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Lauren E. Brown, Ph.D. - Publications

Affiliations: 
University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
Synthetic organic chemistry; heterocyclic chemistry, bio-organic chemistry
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wang Z, Thakare RP, Chitale S, Mishra AK, Goldstein SI, Fan AC, Li R, Zhu LJ, Brown LE, Cencic R, Huang S, Green MR, Pelletier J, Malonia SK, Porco JA. Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. Acs Central Science. 10: 1640-1656. PMID 39220711 DOI: 10.1021/acscentsci.4c01073  0.515
2024 Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, et al. Amidino-Rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis. Antiviral Research. 105976. PMID 39117283 DOI: 10.1016/j.antiviral.2024.105976  0.551
2024 Thirman HL, Hayes MJ, Brown LE, Porco JA, Irish JM. Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. Biorxiv : the Preprint Server For Biology. PMID 38826485 DOI: 10.1101/2024.05.01.591362  0.491
2024 Volegova MP, Brown LE, Banerjee U, Dries R, Sharma B, Kennedy A, Porco JA, George RE. The MYCN 5' UTR as a therapeutic target in neuroblastoma. Cell Reports. 43: 114134. PMID 38662542 DOI: 10.1016/j.celrep.2024.114134  0.525
2024 Goldstein SI, Fan AC, Wang Z, Naineni SK, Lengqvist J, Chernobrovkin A, Garcia-Gutierrez SB, Cencic R, Patel K, Huang S, Brown LE, Emili A, Porco JA. Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR). Biorxiv : the Preprint Server For Biology. PMID 38659867 DOI: 10.1101/2024.04.19.590252  0.502
2024 Fallah S, Duncan D, Reichl KD, Smith MJ, Wang W, Porco JA, Brown LE, Whitesell L, Robbins N, Cowen LE. A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen . Microbiology Spectrum. e0409523. PMID 38376363 DOI: 10.1128/spectrum.04095-23  0.54
2023 Millimaci AM, Trilles RV, McNeely JH, Brown LE, Beeler AB, Porco JA. Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. The Journal of Organic Chemistry. PMID 37657122 DOI: 10.1021/acs.joc.3c01362  0.476
2023 Naineni SK, Cencic R, Robert F, Brown L, Haque M, Scott-Talib J, Senechal P, Schmeing TM, Porco J, Pelletier J. Exploring the Targeting Spectrum of Rocaglates Among eIF4A Homologs. Rna (New York, N.Y.). PMID 36882295 DOI: 10.1261/rna.079318.122  0.499
2023 Kavouris JA, McCall LI, Giardini MA, De Muylder G, Thomas D, Garcia-Pérez A, Cantizani J, Cotillo I, Fiandor JM, McKerrow JH, De Oliveira CI, Siqueira-Neto JL, González S, Brown LE, Schaus SE. Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of infection. Frontiers in Tropical Diseases. 3. PMID 36818551 DOI: 10.3389/fitd.2022.1011124  0.571
2022 Shaashua L, Ben-Shmuel A, Pevsner-Fischer M, Friedman G, Levi-Galibov O, Nandakumar S, Barki D, Nevo R, Brown LE, Zhang W, Stein Y, Lior C, Kim HS, Bojmar L, Jarnagin WR, et al. BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature Communications. 13: 6513. PMID 36316305 DOI: 10.1038/s41467-022-34081-3  0.434
2022 Brown LE, Seitz S, Kondas AV, Marcyk PT, Filone CM, Hossain MM, Schaus SE, Olson VA, Connor JH. Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox. Antimicrobial Agents and Chemotherapy. e0084122. PMID 36222522 DOI: 10.1128/aac.00841-22  0.59
2022 Lehman SL, Wechsler T, Schwartz K, Brown LE, Porco JA, Devine WG, Pelletier J, Shankavaram UT, Camphausen K, Tofilon PJ. Inhibition of the translation initiation factor eIF4A enhances tumor cell radiosensitivity. Molecular Cancer Therapeutics. PMID 35732578 DOI: 10.1158/1535-7163.MCT-22-0037  0.495
2022 Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA, Zhang W, Kinast V, Kirschning A, Vondran FWR, Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Research. 105359. PMID 35728703 DOI: 10.1016/j.antiviral.2022.105359  0.522
2021 Xu W, Brown LE, Porco JA. Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. The Journal of Organic Chemistry. PMID 34730970 DOI: 10.1021/acs.joc.1c01848  0.47
2021 Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to . Iscience. 24: 102845. PMID 34381970 DOI: 10.1016/j.isci.2021.102845  0.441
2020 Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA, Cuomo CA, Williams NS, Ibrahim AS, ... ... Brown LE, et al. An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature Communications. 11: 6429. PMID 33353950 DOI: 10.1038/s41467-020-20183-3  0.491
2020 Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown LE, Zhang W, Friedman G, Nevo R, Golani O, Katz LH, Yaeger R, Laish I, et al. Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature Communications. 11: 6245. PMID 33288768 DOI: 10.1038/s41467-020-20054-x  0.442
2020 Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. Mbio. 11. PMID 32156828 DOI: 10.1128/Mbio.03329-19  0.59
2020 Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA, Pelletier J. Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Reports. PMID 32101697 DOI: 10.1016/J.Celrep.2020.02.002  0.551
2020 Lehman SL, Wechsler T, Schwartz KR, Wahba A, Brown LE, Porco JA, Pelletier J, Camphausen K, Tofilon PJ. Abstract 6507: Inhibition of the translation initiation factor eIF4A1 enhances tumor cell radiosensitivity Cancer Research. 80: 6507-6507. DOI: 10.1158/1538-7445.Am2020-6507  0.548
2019 Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, ... Brown LE, et al. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature Communications. 10: 5151. PMID 31723131 DOI: 10.1038/S41467-019-13086-5  0.544
2019 Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chemical Biology. PMID 31519508 DOI: 10.1016/J.Chembiol.2019.08.008  0.577
