0040  1
2012 Huber KL, Ghosh S, Hardy JA. Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface. Biopolymers. 98: 451-65. PMID 23203690 DOI: 10.1002/Bip.22080  1
2012 Jabaiah AM, Getz JA, Witkowski WA, Hardy JA, Daugherty PS. Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics. Biological Chemistry. 393: 933-41. PMID 22944693 DOI: 10.1515/Hsz-2012-0162  1
2012 Hernandez DG, Nalls MA, Ylikotila P, Keller M, Hardy JA, Majamaa K, Singleton AB. Genome wide assessment of young onset Parkinson's disease from Finland. Plos One. 7: e41859. PMID 22911860 DOI: 10.1371/Journal.Pone.0041859  1
2012 Velázquez-Delgado EM, Hardy JA. Zinc-mediated allosteric inhibition of caspase-6. The Journal of Biological Chemistry. 287: 36000-11. PMID 22891250 DOI: 10.1074/Jbc.M112.397752  1
2012 Jagodzinski F, Hardy J, Streinu I. Using rigidity analysis to probe mutation-induced structural changes in proteins. Journal of Bioinformatics and Computational Biology. 10: 1242010. PMID 22809386 DOI: 10.1142/S0219720012420103  1
2012 Huber KL, Hardy JA. Mechanism of zinc-mediated inhibition of caspase-9. Protein Science : a Publication of the Protein Society. 21: 1056-65. PMID 22573662 DOI: 10.1002/Pro.2090  1
2012 Velázquez-Delgado EM, Hardy JA. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure (London, England : 1993). 20: 742-51. PMID 22483120 DOI: 10.1016/J.Str.2012.02.003  1
2012 Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, ... ... Hardy JA, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. Plos Genetics. 8: e1002548. PMID 22438815 DOI: 10.1371/Journal.Pgen.1002548  1
2012 Matsuki T, Zaka M, Guerreiro R, van der Brug MP, Cooper JA, Cookson MR, Hardy JA, Howell BW. Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice. Plos One. 7: e31152. PMID 22355340 DOI: 10.1371/Journal.Pone.0031152  1
2012 Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR, Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, et al. A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline. Human Molecular Genetics. 21: 2377-88. PMID 22343410 DOI: 10.1093/Hmg/Dds054  1
2012 López GE, Colón-Díaz I, Cruz A, Ghosh S, Nicholls SB, Viswanathan U, Hardy JA, Auerbach SM. Modeling nonaqueous proton wires built from helical peptides: biased proton transfer driven by helical dipoles. The Journal of Physical Chemistry. A. 116: 1283-8. PMID 22188565 DOI: 10.1021/Jp210208M  1
2012 Hardy JA, Friginal E. Filipino and American online communication and linguistic variation World Englishes. 31: 143-161. DOI: 10.1111/J.1467-971X.2011.01728.X  1
2011 Witkowski WA, Hardy JA. A designed redox-controlled caspase. Protein Science : a Publication of the Protein Society. 20: 1421-31. PMID 21674661 DOI: 10.1002/Pro.673  1
2011 Nicholls SB, Chu J, Abbruzzese G, Tremblay KD, Hardy JA. Mechanism of a genetically encoded dark-to-bright reporter for caspase activity. The Journal of Biological Chemistry. 286: 24977-86. PMID 21558267 DOI: 10.1074/Jbc.M111.221648  1
2011 Chibnik LB, Shulman JM, Leurgans SE, Schneider JA, Wilson RS, Tran D, Aubin C, Buchman AS, Heward CB, Myers AJ, Hardy JA, Huentelman MJ, Corneveaux JJ, Reiman EM, Evans DA, et al. CR1 is associated with amyloid plaque burden and age-related cognitive decline. Annals of Neurology. 69: 560-9. PMID 21391232 DOI: 10.1002/Ana.22277  1
2011 Vaidya S, Hardy JA. Caspase-6 latent state stability relies on helical propensity. Biochemistry. 50: 3282-7. PMID 21381717 DOI: 10.1021/Bi2001664  1
2011 Vaidya S, Velázquez-Delgado EM, Abbruzzese G, Hardy JA. Substrate-induced conformational changes occur in all cleaved forms of caspase-6. Journal of Molecular Biology. 406: 75-91. PMID 21111746 DOI: 10.1016/J.Jmb.2010.11.031  1
