Jeffrey R. Brender, Ph.D. - Publications

University of Michigan, Ann Arbor, Ann Arbor, MI 
Structural Enzymology, Protein Processing and Folding

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Miura N, Mushti C, Sail D, AbuSalim JE, Yamamoto K, Brender JR, Seki T, AbuSalim DI, Matsumoto S, Camphausen KA, Krishna MC, Swenson RE, Kesarwala AH. Synthesis of [1- C-5- C]-alpha-ketoglutarate enables noninvasive detection of 2-hydroxyglutarate. Nmr in Biomedicine. e4588. PMID 34263489 DOI: 10.1002/nbm.4588  0.52
2021 Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang SM, Li Y, Larson PEZ, Brender JR, Krishna MC, Xu D, Vigneron DB, Gordon JW. Denoising of hyperpolarized C MR images of the human brain using patch-based higher-order singular value decomposition. Magnetic Resonance in Medicine. PMID 34173268 DOI: 10.1002/mrm.28887  0.52
2021 Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Ardenkjær-Larsen JH, et al. Real-Time insight into in vivo redox status utilizing hyperpolarized [1-C] N-acetyl cysteine. Scientific Reports. 11: 12155. PMID 34108512 DOI: 10.1038/s41598-021-90921-0  0.52
2021 Nagineni CN, Naz S, Choudhuri R, Chandramouli GVR, Krishna MC, Brender JR, Cook JA, Mitchell JB. Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells. International Journal of Molecular Sciences. 22. PMID 34063570 DOI: 10.3390/ijms22094835  0.4
2021 Kawai T, Brender JR, Lee JA, Kramp T, Kishimoto S, Krishna MC, Tofilon P, Camphausen KA. Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized C-MRI. Nmr in Biomedicine. e4514. PMID 33939204 DOI: 10.1002/nbm.4514  0.52
2021 Saida Y, Brender JR, Yamamoto K, Mitchell JB, Krishna MC, Kishimoto S. Multimodal molecular imaging detects early responses to immune checkpoint blockade. Cancer Research. PMID 33837042 DOI: 10.1158/0008-5472.CAN-20-3182  0.52
2020 Kishimoto S, Brender J, Chandramouli GVR, Saida Y, Yamamoto K, Mitchell J, Krishna MC. Hypoxia activated prodrug evofosfamide treatment in pancreatic ductal adenocarcinoma xenografts alters the tumor redox status to potentiate radiotherapy. Antioxidants & Redox Signaling. PMID 32787454 DOI: 10.1089/Ars.2020.8131  0.52
2020 Brender JR, Kishimoto S, Eaton GR, Eaton SS, Saida Y, Mitchell J, Krishna MC. Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI. Magnetic Resonance in Medicine. PMID 32697878 DOI: 10.1002/Mrm.28405  0.4
2020 Ratha BN, Kar RK, Brender JR, Pariary R, Sahoo B, Kalita S, Bhunia A. High Resolution Structure of A Partially Folded Insulin Aggregation Intermediate. Proteins. PMID 32683793 DOI: 10.1002/Prot.25983  0.64
2020 Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, et al. Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized C MRSI. Magnetic Resonance in Medicine. PMID 32501614 DOI: 10.1002/Mrm.28328  0.52
2020 Yamamoto K, Brender JR, Seki T, Kishimoto S, Oshima N, Choudhuri R, Adler SS, Jagoda E, Saito K, Devasahayam N, Choyke PL, Mitchell JB, Krishna MC. Molecular Imaging of the Tumor Microenvironment reveals the Relationship between Tumor Oxygenation, Glucose Uptake and Glycolysis in Pancreatic Ductal Adenocarcinoma. Cancer Research. PMID 32245793 DOI: 10.1158/0008-5472.Can-19-0928  0.52
2020 Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, et al. Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy. Cell Reports. 30: 1798-1810.e4. PMID 32049011 DOI: 10.1016/J.Celrep.2020.01.039  0.52
