Matthew C. Franklin, Ph.D. - Publications

2001 Yale University, New Haven, CT 
Biochemistry, structural chemistry

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Franklin MC, Rudolph MJ, Ginter C, Cassidy MS, Cheung J. Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. Proteins. PMID 27191504 DOI: 10.1002/prot.25073  0.6
2015 Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD. Structural Genomics for Drug Design against the Pathogen Coxiella burnetii. Proteins. PMID 26033498 DOI: 10.1002/prot.24841  0.6
2015 Cheung J, Ginter C, Cassidy M, Franklin MC, Rudolph MJ, Robine N, Darnell RB, Hendrickson WA. Structural insights into mis-regulation of protein kinase A in human tumors. Proceedings of the National Academy of Sciences of the United States of America. 112: 1374-9. PMID 25605907 DOI: 10.1073/pnas.1424206112  0.6
2015 Dutta K, Varshney AK, Franklin MC, Goger M, Wang X, Fries BC. Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies. The Journal of Biological Chemistry. 290: 6715-30. PMID 25572397 DOI: 10.1074/jbc.M114.630715  0.6
2014 Rudolph MJ, Vance DJ, Cheung J, Franklin MC, Burshteyn F, Cassidy MS, Gary EN, Herrera C, Shoemaker CB, Mantis NJ. Crystal structures of ricin toxin's enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies. Journal of Molecular Biology. 426: 3057-68. PMID 24907552 DOI: 10.1016/j.jmb.2014.05.026  0.6
2013 Chaudhury S, Abdulhameed MD, Singh N, Tawa GJ, D'haeseleer PM, Zemla AT, Navid A, Zhou CE, Franklin MC, Cheung J, Rudolph MJ, Love J, Graf JF, Rozak DA, Dankmeyer JL, et al. Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction. Plos One. 8: e63369. PMID 23704901 DOI: 10.1371/journal.pone.0063369  0.6
2012 Cheung J, Rudolph MJ, Burshteyn F, Cassidy MS, Gary EN, Love J, Franklin MC, Height JJ. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. Journal of Medicinal Chemistry. 55: 10282-6. PMID 23035744 DOI: 10.1021/jm300871x  0.6
2012 Flygare JA, Beresini M, Budha N, Chan H, Chan IT, Cheeti S, Cohen F, Deshayes K, Doerner K, Eckhardt SG, Elliott LO, Feng B, Franklin MC, Reisner SF, Gazzard L, et al. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). Journal of Medicinal Chemistry. 55: 4101-13. PMID 22413863 DOI: 10.1021/jm300060k  0.6
2011 Franklin MC, Navarro EC, Wang Y, Patel S, Singh P, Zhang Y, Persaud K, Bari A, Griffith H, Shen L, Balderes P, Kussie P. The structural basis for the function of two anti-VEGF receptor 2 antibodies. Structure (London, England : 1993). 19: 1097-107. PMID 21827946 DOI: 10.1016/j.str.2011.01.019  0.6
2010 Cohen F, Koehler MF, Bergeron P, Elliott LO, Flygare JA, Franklin MC, Gazzard L, Keteltas SF, Lau K, Ly CQ, Tsui V, Fairbrother WJ. Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorganic & Medicinal Chemistry Letters. 20: 2229-33. PMID 20189383 DOI: 10.1016/j.bmcl.2010.02.021  0.6
2009 Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. Journal of Medicinal Chemistry. 52: 1723-30. PMID 19228017 DOI: 10.1021/jm801450c  0.6
2007 Patel D, Lahiji A, Patel S, Franklin M, Jimenez X, Hicklin DJ, Kang X. Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface Anticancer Research. 27: 3355-3366. PMID 17970081  0.6
2006 Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. Acs Chemical Biology. 1: 525-33. PMID 17168540 DOI: 10.1021/cb600276q  0.6
2005 Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. The Biochemical Journal. 385: 11-20. PMID 15485396 DOI: 10.1042/BJ20041108  0.6
2004 Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 5: 317-28. PMID 15093539 DOI: 10.1016/S1535-6108(04)00083-2  0.6
2003 Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP). Biochemistry. 42: 8223-31. PMID 12846571 DOI: 10.1021/bi034227t  0.6
2002 Yang G, Franklin M, Li J, Lin TC, Konigsberg W. A conserved Tyr residue is required for sugar selectivity in a pol α DNA polymerase Biochemistry. 41: 10256-10261. PMID 12162740 DOI: 10.1021/bi0202171  0.6
2002 Yang G, Franklin M, Li J, Lin TC, Konigsberg W. Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure Biochemistry. 41: 2526-2534. PMID 11851399 DOI: 10.1021/bi0119924  0.6
2001 Wang J, Song JJ, Seong IS, Franklin MC, Kamtekar S, Eom SH, Chung CH. Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU. Structure (London, England : 1993). 9: 1107-16. PMID 11709174 DOI: 10.1016/S0969-2126(01)00670-0  0.6
2001 Franklin MC, Wang J, Steitz TA. Structure of the replicating complex of a pol alpha family DNA polymerase. Cell. 105: 657-67. PMID 11389835 DOI: 10.1016/S0092-8674(01)00367-1  0.6
2001 Wang J, Song JJ, Franklin MC, Kamtekar S, Im YJ, Rho SH, Seong IS, Lee CS, Chung CH, Eom SH. Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism. Structure (London, England : 1993). 9: 177-84. PMID 11250202 DOI: 10.1016/S0969-2126(01)00570-6  0.6
2000 Born TL, Franklin M, Blanchard JS. Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Haemophilus influenzae met2-encoded homoserine transacetylase. Biochemistry. 39: 8556-64. PMID 10913262 DOI: 10.1021/bi000462p  0.6
2000 Merali S, Vargas D, Franklin M, Clarkson AB. S-adenosylmethionine and Pneumocystis carinii Journal of Biological Chemistry. 275: 14958-14963. PMID 10809741 DOI: 10.1074/jbc.275.20.14958  0.6
1992 Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS. Cloning and expression of a human ATP-citrate lyase cDNA. European Journal of Biochemistry / Febs. 204: 491-9. PMID 1371749  0.6
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