Sunil Laxman, Ph.D. - Publications

Affiliations: 
 
Area:
metabolism, signaling, amino acids, biochemical networks
Website:
sunillaxmanlab.weebly.com/

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Gupta R, Laxman S. Cycles, sources, and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks. Elife. 10. PMID 33544078 DOI: 10.7554/eLife.63341  1
2020 Walvekar AS, Kadamur G, Sreedharan S, Gupta R, Srinivasan R, Laxman S. Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program. The Journal of Biological Chemistry. 295: 18390-18405. PMID 33453842 DOI: 10.1074/jbc.RA120.014248  1
2020 Srinivasan R, Walvekar AS, Rashida Z, Seshasayee A, Laxman S. Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program. Plos Genetics. 16: e1009252. PMID 33378328 DOI: 10.1371/journal.pgen.1009252  1
2020 Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S. Correction: Metabolic constraints drive self-organization of specialized cell groups. Elife. 9. PMID 33331821 DOI: 10.7554/eLife.65803  1
2020 Walvekar AS, Kadamur G, Sreedharan S, Gupta R, Srinivasan R, Laxman S. Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program. The Journal of Biological Chemistry. PMID 33122193 DOI: 10.1074/jbc.RA120.014248  1
2020 Bhatia M, Thakur J, Suyal S, Oniel R, Chakraborty R, Pradhan S, Sharma M, Sengupta S, Laxman S, Masakapalli SK, Bachhawat AK. Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one carbon metabolism. The Journal of Biological Chemistry. PMID 32934008 DOI: 10.1074/Jbc.Ra120.015129  1
2020 Varahan S, Sinha V, Walvekar A, Krishna S, Laxman S. Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community. Elife. 9. PMID 32876564 DOI: 10.7554/Elife.57609  1
2020 Bruhn C, Ajazi A, Ferrari E, Lanz MC, Batrin R, Choudhary R, Walvekar A, Laxman S, Longhese MP, Fabre E, Smolka MB, Foiani M. The Rad53-Spt21 and Tel1 axes couple glucose tolerance to histone dosage and subtelomeric silencing. Nature Communications. 11: 4154. PMID 32814778 DOI: 10.1038/S41467-020-17961-4  1
2020 Negi H, Reddy PP, Vengayil V, Patole C, Laxman S, Das R. -A novel polyubiquitin chain linkage formed by viral Ubiquitin is resistant to host deubiquitinating enzymes. The Biochemical Journal. PMID 32478812 DOI: 10.1042/Bcj20200289  1
2020 Gupta R, Laxman S. Steady-state and Flux-based Trehalose Estimation as an Indicator of Carbon Flow from Gluconeogenesis or Glycolysis. Bio-Protocol. 10: e3483. PMID 32181267 DOI: 10.21769/BioProtoc.3483  1
2020 Varahan S, Sinha V, Walvekar A, Krishna S, Laxman S. Author response: Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community Elife. DOI: 10.7554/Elife.57609.Sa2  1
2019 Walvekar AS, Laxman S. Methionine at the Heart of Anabolism and Signaling: Perspectives From Budding Yeast. Frontiers in Microbiology. 10: 2624. PMID 31798560 DOI: 10.3389/Fmicb.2019.02624  1
2019 Gupta R, Laxman S. tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state. Current Genetics. PMID 31758251 DOI: 10.1007/S00294-019-01045-Y  1
2019 Shaw E, Talwadekar M, Rashida Z, Mohan N, Acharya A, Khatri S, Laxman S, Kolthur-Seetharam U. Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria. Molecular and Cellular Biology. PMID 31685549 DOI: 10.1128/Mcb.00212-19  1
2019 Vengayil V, Rashida Z, Laxman S. The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability. The Journal of Biological Chemistry. PMID 31604822 DOI: 10.1074/Jbc.Ra119.009822  1
2019 Gupta R, Walvekar A, Liang S, Rashida Z, Shah P, Laxman S. A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis. Elife. 8. PMID 31259691 DOI: 10.7554/Elife.44795  1
2019 Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S. Metabolic constraints drive self-organization of specialized cell groups. Elife. 8. PMID 31241462 DOI: 10.7554/Elife.46735  1
2019 Varahan S, Walvekar A, Sinha V, Krishna S, Laxman S. Author response: Metabolic constraints drive self-organization of specialized cell groups Elife. DOI: 10.7554/Elife.46735.033  1
2019 Gupta R, Walvekar AS, Liang S, Rashida Z, Shah P, Laxman S. Author response: A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis Elife. DOI: 10.7554/Elife.44795.031  1
2018 Walvekar AS, Srinivasan R, Gupta R, Laxman S. Methionine coordinates a hierarchically organized anabolic program enabling proliferation. Molecular Biology of the Cell. mbcE18080515. PMID 30354837 DOI: 10.1091/Mbc.E18-08-0515  1
2018 Walvekar A, Rashida Z, Maddali H, Laxman S. A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways. Wellcome Open Research. 3: 122. PMID 30345389 DOI: 10.12688/wellcomeopenres.14832.1  1
