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Melissa Lambeth Kemp, Ph.D. - Publications

Affiliations: 
Georgia Institute of Technology, Atlanta, GA 
Area:
energetics of cells; systems biology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ji Z, Moore J, Devarie-Baez NO, Lewis J, Wu H, Shukla K, Lopez EIS, Vitvitsky V, Key CC, Porosnicu M, Kemp ML, Banerjee R, Parks JS, Tsang AW, Zhou X, et al. Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSM. Frontiers in Oncology. 12: 946320. PMID 36686772 DOI: 10.3389/fonc.2022.946320  0.486
2021 Finn NA, Raddatz AD, Kemp ML. Systems Biology Approaches to Enzyme Kinetics. Methods in Molecular Biology (Clifton, N.J.). 2342: 419-440. PMID 34272703 DOI: 10.1007/978-1-0716-1554-6_15  0.795
2021 Lewis JE, Kemp ML. Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance. Nature Communications. 12: 2700. PMID 33976213 DOI: 10.1038/s41467-021-22989-1  0.44
2021 Lewis JE, Forshaw TE, Boothman DA, Furdui CM, Kemp ML. Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors. Cell Systems. 12: 68-81.e11. PMID 33476554 DOI: 10.1016/j.cels.2020.12.001  0.458
2020 Shukla K, Singh N, Lewis JE, Tsang AW, Boothman DA, Kemp ML, Furdui CM. MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer. Frontiers in Oncology. 10: 536377. PMID 33262939 DOI: 10.3389/fonc.2020.536377  0.486
2020 Paudel BB, Lewis JE, Hardeman KN, Hayford CE, Robbins CJ, Stauffer PE, Codreanu SG, Sherrod SD, McLean JA, Kemp ML, Quaranta V. An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells. Cancer Research. 80: 4565-4577. PMID 33060170 DOI: 10.1158/0008-5472.CAN-19-3588  0.496
2020 Bailur JK, McCachren SS, Pendleton KE, Vasquez JC, Lim HS, Duffy A, Doxie D, Kaushal A, Foster CJ, DeRyckere D, Castellino SM, Kemp ML, Qiu P, Dhodapkar M, Dhodapkar K. Risk associated alterations in marrow T cells in pediatric leukemia. Jci Insight. PMID 32692727 DOI: 10.1172/Jci.Insight.140179  0.367
2020 Nikitina A, Huang D, Li L, Peterman N, Cleavenger SE, Fernandez FM, Kemp ML. A Co-registration Pipeline for Multi-modal MALDI and Confocal Imaging Analysis of Stem Cell Colonies. Journal of the American Society For Mass Spectrometry. PMID 32176489 DOI: 10.1021/Jasms.9B00094  0.327
2020 Norfleet DA, Park E, Kemp ML. Computational modeling of organoid development Current Opinion in Biomedical Engineering. 13: 113-118. DOI: 10.1016/J.Cobme.2019.12.014  0.344
2019 Jayaram DT, Kumar A, Kippner LE, Ho PY, Kemp ML, Fan Y, Payne CK. TiO nanoparticles generate superoxide and alter gene expression in human lung cells. Rsc Advances. 9: 25039-25047. PMID 35321350 DOI: 10.1039/c9ra04037d  0.767
2019 He L, Raddatz AD, Zhou F, Hwang H, Kemp ML, Lu H. Dynamic Mitochondrial Migratory Features Associated with Calcium Responses during T Cell Antigen Recognition. Journal of Immunology (Baltimore, Md. : 1950). PMID 31201236 DOI: 10.4049/Jimmunol.1800299  0.777
2019 Bailur JK, McCachren SS, Doxie DB, Shrestha M, Pendleton KE, Nooka AK, Neparidze N, Parker TL, Bar N, Kaufman JL, Hofmeister CC, Boise LH, Lonial S, Kemp ML, Dhodapkar KM, et al. Early alterations in stem-like/resident T cells, innate and myeloid cells in the bone marrow in preneoplastic gammopathy. Jci Insight. 5. PMID 31013254 DOI: 10.1172/Jci.Insight.127807  0.378
