Eli Chapman, Ph.D. - Publications

Affiliations: 
2002 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
organic chemistry

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shi T, Kaneko L, Sandino M, Busse R, Zhang M, Mason D, Machulis J, Ambrose AJ, Zhang DD, Chapman E. One-Step Synthesis of Thieno[2,3-]pyrimidin-4(3)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S and Formamide. Acs Sustainable Chemistry & Engineering. 7: 1524-1528. PMID 31754553 DOI: 10.1021/acssuschemeng.8b05276  0.44
2019 Shi T, Teng S, Gopi Krishna Reddy A, Guo X, Zhang Y, Moore KT, Buckley T, Mason DJ, Wang W, Chapman E, Hu W. Catalytic asymmetric synthesis of 2,5-dihydrofurans using synergistic bifunctional Ag catalysis. Organic & Biomolecular Chemistry. PMID 31553003 DOI: 10.1039/c9ob01903k  0.44
2019 Liu P, Tian W, Tao S, Tillotson J, Wijeratne EMK, Gunatilaka AAL, Zhang DD, Chapman E. Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation. Cell Chemical Biology. PMID 31402317 DOI: 10.1016/j.chembiol.2019.07.011  0.44
2019 Shi T, Wijeratne EMK, Solano C, Ambrose AJ, Ross AB, Norwood CR, Orido CK, Grigoryan T, Tillotson J, Kang M, Luo G, Keegan BM, Hu W, Blagg BSJ, Zhang DD, ... ... Chapman E, et al. An isoform-selective PTP1B inhibitor derived from nitrogen-atom augmentation of radicicol. Biochemistry. PMID 31298844 DOI: 10.1021/acs.biochem.9b00499  0.44
2019 Ambrose AJ, Zerio CJ, Sivinski J, Schmidlin CJ, Shi T, Ross AB, Widrick KJ, Johnson SM, Zhang DD, Chapman E. A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorganic & Medicinal Chemistry Letters. PMID 31129054 DOI: 10.1016/j.bmcl.2019.05.041  0.44
2019 Liu P, de la Vega MR, Dodson M, Yue F, Shi B, Fang D, Chapman E, Liu L, Zhang DD. Spermidine confers liver protection by enhancing NRF2 signaling through a MAP1S-mediated non-canonical mechanism. Hepatology (Baltimore, Md.). PMID 30873635 DOI: 10.1002/hep.30616  0.44
2019 Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD. Correction: Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2. Cancer Research. 79: 1015. PMID 30824678 DOI: 10.1158/0008-5472.CAN-19-0070  0.44
2018 Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. Modulating NRF2 in Disease: Timing Is Everything. Annual Review of Pharmacology and Toxicology. PMID 30256716 DOI: 10.1146/annurev-pharmtox-010818-021856  0.44
2018 Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose A, Park Y, Schultz PG, Horwich AL, Hoang Q, Chapman E, Johnson SM. Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry. PMID 30060666 DOI: 10.1021/acs.jmedchem.8b00989  0.92
2018 Peters TL, Tillotson J, Yeomans AM, Wilmore S, Jiménez-Romero C, Amador LA, Amin AD, Li L, Pongtornpipat P, Zerio CJ, Paine-Murrieta G, Vega F, Packham G, Rodriguez AD, Chapman E, et al. Target-Based Screening Against eIF4A1 Reveals the Marine Natural Compound Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Anti-Tumor Activity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29844128 DOI: 10.1158/1078-0432.CCR-17-3645  0.44
2018 Rojo de la Vega M, Chapman E, Zhang DD. NRF2 and the Hallmarks of Cancer. Cancer Cell. PMID 29731393 DOI: 10.1016/j.ccell.2018.03.022  0.44
2018 Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD. Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Molecular and Cellular Biology. PMID 29507186 DOI: 10.1128/MCB.00595-17  0.44
2018 Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicology and Applied Pharmacology. 341: 106-113. PMID 29408041 DOI: 10.1016/j.taap.2018.01.014  0.44
2017 Tao S, de la Vega MR, Chapman E, Ooi A, Zhang DD. The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer. Molecular Carcinogenesis. PMID 28976703 DOI: 10.1002/mc.22745  0.44