2011 Hardy JA, Weatherford RD, Locke BD, Depalma NH, D'Iuso NT. Meeting the demand for college student concerns in college counseling centers: Evaluating a clinical triage system Journal of College Student Psychotherapy. 25: 220-240. DOI: 10.1080/87568225.2011.581929  1
2010 Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW. Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell. 143: 826-36. PMID 21111240 DOI: 10.1016/J.Cell.2010.10.029  1
2010 van de Leemput J, Wavrant-De Vrièze F, Rafferty I, Bras JM, Giunti P, Fisher EM, Hardy JA, Singleton AB, Houlden H. Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 771-3. PMID 20437544 DOI: 10.1002/Mds.22970  1
2010 Wang C, Szpiech ZA, Degnan JH, Jakobsson M, Pemberton TJ, Hardy JA, Singleton AB, Rosenberg NA. Comparing spatial maps of human population-genetic variation using Procrustes analysis. Statistical Applications in Genetics and Molecular Biology. 9: Article 13. PMID 20196748 DOI: 10.2202/1544-6115.1493  1
2010 Hardy JA, Carneiro C, Catlin H. Beginning rails: From novice to professional Beginning Rails: From Novice to Professional. 1-361. DOI: 10.1007/978-1-4302-0319-3  1
2009 Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, ... ... Hardy JA, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nature Genetics. 41: 1308-12. PMID 19915575 DOI: 10.1038/Ng.487  1
2009 Matarin M, Brown WM, Dena H, Britton A, De Vrieze FW, Brott TG, Brown RD, Worrall BB, Case LD, Chanock SJ, Metter EJ, Ferruci L, Gamble D, Hardy JA, Rich SS, et al. Candidate gene polymorphisms for ischemic stroke. Stroke; a Journal of Cerebral Circulation. 40: 3436-42. PMID 19729601 DOI: 10.1161/Strokeaha.109.558015  1
2009 Kumaran R, Vandrovcova J, Luk C, Sharma S, Renton A, Wood NW, Hardy JA, Lees AJ, Bandopadhyay R. Differential DJ-1 gene expression in Parkinson's disease. Neurobiology of Disease. 36: 393-400. PMID 19716892 DOI: 10.1016/j.nbd.2009.08.011  1
2009 Hardy JA, Wells JA. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. The Journal of Biological Chemistry. 284: 26063-9. PMID 19581639 DOI: 10.1074/Jbc.M109.001826  1
2009 Witkowski WA, Hardy JA. L2' loop is critical for caspase-7 active site formation. Protein Science : a Publication of the Protein Society. 18: 1459-68. PMID 19530232 DOI: 10.1002/Pro.151  1
2009 Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, ... ... Hardy JA, et al. SNCA variants are associated with increased risk for multiple system atrophy. Annals of Neurology. 65: 610-4. PMID 19475667 DOI: 10.1002/Ana.21685  1
2009 Huber KL, Olson KD, Hardy JA. Robust production of a peptide library using methodological synchronization. Protein Expression and Purification. 67: 139-47. PMID 19457455 DOI: 10.1016/J.Pep.2009.05.006  1
2009 Huang L, Li Y, Singleton AB, Hardy JA, Abecasis G, Rosenberg NA, Scheet P. Genotype-imputation accuracy across worldwide human populations. American Journal of Human Genetics. 84: 235-50. PMID 19215730 DOI: 10.1016/J.Ajhg.2009.01.013  1
2008 Jain M, Wallis D, Robin NH, De Vrieze FW, Hardy JA, Ghadami M, Bosse K, Betz RC, Nöthen MM, Arcos-Burgos M, Muenke M. Locus homogeneity between syndactyly type 1A and craniosynostosis Philadelphia type? American Journal of Medical Genetics. Part A. 146: 2308-11. PMID 18680190 DOI: 10.1002/ajmg.a.32445  1
2008 Matarin M, Brown WM, Singleton A, Hardy JA, Meschia JF. Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21. Stroke; a Journal of Cerebral Circulation. 39: 1586-9. PMID 18340101 DOI: 10.1161/Strokeaha.107.502963  1
