Christine M. Dunham, Ph.D. - Publications

Affiliations: 
Emory University, Atlanta, GA 
Area:
RNA structure, catalysis and the origin of life

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hoffer E, Hong S, Sunita S, Maehigashi T, Gonzalez RL, Whitford P, Dunham CM. Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing. Elife. 9. PMID 33016876 DOI: 10.7554/eLife.51898  1
2020 Nguyen HA, Sunita S, Dunham CM. Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601241 DOI: 10.1073/pnas.2004170117  1
2019 Nosrati M, Dey D, Mehrani A, Strassler SE, Zelinskaya N, Hoffer ED, Stagg SM, Dunham CM, Conn GL. Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. The Journal of Biological Chemistry. PMID 31594862 DOI: 10.1074/jbc.RA119.011181  1
2019 Pavelich IJ, Maehigashi T, Hoffer ED, Ruangprasert A, Miles SJ, Dunham CM. Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability. Nucleic Acids Research. PMID 31501867 DOI: 10.1093/nar/gkz760  1
2019 Schureck MA, Meisner J, Hoffer ED, Wang D, Onuoha N, Ei Cho S, Lollar P, Dunham CM. Structural basis of transcriptional regulation by the HigA antitoxin. Molecular Microbiology. PMID 30793388 DOI: 10.1111/mmi.14229  1
2019 Nguyen HA, Hoffer ED, Dunham CM. Importance of tRNA anticodon loop modification and a conserved, noncanonical anticodon stem pairing in tRNA for decoding. The Journal of Biological Chemistry. PMID 30782843 DOI: 10.1074/jbc.RA119.007410  1
2018 Hoffer ED, Maehigashi T, Fredrick K, Dunham CM. Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding. Nucleic Acids Research. PMID 30476222 DOI: 10.1093/nar/gky1178  1
2018 Rivera S, Young PG, Hoffer ED, Vansuch GE, Metzler CL, Dunham CM, Weinert EE. Structural Insights into Oxygen-Dependent Signal Transduction within Globin Coupled Sensors. Inorganic Chemistry. PMID 30378421 DOI: 10.1021/acs.inorgchem.8b02584  1
2018 Hong S, Sunita S, Maehigashi T, Hoffer ED, Dunkle JA, Dunham CM. Mechanism of tRNA-mediated +1 ribosomal frameshifting. Proceedings of the National Academy of Sciences of the United States of America. PMID 30262649 DOI: 10.1073/pnas.1809319115  1
2018 Zhang Y, Hong S, Ruangprasert A, Skiniotis G, Dunham CM. Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel. Structure (London, England : 1993). PMID 29456023 DOI: 10.1016/j.str.2018.01.013  1
2017 Nguyen HA, Dunham CM. Genome mining: Digging the tunnel for chemical space. Nature Chemical Biology. 13: 1061-1062. PMID 28926552 DOI: 10.1038/nchembio.2480  0.92
2017 Hoffer ED, Miles SJ, Dunham CM. The structure and function of Mycobacterium tuberculosis MazF-mt6 provides insights into conserved features of MazF endonucleases. The Journal of Biological Chemistry. PMID 28298445 DOI: 10.1074/jbc.M117.779306  1
2017 Ruangprasert A, Maehigashi T, Miles SJ, Dunham CM. Importance of the E. coli DinJ antitoxin carboxy terminus for toxin suppression and regulated proteolysis. Molecular Microbiology. PMID 28164393 DOI: 10.1111/mmi.13641  1
2016 Pierson WE, Hoffer ED, Keedy HE, Simms CL, Dunham CM, Zaher HS. Uniformity of Peptide Release Is Maintained by Methylation of Release Factors. Cell Reports. 17: 11-8. PMID 27681416 DOI: 10.1016/j.celrep.2016.08.085  1
2016 Schureck MA, Repack A, Miles SJ, Marquez J, Dunham CM. Mechanism of endonuclease cleavage by the HigB toxin. Nucleic Acids Research. PMID 27378776 DOI: 10.1093/nar/gkw598  1
2016 Schureck MA, Maehigashi T, Miles SJ, Marquez J, Dunham CM. mRNA bound to the 30S subunit is a HigB toxin substrate. Rna (New York, N.Y.). PMID 27307497 DOI: 10.1261/rna.056218.116  1
