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Maire F. Osborn, Ph.D. - Publications

Affiliations: 
Chemistry and Biochemistry University of Oregon, Eugene, OR, United States 
Area:
Bioinorganic Chemistry, Biophysical Chemistry & Chemical Biology
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16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Biscans A, Coles A, Haraszti R, Echeverria D, Hassler M, Osborn M, Khvorova A. Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo. Nucleic Acids Research. 47: 1082-1096. PMID 30544191 DOI: 10.1093/Nar/Gky1239  0.387
2018 Osborn MF, Coles AH, Biscans A, Haraszti RA, Roux L, Davis S, Ly S, Echeverria D, Hassler MR, Godinho BMDC, Nikan M, Khvorova A. Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways. Nucleic Acids Research. PMID 30535404 DOI: 10.1093/Nar/Gky1232  0.384
2018 Osborn MF, Khvorova A. Improving Small Interfering RNA Delivery In Vivo Through Lipid Conjugation. Nucleic Acid Therapeutics. PMID 29746209 DOI: 10.1089/Nat.2018.0725  0.547
2018 Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A. Efficient gene silencing in brain tumors with hydrophobically modified siRNAs. Molecular Cancer Therapeutics. PMID 29654062 DOI: 10.1158/1535-7163.Mct-17-1144  0.344
2018 Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, et al. Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Research. PMID 29432571 DOI: 10.1093/Nar/Gky037  0.47
2017 Nikan M, Osborn MF, Coles AH, Biscans A, Godinho B, Haraszti R, Sapp E, Echeverria D, DiFiglia M, Aronin N, Khvorova A. Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable, O-phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain. Bioconjugate Chemistry. PMID 28462988 DOI: 10.1021/Acs.Bioconjchem.7B00226  0.345
2016 Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A. Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Molecular Therapy. Nucleic Acids. 5: e344. PMID 27504598 DOI: 10.1038/Mtna.2016.50  0.318
2016 Coles AH, Osborn MF, Golebowski D, Hassler M, Esteves MS, Khvorova A. Abstract PR12: Robust modulation of gene expression in aggressive glioblastoma mouse models: A new approach for in vivo target validation Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-Pr12  0.346
2015 Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A. Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Molecular Therapy. Nucleic Acids. 4: e266. PMID 26623938 DOI: 10.1038/Mtna.2015.38  0.341
2015 Coles AH, Osborn MF, Alterman JF, Turanov AA, Godinho BM, Kennington L, Chase K, Aronin N, Khvorova A. A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Therapeutics. PMID 26595721 DOI: 10.1089/Nat.2015.0578  0.442
2015 Osborn MF, Alterman JF, Nikan M, Cao H, Didiot MC, Hassler MR, Coles AH, Khvorova A. Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs. Nucleic Acids Research. PMID 26400165 DOI: 10.1093/Nar/Gkv942  0.369
2014 Osborn MF, White JD, Haley MM, DeRose VJ. Platinum-RNA modifications following drug treatment in S. cerevisiae identified by click chemistry and enzymatic mapping. Acs Chemical Biology. 9: 2404-11. PMID 25055168 DOI: 10.1021/Cb500395Z  0.758
2014 DeRose VJ, Plakos K, Golden BL, White J, Osborn M, Moghaddam A. RNA Crosslinking and Click Chemistry with Platinum Compounds Biophysical Journal. 106: 494a-495a. DOI: 10.1016/J.Bpj.2013.11.2766  0.784
2013 White JD, Osborn MF, Moghaddam AD, Guzman LE, Haley MM, DeRose VJ. Picazoplatin, an azide-containing platinum(II) derivative for target analysis by click chemistry. Journal of the American Chemical Society. 135: 11680-3. PMID 23879391 DOI: 10.1021/Ja402453K  0.705
2012 Hostetter AA, Osborn MF, DeRose VJ. RNA-Pt adducts following cisplatin treatment of Saccharomyces cerevisiae. Acs Chemical Biology. 7: 218-25. PMID 22004017 DOI: 10.1021/Cb200279P  0.701
2011 Chapman EG, Hostetter AA, Osborn MF, Miller AL, DeRose VJ. Binding of kinetically inert metal ions to RNA: the case of platinum(II). Metal Ions in Life Sciences. 9: 347-77. PMID 22010278 DOI: 10.1039/9781849732512-00347  0.619
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