2008 Matarin M, Simon-Sanchez J, Fung HC, Scholz S, Gibbs JR, Hernandez DG, Crews C, Britton A, De Vrieze FW, Brott TG, Brown RD, Worrall BB, Silliman S, Case LD, Hardy JA, et al. Structural genomic variation in ischemic stroke. Neurogenetics. 9: 101-8. PMID 18288507 DOI: 10.1007/s10048-008-0119-3  1
2008 Jakobsson M, Scholz SW, Scheet P, Gibbs JR, VanLiere JM, Fung HC, Szpiech ZA, Degnan JH, Wang K, Guerreiro R, Bras JM, Schymick JC, Hernandez DG, Traynor BJ, Simon-Sanchez J, ... ... Hardy JA, et al. Genotype, haplotype and copy-number variation in worldwide human populations. Nature. 451: 998-1003. PMID 18288195 DOI: 10.1038/Nature06742  1
2008 Matarin M, Brown WM, Hardy JA, Rich SS, Singleton AB, Brown RD, Brott TG, Worrall BB, Meschia JF. Association of integrin alpha2 gene variants with ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 81-9. PMID 17534386 DOI: 10.1038/sj.jcbfm.9600508  1
2008 Walsh WB. Biennial review of counseling psychology Biennial Review of Counseling Psychology. 1: 1-337. DOI: 10.4324/9780203927519  0.01
2007 Matarín M, Brown WM, Scholz S, Simón-Sánchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, Langefeld CD, Brott TG, Brown RD, Worrall BB, Frankel M, ... ... Hardy JA, et al. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. The Lancet. Neurology. 6: 414-20. PMID 17434096 DOI: 10.1016/S1474-4422(07)70081-9  1
2007 Wiklund PG, Brown WM, Brott TG, Stegmayr B, Brown RD, Nilsson-Ardnor S, Hardy JA, Kissela BM, Singleton A, Holmberg D, Rich SS, Meschia JF. Lack of aggregation of ischemic stroke subtypes within affected sibling pairs. Neurology. 68: 427-31. PMID 17283317 DOI: 10.1212/01.Wnl.0000252955.17126.6A  1
2007 Hardy JA. A link means a lot: Disulfide tethering in structure-based drug design Rsc Biomolecular Sciences. 319-348.  1
2006 Fung HC, Scholz S, Matarin M, Simón-Sánchez J, Hernandez D, Britton A, Gibbs JR, Langefeld C, Stiegert ML, Schymick J, Okun MS, Mandel RJ, Fernandez HH, Foote KD, Rodríguez RL, ... ... Hardy JA, et al. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. The Lancet. Neurology. 5: 911-6. PMID 17052657 DOI: 10.1016/S1474-4422(06)70578-6  1
2006 Hardy J. Discovery and exploitation of allosteric sites for control of protein function Nanomedicine: Nanotechnology, Biology and Medicine. 2: 291. DOI: 10.1016/J.Nano.2006.10.074  0.01
2005 Meschia JF, Brott TG, Brown RD, Kissela BM, Hardy JA, Brown WM, Rich SS. Correlation of proband and sibling stroke latency: the SWISS Study. Neurology. 64: 1061-3. PMID 15781828 DOI: 10.1212/01.WNL.0000154602.20719.E8  1
2005 Bobb AJ, Addington AM, Sidransky E, Gornick MC, Lerch JP, Greenstein DK, Clasen LS, Sharp WS, Inoff-Germain G, Wavrant-De Vrièze F, Arcos-Burgos M, Straub RE, Hardy JA, Castellanos FX, Rapoport JL. Support for association between ADHD and two candidate genes: NET1 and DRD1. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 134: 67-72. PMID 15717291 DOI: 10.1002/Ajmg.B.30142  1
2004 Hardy JA, Wells JA. Searching for new allosteric sites in enzymes. Current Opinion in Structural Biology. 14: 706-15. PMID 15582395 DOI: 10.1016/J.Sbi.2004.10.009  1
2004 Busby J, O'Brien KK, Gibson AM, McKeith IG, Perry RH, Hardy JA, Singleton AB, Morris CM. Dementia with Lewy bodies: no association of polymorphisms in the human synphilin gene. Neurogenetics. 5: 251-2. PMID 15490287 DOI: 10.1007/S10048-004-0188-X  1
2004 Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Discovery of an allosteric site in the caspases. Proceedings of the National Academy of Sciences of the United States of America. 101: 12461-6. PMID 15314233 DOI: 10.1073/Pnas.0404781101  1
