Cyrus Michael Ghajar - Publications

Affiliations: 
Fred Hutchinson Cancer Research Center, Seattle, WA, United States 

23/61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Goddard ET, Linde MH, Srivastava S, Klug G, Shabaneh TB, Iannone S, Grzelak CA, Marsh S, Riggio AI, Shor RE, Linde IL, Guerrero M, Veatch JR, Snyder AG, Welm AL, ... ... Ghajar CM, et al. Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies. Cancer Cell. 42: 119-134.e12. PMID 38194912 DOI: 10.1016/j.ccell.2023.12.011  0.752
2022 Germanos AA, Arora S, Zheng Y, Goddard ET, Coleman IM, Ku AT, Wilkinson S, Song H, Brady NJ, Amezquita RA, Zager M, Long A, Yang YC, Bielas JH, Gottardo R, ... ... Ghajar CM, et al. Defining cellular population dynamics at single-cell resolution during prostate cancer progression. Elife. 11. PMID 36511483 DOI: 10.7554/eLife.79076  0.752
2021 Grzelak CA, Goddard ET, Lederer EE, Rajaram K, Dai J, Shor RE, Lim AR, Kim J, Beronja S, Funnell APW, Ghajar CM. Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings. Cancer Cell. PMID 34861158 DOI: 10.1016/j.ccell.2021.11.004  0.702
2021 Lim AR, Ghajar CM. Thorny ground, rocky soil: tissue-specific mechanisms of tumor dormancy and relapse. Seminars in Cancer Biology. PMID 33979673 DOI: 10.1016/j.semcancer.2021.05.007  0.306
2019 Carlson P, Dasgupta A, Grzelak CA, Kim J, Barrett A, Coleman IM, Shor RE, Goddard ET, Dai J, Schweitzer EM, Lim AR, Crist SB, Cheresh DA, Nelson PS, Hansen KC, ... Ghajar CM, et al. Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy. Nature Cell Biology. PMID 30664790 DOI: 10.1038/S41556-018-0267-0  0.766
2018 Goddard ET, Bozic I, Riddell SR, Ghajar CM. Dormant tumour cells, their niches and the influence of immunity. Nature Cell Biology. 20: 1240-1249. PMID 30361702 DOI: 10.1038/S41556-018-0214-0  0.734
2017 Dasgupta A, Lim AR, Ghajar CM. Circulating and disseminated tumor cells: harbingers or initiators of metastasis? Molecular Oncology. 11: 40-61. PMID 28085223 DOI: 10.1002/1878-0261.12022  0.347
2013 Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, Chen EI, Lyden D, Bissell MJ. The perivascular niche regulates breast tumour dormancy. Nature Cell Biology. 15: 807-17. PMID 23728425 DOI: 10.1038/Ncb2767  0.321
2013 Ghosh S, Ashcraft K, Jahid MJ, April C, Ghajar CM, Ruan J, Wang H, Foster M, Hughes DC, Ramirez AG, Huang T, Fan JB, Hu Y, Li R. Regulation of adipose oestrogen output by mechanical stress. Nature Communications. 4: 1821. PMID 23652009 DOI: 10.1038/Ncomms2794  0.352
2013 Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ. Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development (Cambridge, England). 140: 343-52. PMID 23250208 DOI: 10.1242/Jcs.130054  0.417
2012 Bissell MJ, Ghajar CM, Lee LP. From single cells to biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 357-9. PMID 22436976 DOI: 10.1039/C2Ib90010F  0.349
2011 Alcaraz J, Mori H, Ghajar CM, Brownfield D, Galgoczy R, Bissell MJ. Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 1153-66. PMID 21993836 DOI: 10.1039/C1Ib00073J  0.384
2010 Carrion B, Huang CP, Ghajar CM, Kachgal S, Kniazeva E, Jeon NL, Putnam AJ. Recreating the perivascular niche ex vivo using a microfluidic approach. Biotechnology and Bioengineering. 107: 1020-8. PMID 20672286 DOI: 10.1002/Bit.22891  0.609
2010 Ghajar CM, Kachgal S, Kniazeva E, Mori H, Costes SV, George SC, Putnam AJ. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Experimental Cell Research. 316: 813-25. PMID 20067788 DOI: 10.1016/J.Yexcr.2010.01.013  0.743
2009 Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ, Bissell M, Boudreau N. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Research. 69: 6721-9. PMID 19654314 DOI: 10.1158/0008-5472.Can-08-4069  0.413
2009 Chen X, Aledia AS, Ghajar CM, Griffith CK, Putnam AJ, Hughes CC, George SC. Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Engineering. Part A. 15: 1363-71. PMID 18976155 DOI: 10.1089/Ten.Tea.2008.0314  0.631
2008 Ghajar CM, Bissell MJ. Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochemistry and Cell Biology. 130: 1105-18. PMID 19009245 DOI: 10.1007/S00418-008-0537-1  0.375
