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Kevin C. Slep, Ph.D. - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Protein Folding and Dynamics, Structural Biology
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 McParland ED, Butcher TA, Gurley NJ, Johnson RI, Slep KC, Peifer M. Canoe's Dilute domain is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness. Journal of Cell Science. PMID 38323935 DOI: 10.1242/jcs.261734  0.412
2023 Bolhuis DL, Dixit R, Slep KC. Crystal structure of the Arabidopsis SPIRAL2 C-terminal domain reveals a p80-Katanin-like domain. Plos One. 18: e0290024. PMID 38157339 DOI: 10.1371/journal.pone.0290024  0.49
2023 Fan Y, Bilkey N, Bolhuis DL, Slep KC, Dixit R. A divergent TOG domain and oligomerization contribute to SPIRAL2 function in stabilizing microtubule minus ends. The Plant Cell. PMID 38011314 DOI: 10.1093/plcell/koad294  0.553
2023 McParland ED, Butcher TA, Gurley NJ, Johnson RI, Slep KC, Peifer M. The Dilute domain of Canoe is not essential for Canoe's role in linking adherens junctions to the cytoskeleton but contributes to robustness of morphogenesis. Biorxiv : the Preprint Server For Biology. PMID 37905001 DOI: 10.1101/2023.10.18.562854  0.433
2023 Ryniawec JM, Buster DW, Slevin LK, Boese CJ, Amoiroglou A, Dean SM, Slep KC, Rogers GC. Polo-like kinase 4 homodimerization and condensate formation regulate its own protein levels but are not required for centriole assembly. Molecular Biology of the Cell. mbcE22120572. PMID 37163316 DOI: 10.1091/mbc.E22-12-0572  0.38
2021 Perez-Vale KZ, Yow KD, Johnson RI, Byrnes AE, Finegan TM, Slep KC, Peifer M. Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis. The Journal of Cell Biology. 220. PMID 34762121 DOI: 10.1083/jcb.202104087  0.414
2020 Slep KC. Cytoskeletal Repair: Microtubule Orthopaedics to the Rescue. Current Biology : Cb. 30: R646-R649. PMID 32516614 DOI: 10.1016/J.Cub.2020.04.049  0.418
2019 Leano JB, Slep KC. Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1. Plos One. 14: e0219823. PMID 31323070 DOI: 10.1371/Journal.Pone.0219823  0.548
2019 Slep KC. Cytoskeletal cryptography: structure and mechanism of an eraser. Nature Structural & Molecular Biology. 26: 532-534. PMID 31270475 DOI: 10.1038/S41594-019-0266-2  0.423
2018 Chen Y, Wang P, Slep KC. Mapping multivalency in the CLIP-170-EB1 microtubule plus end complex. The Journal of Biological Chemistry. PMID 30455356 DOI: 10.1074/Jbc.Ra118.006125  0.58
2018 Boese CJ, Nye J, Buster DW, McLamarrah TA, Byrnes AE, Slep KC, Rusan NM, Rogers GC. Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state. Molecular Biology of the Cell. mbcE18070445. PMID 30256714 DOI: 10.1091/Mbc.E18-07-0445  0.366
2018 Slep KC. A Cytoskeletal Symphony: Owed to TOG. Developmental Cell. 46: 5-7. PMID 29974863 DOI: 10.1016/J.Devcel.2018.06.010  0.477
2018 McLamarrah TA, Buster DW, Galletta BJ, Boese CJ, Ryniawec JM, Hollingsworth NA, Byrnes AE, Brownlee CW, Slep KC, Rusan NM, Rogers GC. An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly. The Journal of Cell Biology. PMID 29496738 DOI: 10.1083/Jcb.201605106  0.457
2017 Adikes RC, Hallett RA, Saway BF, Kuhlman B, Slep KC. Control of microtubule dynamics using an optogenetic microtubule plus end-F-actin cross-linker. The Journal of Cell Biology. PMID 29259096 DOI: 10.1083/Jcb.201705190  0.621
2017 Haase KP, Fox JC, Byrnes AE, Adikes RC, Speed SK, Haase J, Friedman B, Cook DM, Bloom K, Rusan NM, Slep KC. Stu2 uses a 15 nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle. Molecular Biology of the Cell. PMID 29187574 DOI: 10.1091/Mbc.E17-01-0057  0.64
2017 Lane TR, Fuchs E, Slep KC. Structure of the ACF7 EF-Hand-GAR Module and Delineation of Microtubule Binding Determinants. Structure (London, England : 1993). PMID 28602822 DOI: 10.1016/J.Str.2017.05.006  0.581
2017 Byrnes AE, Slep KC. TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation. The Journal of Cell Biology. PMID 28512144 DOI: 10.1083/Jcb.201610090  0.573
2016 Slep KC. A microtubule dynamics reconstitutional convention. The Journal of Cell Biology. 215: 305-307. PMID 27821492 DOI: 10.1083/Jcb.201610066  0.388
2016 Galletta BJ, Fagerstrom CJ, Schoborg TA, McLamarrah TA, Ryniawec JM, Buster DW, Slep KC, Rogers GC, Rusan NM. A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4. Nature Communications. 7: 12476. PMID 27558293 DOI: 10.1038/Ncomms12476  0.443
2016 Slep KC. The Secret of Centriole Length: Keep a LID on It. Developmental Cell. 37: 293-5. PMID 27219056 DOI: 10.1016/J.Devcel.2016.05.008  0.387
2015 Plevock KM, Galletta BJ, Slep KC, Rusan NM. Newly Characterized Region of CP190 Associates with Microtubules and Mediates Proper Spindle Morphology in Drosophila Stem Cells. Plos One. 10: e0144174. PMID 26649574 DOI: 10.1371/Journal.Pone.0144174  0.572