2004 Bandopadhyay R, Kingsbury AE, Cookson MR, Reid AR, Evans IM, Hope AD, Pittman AM, Lashley T, Canet-Aviles R, Miller DW, McLendon C, Strand C, Leonard AJ, Abou-Sleiman PM, Healy DG, ... ... Hardy JA, et al. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain : a Journal of Neurology. 127: 420-30. PMID 14662519 DOI: 10.1093/Brain/Awh054  1
2003 Lincoln SJ, Maraganore DM, Lesnick TG, Bounds R, de Andrade M, Bower JH, Hardy JA, Farrer MJ. Parkin variants in North American Parkinson's disease: cases and controls. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 1306-11. PMID 14639672 DOI: 10.1002/mds.10601  1
2003 Maraganore DM, Farrer MJ, Lesnick TG, de Andrade M, Bower JH, Hernandez D, Hardy JA, Rocca WA. Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 1233-9. PMID 14639662 DOI: 10.1002/mds.10547  1
2003 Morris CM, O'Brien KK, Gibson AM, Hardy JA, Singleton AB. Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's disease. Neuroscience Letters. 352: 151-3. PMID 14625045 DOI: 10.1016/j.neulet.2003.08.037  1
2003 Maraganore DM, de Andrade M, Lesnick TG, Farrer MJ, Bower JH, Hardy JA, Rocca WA. Complex interactions in Parkinson's disease: a two-phased approach. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 631-6. PMID 12784265 DOI: 10.1002/mds.10431  1
2003 Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K. APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochemical and Biophysical Research Communications. 305: 502-9. PMID 12763021 DOI: 10.1016/S0006-291X(03)00797-6  1
2002 Goudreau JL, Maraganore DM, Farrer MJ, Lesnick TG, Singleton AB, Bower JH, Hardy JA, Rocca WA. Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 17: 1305-11. PMID 12465073 DOI: 10.1002/Mds.10268  1
2002 West AB, Maraganore D, Crook J, Lesnick T, Lockhart PJ, Wilkes KM, Kapatos G, Hardy JA, Farrer MJ. Functional association of the parkin gene promoter with idiopathic Parkinson's disease. Human Molecular Genetics. 11: 2787-92. PMID 12374768 DOI: 10.1093/Hmg/11.22.2787  1
2002 Maraganore DM, Farrer MJ, McDonnell SK, Elbaz A, Schaid DJ, Hardy JA, Rocca WA. Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 17: 509-12. PMID 12112198 DOI: 10.1002/mds.1253  1
2001 Maraganore DM, Hernandez DG, Singleton AB, Farrer MJ, McDonnell SK, Hutton ML, Hardy JA, Rocca WA. Case-Control study of the extended tau gene haplotype in Parkinson's disease. Annals of Neurology. 50: 658-61. PMID 11706972 DOI: 10.1002/ana.1228  1
2001 Cicero MP, Hubl ST, Harrison CJ, Littlefield O, Hardy JA, Nelson HC. The wing in yeast heat shock transcription factor (HSF) DNA-binding domain is required for full activity. Nucleic Acids Research. 29: 1715-23. PMID 11292844 DOI: 10.1093/Nar/29.8.1715  1
2000 Hardy JA, Nelson HC. Proline in alpha-helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factor. Protein Science : a Publication of the Protein Society. 9: 2128-41. PMID 11305238 DOI: 10.1110/ps.9.11.2128  1
2000 Maraganore DM, Farrer MJ, Hardy JA, McDonnell SK, Schaid DJ, Rocca WA. Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 15: 714-9. PMID 10928584 DOI: 10.1002/1531-8257(200007)15:4<714::AID-MDS1018>3.0.CO;2-3  1
2000 Hardy JA, Walsh ST, Nelson HC. Role of an alpha-helical bulge in the yeast heat shock transcription factor. Journal of Molecular Biology. 295: 393-409. PMID 10623534 DOI: 10.1006/jmbi.1999.3357  1
1999 Maraganore DM, Farrer MJ, Hardy JA, Lincoln SJ, McDonnell SK, Rocca WA. Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease. Neurology. 53: 1858-60. PMID 10563640  1
1996 Hardy JA, Simm I. Low sulfate seawater mitigates barite scale Oil and Gas Journal. 94: 64-71.  1
