Bridget K. Wagner, Ph.D. - Publications

Harvard University, Cambridge, MA, United States 
Chemical biology

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lee M, Maji B, Manna D, Kahraman S, Elgamal RM, Small J, Kokkonda P, Vetere A, Goldberg JM, Lippard SJ, Kulkarni RN, Wagner BK, Choudhary A. Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. Journal of the American Chemical Society. PMID 32175731 DOI: 10.1021/jacs.0c00099  0.6
2019 Li H, Ericsson M, Rabasha B, Budnik B, Chan SH, Freinkman E, Lewis CA, Doench JG, Wagner BK, Garraway LA, Schreiber SL. 6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels. Cell Chemical Biology. PMID 31204288 DOI: 10.1016/j.chembiol.2019.05.006  0.92
2019 Maianti JP, Tan GA, Vetere A, Welsh AJ, Wagner BK, Seeliger MA, Liu DR. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nature Chemical Biology. PMID 31086331 DOI: 10.1038/s41589-019-0271-0  0.6
2019 Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, ... ... Wagner BK, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 177: 1067-1079.e19. PMID 31051099 DOI: 10.1016/j.cell.2019.04.009  0.92
2019 Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, ... Wagner BK, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nature Communications. 10: 1617. PMID 30962421 DOI: 10.1038/s41467-019-09277-9  0.92
2017 Dirice E, Ng R, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. The Journal of Biological Chemistry. PMID 28860191 DOI: 10.1074/jbc.M117.804328  0.52
2017 Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, ... ... Wagner BK, et al. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 170: 199-212.e20. PMID 28666119 DOI: 10.1016/j.cell.2017.06.011  0.92
2017 Schwartzman O, Savino AM, Gombert M, Palmi C, Cario G, Schrappe M, Eckert C, von Stackelberg A, Huang JY, Hameiri-Grossman M, Avigad S, Te Kronnie G, Geron I, Birger Y, Rein A, ... ... Wagner BK, et al. Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 28461505 DOI: 10.1073/pnas.1702489114  0.6
2016 Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure. Cell Systems. PMID 27667365 DOI: 10.1016/j.cels.2016.08.011  0.6
2016 Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR. PMID 27401613 DOI: 10.1158/1541-7786.MCR-16-0090  0.92
2016 Gerry CJ, Hua BK, Wawer MJ, Knowles JP, Nelson SD, Verho O, Dandapani S, Wagner BK, Clemons PA, Booker-Milburn KI, Boskovic ZV, Schreiber SL. Real-Time Biological Annotation of Synthetic Compounds. Journal of the American Chemical Society. PMID 27398798 DOI: 10.1021/jacs.6b04614  0.92
2016 Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A stimulates human beta-cell proliferation. Diabetes. PMID 26953159 DOI: 10.2337/db15-1127  0.92
2016 Wagner BK, Schreiber SL. The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods. Cell Chemical Biology. 23: 3-9. PMID 26933731 DOI: 10.1016/j.chembiol.2015.11.008  0.92
2015 Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, ... ... Wagner BK, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nature Chemical Biology. PMID 26656090 DOI: 10.1038/nchembio.1986  0.92
2015 de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nature Chemical Biology. PMID 26656089 DOI: 10.1038/nchembio.1984  0.92
2015 Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, ... ... Wagner BK, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. Acs Chemical Biology. PMID 26640968 DOI: 10.1021/acschembio.5b00640  0.92
2015 Wagner BK. The resurgence of phenotypic screening in drug discovery and development. Expert Opinion On Drug Discovery. PMID 26593688 DOI: 10.1517/17460441.2016.1122589  0.36
2015 Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dan?ík V, Ciarlo C, Paulk J, ... ... Wagner BK, et al. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. 137: 7929-34. PMID 26042473 DOI: 10.1021/jacs.5b04284  0.92
2015 Scully SS, Zheng SL, Wagner BK, Schreiber SL. Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides. Organic Letters. 17: 418-21. PMID 25569027 DOI: 10.1021/ol503273v  0.92
2015 Burns SM, Vetere A, Walpita D, Dan?ík V, Khodier C, Perez J, Clemons PA, Wagner BK, Altshuler D. High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function. Cell Metabolism. 21: 126-37. PMID 25565210 DOI: 10.1016/j.cmet.2014.12.010  0.92
