Alexey A. Lugovskoy, Ph.D. - Publications

Harvard University, Cambridge, MA, United States 
structural aspects of protein function

31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Reichert JM, Beck A, Lugovskoy AA, Wurch T, Coats S, Brezski RJ. 9th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland. Mabs. 6: 309-26. PMID 24492298 DOI: 10.4161/Mabs.27903  0.36
2014 Fitzgerald JB, Johnson BW, Baum J, Adams S, Iadevaia S, Tang J, Rimkunas V, Xu L, Kohli N, Rennard R, Razlog M, Jiao Y, Harms BD, Olivier KJ, Schoeberl B, ... ... Lugovskoy AA, et al. MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Molecular Cancer Therapeutics. 13: 410-25. PMID 24282274 DOI: 10.1158/1535-7163.Mct-13-0255  0.36
2014 Harms BD, Kearns JD, Iadevaia S, Lugovskoy AA. Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies. Methods (San Diego, Calif.). 65: 95-104. PMID 23872324 DOI: 10.1016/J.Ymeth.2013.07.017  0.36
2013 Beck A, Carter PJ, Gerber HP, Lugovskoy AA, Wurch T, Junutula JR, Kontermann RE, Mabry R. 8(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland. Mabs. 5: 339-57. PMID 23493119 DOI: 10.4161/Mabs.24105  0.36
2011 Gorelik L, Reid C, Testa M, Brickelmaier M, Bossolasco S, Pazzi A, Bestetti A, Carmillo P, Wilson E, McAuliffe M, Tonkin C, Carulli JP, Lugovskoy A, Lazzarin A, Sunyaev S, et al. Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity. The Journal of Infectious Diseases. 204: 103-14. PMID 21628664 DOI: 10.1093/Infdis/Jir198  0.36
2011 Dong J, Sereno A, Snyder WB, Miller BR, Tamraz S, Doern A, Favis M, Wu X, Tran H, Langley E, Joseph I, Boccia A, Kelly R, Wortham K, Wang Q, ... ... Lugovskoy A, et al. Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity. The Journal of Biological Chemistry. 286: 4703-17. PMID 21123183 DOI: 10.1074/Jbc.M110.184317  0.36
2010 Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proceedings of the National Academy of Sciences of the United States of America. 107: 20126-31. PMID 21041639 DOI: 10.1073/Pnas.1004522107  0.36
2010 di Clemente N, Jamin SP, Lugovskoy A, Carmillo P, Ehrenfels C, Picard JY, Whitty A, Josso N, Pepinsky RB, Cate RL. Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta. Molecular Endocrinology (Baltimore, Md.). 24: 2193-206. PMID 20861221 DOI: 10.1210/Me.2010-0273  0.36
2010 Miller BR, Demarest SJ, Lugovskoy A, Huang F, Wu X, Snyder WB, Croner LJ, Wang N, Amatucci A, Michaelson JS, Glaser SM. Stability engineering of scFvs for the development of bispecific and multivalent antibodies. Protein Engineering, Design & Selection : Peds. 23: 549-57. PMID 20457695 DOI: 10.1093/Protein/Gzq028  0.36
2009 Michaelson JS, Demarest SJ, Miller B, Amatucci A, Snyder WB, Wu X, Huang F, Phan S, Gao S, Doern A, Farrington GK, Lugovskoy A, Joseph I, Bailly V, Wang X, et al. Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR. Mabs. 1: 128-41. PMID 20061822 DOI: 10.4161/Mabs.1.2.7631  0.36
2009 Yin S, Proctor EA, Lugovskoy AA, Dokholyan NV. Fast screening of protein surfaces using geometric invariant fingerprints. Proceedings of the National Academy of Sciences of the United States of America. 106: 16622-6. PMID 19805347 DOI: 10.1073/Pnas.0906146106  0.36
2009 Jordan JL, Arndt JW, Hanf K, Li G, Hall J, Demarest S, Huang F, Wu X, Miller B, Glaser S, Fernandez EJ, Wang D, Lugovskoy A. Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules. Proteins. 77: 832-41. PMID 19626705 DOI: 10.1002/Prot.22502  0.36
2009 Brickelmaier M, Lugovskoy A, Kartikeyan R, Reviriego-Mendoza MM, Allaire N, Simon K, Frisque RJ, Gorelik L. Identification and characterization of mefloquine efficacy against JC virus in vitro. Antimicrobial Agents and Chemotherapy. 53: 1840-9. PMID 19258267 DOI: 10.1128/Aac.01614-08  0.36
2009 Sunyaev SR, Lugovskoy A, Simon K, Gorelik L. Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). Plos Genetics. 5: e1000368. PMID 19197354 DOI: 10.1371/Journal.Pgen.1000368  0.36
