Year |
Citation |
Score |
2020 |
Hengst JA, Dick TE, Smith CD, Yun JK. Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA). Cancer Biology & Therapy. 1-12. PMID 32835586 DOI: 10.1080/15384047.2020.1798696 |
0.332 |
|
2020 |
Hengst JA, Hegde S, Paulson RF, Yun JK. Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization. Bioorganic & Medicinal Chemistry Letters. 127453. PMID 32736077 DOI: 10.1016/J.Bmcl.2020.127453 |
0.376 |
|
2017 |
Hengst JA, Dick TE, Sharma A, Doi K, Hegde S, Tan SF, Geffert LM, Fox TE, Sharma AK, Desai D, Amin S, Kester M, Loughran TP, Paulson RF, Claxton DF, et al. SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Translational Medicine. 3: 109-121. PMID 28890935 DOI: 10.4103/Ctm.Ctm_7_17 |
0.312 |
|
2016 |
Desai DH, Kale VP, Hengst JA, Dick TE, Colledge AL, Amin SG, Yun JK. Abstract 4805: In vitro characterization of novel inhibitors of ROCK and MRCK kinases as anticancer agents Cancer Research. 76: 4805-4805. DOI: 10.1158/1538-7445.Am2016-4805 |
0.389 |
|
2016 |
Lee S, Hengst J. DDIS-15. SPECIFIC SPHINGOSINE KINASE 1 INHIBITORS FOR MALIGNANT GLIOMA TREATMENT Neuro-Oncology. 18: vi50-vi50. DOI: 10.1093/Neuonc/Now212.206 |
0.315 |
|
2015 |
LeBlanc FR, Liu X, Hengst J, Fox T, Calvert V, Petricoin EF, Yun J, Feith DJ, Loughran TP. Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. Cancer Biology & Therapy. 0. PMID 26252351 DOI: 10.1080/15384047.2015.1078949 |
0.355 |
|
2015 |
Kale VP, Hengst JA, Desai DH, Amin SG, Yun JK. The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration. Cancer Letters. 361: 185-96. PMID 25796438 DOI: 10.1016/J.Canlet.2015.03.017 |
0.344 |
|
2015 |
Dick TE, Hengst JA, Fox TE, Colledge AL, Kale VP, Sung SS, Sharma A, Amin S, Loughran TP, Kester M, Wang HG, Yun JK. The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. The Journal of Pharmacology and Experimental Therapeutics. 352: 494-508. PMID 25563902 DOI: 10.1124/Jpet.114.219659 |
0.359 |
|
2015 |
Dick TE, Hengst J, Kale V, Colledge A, Yun JK. Abstract 2933: The apoptotic mechanism of action of SKI-178, a novel Sphingosine kinase 1 selective inhibitor Cancer Research. 75: 2933-2933. DOI: 10.1158/1538-7445.Am2015-2933 |
0.389 |
|
2014 |
Kale VP, Hengst JA, Desai DH, Dick TE, Choe KN, Colledge AL, Takahashi Y, Sung SS, Amin SG, Yun JK. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Letters. 354: 299-310. PMID 25172415 DOI: 10.1016/J.Canlet.2014.08.032 |
0.39 |
|
2014 |
Carkaci-Salli N, Salli U, Tekin I, Hengst JA, Zhao MK, Gilman TL, Andrews AM, Vrana KE. Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2. Journal of Neurochemistry. 130: 748-58. PMID 24899127 DOI: 10.1111/Jnc.12779 |
0.341 |
|
2014 |
Kale VP, Desai D, Dick T, Choe K, Colledge A, Amin S, Hengst J, Yun J. Abstract 736: DJ4, a novel ROCK and MRCK inhibitor, potently inhibits migration and invasion of cancer cells Cancer Research. 74: 736-736. DOI: 10.1158/1538-7445.Am2014-736 |
0.38 |
|
2013 |
Barth BM, Shanmugavelandy SS, Kaiser JM, McGovern C, Altınoğlu Eİ, Haakenson JK, Hengst JA, Gilius EL, Knupp SA, Fox TE, Smith JP, Ritty TM, Adair JH, Kester M. PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate. Acs Nano. 7: 2132-44. PMID 23373542 DOI: 10.1021/Nn304862B |
0.369 |
|
2012 |