2015 Johannessen CM, Clemons PA, Wagner BK. Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery. Trends in Genetics : Tig. 31: 16-23. PMID 25498789 DOI: 10.1016/j.tig.2014.11.002  0.92
2015 Dahllöf MS, Christensen DP, Harving M, Wagner BK, Mandrup-Poulsen T, Lundh M. HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 35: 63-70. PMID 25062500 DOI: 10.1089/jir.2014.0022  0.92
2014 Walpita D, Wagner BK. Evaluation of compounds in primary human islet cell culture. Current Protocols in Chemical Biology. 6: 157-68. PMID 25205564 DOI: 10.1002/9780470559277.ch140088  0.4
2014 Meier BC, Wagner BK. Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics. Epigenomics. 6: 209-14. PMID 24811789 DOI: 10.2217/epi.14.11  0.92
2014 Choudhary A, Hu He K, Mertins P, Udeshi ND, Dan?ík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. Plos One. 9: e95194. PMID 24759943 DOI: 10.1371/journal.pone.0095194  0.92
2014 Wawer MJ, Jaramillo DE, Dan?ík V, Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, Clemons PA. Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. Journal of Biomolecular Screening. 19: 738-748. PMID 24710340 DOI: 10.1177/1087057114530783  0.92
2014 Vetere A, Choudhary A, Burns SM, Wagner BK. Targeting the pancreatic β-cell to treat diabetes. Nature Reviews. Drug Discovery. 13: 278-89. PMID 24525781 DOI: 10.1038/nrd4231  0.92
2014 Dan?ík V, Carrel H, Bodycombe NE, Seiler KP, Fomina-Yadlin D, Kubicek ST, Hartwell K, Shamji AF, Wagner BK, Clemons PA. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses. Journal of Biomolecular Screening. 19: 771-781. PMID 24464433 DOI: 10.1177/1087057113520226  0.92
2013 Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Lysy PA, Zhong C, Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, Wagner BK. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chemistry & Biology. 20: 1513-22. PMID 24290880 DOI: 10.1016/j.chembiol.2013.10.013  0.92
2013 Lundh M, Scully SS, Mandrup-Poulsen T, Wagner BK. Small-molecule inhibition of inflammatory β-cell death. Diabetes, Obesity & Metabolism. 15: 176-84. PMID 24003935 DOI: 10.1111/dom.12158  0.52
2013 Yuan Y, Tang AJ, Castoreno AB, Kuo SY, Wang Q, Kuballa P, Xavier R, Shamji AF, Schreiber SL, Wagner BK. Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death & Disease. 4: e690. PMID 23807219 DOI: 10.1038/cddis.2013.191  0.92
2013 Scully SS, Tang AJ, Lundh M, Mosher CM, Perkins KM, Wagner BK. Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility. Journal of Medicinal Chemistry. 56: 4125-9. PMID 23617753 DOI: 10.1021/jm400397x  0.92
2013 Schenone M, Dan?ík V, Wagner BK, Clemons PA. Target identification and mechanism of action in chemical biology and drug discovery. Nature Chemical Biology. 9: 232-40. PMID 23508189 DOI: 10.1038/nchembio.1199  0.92
2013 Adams DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, Schreiber SL. Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death. Acs Chemical Biology. 8: 923-9. PMID 23477340 DOI: 10.1021/cb300653v  0.92
2012 Adams DJ, Dai M, Pellegrino G, Wagner BK, Stern AM, Shamji AF, Schreiber SL. Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs. Proceedings of the National Academy of Sciences of the United States of America. 109: 15115-20. PMID 22949699 DOI: 10.1073/pnas.1212802109  0.92
2012 Vetere A, Wagner BK. Chemical methods to induce Beta-cell proliferation. International Journal of Endocrinology. 2012: 925143. PMID 22811709 DOI: 10.1155/2012/925143  0.6
2012 Chou DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, Wagner BK. Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis. Chemistry & Biology. 19: 669-73. PMID 22726680 DOI: 10.1016/j.chembiol.2012.05.010  0.92
2012 Yuan Y, Wang Q, Paulk J, Kubicek S, Kemp MM, Adams DJ, Shamji AF, Wagner BK, Schreiber SL. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. Acs Chemical Biology. 7: 1152-7. PMID 22536950 DOI: 10.1021/cb300139y  0.92
2012 Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylor B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 5364-9. PMID 22434908 DOI: 10.1073/pnas.1201079109  0.92
2012 Fomina-Yadlin D, Kubicek S, Vetere A, He KH, He KH, Schreiber SL, Wagner BK. GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. Plos One. 7: e28808. PMID 22242153 DOI: 10.1371/journal.pone.0028808  0.92
2012 Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. A human islet cell culture system for high-throughput screening. Journal of Biomolecular Screening. 17: 509-18. PMID 22156222 DOI: 10.1177/1087057111430253  0.92
