Year |
Citation |
Score |
2007 |
Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt BF, Boger DL. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 1058-68. PMID 17279740 DOI: 10.1021/Jm0611509 |
0.304 |
|
2005 |
Grunewald GL, Romero FA, Criscione KR. Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1. Journal of Medicinal Chemistry. 48: 1806-12. PMID 15771426 DOI: 10.1021/Jm049594X |
0.571 |
|
2005 |
Grunewald GL, Romero FA, Seim MR, Criscione KR, Deupree JD, Spackman CC, Bylund DB. Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. Bioorganic & Medicinal Chemistry Letters. 15: 1143-7. PMID 15686930 DOI: 10.1016/J.Bmcl.2004.12.013 |
0.528 |
|
2005 |
Grunewald GL, Romero FA, Chieu AD, Fincham KJ, Bhat SR, Criscione KR. Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors. Bioorganic & Medicinal Chemistry. 13: 1261-73. PMID 15670935 DOI: 10.1016/J.Bmc.2004.11.015 |
0.674 |
|
2005 |
Grunewald GL, Romero FA, Criscione KR. 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity. Journal of Medicinal Chemistry. 48: 134-40. PMID 15634007 DOI: 10.1021/Jm049368N |
0.628 |
|
2004 |
Romero FA, Vodonick SM, Criscione KR, McLeish MJ, Grunewald GL. Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor. Journal of Medicinal Chemistry. 47: 4483-93. PMID 15317460 DOI: 10.1021/Jm0400653 |
0.663 |
|
2002 |
Lankin DC, Grunewald GL, Romero FA, Oren IY, Snyder JP. The NH---FC dipole orientation effect for pendant exocyclic CH(2)F. Organic Letters. 4: 3557-60. PMID 12375886 DOI: 10.1021/ol026358c |
0.477 |
|
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