2019 Glen CM, Kemp ML, Voit EO. Agent-based modeling of morphogenetic systems: Advantages and challenges. Plos Computational Biology. 15: e1006577. PMID 30921323 DOI: 10.1371/Journal.Pcbi.1006577  0.77
2019 Forshaw TE, Holmila R, Nelson KJ, Lewis JE, Kemp ML, Tsang AW, Poole LB, Lowther WT, Furdui CM. Peroxiredoxins in Cancer and Response to Radiation Therapies. Antioxidants (Basel, Switzerland). 8. PMID 30609657 DOI: 10.3390/Antiox8010011  0.531
2019 Lewis JE, Singh N, Holmila RJ, Sumer BD, Williams NS, Furdui CM, Kemp ML, Boothman DA. Targeting NAD Metabolism to Enhance Radiation Therapy Responses. Seminars in Radiation Oncology. 29: 6-15. PMID 30573185 DOI: 10.1016/J.Semradonc.2018.10.009  0.501
2019 Jayaram DT, Kumar A, Kippner LE, Ho P, Kemp ML, Fan Y, Payne CK. TiO2 nanoparticles generate superoxide and alter gene expression in human lung cells Rsc Advances. 9: 25039-25047. DOI: 10.1039/C9Ra04037D  0.759
2018 Glen CM, McDevitt TC, Kemp ML. Author Correction: Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment. Nature Communications. 9: 4901. PMID 30446658 DOI: 10.1038/S41467-018-07442-0  0.748
2018 Glen CM, McDevitt TC, Kemp ML. Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment. Nature Communications. 9: 4111. PMID 30291250 DOI: 10.1038/S41467-018-06693-1  0.787
2018 Kippner LE, Kemp ML. Oscillatory IL-2 stimulus reveals pertinent signaling timescales of T cell responsiveness. Plos One. 13: e0203759. PMID 30226854 DOI: 10.1371/Journal.Pone.0203759  0.792
2017 Lewis JE, Costantini F, Mims J, Chen X, Furdui C, Boothman DA, Kemp ML. Genome-scale modeling of NADPH-driven β-lapachone sensitization in head and neck squamous cell carcinoma. Antioxidants & Redox Signaling. PMID 28762750 DOI: 10.1089/Ars.2017.7048  0.524
2017 Kniss-James AS, Rivet CA, Chingozha L, Lu H, Kemp ML. Single-cell resolution of intracellular T cell Ca(2+) dynamics in response to frequency-based H2O2 stimulation. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28164205 DOI: 10.1039/C6Ib00186F  0.774
2017 Lewis JE, Kemp ML. Genome-scale Modeling of NADPH Metabolism in Radiation-resistant Head and Neck Squamous Cell Carcinoma Patients Free Radical Biology and Medicine. 112: 170-171. DOI: 10.1016/J.Freeradbiomed.2017.10.265  0.305
2016 Prasanphanich AF, White DE, Gran MA, Kemp ML. Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay. Plos Computational Biology. 12: e1005188. PMID 27851764 DOI: 10.1371/Journal.Pcbi.1005188  0.777
2016 Rivet CA, Kniss-James AS, Gran MA, Potnis A, Hill A, Lu H, Kemp ML. Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism. Plos One. 11: e0159248. PMID 27526200 DOI: 10.1371/Journal.Pone.0159248  0.758
2015 Warren EA, Netterfield TS, Sarkar S, Kemp ML, Payne CK. Spatially-resolved intracellular sensing of hydrogen peroxide in living cells. Scientific Reports. 5: 16929. PMID 26585385 DOI: 10.1038/Srep16929  0.315
2015 Dwivedi G, Gran MA, Bagchi P, Kemp ML. Dynamic Redox Regulation of IL-4 Signaling. Plos Computational Biology. 11: e1004582. PMID 26562652 DOI: 10.1371/Journal.Pcbi.1004582  0.672