2020 Oshima N, Ishida R, Kishimoto S, Brender JR, Okada T, Obama K, Sakai Y, Krishna MC, Neckers LM. Abstract 2783: Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized13C MRI Tumor Biology. DOI: 10.1158/1538-7445.Am2020-2783  0.4
2019 Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, et al. Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice. Elife. 8. PMID 31408004 DOI: 10.7554/Elife.46312  0.52
2019 Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A. Probing transient non-native states in amyloid beta fiber elongation by NMR. Chemical Communications (Cambridge, England). PMID 30917192 DOI: 10.1039/C9Cc01067J  1
2019 Brender JR, Kishimoto S, Merkle H, Reed G, Hurd RE, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Seki T, Oshima N, Yamamoto K, Choyke PL, Mitchell J, Krishna MC. Dynamic Imaging of Glucose and Lactate Metabolism by C-MRS without Hyperpolarization. Scientific Reports. 9: 3410. PMID 30833588 DOI: 10.1038/S41598-019-38981-1  0.52
2019 Kishimoto S, Brender JR, Crooks DR, Matsumoto S, Seki T, Oshima N, Merkle H, Lin P, Reed G, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Yamamoto K, Choyke PL, et al. Author response: Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice Elife. DOI: 10.7554/Elife.46312.016  0.52
2019 Kawai T, Krishna MC, Kramp T, Brender JR, Tofilon P, Camphausen KA. Abstract 1944: Detection of metabolic change in glioblastoma after radiotherapy using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model Cancer Research. 79: 1944-1944. DOI: 10.1158/1538-7445.Sabcs18-1944  0.52
2018 Pursley R, Enomoto A, Wu H, Brender JR, Pohida T, Subramanian S, Krishna MC, Devasahayam N. Towards reduction of SAR in scaling up in vivo pulsed EPR imaging to larger objects. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 299: 42-48. PMID 30579225 DOI: 10.1016/J.Jmr.2018.12.011  0.4
2018 Saito K, Sail D, Yamamoto K, Matsumoto S, Blackman B, Kishimoto S, Brender J, Swenson RE, Mitchell JB, Krishna MC. Synthesis and evaluation of C-labeled 5-5-dimethyl-1-pyrroline-N-oxide aimed at in vivo detection of reactive oxygen species using hyperpolarized C-MRI. Free Radical Biology & Medicine. PMID 30471347 DOI: 10.1016/J.Freeradbiomed.2018.11.013  0.52
2018 Kar RK, Brender JR, Ghosh A, Bhunia A. Non-productive Binding Modes as a Prominent Feature of Aβ40 Fiber Elongation: Insights from Molecular Dynamics Simulation. Journal of Chemical Information and Modeling. PMID 30047732 DOI: 10.1021/Acs.Jcim.8B00169  0.64
2018 Brender JR, Krishnamoorthy J, Ghosh A, Bhunia A. Binding Moiety Mapping by Saturation Transfer Difference NMR. Methods in Molecular Biology (Clifton, N.J.). 1824: 49-65. PMID 30039401 DOI: 10.1007/978-1-4939-8630-9_4  1
2018 Setiawan D, Brender J, Zhang Y. Recent advances in automated protein design and its future challenges. Expert Opinion On Drug Discovery. 1-18. PMID 29695210 DOI: 10.1080/17460441.2018.1465922  1
2018 Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D. A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage. Biochimica Et Biophysica Acta. PMID 29555190 DOI: 10.1016/J.Bbamem.2018.03.012  1
2018 Kawai T, Krishna MC, Brender JR, Lee J, Kramp T, Yamamoto K, Kishimoto S, Seki T, Camphausen KA. Abstract 4110: Metabolic imaging of glioblastoma using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model Cancer Research. 78: 4110-4110. DOI: 10.1158/1538-7445.Am2018-4110  0.52
2017 Brender JR, Shultis D, Khattak NA, Zhang Y. An Evolution-Based Approach to De Novo Protein Design. Methods in Molecular Biology (Clifton, N.J.). 1529: 243-264. PMID 27914055 DOI: 10.1007/978-1-4939-6637-0_12  1