2017 Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorganic & Medicinal Chemistry Letters. PMID 28757063 DOI: 10.1016/j.bmcl.2017.07.045  0.44
2017 Tillotson J, Zerio CJ, Harder B, Ambrose A, Jung KS, Kang M, Zhang DD, Chapman E. Arsenic compromises both p97 and proteasome functions. Chemical Research in Toxicology. PMID 28636814 DOI: 10.1021/acs.chemrestox.7b00158  0.44
2017 Bashyal BP, Wijeratne EM, Tillotson J, Arnold AE, Chapman E, Gunatilaka AA. Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus. Journal of Natural Products. PMID 28139929 DOI: 10.1021/acs.jnatprod.6b00960  0.44
2017 Tao S, Liu P, Luo G, Rojo de la Vega M, Chen H, Wu T, Tillotson J, Chapman E, Zhang DD. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex. Molecular and Cellular Biology. PMID 28115426 DOI: 10.1128/MCB.00660-16  0.44
2017 Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kanduluru AK, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ. Ritterostatin GN1N, a Cephalostatin-Ritterazine bis-Steroidal Pyrazine Hybrid, Selectively Targets GRP78. Chembiochem : a European Journal of Chemical Biology. PMID 28074539 DOI: 10.1002/cbic.201600669  0.36
2016 de la Vega MR, Dodson M, Chapman E, Zhang DD. NRF2-targeted therapeutics: New targets and modes of NRF2 regulation. Current Opinion in Toxicology. 1: 62-70. PMID 29082352 DOI: 10.1016/j.cotox.2016.10.005  0.44
2016 Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, Zhang DD. Brusatol overcomes chemoresistance through inhibition of protein translation. Molecular Carcinogenesis. PMID 28019675 DOI: 10.1002/mc.22609  0.44
2016 Abdeen S, Salim N, Mammadova N, Summers CM, Goldsmith-Pestana K, McMahon-Pratt D, Schultz PG, Horwich AL, Chapman E, Johnson SM. Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness. Bioorganic & Medicinal Chemistry Letters. PMID 27720295 DOI: 10.1016/j.bmcl.2016.09.051  0.92
2016 de la Vega MR, Dodson M, Gross C, Manzour H, Lantz RC, Chapman E, Wang T, Black SM, Garcia JG, Zhang DD. Role of Nrf2 and Autophagy in Acute Lung Injury. Current Pharmacology Reports. 2: 91-101. PMID 27313980 DOI: 10.1007/s40495-016-0053-2  0.44
2016 Tillotson J, Bashyal BP, Kang M, Shi T, De La Cruz F, Gunatilaka AA, Chapman E. Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin. Organic & Biomolecular Chemistry. PMID 27223265 DOI: 10.1039/c6ob00560h  0.44
2016 Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM. GroEL/ES inhibitors as potential antibiotics. Bioorganic & Medicinal Chemistry Letters. 26: 3127-34. PMID 27184767 DOI: 10.1016/j.bmcl.2016.04.089  0.92
2016 Lee TC, Kang M, Kim CH, Schultz PG, Chapman E, Deniz AA. Dual Unnatural Amino Acid Incorporation and Click-Chemistry Labeling to Enable Single-Molecule FRET Studies of p97 Folding. Chembiochem : a European Journal of Chemical Biology. 17: 981-4. PMID 27115850 DOI: 10.1002/cbic.201500695  0.92
2016 Wijeratne EM, Gunaherath GM, Chapla VM, Tillotson J, de la Cruz F, Kang M, U Ren JM, Araujo AR, Arnold AE, Chapman E, Gunatilaka AA. Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii. Journal of Natural Products. PMID 26812276 DOI: 10.1021/acs.jnatprod.5b00986  0.92
2015 Harder B, Jiang T, Wu T, Tao S, de la Vega MR, Tian W, Chapman E, Zhang DD. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochemical Society Transactions. 43: 680-6. PMID 26551712 DOI: 10.1042/BST20150020  0.44
2015 Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway. Chembiochem : a European Journal of Chemical Biology. 16: 2002-6. PMID 26267855 DOI: 10.1002/cbic.201500229  0.92
2015 Jiang T, Harder B, Vega MR, Wong PK, Chapman E, Zhang DD. p62 links autophagy and Nrf2 signaling. Free Radical Biology & Medicine. PMID 26117325 DOI: 10.1016/j.freeradbiomed.2015.06.014  0.44