1995 Hardy JA, Aust AE. The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks. Carcinogenesis. 16: 319-25. PMID 7859364 DOI: 10.1093/Carcin/16.2.319  1
1995 Werner AJ, Hochella MF, Guthrie GD, Hardy JA, Aust AE, Rimstidt JD. Asbestiform riebeckite (crocidolite) dissolution in the presence of Fe chelators: implications for mineral-induced disease American Mineralogist. 80: 1093-1103. DOI: 10.2138/Am-1995-11-1201  1
1995 Hardy JA, Aust AE. Iron in asbestos chemistry and carcinogenicity Chemical Reviews. 95: 97-118. DOI: 10.1021/Cr00033A005  1
1994 Hardy JA, Barthorpe RT, Plummer MA, Rhudy JS. Scale control in the South Brae field Spe Production and Facilities. 9: 127-131.  1
1993 Rooke K, Talbot C, James L, Anand R, Hardy JA, Goate AM. A physical map of the human APP gene in YACs. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 4: 662-9. PMID 8281016 DOI: 10.1007/Bf00360904  1
1992 Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science (New York, N.Y.). 256: 184-5. PMID 1566067  1
1991 van Duijn CM, van Broeckhoven C, Hardy JA, Goate AM, Rossor MN, Vandenberghe A, Martin JJ, Hofman A, Mullan MJ. Evidence for allelic heterogeneity in familial early-onset Alzheimer's disease. The British Journal of Psychiatry : the Journal of Mental Science. 158: 471-4. PMID 2054561 DOI: 10.1192/Bjp.158.4.471  1
1991 Owen MJ, Goate AM, Hardy JA. A polymorphic microsatellite repeat sequence on chromosome 21 (D21S80). Nucleic Acids Research. 19: 4574. PMID 1886795 DOI: 10.1093/Nar/19.16.4574  1
1991 Mullan MJ, Giuffra L, Hardy JA, Ovenstone I, Haynes AR, James LA, Williamson R, Newton PJ, Owen MJ, Roques P. Clinical and pathologic features of chromosome 21-linked familial Alzheimer's disease. Annals of the New York Academy of Sciences. 640: 177-80. PMID 1776736 DOI: 10.1111/J.1749-6632.1991.Tb00212.X  1
1991 Haan J, Hardy JA, Roos RA. Hereditary cerebral hemorrhage with amyloidosis--Dutch type: its importance for Alzheimer research. Trends in Neurosciences. 14: 231-4. PMID 1716015 DOI: 10.1016/0166-2236(91)90120-J  1
1991 van Duijn CM, Hendriks L, Cruts M, Hardy JA, Hofman A, Van Broeckhoven C. Amyloid precursor protein gene mutation in early-onset Alzheimer's disease. Lancet (London, England). 337: 978. PMID 1678057 DOI: 10.1016/0140-6736(91)91611-W  1
1991 Irving NG, Hardy JA, Brown SD. The multipoint genetic mapping of mouse chromosome 16. Genomics. 9: 386-9. PMID 1672298 DOI: 10.1016/0888-7543(91)90271-F  1
1991 Ryan JJ, Conacher HBS, Panopio LG, Lau BPY, Hardy JA, Masuda Y. Gas chromatographic separations of all 136 tetra- to octapolychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans on nine different stationary phases Journal of Chromatography A. 541: 131-183. DOI: 10.1016/S0021-9673(01)95990-4  1
1990 Goate AM, Hardy JA, Owen MJ, Haynes A, James L, Farrall M, Mullan MJ, Roques P, Rossor MN. Genetics of Alzheimer's disease. Advances in Neurology. 51: 197-8. PMID 2403711  1
1990 St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, McLachlan DR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollen D, Cantu JM, Tupler R, ... ... Hardy JA, et al. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature. 347: 194-7. PMID 2395471 DOI: 10.1038/347194A0  1
1990 Owen MJ, James LA, Hardy JA, Williamson R, Goate AM. Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21. American Journal of Human Genetics. 46: 316-22. PMID 2301399  1
1990 Cowburn RF, Hardy JA, Roberts PJ. Glutamatergic neurotransmission in Alzheimer's disease. Biochemical Society Transactions. 18: 390-2. PMID 2164981  1