2016 Neveu MA, De Preter G, Joudiou N, Bol A, Brender JR, Saito K, Kishimoto S, Grégoire V, Jordan BF, Krishna MC, Feron O, Gallez B. Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models. Oncotarget. 7: 81741-81749. PMID 28082726 DOI: 10.18632/Oncotarget.13176  0.4
2016 Neveu MA, De Preter G, Marchand V, Bol A, Brender JR, Saito K, Kishimoto S, Porporato PE, Sonveaux P, Grégoire V, Feron O, Jordan BF, Krishna MC, Gallez B. Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo. Neoplasia (New York, N.Y.). 18: 742-752. PMID 27889643 DOI: 10.1016/J.Neo.2016.10.010  0.4
2016 Ratha BN, Ghosh A, Brender JR, Gayen N, Ilyas H, Neeraja C, Das KP, Mandal AK, Bhunia A. Inhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: Mechanistic Details Studied by Spectroscopy in Combination with Microscopy. The Journal of Biological Chemistry. PMID 27679488 DOI: 10.1074/Jbc.M116.742460  0.64
2016 Pithadia A, Brender JR, Fierke CA, Ramamoorthy A. Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives. Journal of Diabetes Research. 2016: 2046327. PMID 26649317 DOI: 10.1155/2016/2046327  1
2015 Brender JR, Zhang Y. Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles. Plos Computational Biology. 11: e1004494. PMID 26506533 DOI: 10.1371/Journal.Pcbi.1004494  1
2015 Kotler SA, Brender JR, Vivekanandan S, Suzuki Y, Yamamoto K, Monette M, Krishnamoorthy J, Walsh P, Cauble M, Holl MM, Marsh EN, Ramamoorthy A. High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification. Scientific Reports. 5: 11811. PMID 26138908 DOI: 10.1038/Srep11811  1
2015 Chan WK, Zhang H, Yang J, Brender JR, Hur J, Özgür A, Zhang Y. GLASS: a comprehensive database for experimentally validated GPCR-ligand associations. Bioinformatics (Oxford, England). PMID 25971743 DOI: 10.1093/Bioinformatics/Btv302  1
2015 Brender JR, Krishnamoorthy J, Sciacca MF, Vivekanandan S, D'Urso L, Chen J, La Rosa C, Ramamoorthy A. Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP. The Journal of Physical Chemistry. B. 119: 2886-96. PMID 25645610 DOI: 10.1021/Jp511758W  1
2015 Du H, Brender JR, Zhang J, Zhang Y. Protein structure prediction provides comparable performance to crystallographic structures in docking-based virtual screening. Methods (San Diego, Calif.). 71: 77-84. PMID 25220914 DOI: 10.1016/J.Ymeth.2014.08.017  1
2014 Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In Search of Aggregation Pathways of IAPP and Other Amyloidogenic Proteins: Finding Answers through NMR Spectroscopy. The Journal of Physical Chemistry Letters. 5: 1864-70. PMID 26273866 DOI: 10.1021/Jz5001775  1
2014 DeToma AS, Krishnamoorthy J, Nam Y, Lee HJ, Brender JR, Kochi A, Lee D, Onnis V, Congiu C, Manfredini S, Vertuani S, Balboni G, Ramamoorthy A, Lim MH. Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species. Chemical Science. 5: 4851-4862. PMID 25383163 DOI: 10.1039/C4Sc01531B  1
2014 Kotler SA, Walsh P, Brender JR, Ramamoorthy A. Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease. Chemical Society Reviews. 43: 6692-700. PMID 24464312 DOI: 10.1039/C3Cs60431D  1
2014 Lee S, Zheng X, Krishnamoorthy J, Savelieff MG, Park HM, Brender JR, Kim JH, Derrick JS, Kochi A, Lee HJ, Kim C, Ramamoorthy A, Bowers MT, Lim MH. Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. Journal of the American Chemical Society. 136: 299-310. PMID 24397771 DOI: 10.1021/Ja409801P  1