2015 Tao S, Tillotson J, Wijeratne EM, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, La Clair JJ, Gunatilaka AA, Zhang DD, Chapman E. Withaferin A Analogs That Target the AAA+ Chaperone p97. Acs Chemical Biology. PMID 26006219 DOI: 10.1021/acschembio.5b00367  0.92
2015 Shen T, Jiang T, Long M, Chen J, Ren D, Wong PK, Chapman E, Zhou B, Zhang DD. A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response. Antioxidants & Redox Signaling. PMID 25891177 DOI: 10.1089/ars.2014.6074  0.92
2015 Chapman E, Maksim N, de la Cruz F, La Clair JJ. Correction: Chapman, E.; et al. Inhibitors of the AAA+ chaperone p97. Molecules 2015, 20, 3027-3049. Molecules (Basel, Switzerland). 20: 4357-8. PMID 25759952 DOI: 10.3390/molecules20034357  0.36
2015 Chapman E, Maksim N, de la Cruz F, La Clair JJ. Inhibitors of the AAA+ chaperone p97. Molecules (Basel, Switzerland). 20: 3027-49. PMID 25685910 DOI: 10.3390/molecules20023027  0.92
2015 Ambrose AJ, Fenton W, Mason DJ, Chapman E, Horwich AL. Unfolded DapA forms aggregates when diluted into free solution, confounding comparison with folding by the GroEL/GroES chaperonin system. Febs Letters. 589: 497-9. PMID 25601566 DOI: 10.1016/j.febslet.2015.01.008  0.92
2015 Lau EC, Mason DJ, Eichhorst N, Engelder P, Mesa C, Kithsiri Wijeratne EM, Gunaherath GM, Gunatilaka AA, La Clair JJ, Chapman E. Functional chromatographic technique for natural product isolation. Organic & Biomolecular Chemistry. 13: 2255-9. PMID 25588099 DOI: 10.1039/c4ob02292k  0.92
2015 Harder B, Jiang T, Wu T, Tao S, De La Vega MR, Tian W, Chapman E, Zhang DD. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention Biochemical Society Transactions. 43: 680-686. DOI: 10.1042/BST20150020  0.92
2015 Chapman E. Handbook of Chemical and Biological Plant Analytical Methods. Edited by Kurt Hostettmann, Shilin Chen, Andrew Marston, Hermann Stuppner Chembiochem. DOI: 10.1002/cbic.201500252  0.92
2014 Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD. Oncogenic KRAS confers chemoresistance by upregulating NRF2. Cancer Research. 74: 7430-41. PMID 25339352 DOI: 10.1158/0008-5472.CAN-14-1439  0.92
2014 Kang MJ, Wu T, Wijeratne EM, Lau EC, Mason DJ, Mesa C, Tillotson J, Zhang DD, Gunatilaka AA, La Clair JJ, Chapman E. Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action. Chembiochem : a European Journal of Chemical Biology. 15: 2125-31. PMID 25125376 DOI: 10.1002/cbic.201402258  0.92
2014 La Clair JJ, Loveridge ST, Tenney K, O'Neil-Johnson M, Chapman E, Crews P. In situ natural product discovery via an artificial marine sponge. Plos One. 9: e100474. PMID 25004127 DOI: 10.1371/journal.pone.0100474  0.36
2014 Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes & Development. 28: 708-22. PMID 24636985 DOI: 10.1101/gad.238246.114  0.92
2014 Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E. A biochemical screen for GroEL/GroES inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 786-9. PMID 24418775 DOI: 10.1016/j.bmcl.2013.12.100  0.92
2014 La Clair JJ, Loveridge ST, Tenney K, O'Neil-Johnson M, Chapman E, Crews P. In Situ natural product discovery via an artificial marine sponge Plos One. 9. DOI: 10.1371/journal.pone.0100474  0.92
2013 Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD. USP15 negatively regulates Nrf2 through deubiquitination of Keap1. Molecular Cell. 51: 68-79. PMID 23727018 DOI: 10.1016/j.molcel.2013.04.022  0.92
2013 Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart MD. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. Journal of the American Chemical Society. 135: 5962-5. PMID 23550886 DOI: 10.1021/ja400795m  0.92
2011 Charbon G, Wang J, Brustad E, Schultz PG, Horwich AL, Jacobs-Wagner C, Chapman E. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid. Bioorganic & Medicinal Chemistry Letters. 21: 6067-70. PMID 21890355 DOI: 10.1016/j.bmcl.2011.08.057  0.92