2008 Ghajar CM, George SC, Putnam AJ. Matrix metalloproteinase control of capillary morphogenesis. Critical Reviews in Eukaryotic Gene Expression. 18: 251-78. PMID 18540825 DOI: 10.1615/Critreveukargeneexpr.V18.I3.30  0.657
2008 Peyton SR, Kim PD, Ghajar CM, Seliktar D, Putnam AJ. The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system. Biomaterials. 29: 2597-607. PMID 18342366 DOI: 10.1016/J.Biomaterials.2008.02.005  0.756
2008 Ghajar CM, Chen X, Harris JW, Suresh V, Hughes CC, Jeon NL, Putnam AJ, George SC. The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophysical Journal. 94: 1930-41. PMID 17993494 DOI: 10.1529/Biophysj.107.120774  0.648
2007 Peyton SR, Ghajar CM, Khatiwala CB, Putnam AJ. The emergence of ECM mechanics and cytoskeletal tension as important regulators of cell function. Cell Biochemistry and Biophysics. 47: 300-20. PMID 17652777 DOI: 10.1007/S12013-007-0004-Y  0.744
2007 Ghajar CM, Suresh V, Peyton SR, Raub CB, Meyskens FL, George SC, Putnam AJ. A novel three-dimensional model to quantify metastatic melanoma invasion. Molecular Cancer Therapeutics. 6: 552-61. PMID 17267658 DOI: 10.1158/1535-7163.Mct-06-0593  0.752
2006 Ghajar CM, Blevins KS, Hughes CC, George SC, Putnam AJ. Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue Engineering. 12: 2875-88. PMID 17518656 DOI: 10.1089/Ten.2006.12.2875  0.705
Low-probability matches (unlikely to be authored by this person)
2015 Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, ... ... Ghajar CM, et al. Tumour exosome integrins determine organotropic metastasis. Nature. PMID 26524530 DOI: 10.1038/Nature15756  0.299
2016 Ghajar CM, Bissell MJ. Metastasis: Pathways of parallel progression. Nature. PMID 27974802 DOI: 10.1038/Nature21104  0.296
2017 Grzelak CA, Ghajar CM. Metastasis 'systems' biology: how are macro-environmental signals transmitted into microenvironmental cues for disseminated tumor cells? Current Opinion in Cell Biology. 48: 79-86. PMID 28715713 DOI: 10.1016/j.ceb.2017.06.002  0.293
2022 Lyden D, Ghajar CM, Correia AL, Aguirre-Ghiso JA, Cai S, Rescigno M, Zhang P, Hu G, Fendt SM, Boire A, Weichselbaum RR, Katipally RR. Metastasis. Cancer Cell. 40: 787-791. PMID 35944497 DOI: 10.1016/j.ccell.2022.07.010  0.287
2017 Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, ... Ghajar CM, et al. Pre-metastatic niches: organ-specific homes for metastases. Nature Reviews. Cancer. PMID 28303905 DOI: 10.1038/Nrc.2017.6  0.272
2020 Crist SB, Ghajar CM. When a House Is Not a Home: A Survey of Antimetastatic Niches and Potential Mechanisms of Disseminated Tumor Cell Suppression. Annual Review of Pathology. PMID 33276706 DOI: 10.1146/annurev-pathmechdis-012419-032647  0.267
2011 Furuta S, Ghajar CM, Bissell MJ. Caveolin-1: would-be Achilles' heel of tumor microenvironment? Cell Cycle (Georgetown, Tex.). 10: 3431. PMID 22030625 DOI: 10.4161/Cc.10.20.17648  0.258
2021 Dai J, Cimino PJ, Gouin KH, Grzelak CA, Barrett A, Lim AR, Long A, Weaver S, Saldin LT, Uzamere A, Schulte V, Clegg N, Pisarsky L, Lyden D, Bissell MJ, ... ... Ghajar CM, et al. Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain. Nature Cancer. 3: 25-42. PMID 35121993 DOI: 10.1038/s43018-021-00297-3  0.256
2012 Peinado H, Ale?kovi? M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature Medicine. 18: 883-91. PMID 22635005 DOI: 10.1038/Nm.2753  0.25
2011 Matei I, Ghajar CM, Lyden D. A TeNaCious foundation for the metastatic niche. Cancer Cell. 20: 139-41. PMID 21840480 DOI: 10.1016/J.Ccr.2011.08.004  0.248
2019 Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tešić Mark M, Dill BD, ... ... Ghajar CM, et al. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nature Cell Biology. PMID 31685984 DOI: 10.1038/S41556-019-0404-4  0.247
2010 Ghajar CM, Bissell MJ. Tumor engineering: the other face of tissue engineering. Tissue Engineering. Part A. 16: 2153-6. PMID 20214448 DOI: 10.1089/Ten.Tea.2010.0135  0.246
2015 Ghajar CM. Metastasis prevention by targeting the dormant niche. Nature Reviews. Cancer. 15: 238-47. PMID 25801619 DOI: 10.1038/nrc3910  0.245
2016 Peinado H, Alecˇković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar CM, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, et al. Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature Medicine. 22: 1502. PMID 27923027 DOI: 10.1038/Nm1216-1502B  0.235