2015 Schureck MA, Dunkle JA, Maehigashi T, Miles SJ, Dunham CM. Defining the mRNA recognition signature of a bacterial toxin protein. Proceedings of the National Academy of Sciences of the United States of America. 112: 13862-7. PMID 26508639 DOI: 10.1073/pnas.1512959112  1
2015 Maehigashi T, Ruangprasert A, Miles SJ, Dunham CM. Molecular basis of ribosome recognition and mRNA hydrolysis by the E. coli YafQ toxin. Nucleic Acids Research. 43: 8002-12. PMID 26261214 DOI: 10.1093/nar/gkv791  1
2015 Cruz JW, Sharp JD, Hoffer ED, Maehigashi T, Vvedenskaya IO, Konkimalla A, Husson RN, Nickels BE, Dunham CM, Woychik NA. Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase. Nature Communications. 6: 7480. PMID 26158745 DOI: 10.1038/ncomms8480  1
2015 Dunkle JA, Dunham CM. Mechanisms of mRNA frame maintenance and its subversion during translation of the genetic code. Biochimie. 114: 90-6. PMID 25708857 DOI: 10.1016/j.biochi.2015.02.007  1
2014 Fagan CE, Maehigashi T, Dunkle JA, Miles SJ, Dunham CM. Structural insights into translational recoding by frameshift suppressor tRNASufJ. Rna (New York, N.Y.). 20: 1944-54. PMID 25352689 DOI: 10.1261/rna.046953.114  1
2014 Washington AZ, Benicewicz DB, Canzoneri JC, Fagan CE, Mwakwari SC, Maehigashi T, Dunham CM, Oyelere AK. Macrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome. Acs Chemical Biology. 9: 2621-31. PMID 25198768 DOI: 10.1021/cb5003224  1
2014 Maehigashi T, Dunkle JA, Miles SJ, Dunham CM. Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops. Proceedings of the National Academy of Sciences of the United States of America. 111: 12740-5. PMID 25128388 DOI: 10.1073/pnas.1409436111  1
2014 Ruangprasert A, Maehigashi T, Miles SJ, Giridharan N, Liu JX, Dunham CM. Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ. The Journal of Biological Chemistry. 289: 20559-69. PMID 24898247 DOI: 10.1074/jbc.M114.573006  1
2014 Schureck MA, Dunham CM. Bacterial warfare again targets the ribosome. Structure (London, England : 1993). 22: 661-2. PMID 24807074 DOI: 10.1016/j.str.2014.04.007  1
2014 Dunkle JA, Vinal K, Desai PM, Zelinskaya N, Savic M, West DM, Conn GL, Dunham CM. Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proceedings of the National Academy of Sciences of the United States of America. 111: 6275-80. PMID 24717845 DOI: 10.1073/pnas.1402789111  1
2014 Cruz JW, Rothenbacher FP, Maehigashi T, Lane WS, Dunham CM, Woychik NA. Doc toxin is a kinase that inactivates elongation factor Tu. The Journal of Biological Chemistry. 289: 7788-98. PMID 24448800 DOI: 10.1074/jbc.M113.544429  1
2014 Schureck MA, Maehigashi T, Miles SJ, Marquez J, Cho SE, Erdman R, Dunham CM. Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. The Journal of Biological Chemistry. 289: 1060-70. PMID 24257752 DOI: 10.1074/jbc.M113.512095  1
2014 Cruz JW, Rothenbacher FP, Maehigashi T, Lane WS, Dunham CM, Woychik NA. Doc toxin is a kinase that inactivates elongation factor Tu (Journal of Biological Chemistry (2014) 289 (7788-7798)) Journal of Biological Chemistry. 289: 19276. DOI: 10.1074/jbc.A113.544429  1
2013 Jones BL, VanLoozen J, Kim MH, Miles SJ, Dunham CM, Williams LD, Snell TW. Stress granules form in Brachionus manjavacas (Rotifera) in response to a variety of stressors. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 166: 375-84. PMID 23856158 DOI: 10.1016/j.cbpa.2013.07.009  1