2015 Fine EJ, Appleton CM, White DE, Brown MT, Deshmukh H, Kemp ML, Bao G. Trans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human cells using compact expression cassettes. Scientific Reports. 5: 10777. PMID 26126518 DOI: 10.1038/Srep10777  0.673
2015 White DE, Sylvester JB, Levario TJ, Lu H, Todd Streelman J, McDevitt TC, Kemp ML. Quantitative multivariate analysis of dynamic multicellular morphogenic trajectories. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 26095427 DOI: 10.1039/C5Ib00072F  0.755
2015 He L, Kniss A, San-Miguel A, Rouse T, Kemp ML, Lu H. An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies. Lab On a Chip. 15: 1497-507. PMID 25609410 DOI: 10.1039/C4Lc01070A  0.788
2014 Prasanphanich AF, Arencibia CA, Kemp ML. Redox processes inform multivariate transdifferentiation trajectories associated with TGFβ-induced epithelial-mesenchymal transition. Free Radical Biology & Medicine. 76: 1-13. PMID 25088330 DOI: 10.1016/J.Freeradbiomed.2014.07.032  0.785
2014 Kippner LE, Kim J, Gibson G, Kemp ML. Single cell transcriptional analysis reveals novel innate immune cell types. Peerj. 2: e452. PMID 25024920 DOI: 10.7717/Peerj.452  0.796
2014 Finn NA, Kemp ML. Systems biology approaches to enzyme kinetics: analyzing network models of drug metabolism. Methods in Molecular Biology (Clifton, N.J.). 1113: 317-34. PMID 24523119 DOI: 10.1007/978-1-62703-758-7_15  0.79
2014 Rinker TE, Hammoudi TM, Kemp ML, Lu H, Temenoff JS. Interactions between mesenchymal stem cells, adipocytes, and osteoblasts in a 3D tri-culture model of hyperglycemic conditions in the bone marrow microenvironment. Integrative Biology : Quantitative Biosciences From Nano to Macro. 6: 324-37. PMID 24463781 DOI: 10.1039/C3Ib40194D  0.56
2014 Dwivedi G, Kemp ML. Computational Modeling Predicts Phosphatase Oxidation as an Important Axis of Redox Regulation in IL-4 Signaling Biophysical Journal. 106: 379a. DOI: 10.1016/J.Bpj.2013.11.2143  0.684
2013 Sarkar S, Payne CK, Kemp ML. Conditioned Media Downregulates Nuclear Expression of Nrf2. Cellular and Molecular Bioengineering. 6: 130-137. PMID 24073021 DOI: 10.1007/S12195-013-0272-0  0.36
2013 Kniss A, Lu H, Jones DP, Kemp ML. A microfluidic systems biology approach for live single-cell mitochondrial ROS imaging. Methods in Enzymology. 526: 219-30. PMID 23791103 DOI: 10.1016/B978-0-12-405883-5.00013-2  0.588
2013 White DE, Kinney MA, McDevitt TC, Kemp ML. Spatial Pattern Dynamics of 3D Stem Cell Loss of Pluripotency via Rules-Based Computational Modeling Plos Computational Biology. 9. PMID 23516345 DOI: 10.1371/Journal.Pcbi.1002952  0.798
2012 Nair R, Ngangan AV, Kemp ML, McDevitt TC. Gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation. Plos One. 7: e42580. PMID 23077480 DOI: 10.1371/Journal.Pone.0042580  0.372
2012 Li Y, Dwivedi G, Huang W, Kemp ML, Yi Y. Quantification of degeneracy in biological systems for characterization of functional interactions between modules. Journal of Theoretical Biology. 302: 29-38. PMID 22619750 DOI: 10.1016/J.Jtbi.2012.02.020  0.68
2012 Hammoudi TM, Rivet CA, Kemp ML, Lu H, Temenoff JS. Three-dimensional in vitro tri-culture platform to investigate effects of crosstalk between mesenchymal stem cells, osteoblasts, and adipocytes. Tissue Engineering. Part A. 18: 1686-97. PMID 22472084 DOI: 10.1089/Ten.Tea.2011.0691  0.72