2014 Zhao J, Hu R, Sciacca MF, Brender JR, Chen H, Ramamoorthy A, Zheng J. Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels. Physical Chemistry Chemical Physics : Pccp. 16: 2368-77. PMID 24352606 DOI: 10.1039/C3Cp53345J  1
2014 Patel HR, Pithadia AS, Brender JR, Fierke CA, Ramamoorthy A. In search of aggregation pathways of IAPP and other amyloidogenic proteins: Finding answers through NMR spectroscopy Journal of Physical Chemistry Letters. 5: 1864-1870. DOI: 10.1021/jz5001775  1
2013 Mitra P, Shultis D, Brender JR, Czajka J, Marsh D, Gray F, Cierpicki T, Zhang Y. An evolution-based approach to De Novo protein design and case study on Mycobacterium tuberculosis. Plos Computational Biology. 9: e1003298. PMID 24204234 DOI: 10.1371/Journal.Pcbi.1003298  1
2013 Hartman K, Brender JR, Monde K, Ono A, Evans ML, Popovych N, Chapman MR, Ramamoorthy A. Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences. Peerj. 1: e5. PMID 23638387 DOI: 10.7717/Peerj.5  1
2013 Lee DK, Brender JR, Sciacca MF, Krishnamoorthy J, Yu C, Ramamoorthy A. Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78). Biochemistry. 52: 3254-63. PMID 23590672 DOI: 10.1021/Bi400087N  1
2013 Brender JR, Krishnamoorthy J, Messina GM, Deb A, Vivekanandan S, La Rosa C, Penner-Hahn JE, Ramamoorthy A. Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide. Chemical Communications (Cambridge, England). 49: 3339-41. PMID 23505632 DOI: 10.1039/C3Cc40383A  1
2013 Brender JR, Heyl DL, Samisetti S, Kotler SA, Osborne JM, Pesaru RR, Ramamoorthy A. Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragments. Physical Chemistry Chemical Physics : Pccp. 15: 8908-15. PMID 23493863 DOI: 10.1039/C3Cp44696D  1
2013 Suzuki Y, Brender JR, Soper MT, Krishnamoorthy J, Zhou Y, Ruotolo BT, Kotov NA, Ramamoorthy A, Marsh EN. Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR. Biochemistry. 52: 1903-12. PMID 23445400 DOI: 10.1021/Bi400027Y  1
2013 Hyung SJ, DeToma AS, Brender JR, Lee S, Vivekanandan S, Kochi A, Choi JS, Ramamoorthy A, Ruotolo BT, Lim MH. Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Proceedings of the National Academy of Sciences of the United States of America. 110: 3743-8. PMID 23426629 DOI: 10.1073/Pnas.1220326110  1
2013 Sciacca MF, Milardi D, Messina GM, Marletta G, Brender JR, Ramamoorthy A, La Rosa C. Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP. Biophysical Journal. 104: 173-84. PMID 23332070 DOI: 10.1016/J.Bpj.2012.11.3811  1
2013 Mitra P, Shultis D, Brender JR, Czajka J, Marsh D, Gray F, Cierpicki T, Zhang Y. Illustrative examples of the EBM design on M. tuberculosis proteins. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1003298.G006  1
2012 Krishnamoorthy J, Brender JR, Vivekanandan S, Jahr N, Ramamoorthy A. Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers. The Journal of Physical Chemistry. B. 116: 13618-23. PMID 23116141 DOI: 10.1021/Jp305279W  1
2012 Suzuki Y, Brender JR, Hartman K, Ramamoorthy A, Marsh EN. Alternative pathways of human islet amyloid polypeptide aggregation distinguished by (19)f nuclear magnetic resonance-detected kinetics of monomer consumption. Biochemistry. 51: 8154-62. PMID 22998665 DOI: 10.1021/Bi3012548  1
2012 Sciacca MF, Brender JR, Lee DK, Ramamoorthy A. Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry. 51: 7676-84. PMID 22970795 DOI: 10.1021/bi3009888  1