1990 Barton AJ, Harrison PJ, Najlerahim A, Heffernan J, McDonald B, Robinson JR, Davies DC, Harrison WJ, Mitra P, Hardy JA. Increased tau messenger RNA in Alzheimer's disease hippocampus. The American Journal of Pathology. 137: 497-502. PMID 2119143  1
1990 Van Broeckhoven C, Haan J, Bakker E, Hardy JA, Van Hul W, Wehnert A, Vegter-Van der Vlis M, Roos RA. Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science (New York, N.Y.). 248: 1120-2. PMID 1971458  1
1990 Walker AP, Collins FS, Siddique T, Yamaoka LH, Herbstreith MH, Pericak-Vance MA, Secore SL, Hung WY, Goate AM, Hardy JA. D21S194, a jump clone from D21S16. Nucleic Acids Research. 18: 1931. PMID 1970875 DOI: 10.1093/Nar/18.7.1931-A  1
1989 Hardy JA, Goate AM, Owen MJ, Mullan MJ, Rossor MN, Pearson RC. Modelling the occurrence and pathology of Alzheimer's disease. Neurobiology of Aging. 10: 429-31; discussion 4. PMID 2812201 DOI: 10.1016/0197-4580(89)90084-5  1
1989 Willoughby J, Cowburn RF, Hardy JA, Glover V, Sandler M. 1-Methyl-4-phenylpyridinium uptake by human and rat striatal synaptosomes. Journal of Neurochemistry. 52: 627-31. PMID 2783454  1
1989 Irving NG, Hardy JA, Bahary N, Friedman JM, Brown SD. The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6. Cytogenetics and Cell Genetics. 50: 121-2. PMID 2776477 DOI: 10.1159/000132737  1
1989 Dodd PR, Watson WE, Morrison MM, Johnston GA, Bird ED, Cowburn RF, Hardy JA. Uptake of gamma-aminobutyric acid and L-glutamic acid by synaptosomes from postmortem human cerebral cortex: multiple sites, sodium dependence and effect of tissue preparation. Brain Research. 490: 320-31. PMID 2569904 DOI: 10.1016/0006-8993(89)90249-7  1
1989 Cowburn RF, Hardy JA, Briggs RS, Roberts PJ. Characterisation, density, and distribution of kainate receptors in normal and Alzheimer's diseased human brain. Journal of Neurochemistry. 52: 140-7. PMID 2535708  1
1989 Hardy JA, Owen MJ, Goate AM, James LA, Haynes AR, Rossor MN, Roques P, Mullan MJ. Molecular genetics of Alzheimer's disease. Biochemical Society Transactions. 17: 75-6. PMID 2523829 DOI: 10.1042/Bst0170075  1
1989 Goate AM, Hardy JA, Owen MJ. The genetic aetiology of alzheimer's disease International Review of Psychiatry. 1: 243-248. DOI: 10.3109/09540268909089418  1
1988 Davies DC, Hardy JA. Blood brain barrier in ageing and Alzheimer's disease. Neurobiology of Aging. 9: 46-8. PMID 3380253 DOI: 10.1016/S0197-4580(88)80017-4  1
1988 Hardy JA, Davies DC. Alzheimer's disease. British Journal of Hospital Medicine. 39: 372-3, 376-7. PMID 3289659  1
1988 Bateman DE, Hardy JA, McDermott JR, Parker DS, Edwardson JA. Amino acid neurotransmitter levels in gliomas and their relationship to the incidence of epilepsy. Neurological Research. 10: 112-4. PMID 2902524  1
1988 O'Connor I, Cowburn RF, Hardy JA, Fowler CJ. Dopamine and apomorphine do not modulate the uptake of [3H]D-aspartate in the rat striatum in-vitro. The Journal of Pharmacy and Pharmacology. 40: 307-8. PMID 2900322  1
1988 Cowburn RF, Hardy JA, Roberts PJ. Characterisation of Na+-independent L-[3H]glutamate binding sites in human temporal cortex. Journal of Neurochemistry. 50: 1872-8. PMID 2897429  1
1988 Dodd PR, Hambley JW, Cowburn RF, Hardy JA. A comparison of methodologies for the study of functional transmitter neurochemistry in human brain. Journal of Neurochemistry. 50: 1333-45. PMID 2896227  1
1988 Randell J, Hardy JA, Cox AP. The microwave spectrum and potential function of propanal Journal of the Chemical Society, Faraday Transactions 2: Molecular and Chemical Physics. 84: 1199-1212. DOI: 10.1039/F29888401199  1