2021 Shor RE, Dai J, Lee SY, Pisarsky L, Matei I, Lucotti S, Lyden D, Bissell MJ, Ghajar CM. The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Molecular Oncology. PMID 34058066 DOI: 10.1002/1878-0261.13031  0.207
2014 Weigelt B, Ghajar CM, Bissell MJ. The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer. Advanced Drug Delivery Reviews. 69: 42-51. PMID 24412474 DOI: 10.1016/J.Addr.2014.01.001  0.189
2012 Mori H, Borowsky AD, Bhat R, Ghajar CM, Seiki M, Bissell MJ. Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues. The American Journal of Pathology. 180: 2249-56. PMID 22542846 DOI: 10.1016/J.Ajpath.2012.02.032  0.187
2014 Ghajar CM, Correia AL, Bissell MJ. The Role of the Microenvironment in Tumor Initiation, Progression, and Metastasis The Molecular Basis of Cancer: Fourth Edition. 239-256.e5. DOI: 10.1016/B978-1-4557-4066-6.00016-0  0.178
2018 Pisarsky L, Ghajar CM. Anti-angiogenic Therapy-Mediated Endothelial Damage: A Driver of Breast Cancer Recurrence? Advances in Experimental Medicine and Biology. 1100: 19-45. PMID 30411258 DOI: 10.1007/978-3-319-97746-1_2  0.174
2022 Crist SB, Nemkov T, Dumpit RF, Dai J, Tapscott SJ, True LD, Swarbrick A, Sullivan LB, Nelson PS, Hansen KC, Ghajar CM. Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells. Nature Cell Biology. PMID 35411081 DOI: 10.1038/s41556-022-00881-4  0.17
2014 Ghajar CM. A stiffness-mediated oncogenic hammer. Science Translational Medicine. 6: 237fs21. PMID 24848253 DOI: 10.1126/scitranslmed.3009154  0.167
2020 Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, ... ... Ghajar CM, et al. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. PMID 32795414 DOI: 10.1016/J.Cell.2020.07.009  0.154
2023 Grzelak CA, Ghajar CM. Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele. Immunohorizons. 7: 64-70. PMID 36637515 DOI: 10.4049/immunohorizons.2200101  0.145
2017 Pisarsky L, Dai J, Ghajar CM. Taking inventory of metastasis effectors. Nature Medicine. 23: 275-276. PMID 28267712 DOI: 10.1038/nm.4301  0.144
2013 Ghajar CM. Keeping metastasis at bay Science Translational Medicine. 5. DOI: 10.1126/scitranslmed.3006621  0.126
2013 Ghajar CM. Lucky VII? A dual role for collagen in wound healing Science Translational Medicine. 5. DOI: 10.1126/scitranslmed.3006925  0.124
2022 Crist SB, Nemkov T, Dumpit RF, Dai J, Tapscott SJ, True LD, Swarbrick A, Sullivan LB, Nelson PS, Hansen KC, Ghajar CM. Publisher Correction: Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells. Nature Cell Biology. PMID 35610516 DOI: 10.1038/s41556-022-00945-5  0.122
2013 Ghajar CM. A one-man show: Glioblastoma constructs its own niche Science Translational Medicine. 5. DOI: 10.1126/scitranslmed.3006348  0.117
2012 Ghajar CM. On leukocytes in mammary development and cancer. Cold Spring Harbor Perspectives in Biology. 4. PMID 22550234 DOI: 10.1101/cshperspect.a013276  0.094
2013 Ghajar CM. Perivascular niche: A jagged edge to cancer chemoresistance Science Translational Medicine. 5. DOI: 10.1126/scitranslmed.3006076  0.093
2018 Crist SB, Ghajar CM. Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer. Cell Systems. 6: 268-270. PMID 29596781 DOI: 10.1016/j.cels.2018.03.005  0.089
2009 Ghajar CM, Meier R, Bissell MJ. Quis custodiet ipsos custodies: who watches the watchmen? The American Journal of Pathology. 174: 1996-9. PMID 19465642 DOI: 10.2353/Ajpath.2009.090363  0.085
2019 Grzelak CA, Ghajar CM. Illuminating MSK1's role in tumour dormancy. Nature Cell Biology. 20: 124-126. PMID 29371707 DOI: 10.1038/s41556-018-0035-1  0.077
2013 Ghajar CM. Cancer: My house is not your house | Cancer: Mi casa no es su casa Science Translational Medicine. 5. DOI: 10.1126/scitranslmed.3007984  0.066
2014 Ghajar CM. A fine line between healing and fibrosis Science Translational Medicine. 6. DOI: 10.1126/scitranslmed.3008648  0.041
2013 Ghajar CM. Creating refuge Science Translational Medicine. 5. DOI: 10.1126/scitranslmed.3007714  0.04
2014 Ghajar CM. Hold the sugar Science Translational Medicine. 6. DOI: 10.1126/scitranslmed.3008245  0.019
2013 Ghajar CM. Nothing but NET Science Translational Medicine. 5: 200ec143-200ec143. DOI: 10.1126/scitranslmed.3007311  0.012
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