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James R. Fuchs, Ph.D. - Publications

Affiliations: 
Pennsylvania State University, State College, PA, United States 
 2007- Medicinal Chemistry and Pharmacognosy Ohio State University, Columbus, Columbus, OH 
Area:
Natural products synthesis
Website:
http://pharmacy.osu.edu/faculty-staff/users/fuchs42

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR. Indole-based allosteric inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters. PMID 27568085 DOI: 10.1016/j.bmcl.2016.08.037  1
2015 Yan J, Wang Q, Zou K, Wang L, Schwartz EB, Fuchs JR, Zheng Z, Wu J. Inhibition of the JAK2/STAT3 signaling pathway exerts a therapeutic effect on osteosarcoma. Molecular Medicine Reports. 12: 498-502. PMID 25760445 DOI: 10.3892/mmr.2015.3439  1
2015 Ren Y, Yuan C, Deng Y, Kanagasabai R, Ninh TN, Tu VT, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Kinghorn AD. Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis. Phytochemistry. 111: 132-40. PMID 25596805 DOI: 10.1016/j.phytochem.2014.12.014  1
2015 Luo S, Kang HS, Krunic A, Chen WL, Yang J, Woodard JL, Fuchs JR, Hyun Cho S, Franzblau SG, Swanson SM, Orjala J. Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscillatoria sp. UIC 10045 Bioorganic and Medicinal Chemistry. DOI: 10.1016/j.bmc.2015.04.073  1
2014 Luo S, Krunic A, Kang HS, Chen WL, Woodard JL, Fuchs JR, Swanson SM, Orjala J. Trichormamides A and B with Antiproliferative Activity from the Cultured Freshwater Cyanobacterium Trichormus sp. UIC 10339. Journal of Natural Products. PMID 25089652 DOI: 10.1021/np5003548  1
2014 Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. Journal of Virology. 88: 9704-17. PMID 24942577 DOI: 10.1128/JVI.01397-14  1
2014 Ren Y, Lantvit DD, Deng Y, Kanagasabai R, Gallucci JC, Ninh TN, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Swanson SM, Kinghorn AD. Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei. Journal of Natural Products. 77: 1494-504. PMID 24937209 DOI: 10.1021/np5002785  1
2014 Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. American Journal of Translational Research. 6: 236-47. PMID 24936217  1
2014 Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. Plos Pathogens. 10: e1004171. PMID 24874515 DOI: 10.1371/journal.ppat.1004171  1
2014 Pan L, Woodard JL, Lucas DM, Fuchs JR, Kinghorn AD. Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species. Natural Product Reports. 31: 924-39. PMID 24788392 DOI: 10.1039/c4np00006d  1
2014 Wu J, Patmore DM, Jousma E, Eaves DW, Breving K, Patel AV, Schwartz EB, Fuchs JR, Cripe TP, Stemmer-Rachamimov AO, Ratner N. EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene. 33: 173-80. PMID 23318430 DOI: 10.1038/onc.2012.579  1
2013 Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, Fuchs JR, Eubank TD, Frankel WL, Bekaii-Saab T, Bloomston M, Lesinski GB. Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Research. 73: 3007-18. PMID 23514705 DOI: 10.1158/0008-5472.CAN-12-4601  1
2013 Pan L, Acuña UM, Li J, Jena N, Ninh TN, Pannell CM, Chai H, Fuchs JR, Carcache de Blanco EJ, Soejarto DD, Kinghorn AD. Bioactive flavaglines and other constituents isolated from Aglaia perviridis. Journal of Natural Products. 76: 394-404. PMID 23301897 DOI: 10.1021/np3007588  1
2012 Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM. Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi. Methods in Molecular Biology (Clifton, N.J.). 944: 267-77. PMID 23065624 DOI: 10.1007/978-1-62703-122-6_20  1
2012 Bill MA, Nicholas C, Mace TA, Etter JP, Li C, Schwartz EB, Fuchs JR, Young GS, Lin L, Lin J, He L, Phelps M, Li PK, Lesinski GB. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. Plos One. 7: e40724. PMID 22899991 DOI: 10.1371/journal.pone.0040724  1
2012 Pan L, Lezama-Davila CM, Isaac-Marquez AP, Calomeni EP, Fuchs JR, Satoskar AR, Kinghorn AD. Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii. Phytochemistry. 82: 128-35. PMID 22840389 DOI: 10.1016/j.phytochem.2012.06.012  1
2012 Onimoe GI, Liu A, Lin L, Wei CC, Schwartz EB, Bhasin D, Li C, Fuchs JR, Li PK, Houghton P, Termuhlen A, Gross T, Lin J. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational New Drugs. 30: 916-26. PMID 21340507 DOI: 10.1007/s10637-011-9645-1  1