2018 Krishna S, Laxman S. A minimal "push-pull" bistability model explains oscillations between quiescent and proliferative cell states. Molecular Biology of the Cell. mbcE18010017. PMID 30044724 DOI: 10.1091/Mbc.E18-01-0017  1
2017 Laxman S. Conceptualizing Eukaryotic Metabolic Sensing and Signaling. Journal of the Indian Institute of Science. 97: 59-77. PMID 29176927 DOI: 10.1007/S41745-016-0013-1  0.01
2017 Deshpande AA, Bhatia M, Laxman S, Bachhawat AK. Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload. Microbial Cell (Graz, Austria). 4: 112-126. PMID 28435838 DOI: 10.15698/Mic2017.04.567  0.01
2016 Erkut C, Gade VR, Laxman S, Kurzchalia TV. The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast. Elife. 5. PMID 27090086 DOI: 10.7554/Elife.13614  0.01
2016 Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu B, MacMillan JB, De Brabander JK, Veech RL, Uyeda K. Metabolite Regulation of Nuclear Localization of Carbohydrate Response Element-binding Protein (ChREBP). Role of AMP as an Allosteric Inhibitor. The Journal of Biological Chemistry. PMID 26984404 DOI: 10.1074/Jbc.M115.708982  1
2016 Erkut C, Gade VR, Laxman S, Kurzchalia TV. Author response: The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast Elife. DOI: 10.7554/Elife.13614.021  1
2015 Dhawan J, Laxman S. Decoding the stem cell quiescence cycle - lessons from yeast for regenerative biology. Journal of Cell Science. 128: 4467-74. PMID 26672015 DOI: 10.1242/Jcs.177758  1
2015 Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP. Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Reports. 12: 371-9. PMID 26166573 DOI: 10.1016/J.Celrep.2015.06.042  1
2014 Laxman S, Sutter BM, Shi L, Tu BP. Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites. Science Signaling. 7: ra120. PMID 25515537 DOI: 10.1126/Scisignal.2005948  1
2014 Laxman S, Tu BP, McKnight SL. Concerted effort: oscillations in global gene expression during nematode development. Molecular Cell. 53: 363-4. PMID 24507713 DOI: 10.1016/J.Molcel.2014.01.023  1
2014 Laxman S, Sutter BM, Tu BP. Methionine is a signal of amino acid sufficiency that inhibits autophagy through the methylation of PP2A. Autophagy. 10: 386-7. PMID 24362312 DOI: 10.4161/Auto.27485  1
2013 Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP. Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation. Cell. 154: 416-29. PMID 23870129 DOI: 10.1016/J.Cell.2013.06.043  1
2013 Sutter BM, Wu X, Laxman S, Tu BP. Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A. Cell. 154: 403-15. PMID 23870128 DOI: 10.1016/J.Cell.2013.06.041  1
2013 Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, et al. Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase. Proceedings of the National Academy of Sciences of the United States of America. 110: 9728-33. PMID 23716694 DOI: 10.1073/Pnas.1303220110  1
2011 Laxman S, Tu BP. Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae. Plos One. 6: e26081. PMID 22043304 DOI: 10.1371/Journal.Pone.0026081  1
2011 Narula A, Laxman S, Beavo JA. Phosphodiesterase 10 Xpharm: the Comprehensive Pharmacology Reference. 1-11. DOI: 10.1016/B978-008055232-3.60551-3  1
2010 Laxman S, Tu BP. Systems approaches for the study of metabolic cycles in yeast. Current Opinion in Genetics & Development. 20: 599-604. PMID 21051220 DOI: 10.1016/J.Gde.2010.09.008  1
2010 Laxman S, Sutter BM, Tu BP. Behavior of a metabolic cycling population at the single cell level as visualized by fluorescent gene expression reporters. Plos One. 5: e12595. PMID 20830298 DOI: 10.1371/Journal.Pone.0012595  1
2007 Laxman S, Beavo JA. Cyclic nucleotide signaling mechanisms in trypanosomes: possible targets for therapeutic agents. Molecular Interventions. 7: 203-15. PMID 17827441 DOI: 10.1124/Mi.7.4.7  1
2006 Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA. Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proceedings of the National Academy of Sciences of the United States of America. 103: 19194-9. PMID 17142316 DOI: 10.1073/Pnas.0608971103  1
2006 Díaz-Benjumea R, Laxman S, Hinds TR, Beavo JA, Rascón A. Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi. The Biochemical Journal. 399: 305-14. PMID 16776650 DOI: 10.1042/Bj20060757  1
2006 Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T. Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature. Molecular and Biochemical Parasitology. 145: 133-5. PMID 16280178 DOI: 10.1016/J.Molbiopara.2005.09.018  1
2005 Laxman S, Rascón A, Beavo JA. Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain. The Journal of Biological Chemistry. 280: 3771-9. PMID 15563461 DOI: 10.1074/Jbc.M408111200  1
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