1988 Hardy JA. Recent advances in the genetics and molecular biology of Alzheimer's disease Current Opinion in Psychiatry. 1: 453-457.  1
1987 Hardy JA, Wester P, Backstrom I, Gottfries J, Oreland L, Stenstrom A, Winblad B. The regional distribution of dopamine and serotonin uptake and transmitter concentrations in the human brain. Neurochemistry International. 10: 445-50. PMID 20501116 DOI: 10.1016/0197-0186(87)90070-2  1
1987 Cowburn RF, Dodd PR, Hardy JA, Johnston GA. A comparison of high affinity synaptosomal uptake of d-aspartate in rat and human brain. Neurochemistry International. 10: 339-46. PMID 20501104 DOI: 10.1016/0197-0186(87)90108-2  1
1987 Van Broeckhoven C, Genthe AM, Vandenberghe A, Horsthemke B, Backhovens H, Raeymaekers P, Van Hul W, Wehnert A, Gheuens J, Cras P. Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature. 329: 153-5. PMID 3306405 DOI: 10.1038/329153A0  1
1987 Turner JD, Boakes RJ, Hardy JA, Virmani MA. Efflux of putative transmitters from superfused rat brain slices induced by low chloride ion concentrations. Journal of Neurochemistry. 48: 1060-8. PMID 2880928  1
1987 Hicks TP, Lodge D, McClennan H, Hardy JA, Cowburn RF. Excitatory amino acid transmission. Neurology and neurobiology, volume 24 Febs Letters. 220: 395.  1
1986 Hardy JA, Barton A, Lofdahl E, Cheetham SC, Johnston GA, Dodd PR. Uptake of gamma-aminobutyric acid and glycine by synaptosomes from postmortem human brain. Journal of Neurochemistry. 47: 460-7. PMID 3734788  1
1986 Dodd PR, Hardy JA, Baig EB, Kidd AM, Bird ED, Watson WE, Johnston GA. Optimization of freezing, storage, and thawing conditions for the preparation of metabolically active synaptosomes from frozen rat and human brain. Neurochemical Pathology. 4: 177-98. PMID 3561893 DOI: 10.1007/Bf02834357  1
1986 Hardy JA, Mann DM, Wester P, Winblad B. An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiology of Aging. 7: 489-502. PMID 2882432 DOI: 10.1016/0197-4580(86)90086-2  1
1986 Venables GS, Strong AJ, Miller SA, Gibson G, Hardy JA. The effects of etomidate in the cat middle cerebral artery occlusion model of brain ischaemia. An experimental study. Neurological Research. 8: 209-13. PMID 2880310 DOI: 10.1080/01616412.1986.11739756  1
1986 Almqvist P, Carlsson SR, Hardy JA, Winblad B. Regional and subcellular distribution of Thy-1 in human brain assayed by a solid-phase radioimmunoassay. Journal of Neurochemistry. 46: 681-5. PMID 2419494  1
1986 Hardy JA, Mann DMA, Wester P, Winblad B. Author's response to commentaries Neurobiology of Aging. 7: 520-522. DOI: 10.1016/0197-4580(86)90099-0  1
1986 Ryan JJ, Lau BPY, Hardy JA, Stone WB, O'Keefe P, Gierthy JF. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxins and furans in snapping turtle (Chelydra serpentina) tissues from the upper St. Lawrence River Chemosphere. 15: 537-548. DOI: 10.1016/0045-6535(86)90002-0  1
1985 Wester P, Bateman DE, Dodd PR, Edwardson JA, Hardy JA, Kidd AM, Perry RH, Singh GB. Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain. Neurochemical Pathology. 3: 169-80. PMID 4094727 DOI: 10.1007/Bf02834269  1
1985 Hardy JA, Wester P, Winblad B, Gezelius C, Bring G, Eriksson A. The patients dying after long terminal phase have acidotic brains; implications for biochemical measurements on autopsy tissue Journal of Neural Transmission. 61: 253-264. PMID 3989524 DOI: 10.1007/BF01251916  1
1985 Hardy JA. Misapprehension over Alzheimer's disease [9] Nature. 316: 220. DOI: 10.1038/316220b0  1
1985 Whittingham KP, Hardy JA. MICROBIAL CORROSION CONTROL IN WATER INJECTION SYSTEMS . 271-280.  1
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