2011 Abuzeid WM, Davis S, Tang AL, Saunders L, Brenner JC, Lin J, Fuchs JR, Light E, Bradford CR, Prince ME, Carey TE. Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog. Archives of Otolaryngology--Head & Neck Surgery. 137: 499-507. PMID 21576562 DOI: 10.1001/archoto.2011.63  1
2011 Fossey SL, Bear MD, Lin J, Li C, Schwartz EB, Li PK, Fuchs JR, Fenger J, Kisseberth WC, London CA. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. Bmc Cancer. 11: 112. PMID 21443800 DOI: 10.1186/1471-2407-11-112  1
2011 Ren Y, Matthew S, Lantvit DD, Ninh TN, Chai H, Fuchs JR, Soejarto DD, de Blanco EJ, Swanson SM, Kinghorn AD. Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues. Journal of Natural Products. 74: 1117-25. PMID 21428375 DOI: 10.1021/np200051j  1
2011 Wei CC, Ball S, Lin L, Liu A, Fuchs JR, Li PK, Li C, Lin J. Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells. International Journal of Oncology. 38: 279-85. PMID 21109950 DOI: 10.3892/ijo-00000848  1
2010 Vijaya Saradhi UV, Ling Y, Wang J, Chiu M, Schwartz EB, Fuchs JR, Chan KK, Liu Z. A liquid chromatography-tandem mass spectrometric method for quantification of curcuminoids in cell medium and mouse plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 878: 3045-51. PMID 20934924 DOI: 10.1016/j.jchromb.2010.08.039  1
2010 Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE, Li PK, Lesinski GB. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular Cancer. 9: 165. PMID 20576164 DOI: 10.1186/1476-4598-9-165  1
2009 Cen L, Hutzen B, Ball S, DeAngelis S, Chen CL, Fuchs JR, Li C, Li PK, Lin J. New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells. Bmc Cancer. 9: 99. PMID 19331692 DOI: 10.1186/1471-2407-9-99  1
2009 Fuchs JR, Pandit B, Bhasin D, Etter JP, Regan N, Abdelhamid D, Li C, Lin J, Li PK. Structure-activity relationship studies of curcumin analogues. Bioorganic & Medicinal Chemistry Letters. 19: 2065-9. PMID 19249204 DOI: 10.1016/j.bmcl.2009.01.104  1
2009 Liu Z, Liu S, Xie Z, Pavlovicz RE, Wu J, Chen P, Aimiuwu J, Pang J, Bhasin D, Neviani P, Fuchs JR, Plass C, Li PK, Li C, Huang TH, et al. Modulation of DNA methylation by a sesquiterpene lactone parthenolide. The Journal of Pharmacology and Experimental Therapeutics. 329: 505-14. PMID 19201992 DOI: 10.1124/jpet.108.147934  1
2009 Liu Z, Xie Z, Jones W, Pavlovicz RE, Liu S, Yu J, Li PK, Lin J, Fuchs JR, Marcucci G, Li C, Chan KK. Curcumin is a potent DNA hypomethylation agent. Bioorganic & Medicinal Chemistry Letters. 19: 706-9. PMID 19112019 DOI: 10.1016/j.bmcl.2008.12.041  1
2006 Elliott GI, Fuchs JR, Blagg BS, Ishikawa H, Tao H, Yuan ZQ, Boger DL. Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 128: 10589-95. PMID 16895427 DOI: 10.1021/ja0612549  1
2005 Fuchs JR, Funk RL. Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of (+/-)-flustramines A and C. Organic Letters. 7: 677-80. PMID 15704923 DOI: 10.1021/ol047532v  1
2004 Fuchs JR, Funk RL. Total synthesis of (+/-)-perophoramidine. Journal of the American Chemical Society. 126: 5068-9. PMID 15099080 DOI: 10.1021/ja049569g  1
2001 Fuchs JR, Funk RL. Total synthesis of (+/-)-lennoxamine and (+/-)-aphanorphine by intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins. Organic Letters. 3: 3923-5. PMID 11720570 DOI: 10.1021/ol016795b  1
2001 Fuchs JR, Funk RL. Intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins: a new method for the preparation of tetrahydroisoquinolines, tetrahydro-3-benzazepines, and hexahydro-3-benzazocines. Organic Letters. 3: 3349-51. PMID 11594831 DOI: 10.1021/ol016592n  1
2000 Miller RS, Sealy JM, Shabangi M, Kuhlman ML, Fuchs JR, Flowers RA. Reactions of SmI2 with alkyl halides and ketones: Inner-sphere vs outer-sphere electron transfer in reactions of Sm(II) reductants Journal of the American Chemical Society. 122: 7718-7722. DOI: 10.1021/ja001260j  1
1998 Shabangi M, Sealy JM, Fuchs JR, Flowers RA. The effect of cosolvent on the reducing power of SmI2 in tetrahydrofuran Tetrahedron Letters. 39: 4429-4432. DOI: 10.1016/S0040-4039(98)00839-9  1
1997 Fuchs JR, Mitchell ML, Shabangi M, Flowers RA. The effect of lithium bromide and lithium chloride on the reactivity of SmI2 in THF Tetrahedron Letters. 38: 8157-8158.  1
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