2019 Huang D, LeBlanc E, Shekhar-Guturja T, Robbins N, Krysan D, Pizarro JC, Whitesell L, Cowen L, Brown LE. Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors. Journal of Medicinal Chemistry. PMID 31513387 DOI: 10.1021/Acs.Jmedchem.9B00826  0.366
2019 Zhang W, Chu J, Cyr AM, Yueh H, Brown LE, Wang TT, Pelletier J, Porco JA. Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. Journal of the American Chemical Society. PMID 31310112 DOI: 10.1021/Jacs.9B06446  0.605
2019 Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA, et al. Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia. PMID 31171817 DOI: 10.1038/S41375-019-0503-Z  0.586
2019 Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Journal of Alzheimer's Disease : Jad. 67: 1089-1106. PMID 30776010 DOI: 10.3233/Jad-180923  0.53
2019 Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA, Pelletier J. Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Scientific Reports. 9: 1265. PMID 30718665 DOI: 10.1038/S41598-018-37666-5  0.6
2019 Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, ... ... Brown LE, et al. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nature Communications. 10: 402. PMID 30679438 DOI: 10.1038/s41467-018-08248-w  0.545
2019 Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529  0.579
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Brown LE, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747  0.573
2018 Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for HCV Infection. Journal of the American Chemical Society. PMID 30590924 DOI: 10.1021/Jacs.8B11477  0.575
2018 Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Scientific Reports. 8: 17519. PMID 30504817 DOI: 10.1038/S41598-018-35908-0  0.538
2018 Chennamadhavuni S, Panek JS, Porco JA, Brown LE. Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence. The Journal of Organic Chemistry. PMID 30458107 DOI: 10.1021/Acs.Joc.8B02724  0.56
2018 Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. PMID 29894316 DOI: 10.1097/Aln.0000000000002281  0.676
2018 Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463745 DOI: 10.1073/Pnas.1713000115  0.545
2017 Porco J, Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J. Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B via Selective ESIPT Photocycloaddition. Angewandte Chemie (International Ed. in English). PMID 28950418 DOI: 10.1002/Anie.201707539  0.533
2017 Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. Dihydropyrimidine-thiones and clioquinol synergize to target β-amyloid cellular pathologies through a metal-dependent mechanism. Acs Chemical Neuroscience. PMID 28628299 DOI: 10.1021/Acschemneuro.7B00187  0.61
2017 Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, ... ... Brown LE, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Science Translational Medicine. 9. PMID 28490664 DOI: 10.1126/Scitranslmed.Aal2668  0.559
2016 Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European Journal of Organic Chemistry. 2016: 4800-4804. PMID 28082832 DOI: 10.1002/Ejoc.201601003  0.545
2016 Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201601003  0.497
2015 Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. Ebiomedicine. 2: 1600-6. PMID 26870784 DOI: 10.1016/J.Ebiom.2015.09.018  0.546
2015 Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway Ebiomedicine. DOI: 10.1016/j.ebiom.2015.09.018  0.516
2012 Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. Journal of Virology. 86: 2632-40. PMID 22205744 DOI: 10.1128/Jvi.05416-11  0.63
2011 Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Organic Letters. 13: 4228-31. PMID 21749159 DOI: 10.1021/Ol2015658  0.688
2011 Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, et al. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proceedings of the National Academy of Sciences of the United States of America. 108: 6775-80. PMID 21498685 DOI: 10.1073/Pnas.1017666108  0.701
2009 Brown LE, Landaverry YR, Davies JR, Milinkevich KA, Ast S, Carlson JS, Oliver AG, Konopelski JP. Progress toward the total synthesis of psymberin/irciniastatin A. The Journal of Organic Chemistry. 74: 5405-10. PMID 19572569 DOI: 10.1021/Jo9009003  0.715
2009 Chen W, Brown LE, Konopelski JP, Chen S. Intervalence transfer of ferrocene moieties adsorbed on electrode surfaces by a conjugated linkage Chemical Physics Letters. 471: 283-285. DOI: 10.1016/J.Cplett.2009.02.057  0.535
2009 Pradhan S, Brown LE, Konopelski JP, Chen S. Janus nanoparticles: Reaction dynamics and NOESY characterization Journal of Nanoparticle Research. 11: 1895-1903. DOI: 10.1007/S11051-008-9543-4  0.531
2008 Chen W, Chen S, Ding F, Wang H, Brown LE, Konopelski JP. Nanoparticle-mediated intervalence transfer. Journal of the American Chemical Society. 130: 12156-62. PMID 18710225 DOI: 10.1021/Ja803887B  0.532
2008 Gerstenberger BS, Lin J, Mimieux YS, Brown LE, Oliver AG, Konopelski JP. Structural characterization of an enantiomerically pure amino acid imidazolide and direct formation of the beta-lactam nucleus from an alpha-amino acid. Organic Letters. 10: 369-72. PMID 18181633 DOI: 10.1021/Ol7025922  0.729
2008 Brown LE, Konopelski JP. Turning the corner: Recent advances in the synthesis of the welwitindolinones Organic Preparations and Procedures International. 40: 411-445. DOI: 10.1080/00304940809458104  0.587
2007 Xia J, Brown LE, Konopelski JP. Welwistatin support studies: expansion and limitation of aryllead(IV) coupling reactions. The Journal of Organic Chemistry. 72: 6885-90. PMID 17685656 DOI: 10.1021/Jo071156L  0.71
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