2013 Fagan CE, Dunkle JA, Maehigashi T, Dang MN, Devaraj A, Miles SJ, Qin D, Fredrick K, Dunham CM. Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state. Proceedings of the National Academy of Sciences of the United States of America. 110: 9716-21. PMID 23630274 DOI: 10.1073/pnas.1301585110  1
2012 Meisner J, Maehigashi T, André I, Dunham CM, Moran CP. Structure of the basal components of a bacterial transporter. Proceedings of the National Academy of Sciences of the United States of America. 109: 5446-51. PMID 22431613 DOI: 10.1073/pnas.1120113109  1
2009 Neubauer C, Gao YG, Andersen KR, Dunham CM, Kelley AC, Hentschel J, Gerdes K, Ramakrishnan V, Brodersen DE. The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell. 139: 1084-95. PMID 20005802 DOI: 10.1016/j.cell.2009.11.015  1
2009 Gao YG, Selmer M, Dunham CM, Weixlbaumer A, Kelley AC, Ramakrishnan V. The structure of the ribosome with elongation factor G trapped in the posttranslocational state. Science (New York, N.Y.). 326: 694-9. PMID 19833919 DOI: 10.1126/science.1179709  1
2009 Leung SW, Apponi LH, Cornejo OE, Kitchen CM, Valentini SR, Pavlath GK, Dunham CM, Corbett AH. Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein. Gene. 439: 71-8. PMID 19303045 DOI: 10.1016/j.gene.2009.02.022  1
2007 Weixlbaumer A, Petry S, Dunham CM, Selmer M, Kelley AC, Ramakrishnan V. Crystal structure of the ribosome recycling factor bound to the ribosome. Nature Structural & Molecular Biology. 14: 733-7. PMID 17660830 DOI: 10.1038/nsmb1282  1
2007 Dunham CM, Conn GL. Recombinant RNA expression. Nature Methods. 4: 547-8. PMID 17599081 DOI: 10.1038/nmeth0707-547  1
2007 Dunham CM, Selmer M, Phelps SS, Kelley AC, Suzuki T, Joseph S, Ramakrishnan V. Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit. Rna (New York, N.Y.). 13: 817-23. PMID 17416634 DOI: 10.1261/rna.367307  1
2006 Selmer M, Dunham CM, Murphy FV, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V. Structure of the 70S ribosome complexed with mRNA and tRNA. Science (New York, N.Y.). 313: 1935-42. PMID 16959973 DOI: 10.1126/science.1131127  1
2005 Petry S, Brodersen DE, Murphy FV, Dunham CM, Selmer M, Tarry MJ, Kelley AC, Ramakrishnan V. Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon. Cell. 123: 1255-66. PMID 16377566 DOI: 10.1016/j.cell.2005.09.039  1
2003 Dunham CM, Murray JB, Scott WG. A helical twist-induced conformational switch activates cleavage in the hammerhead ribozyme. Journal of Molecular Biology. 332: 327-36. PMID 12948485 DOI: 10.1016/S0022-2836(03)00843-X  1
2003 Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA. A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry. 42: 7701-8. PMID 12820879 DOI: 10.1021/bi0343370  1
2002 Burns CS, Aronoff-Spencer E, Dunham CM, Lario P, Avdievich NI, Antholine WE, Olmstead MM, Vrielink A, Gerfen GJ, Peisach J, Scott WG, Millhauser GL. Molecular features of the copper binding sites in the octarepeat domain of the prion protein. Biochemistry. 41: 3991-4001. PMID 11900542 DOI: 10.1021/bi011922x  1
2002 Murray JB, Dunham CM, Scott WG. A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction. Journal of Molecular Biology. 315: 121-30. PMID 11779233 DOI: 10.1006/jmbi.2001.5145  1
2001 Asensio JA, Chahwan S, Forno W, MacKersie R, Wall M, Lake J, Minard G, Kirton O, Nagy K, Karmy-Jones R, Brundage S, Hoyt D, Winchell R, Kralovich K, Shapiro M, ... ... Dunham CM, et al. Penetrating esophageal injuries: multicenter study of the American Association for the Surgery of Trauma. The Journal of Trauma. 50: 289-96. PMID 11242294 DOI: 10.1097/00005373-200102000-00015  0.52
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