2012 Sciacca MF, Kotler SA, Brender JR, Chen J, Lee DK, Ramamoorthy A. Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophysical Journal. 103: 702-10. PMID 22947931 DOI: 10.1016/J.Bpj.2012.06.045  1
2012 McHenry AJ, Sciacca MF, Brender JR, Ramamoorthy A. Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes? Biochimica Et Biophysica Acta. 1818: 3019-24. PMID 22885355 DOI: 10.1016/J.Bbamem.2012.07.021  1
2012 Brender JR, McHenry AJ, Ramamoorthy A. Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides? Frontiers in Immunology. 3: 195. PMID 22822405 DOI: 10.3389/Fimmu.2012.00195  1
2012 Popovych N, Brender JR, Soong R, Vivekanandan S, Hartman K, Basrur V, Macdonald PM, Ramamoorthy A. Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286). The Journal of Physical Chemistry. B. 116: 3650-8. PMID 22360607 DOI: 10.1021/Jp2121577  1
2012 Huang R, Vivekanandan S, Brender JR, Abe Y, Naito A, Ramamoorthy A. NMR characterization of monomeric and oligomeric conformations of human calcitonin and its interaction with EGCG. Journal of Molecular Biology. 416: 108-20. PMID 22200484 DOI: 10.1016/J.Jmb.2011.12.023  1
2012 Brender JR, Salamekh S, Ramamoorthy A. Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective. Accounts of Chemical Research. 45: 454-62. PMID 21942864 DOI: 10.1021/Ar200189B  1
2012 Popovych N, Brender J, Soong R, Vivekanandan S, Hartman K, Basrur V, MacDonald P, Ramamoorthy A. Backbone and sidechain 1H chemical shifts for PAP248-286 (SEVI) in solution at pH 6 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr18287  1
2011 Vivekanandan S, Brender JR, Lee SY, Ramamoorthy A. A partially folded structure of amyloid-beta(1-40) in an aqueous environment. Biochemical and Biophysical Research Communications. 411: 312-6. PMID 21726530 DOI: 10.1016/J.Bbrc.2011.06.133  1
2011 Nanga RP, Brender JR, Vivekanandan S, Ramamoorthy A. Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment. Biochimica Et Biophysica Acta. 1808: 2337-42. PMID 21723249 DOI: 10.1016/J.Bbamem.2011.06.012  1
2011 Salamekh S, Brender JR, Hyung SJ, Nanga RP, Vivekanandan S, Ruotolo BT, Ramamoorthy A. A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc. Journal of Molecular Biology. 410: 294-306. PMID 21616080 DOI: 10.1016/J.Jmb.2011.05.015  1
2011 Yoo SI, Yang M, Brender JR, Subramanian V, Sun K, Joo NE, Jeong SH, Ramamoorthy A, Kotov NA. Inhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteins. Angewandte Chemie (International Ed. in English). 50: 5110-5. PMID 21495130 DOI: 10.1002/Anie.201007824  1
2011 Brender JR, Lee EL, Hartman K, Wong PT, Ramamoorthy A, Steel DG, Gafni A. Biphasic effects of insulin on islet amyloid polypeptide membrane disruption. Biophysical Journal. 100: 685-92. PMID 21281583 DOI: 10.1016/J.Bpj.2010.09.070  1
2011 Brender JR, Nanga RP, Popovych N, Soong R, Macdonald PM, Ramamoorthy A. The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency. Biochimica Et Biophysica Acta. 1808: 1161-9. PMID 21262195 DOI: 10.1016/J.Bbamem.2011.01.010  1
2011 Zimmerman LB, Worley BV, Palermo EF, Brender JR, Lee KD, Kuroda K, Ramamoorthy A, Meyerhoff ME. Absorbance-based assay for membrane disruption by antimicrobial peptides and synthetic copolymers using pyrroloquinoline quinone-loaded liposomes. Analytical Biochemistry. 411: 194-9. PMID 21237129 DOI: 10.1016/J.Ab.2011.01.009  1
2010 Brender JR, Hartman K, Nanga RP, Popovych N, de la Salud Bea R, Vivekanandan S, Marsh EN, Ramamoorthy A. Role of zinc in human islet amyloid polypeptide aggregation. Journal of the American Chemical Society. 132: 8973-83. PMID 20536124 DOI: 10.1021/Ja1007867  1