2011 Chou DH, Duvall JR, Gerard B, Liu H, Pandya BA, Suh BC, Forbeck EM, Faloon P, Wagner BK, Marcaurelle LA. Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis. Acs Medicinal Chemistry Letters. 2: 698-702. PMID 21927648 DOI: 10.1021/ml200120m  0.92
2011 Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK. A small-molecule screening strategy to identify suppressors of statin myopathy. Acs Chemical Biology. 6: 900-4. PMID 21732624 DOI: 10.1021/cb200206w  0.92
2011 Clemons PA, Wilson JA, Dan?ík V, Muller S, Carrinski HA, Wagner BK, Koehler AN, Schreiber SL. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections. Proceedings of the National Academy of Sciences of the United States of America. 108: 6817-22. PMID 21482810 DOI: 10.1073/pnas.1015024108  0.92
2011 Bochner BR, Siri M, Huang RH, Noble S, Lei XH, Clemons PA, Wagner BK. Assay of the multiple energy-producing pathways of mammalian cells. Plos One. 6: e18147. PMID 21455318 DOI: 10.1371/journal.pone.0018147  0.92
2011 Wagner BK. Screening: Low-fat worms on drugs. Nature Chemical Biology. 7: 194-5. PMID 21423161 DOI: 10.1038/nchembio.540  0.2
2011 Kim YK, Lee JS, Bi X, Ha HH, Ng SH, Ahn YH, Lee JJ, Wagner BK, Clemons PA, Chang YT. The binding of fluorophores to proteins depends on the cellular environment. Angewandte Chemie (International Ed. in English). 50: 2761-3. PMID 21370369 DOI: 10.1002/anie.201007626  0.92
2010 Wagner BK. Grand challenge commentary: Chemical transdifferentiation and regenerative medicine. Nature Chemical Biology. 6: 877-9. PMID 21079596 DOI: 10.1038/nchembio.472  0.52
2010 Clemons PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, Schreiber SL. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles. Proceedings of the National Academy of Sciences of the United States of America. 107: 18787-92. PMID 20956335 DOI: 10.1073/pnas.1012741107  0.92
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/nbt0910-904  0.92
2010 Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 15099-104. PMID 20696901 DOI: 10.1073/pnas.1010018107  0.92
2010 Chou DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, Wagner BK. Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. Acs Chemical Biology. 5: 729-34. PMID 20550176 DOI: 10.1021/cb100129d  0.92
2009 Wagner BK, Clemons PA. Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling. Current Opinion in Chemical Biology. 13: 539-48. PMID 19825513 DOI: 10.1016/j.cbpa.2009.09.018  0.92
2009 Tanikawa T, Fridman M, Zhu W, Faulk B, Joseph IC, Kahne D, Wagner BK, Clemons PA. Using biological performance similarity to inform disaccharide library design. Journal of the American Chemical Society. 131: 5075-83. PMID 19298063 DOI: 10.1021/ja806583y  0.92
2008 Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 105: 4721-6. PMID 18347329 DOI: 10.1073/pnas.0800979105  0.92
2008 Wagner BK, Carrinski HA, Ahn YH, Kim YK, Gilbert TJ, Fomina DA, Schreiber SL, Chang YT, Clemons PA. Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Journal of the American Chemical Society. 130: 4208-9. PMID 18327938 DOI: 10.1021/ja077656d  0.92
2008 Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK. Large-scale chemical dissection of mitochondrial function. Nature Biotechnology. 26: 343-51. PMID 18297058 DOI: 10.1038/nbt1387  0.92
2004 Wagner BK, Haggarty SJ, Clemons PA. Chemical genomics: probing protein function using small molecules. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 4: 313-20. PMID 15462609 DOI: 10.2165/00129785-200404050-00004  0.92
2004 Wagner BK. Hospital-based emergency contraception. American Journal of Health-System Pharmacy : Ajhp : Official Journal of the American Society of Health-System Pharmacists. 61: 1771-2; author reply. PMID 15462246  0.36
2001 Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2  0.92
1996 Wagner BK. Pharmacists should not participate in abortion or assisted suicide. The Annals of Pharmacotherapy. 30: 1192-6. PMID 8893131  0.44
1993 Wagner BK, D'Amelio LF. Pharmacologic and clinical considerations in selecting crystalloid, colloidal, and oxygen-carrying resuscitation fluids, Part 1. Clinical Pharmacy. 12: 335-46. PMID 8319418  0.01
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