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Alexis C. Komor, Ph.D. - Publications

Affiliations: 
Chemistry California Institute of Technology, Pasadena, CA 
Area:
application of transition metal complexes to probe recognition and reactions of double helical DNA
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Rallapalli KL, Komor AC. The Design and Application of DNA-Editing Enzymes as Base Editors. Annual Review of Biochemistry. PMID 37018843 DOI: 10.1146/annurev-biochem-052521-013938  0.351
2023 Ranzau BL, Rallapalli KL, Evanoff M, Paesani F, Komor A. The wild-type tRNA adenosine deaminase enzyme TadA is capable of sequence-specific DNA base editing. Chembiochem : a European Journal of Chemical Biology. e202200788. PMID 36947856 DOI: 10.1002/cbic.202200788  0.414
2022 Burnett CA, Wong AT, Vasquez CA, McHugh CA, Yeo GW, Komor AC. Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors. Frontiers in Genome Editing. 4: 923718. PMID 35910415 DOI: 10.3389/fgeed.2022.923718  0.439
2022 Bodai Z, Bishop AL, Gantz VM, Komor AC. Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies. Nature Communications. 13: 2351. PMID 35534455 DOI: 10.1038/s41467-022-29989-9  0.337
2021 Rees HA, Minella AC, Burnett CA, Komor AC, Gaudelli NM. CRISPR-derived genome editing therapies: Progress from bench to bedside. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 34619370 DOI: 10.1016/j.ymthe.2021.09.027  0.316
2021 Gu S, Bodai Z, Cowan QT, Komor AC. Base Editors: Expanding the Types of DNA Damage Products Harnessed for Genome Editing. Gene and Genome Editing. 1. PMID 34368792 DOI: 10.1016/j.ggedit.2021.100005  0.449
2020 Vasquez CA, Cowan QT, Komor AC. Base Editing in Human Cells to Produce Single-Nucleotide-Variant Clonal Cell Lines. Current Protocols in Molecular Biology. 133: e129. PMID 33151638 DOI: 10.1002/cpmb.129  0.332
2020 Porto EM, Komor AC, Slaymaker IM, Yeo GW. Base editing: advances and therapeutic opportunities. Nature Reviews. Drug Discovery. PMID 33077937 DOI: 10.1038/s41573-020-0084-6  0.356
2020 Rallapalli KL, Komor AC, Paesani F. Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. Science Advances. 6: eaaz2309. PMID 32181363 DOI: 10.1126/Sciadv.Aaz2309  0.442
2019 Evanoff M, Komor AC. Base Editors: Modular Tools for the Introduction of Point Mutations in Living Cells. Emerging Topics in Life Sciences. 3: 483-491. PMID 32270050 DOI: 10.1042/etls20190088  0.304
2019 Ranzau BL, Komor AC. Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells. Biochemistry. 58: 330-335. PMID 30500171 DOI: 10.1021/Acs.Biochem.8B00958  0.454
2018 Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. PMID 29720650 DOI: 10.1038/S41586-018-0070-X  0.392
2017 Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. PMID 29160308 DOI: 10.1038/Nature24644  0.521
2017 Komor AC, Badran AH, Liu DR. Editing the Genome Without Double-Stranded DNA Breaks. Acs Chemical Biology. PMID 28957631 DOI: 10.1021/Acschembio.7B00710  0.494
2017 Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Science Advances. 3: eaao4774. PMID 28875174 DOI: 10.1126/Sciadv.Aao4774  0.356
2017 Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nature Communications. 8: 15790. PMID 28585549 DOI: 10.1038/Ncomms15790  0.54
2017 Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nature Biotechnology. PMID 28191901 DOI: 10.1038/Nbt.3803  0.497
2016 Komor AC, Badran AH, Liu DR. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. PMID 27866654 DOI: 10.1016/J.Cell.2016.10.044  0.438
2016 Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. PMID 27096365 DOI: 10.1038/Nature17946  0.533
2014 Weidmann AG, Komor AC, Barton JK. Targeted Chemotherapy with Metal Complexes. Comments On Modern Chemistry. Part a, Comments On Inorganic Chemistry : a Journal of Critical Discussion of the Current Literature. 34: 114-123. PMID 25642012 DOI: 10.1080/02603594.2014.890099  0.557
2014 Komor AC, Barton JK. An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency. Journal of the American Chemical Society. 136: 14160-72. PMID 25254630 DOI: 10.1021/Ja5072064  0.606
2013 Bailis JM, Gordon ML, Gurgel JL, Komor AC, Barton JK, Kirsch IR. An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. Plos One. 8: e78726. PMID 24205301 DOI: 10.1371/Journal.Pone.0078726  0.561
2013 Weidmann AG, Komor AC, Barton JK. Biological effects of simple changes in functionality on rhodium metalloinsertors. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 371: 20120117. PMID 23776288 DOI: 10.1098/Rsta.2012.0117  0.648
2013 Komor AC, Barton JK. The path for metal complexes to a DNA target. Chemical Communications (Cambridge, England). 49: 3617-30. PMID 23423158 DOI: 10.1039/C3Cc00177F  0.57
2013 Komor AC, Schneider CJ, Weidmann AG, Barton JK. Correction to Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization Journal of the American Chemical Society. 135: 2863-2863. DOI: 10.1021/Ja400471Q  0.465
2012 Komor AC, Schneider CJ, Weidmann AG, Barton JK. Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization. Journal of the American Chemical Society. 134: 19223-33. PMID 23137296 DOI: 10.1021/Ja3090687  0.616
2011 Ernst RJ, Komor AC, Barton JK. Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells. Biochemistry. 50: 10919-28. PMID 22103240 DOI: 10.1021/Bi2015822  0.627
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