John E. Weldon, Ph.D. - Publications

Johns Hopkins University, Baltimore, MD 
biochemical and biophysical principles involved in protein function

12 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Weldon JE, Skarzynski M, Therres JA, Ostovitz JR, Zhou H, Kreitman RJ, Pastan I. Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A. Bioconjugate Chemistry. 26: 1120-8. PMID 25997032 DOI: 10.1021/acs.bioconjchem.5b00190  1
2013 Weldon JE, Xiang L, Zhang J, Beers R, Walker DA, Onda M, Hassan R, Pastan I. A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity. Molecular Cancer Therapeutics. 12: 48-57. PMID 23136186 DOI: 10.1158/1535-7163.MCT-12-0336  1
2012 Mazor R, Vassall AN, Eberle JA, Beers R, Weldon JE, Venzon DJ, Tsang KY, Benhar I, Pastan I. Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. Proceedings of the National Academy of Sciences of the United States of America. 109: E3597-603. PMID 23213206 DOI: 10.1073/pnas.1218138109  1
2012 Liu W, Onda M, Kim C, Xiang L, Weldon JE, Lee B, Pastan I. A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. Protein Engineering, Design & Selection : Peds. 25: 1-6. PMID 22101015 DOI: 10.1093/protein/gzr053  1
2011 Weldon JE, Pastan I. A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. The Febs Journal. 278: 4683-700. PMID 21585657 DOI: 10.1111/j.1742-4658.2011.08182.x  1
2011 Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, Pastan I. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 108: 5742-7. PMID 21436054 DOI: 10.1073/pnas.1102746108  1
2010 Hansen JK, Weldon JE, Xiang L, Beers R, Onda M, Pastan I. A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 297-304. PMID 20445350 DOI: 10.1097/CJI.0b013e3181cd1164  1
2009 Weldon JE, Xiang L, Chertov O, Margulies I, Kreitman RJ, FitzGerald DJ, Pastan I. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. Blood. 113: 3792-800. PMID 18988862 DOI: 10.1182/blood-2008-08-173195  1
2008 Becerra SP, Perez-Mediavilla LA, Weldon JE, Locatelli-Hoops S, Senanayake P, Notari L, Notario V, Hollyfield JG. Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site. The Journal of Biological Chemistry. 283: 33310-20. PMID 18805795 DOI: 10.1074/jbc.M801287200  1
2007 Weldon JE, Rodgers ME, Larkin C, Schleif RF. Structure and properties of a truely apo form of AraC dimerization domain. Proteins. 66: 646-54. PMID 17173282 DOI: 10.1002/prot.21267  1
2006 Weldon JE, Schleif RF. Specific interactions by the N-terminal arm inhibit self-association of the AraC dimerization domain. Protein Science : a Publication of the Protein Society. 15: 2828-35. PMID 17132863 DOI: 10.1110/ps.062327506  1
2001 Bessman MJ, Walsh JD, Dunn CA, Swaminathan J, Weldon JE, Shen J. The gene ygdP, associated with the invasiveness of Escherichia coli K1, designates a Nudix hydrolase, Orf176, active on adenosine (5')-pentaphospho-(5')-adenosine (Ap5A). The Journal of Biological Chemistry. 276: 37834-8. PMID 11479323 DOI: 10.1074/jbc.M107032200  1
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