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Lance D. Langston, Ph.D. - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Genetics and biochemistry of DNA recombination and repair in yeast
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Langston LD, Georgescu RE, O'Donnell ME. Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process. Proceedings of the National Academy of Sciences of the United States of America. 120: e2316466120. PMID 38109526 DOI: 10.1073/pnas.2316466120  0.579
2022 Langston LD, Yuan Z, Georgescu R, Li H, O'Donnell ME. SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding. Proceedings of the National Academy of Sciences of the United States of America. 119: e2216240119. PMID 36442086 DOI: 10.1073/pnas.2216240119  0.508
2019 Langston LD, O'Donnell ME. An explanation for origin unwinding in eukaryotes. Elife. 8. PMID 31282859 DOI: 10.7554/Elife.46515  0.596
2018 Mayle R, Langston L, Molloy KR, Zhang D, Chait BT, O'Donnell ME. Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression. Proceedings of the National Academy of Sciences of the United States of America. PMID 30598452 DOI: 10.1073/Pnas.1819107116  0.577
2017 Langston LD, Mayle R, Schauer GD, Yurieva O, Zhang D, Yao NY, Georgescu RE, O'Donnell ME. Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks. Elife. 6. PMID 28869037 DOI: 10.7554/Elife.29118  0.639
2017 Langston LD, O'Donnell ME. Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase. Elife. 6. PMID 28346143 DOI: 10.7554/Elife.23449  0.633
2017 Langston LD, Mayle R, Schauer GD, Yurieva O, Zhang D, Yao NY, Georgescu RE, O'Donnell ME. Author response: Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks Elife. DOI: 10.7554/Elife.29118.020  0.599
2017 Langston L, O’Donnell M. Author response: Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase Elife. DOI: 10.7554/Elife.23449.023  0.55
2016 Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty BK, Bacal J, Langston LD, Pasero P, O'Donnell ME. Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298353 DOI: 10.1073/Pnas.1607552113  0.46
2015 Georgescu RE, Schauer GD, Yao NY, Langston LD, Yurieva O, Zhang D, Finkelstein J, O'Donnell ME. Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. Elife. 4: e04988. PMID 25871847 DOI: 10.7554/Elife.04988  0.481
2015 Georgescu R, Langston L, O'Donnell M. A proposal: Evolution of PCNA's role as a marker of newly replicated DNA. Dna Repair. 29: 4-15. PMID 25704660 DOI: 10.1016/J.Dnarep.2015.01.015  0.591
2014 Langston LD, Zhang D, Yurieva O, Georgescu RE, Finkelstein J, Yao NY, Indiani C, O'Donnell ME. CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 111: 15390-5. PMID 25313033 DOI: 10.1073/Pnas.1418334111  0.61
2014 Georgescu RE, Langston L, Yao NY, Yurieva O, Zhang D, Finkelstein J, Agarwal T, O'Donnell ME. Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. Nature Structural & Molecular Biology. 21: 664-70. PMID 24997598 DOI: 10.1038/Nsmb.2851  0.594
2013 O'Donnell M, Langston L, Stillman B. Principles and concepts of DNA replication in bacteria, archaea, and eukarya Cold Spring Harbor Perspectives in Biology. 5. PMID 23818497 DOI: 10.1101/Cshperspect.A010108  0.571
2012 Langston LD, O'Donnell M. Subunit sharing among high- and low-fidelity DNA polymerases. Proceedings of the National Academy of Sciences of the United States of America. 109: 12268-9. PMID 22826240 DOI: 10.1073/Pnas.1209533109  0.622
2012 Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 484: 125-9. PMID 22425997 DOI: 10.1038/Nature10936  0.329
2011 Mukherjee A, Langston LD, Ouellette M. Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in Leishmania. Nucleic Acids Research. 39: 7499-511. PMID 21693561 DOI: 10.1093/Nar/Gkr494  0.372
2009 Langston LD, Indiani C, O'Donnell M. Whither the replisome: emerging perspectives on the dynamic nature of the DNA replication machinery. Cell Cycle (Georgetown, Tex.). 8: 2686-91. PMID 19652539 DOI: 10.4161/Cc.8.17.9390  0.552
2009 Indiani C, Langston LD, Yurieva O, Goodman MF, O'Donnell M. Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase. Proceedings of the National Academy of Sciences of the United States of America. 106: 6031-8. PMID 19279203 DOI: 10.1073/Pnas.0901403106  0.542
2008 Langston LD, O'Donnell M. DNA polymerase delta is highly processive with proliferating cell nuclear antigen and undergoes collision release upon completing DNA. The Journal of Biological Chemistry. 283: 29522-31. PMID 18635534 DOI: 10.1074/Jbc.M804488200  0.623
2006 Langston LD, O'Donnell M. DNA replication: keep moving and don't mind the gap. Molecular Cell. 23: 155-60. PMID 16857582 DOI: 10.1016/J.Molcel.2006.05.034  0.571
2005 Langston LD, Symington LS. Opposing roles for DNA structure-specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting. The Embo Journal. 24: 2214-23. PMID 15920474 DOI: 10.1038/Sj.Emboj.7600698  0.644
2004 Langston LD, Symington LS. Gene targeting in yeast is initiated by two independent strand invasions. Proceedings of the National Academy of Sciences of the United States of America. 101: 15392-7. PMID 15489271 DOI: 10.1073/Pnas.0403748101  0.641
1999 Maftahi M, Han CS, Langston LD, Hope JC, Zigouras N, Freyer GA. The top3(+) gene is essential in Schizosaccharomyces pombe and the lethality associated with its loss is caused by Rad12 helicase activity. Nucleic Acids Research. 27: 4715-24. PMID 10572171 DOI: 10.1093/Nar/27.24.4715  0.394
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