Hengst JA, Yun JK. Sphingosine kinase: a key to solving the 'French Paradox'? British Journal of Pharmacology. 166: 1603-4. PMID 22335554 DOI: 10.1111/J.1476-5381.2012.01898.X |
0.337 |
|
2012 |
Madhunapantula SV, Hengst J, Gowda R, Fox TE, Yun JK, Robertson GP. Targeting sphingosine kinase-1 to inhibit melanoma. Pigment Cell & Melanoma Research. 25: 259-74. PMID 22236408 DOI: 10.1111/J.1755-148X.2012.00970.X |
0.352 |
|
2011 |
Ali-Rahmani F, Hengst JA, Connor JR, Schengrund CL. Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells. Neurochemical Research. 36: 1687-96. PMID 21243428 DOI: 10.1007/S11064-011-0403-8 |
0.331 |
|
2010 |
Hengst JA, Wang X, Sk UH, Sharma AK, Amin S, Yun JK. Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorganic & Medicinal Chemistry Letters. 20: 7498-502. PMID 21050755 DOI: 10.1016/J.Bmcl.2010.10.005 |
0.341 |
|
2010 |
Karelia N, Desai D, Hengst JA, Amin S, Rudrabhatla SV, Yun J. Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells. Bioorganic & Medicinal Chemistry Letters. 20: 6816-9. PMID 20855208 DOI: 10.1016/J.Bmcl.2010.08.113 |
0.368 |
|
2010 |
Sharma AK, Sk UH, Gimbor MA, Hengst JA, Wang X, Yun J, Amin S. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. European Journal of Medicinal Chemistry. 45: 4149-56. PMID 20598402 DOI: 10.1016/J.Ejmech.2010.06.005 |
0.379 |
|
2010 |
Hengst JA, Guilford JM, Conroy EJ, Wang X, Yun JK. Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus. Archives of Biochemistry and Biophysics. 494: 23-31. PMID 19914200 DOI: 10.1016/J.Abb.2009.11.006 |
0.403 |
|
2010 |
Hengst JA, Wang X, Desai D, Amin S, Yun JK. Abstract B68: EGCG and theaflavin are direct inhibitors of the oncogenic lipid kinase, sphingosine kinase 1 Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-10-B68 |
0.432 |
|
2009 |
Hengst JA, Guilford JM, Fox TE, Wang X, Conroy EJ, Yun JK. Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition. Archives of Biochemistry and Biophysics. 492: 62-73. PMID 19782042 DOI: 10.1016/J.Abb.2009.09.013 |
0.327 |
|
2008 |
Bayerl MG, Bruggeman RD, Conroy EJ, Hengst JA, King TS, Jimenez M, Claxton DF, Yun JK. Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions. Leukemia & Lymphoma. 49: 948-54. PMID 18452097 DOI: 10.1080/10428190801911654 |
0.32 |
|
2007 |
Francy JM, Nag A, Conroy EJ, Hengst JA, Yun JK. Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells. Biochimica Et Biophysica Acta. 1769: 253-65. PMID 17482291 DOI: 10.1016/J.Bbaexp.2007.03.005 |
0.341 |
|
2004 |
Hengst JA, Bond JS. Transport of meprin subunits through the secretory pathway: Role of the transmembrane and cytoplasmic domains and oligomerization Journal of Biological Chemistry. 279: 34856-34864. PMID 15187079 DOI: 10.1074/Jbc.M405774200 |
0.54 |
|
2002 |
Bertenshaw GP, Villa JP, Hengst JA, Bond JS. Probing the active sites and mechanisms of rat metalloproteases meprin A and B Biological Chemistry. 383: 1175-1183. PMID 12437103 DOI: 10.1515/Bc.2002.129 |
0.443 |
|
2002 |
Tsukuba T, Kadowaki T, Hengst JA, Bond JS. Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway Archives of Biochemistry and Biophysics. 397: 191-198. PMID 11795871 DOI: 10.1006/Abbi.2001.2672 |
0.547 |
|
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