2012 Reddie KG, Humphries WH, Bain CP, Payne CK, Kemp ML, Murthy N. Fluorescent coumarin thiols measure biological redox couples. Organic Letters. 14: 680-3. PMID 22264005 DOI: 10.1021/Ol203105C  0.316
2012 Finn NA, Kemp ML. Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells. Molecular Biosystems. 8: 650-62. PMID 22134636 DOI: 10.1039/C1Mb05315A  0.768
2012 Dwivedi G, Kemp ML. Systemic redox regulation of cellular information processing. Antioxidants & Redox Signaling. 16: 374-80. PMID 21939387 DOI: 10.1089/Ars.2011.4034  0.683
2011 Kippner LE, Finn NA, Shukla S, Kemp ML. Systemic remodeling of the redox regulatory network due to RNAi perturbations of glutaredoxin 1, thioredoxin 1, and glucose-6-phosphate dehydrogenase. Bmc Systems Biology. 5: 164. PMID 21995976 DOI: 10.1186/1752-0509-5-164  0.749
2011 Finn NA, Findley HW, Kemp ML. A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity. Plos Computational Biology. 7: e1002151. PMID 21935349 DOI: 10.1371/Journal.Pcbi.1002151  0.797
2011 Chung K, Rivet CA, Kemp ML, Lu H. Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array. Analytical Chemistry. 83: 7044-52. PMID 21809821 DOI: 10.1021/Ac2011153  0.734
2011 Rivet CA, Hill AS, Lu H, Kemp ML. Predicting cytotoxic T-cell age from multivariate analysis of static and dynamic biomarkers. Molecular & Cellular Proteomics : McP. 10: M110.003921. PMID 21193537 DOI: 10.1074/Mcp.M110.003921  0.738
2011 Prasanphanich AF, Kemp ML. Tgfβ-Mediated Epithelial-Mesenchymal Transition is a Function of Cellular Redox Reprogramming Free Radical Biology and Medicine. 51: S16. DOI: 10.1016/J.Freeradbiomed.2011.10.035  0.762
2010 Adimora NJ, Jones DP, Kemp ML. A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses. Antioxidants & Redox Signaling. 13: 731-43. PMID 20121341 DOI: 10.1089/Ars.2009.2968  0.316
2010 Adimora NJ, Vaughns JC, Kemp ML. Mediation of Doxorubicin Toxicity in Cancer Cells by Coupled Redox Reactions Free Radical Biology and Medicine. 49: S54. DOI: 10.1016/J.Freeradbiomed.2010.10.119  0.302
2009 Hirsch AM, Rivet CA, Zhang B, Kemp ML, Lu H. Parallel multi-time point cell stimulation and lysis on-chip for studying early signaling events in T cell activation. Lab On a Chip. 9: 536-44. PMID 19190789 DOI: 10.1039/B810896J  0.738
2008 Kemp M, Go YM, Jones DP. Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology. Free Radical Biology & Medicine. 44: 921-37. PMID 18155672 DOI: 10.1016/J.Freeradbiomed.2007.11.008  0.346
2007 Wille L, Kemp ML, Sandy P, Lewis CL, Lauffenburger DA. Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production. Molecular Immunology. 44: 3085-91. PMID 17418417 DOI: 10.1016/J.Molimm.2007.02.008  0.485
2007 Kemp ML, Wille L, Lewis CL, Nicholson LB, Lauffenburger DA. Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response. Journal of Immunology (Baltimore, Md. : 1950). 178: 4984-92. PMID 17404280 DOI: 10.4049/Jimmunol.178.8.4984  0.566
2006 Vinnakota K, Kemp ML, Kushmerick MJ. Dynamics of muscle glycogenolysis modeled with pH time course computation and pH-dependent reaction equilibria and enzyme kinetics. Biophysical Journal. 91: 1264-87. PMID 16617075 DOI: 10.1529/Biophysj.105.073296  0.747
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