2011 Charbon G, Brustad E, Scott KA, Wang J, Løbner-Olesen A, Schultz PG, Jacobs-Wagner C, Chapman E. Subcellular protein localization by using a genetically encoded fluorescent amino acid. Chembiochem : a European Journal of Chemical Biology. 12: 1818-21. PMID 21681882 DOI: 10.1002/cbic.201100282  0.92
2011 Chapman E, Fry AN, Kang M. The complexities of p97 function in health and disease. Molecular Biosystems. 7: 700-10. PMID 21152665 DOI: 10.1039/c0mb00176g  0.92
2009 Chapman E, Farr GW, Furtak K, Horwich AL. A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL. Bioorganic & Medicinal Chemistry Letters. 19: 811-3. PMID 19110421 DOI: 10.1016/j.bmcl.2008.12.015  0.92
2008 Chapman E, Farr GW, Fenton WA, Johnson SM, Horwich AL. Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state. Proceedings of the National Academy of Sciences of the United States of America. 105: 19205-10. PMID 19050077 DOI: 10.1073/pnas.0810657105  0.92
2007 Horwich AL, Fenton WA, Chapman E, Farr GW. Two families of chaperonin: physiology and mechanism. Annual Review of Cell and Developmental Biology. 23: 115-45. PMID 17489689 DOI: 10.1146/annurev.cellbio.23.090506.123555  0.92
2006 Chapman E, Farr GW, Usaite R, Furtak K, Fenton WA, Chaudhuri TK, Hondorp ER, Matthews RG, Wolf SG, Yates JR, Pypaert M, Horwich AL. Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL. Proceedings of the National Academy of Sciences of the United States of America. 103: 15800-5. PMID 17043235 DOI: 10.1073/pnas.0607534103  0.92
2004 Chapman E, Best MD, Hanson SR, Wong CH. Sulfotransferases: structure, mechanism, biological activity, inhibition, and synthetic utility. Angewandte Chemie (International Ed. in English). 43: 3526-48. PMID 15293241 DOI: 10.1002/anie.200300631  0.92
2004 Best MD, Brik A, Chapman E, Lee LV, Cheng WC, Wong CH. Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening. Chembiochem : a European Journal of Chemical Biology. 5: 811-9. PMID 15174164 DOI: 10.1002/cbic.200300841  0.92
2003 Chapman E, Bryan MC, Wong CH. Mechanistic studies of beta-arylsulfotransferase IV. Proceedings of the National Academy of Sciences of the United States of America. 100: 910-5. PMID 12547913 DOI: 10.1073/pnas.0337638100  0.92
2003 Wong CH, Bryan MC, Nyffeler PT, Liu H, Chapman E. Synthesis of carbohydrate-based antibiotics Pure and Applied Chemistry. 75: 179-186.  0.92
2002 Chapman E, Ding S, Schultz PG, Wong CH. A potent and highly selective sulfotransferase inhibitor. Journal of the American Chemical Society. 124: 14524-5. PMID 12465948 DOI: 10.1021/ja021086u  0.92
2002 Chapman E, Wong CH. A pH sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: a case study using kinases. Bioorganic & Medicinal Chemistry. 10: 551-5. PMID 11814841 DOI: 10.1016/S0968-0896(01)00306-6  0.92
2000 Burkart MD, Izumi M, Chapman E, Lin CH, Wong CH. Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides. The Journal of Organic Chemistry. 65: 5565-74. PMID 10970295 DOI: 10.1021/jo000266o  0.92
1997 Chapman E, Thorson JS, Schultz PG. Mutational analysis of backbone hydrogen bonds in staphylococcal nuclease [2] Journal of the American Chemical Society. 119: 7151-7152. DOI: 10.1021/ja970826+  0.92
1995 Thorson JS, Chapman E, Schultz PG. Analysis of hydrogen bonding strengths in proteins using unnatural amino acids Journal of the American Chemical Society. 117: 9361-9362. DOI: 10.1021/ja00141a032  0.92
1995 Thorson JS, Chapman E, Murphy EC, Schultz PG, Judice JK. Linear free energy analysis of hydrogen bonding in proteins Journal of the American Chemical Society. 117: 1157-1158.  0.92
Show low-probability matches.