2015 Das A, Dickinson DJ, Wood CC, Goldstein B, Slep KC. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Molecular Biology of the Cell. PMID 26378256 DOI: 10.1091/Mbc.E15-08-0603  0.594
2015 Howard AE, Fox JC, Slep KC. Drosophila melanogaster mini spindles TOG3 utilizes unique structural elements to promote domain stability and maintain a TOG1- and TOG2-like tubulin-binding surface. The Journal of Biological Chemistry. 290: 10149-62. PMID 25720490 DOI: 10.1074/Jbc.M114.633826  0.615
2015 Klebba JE, Galletta BJ, Nye J, Plevock KM, Buster DW, Hollingsworth NA, Slep KC, Rusan NM, Rogers GC. Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability. The Journal of Cell Biology. 208: 401-14. PMID 25688134 DOI: 10.1083/Jcb.201410105  0.492
2014 Fox JC, Howard AE, Currie JD, Rogers SL, Slep KC. The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array. Molecular Biology of the Cell. 25: 2375-92. PMID 24966168 DOI: 10.1091/Mbc.E13-08-0501  0.591
2014 Slevin LK, Romes EM, Dandulakis MG, Slep KC. The mechanism of dynein light chain LC8-mediated oligomerization of the Ana2 centriole duplication factor. The Journal of Biological Chemistry. 289: 20727-39. PMID 24920673 DOI: 10.1074/Jbc.M114.576041  0.413
2013 Rao L, Romes EM, Nicholas MP, Brenner S, Tripathy A, Gennerich A, Slep KC. The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization. Molecular Biology of the Cell. 24: 2362-77. PMID 23761070 DOI: 10.1091/Mbc.E13-03-0166  0.399
2013 Leano JB, Rogers SL, Slep KC. A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation. Structure (London, England : 1993). 21: 939-50. PMID 23727231 DOI: 10.1016/J.Str.2013.04.018  0.597
2012 Slep KC. Structure of the human discs large 1 PDZ2- adenomatous polyposis coli cytoskeletal polarity complex: insight into peptide engagement and PDZ clustering. Plos One. 7: e50097. PMID 23185543 DOI: 10.1371/Journal.Pone.0050097  0.494
2012 Slevin LK, Nye J, Pinkerton DC, Buster DW, Rogers GC, Slep KC. The structure of the plk4 cryptic polo box reveals two tandem polo boxes required for centriole duplication. Structure (London, England : 1993). 20: 1905-17. PMID 23000383 DOI: 10.1016/J.Str.2012.08.025  0.475
2012 Romes EM, Tripathy A, Slep KC. Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction. The Journal of Biological Chemistry. 287: 15862-73. PMID 22411995 DOI: 10.1074/Jbc.M111.336172  0.436
2011 Currie JD, Stewman S, Schimizzi G, Slep KC, Ma A, Rogers SL. The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics. Molecular Biology of the Cell. 22: 4343-61. PMID 21965297 DOI: 10.1091/Mbc.E11-06-0520  0.593
2011 Campbell JN, Slep KC. αβ-Tubulin and microtubule-binding assays. Methods in Molecular Biology (Clifton, N.J.). 777: 87-97. PMID 21773922 DOI: 10.1007/978-1-61779-252-6_6  0.511
2010 Applewhite DA, Grode KD, Keller D, Zadeh AD, Zadeh A, Slep KC, Rogers SL. The spectraplakin Short stop is an actin-microtubule cross-linker that contributes to organization of the microtubule network. Molecular Biology of the Cell. 21: 1714-24. PMID 20335501 DOI: 10.1091/Mbc.E10-01-0011  0.513
2010 Slep KC. Structural and mechanistic insights into microtubule end-binding proteins. Current Opinion in Cell Biology. 22: 88-95. PMID 19959349 DOI: 10.1016/J.Ceb.2009.10.009  0.534
2009 Slep KC. The role of TOG domains in microtubule plus end dynamics. Biochemical Society Transactions. 37: 1002-6. PMID 19754440 DOI: 10.1042/Bst0371002  0.591
2009 Sawyer JK, Harris NJ, Slep KC, Gaul U, Peifer M. The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. The Journal of Cell Biology. 186: 57-73. PMID 19596848 DOI: 10.1083/Jcb.200904001  0.438
2008 Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB. Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 6243-8. PMID 18434540 DOI: 10.1073/Pnas.0801569105  0.358
2007 Slep KC, Vale RD. Structural basis of microtubule plus end tracking by XMAP215, CLIP-170, and EB1. Molecular Cell. 27: 976-91. PMID 17889670 DOI: 10.1016/J.Molcel.2007.07.023  0.532
2005 Slep KC, Rogers SL, Elliott SL, Ohkura H, Kolodziej PA, Vale RD. Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end. The Journal of Cell Biology. 168: 587-98. PMID 15699215 DOI: 10.1083/Jcb.200410114  0.536
2001 Sowa ME, He W, Slep KC, Kercher MA, Lichtarge O, Wensel TG. Prediction and confirmation of a site critical for effector regulation of RGS domain activity. Nature Structural Biology. 8: 234-7. PMID 11224568 DOI: 10.1038/84974  0.386
2000 He W, Lu L, Zhang X, El-Hodiri HM, Chen CK, Slep KC, Simon MI, Jamrich M, Wensel TG. Modules in the photoreceptor RGS9-1.Gbeta 5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability. The Journal of Biological Chemistry. 275: 37093-100. PMID 10978345 DOI: 10.1074/Jbc.M006982200  0.319
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