2009 Wang N, Smith WF, Miller BR, Aivazian D, Lugovskoy AA, Reff ME, Glaser SM, Croner LJ, Demarest SJ. Conserved amino acid networks involved in antibody variable domain interactions. Proteins. 76: 99-114. PMID 19089973 DOI: 10.1002/Prot.22319  0.36
2008 Rushe M, Silvian L, Bixler S, Chen LL, Cheung A, Bowes S, Cuervo H, Berkowitz S, Zheng T, Guckian K, Pellegrini M, Lugovskoy A. Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site. Structure (London, England : 1993). 16: 798-808. PMID 18462684 DOI: 10.1016/J.Str.2008.02.012  0.36
2008 Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/Nchembio.83  0.36
2007 Zhong W, Dixit SB, Mallis RJ, Arthanari H, Lugovskoy AA, Beveridge DL, Wagner G, Reinherz EL. CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications. Journal of Molecular Biology. 372: 535-48. PMID 17658550 DOI: 10.1016/J.Jmb.2007.06.057  0.36
2007 Shi X, Kachirskaia I, Walter KL, Kuo JH, Lake A, Davrazou F, Chan SM, Martin DG, Fingerman IM, Briggs SD, Howe L, Utz PJ, Kutateladze TG, Lugovskoy AA, Bedford MT, et al. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. The Journal of Biological Chemistry. 282: 2450-5. PMID 17142463 DOI: 10.1074/Jbc.C600286200  0.36
2006 Clark LA, Boriack-Sjodin PA, Eldredge J, Fitch C, Friedman B, Hanf KJ, Jarpe M, Liparoto SF, Li Y, Lugovskoy A, Miller S, Rushe M, Sherman W, Simon K, Van Vlijmen H. Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design. Protein Science : a Publication of the Protein Society. 15: 949-60. PMID 16597831 DOI: 10.1110/Ps.052030506  0.36
2006 Cachero TG, Schwartz IM, Qian F, Day ES, Bossen C, Ingold K, Tardivel A, Krushinskie D, Eldredge J, Silvian L, Lugovskoy A, Farrington GK, Strauch K, Schneider P, Whitty A. Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor). Biochemistry. 45: 2006-13. PMID 16475789 DOI: 10.1021/Bi051685O  0.36
2005 He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, et al. Small-molecule inhibition of TNF-alpha. Science (New York, N.Y.). 310: 1022-5. PMID 16284179 DOI: 10.1126/Science.1116304  0.36
2003 Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G. Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell. 115: 739-50. PMID 14675538 DOI: 10.1016/S0092-8674(03)00975-9  0.6
2003 Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, et al. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 114: 99-111. PMID 12859901 DOI: 10.1016/S0092-8674(03)00480-X  0.36
2002 Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. Journal of the American Chemical Society. 124: 1234-40. PMID 11841292 DOI: 10.1021/Ja011239Y  0.36
2002 Müller J, Lugovskoy AA, Wagner G, Lippard SJ. NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase. Biochemistry. 41: 42-51. PMID 11772001 DOI: 10.1021/Bi015668K  0.6
2001 Zhou P, Lugovskoy AA, Wagner G. A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins. Journal of Biomolecular Nmr. 20: 11-4. PMID 11430750 DOI: 10.1023/A:1011258906244  0.6
2001 Zhou P, Lugovskoy AA, McCarty JS, Li P, Wagner G. Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. Proceedings of the National Academy of Sciences of the United States of America. 98: 6051-5. PMID 11371636 DOI: 10.1073/Pnas.111145098  0.6
2001 Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL Nature Cell Biology. 3: 173-182. PMID 11175750 DOI: 10.1038/35055085  0.36
1999 Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell. 99: 747-55. PMID 10619428 DOI: 10.1016/S0092-8674(00)81672-4  0.6
1998 Lugovskoy AA, Maslennikov IV, Utkin YN, Tsetlin VI, Cohen JB, Arseniev AS. Spatial structure of the M3 transmembrane segment of the nicotinic acetylcholine receptor alpha subunit. European Journal of Biochemistry / Febs. 255: 455-61. PMID 9716388 DOI: 10.1046/J.1432-1327.1998.2550455.X  0.36
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