2010 Smith PE, Brender JR, Dürr UH, Xu J, Mullen DG, Banaszak Holl MM, Ramamoorthy A. Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes. Journal of the American Chemical Society. 132: 8087-97. PMID 20481633 DOI: 10.1021/Ja101524Z  1
2009 Nanga RP, Brender JR, Vivekanandan S, Popovych N, Ramamoorthy A. NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286). Journal of the American Chemical Society. 131: 17972-9. PMID 19995078 DOI: 10.1021/Ja908170S  1
2009 Brender JR, Hartman K, Gottler LM, Cavitt ME, Youngstrom DW, Ramamoorthy A. Helical conformation of the SEVI precursor peptide PAP248-286, a dramatic enhancer of HIV infectivity, promotes lipid aggregation and fusion. Biophysical Journal. 97: 2474-83. PMID 19883590 DOI: 10.1016/J.Bpj.2009.08.034  1
2009 Nanga RP, Brender JR, Xu J, Hartman K, Subramanian V, Ramamoorthy A. Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. Journal of the American Chemical Society. 131: 8252-61. PMID 19456151 DOI: 10.1021/Ja9010095  1
2009 Soong R, Brender JR, Macdonald PM, Ramamoorthy A. Association of highly compact type II diabetes related islet amyloid polypeptide intermediate species at physiological temperature revealed by diffusion NMR spectroscopy. Journal of the American Chemical Society. 131: 7079-85. PMID 19405534 DOI: 10.1021/Ja900285Z  1
2009 Smith PE, Brender JR, Ramamoorthy A. Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide. Journal of the American Chemical Society. 131: 4470-8. PMID 19278224 DOI: 10.1021/Ja809002A  1
2009 Barry J, Fritz M, Brender JR, Smith PE, Lee DK, Ramamoorthy A. Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. Journal of the American Chemical Society. 131: 4490-8. PMID 19256547 DOI: 10.1021/Ja809217U  1
2008 Brender JR, Hartman K, Reid KR, Kennedy RT, Ramamoorthy A. A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity. Biochemistry. 47: 12680-8. PMID 18989933 DOI: 10.1021/Bi801427C  1
2008 Nanga RP, Brender JR, Xu J, Veglia G, Ramamoorthy A. Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy. Biochemistry. 47: 12689-97. PMID 18989932 DOI: 10.1021/Bi8014357  1
2008 Brender JR, Lee EL, Cavitt MA, Gafni A, Steel DG, Ramamoorthy A. Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide. Journal of the American Chemical Society. 130: 6424-9. PMID 18444645 DOI: 10.1021/Ja710484D  1
2007 Brender JR, Dürr UH, Heyl D, Budarapu MB, Ramamoorthy A. Membrane fragmentation by an amyloidogenic fragment of human Islet Amyloid Polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes. Biochimica Et Biophysica Acta. 1768: 2026-9. PMID 17662957 DOI: 10.1016/J.Bbamem.2007.07.001  1
2005 Brender JR, Dertouzos J, Ballou DP, Massey V, Palfey BA, Entsch B, Steel DG, Gafni A. Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies. Journal of the American Chemical Society. 127: 18171-8. PMID 16366570 DOI: 10.1021/Ja055171O  1
2001 Brender JR, Taylor DM, Ramamoorthy A. Orientation of amide-nitrogen-15 chemical shift tensors in peptides: a quantum chemical study. Journal of the American Chemical Society. 123: 914-22. PMID 11456625 DOI: 10.1021/Ja001980Q  1
2001 Wang L, Pang Y, Holder T, Brender JR, Kurochkin AV, Zuiderweg ER. Functional dynamics in the active site of the ribonuclease binase. Proceedings of the National Academy of Sciences of the United States of America. 98: 7684-9. PMID 11438724 DOI: 10.1073/Pnas.121069998  1
Show low-probability matches.