Corey R. Hopkins, Ph.D. - Publications

Affiliations: 
2002 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Chemical Biology

94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ. Development and antiparkinsonian activity of VU0418506, a selective positive allosteric modulator of metabotropic glutamate receptor 4 homomers without activity at mGlu2/4 heteromers. Acs Chemical Neuroscience. PMID 27441572 DOI: 10.1021/acschemneuro.6b00036  1
2016 Gogliotti RD, Blobaum AL, Morrison RM, Daniels JS, Salovich JM, Cheung YY, Rodriguez AL, Loch MT, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). Bioorganic & Medicinal Chemistry Letters. PMID 27234146 DOI: 10.1016/j.bmcl.2016.05.029  1
2016 Wood MR, Noetzel MJ, Engers JL, Bollinger KA, Melancon BJ, Tarr JC, Han C, West M, Gregro AR, Lamsal A, Chang S, Ajmera S, Smith E, Chase P, Hodder PS, ... ... Hopkins CR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorganic & Medicinal Chemistry Letters. PMID 27185330 DOI: 10.1016/j.bmcl.2016.05.010  1
2016 Swale DR, Kurata H, Kharade SV, Sheehan JH, Raphemot RR, Voigtritter KR, Figueroa E, Meiler J, Flobaum AL, Lindsley CW, Hopkins CR, Denton JS. ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. Acs Chemical Neuroscience. PMID 27184474 DOI: 10.1021/acschemneuro.6b00111  1
2016 Gogliotti RD, Engers DW, Garcia-Barrantes PM, Panarese JD, Gentry PR, Blobaum AL, Morrison RD, Daniels JS, Thompson AD, Jones CK, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. Bioorganic & Medicinal Chemistry Letters. PMID 27131990 DOI: 10.1016/j.bmcl.2016.04.041  1
2016 Witt JO, McCollum AL, Hurtado MA, Huseman ED, Jeffries DE, Temple KJ, Plumley HC, Blobaum AL, Lindsley CW, Hopkins CR. Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 27080176 DOI: 10.1016/j.bmcl.2016.03.102  1
2016 Engers DW, Blobaum AL, Gogliotti RD, Cheung YY, Salovich JM, Garcia-Barrantes PM, Daniels JS, Morrison R, Jones CK, Soars MG, Zhuo X, Hurley J, Macor JE, Bronson JJ, Conn PJ, ... ... Hopkins CR, et al. Discovery, Synthesis and Pre-Clinical Characterization of N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4). Acs Chemical Neuroscience. PMID 27075300 DOI: 10.1021/acschemneuro.6b00035  1
2016 Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ. Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. Chemical Reviews. PMID 26882314 DOI: 10.1021/acs.chemrev.5b00656  1
2015 Hover LD, Owens P, Munden AL, Wang J, Chambless LB, Hopkins CR, Hong CC, Moses HL, Abel TW. Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma. Neuro-Oncology. PMID 26683138 DOI: 10.1093/neuonc/nov310  1
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, ... ... Hopkins CR, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/j.cell.2015.05.023  1
2015 Klar R, Walker AG, Ghose D, Grueter BA, Engers DW, Hopkins CR, Lindsley CW, Xiang Z, Conn PJ, Niswender CM. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7600-15. PMID 25972184 DOI: 10.1523/JNEUROSCI.4543-14.2015  1
2015 Bollinger SR, Engers DW, Ennis EA, Wright J, Locuson CW, Lindsley CW, Blakely RD, Hopkins CR. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorganic & Medicinal Chemistry Letters. 25: 1757-60. PMID 25801932 DOI: 10.1016/j.bmcl.2015.02.058  1
2015 Iderberg H, Maslava N, Thompson AD, Bubser M, Niswender CM, Hopkins CR, Lindsley CW, Conn PJ, Jones CK, Cenci MA. Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist. Neuropharmacology. 95: 121-9. PMID 25749357 DOI: 10.1016/j.neuropharm.2015.02.023  1
2015 Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. Acs Chemical Neuroscience. 6: 417-27. PMID 25560927 DOI: 10.1021/cn5001809  1
2015 Wen W, Wang Y, Li Z, Tseng PY, McManus OB, Wu M, Li M, Lindsley CW, Dong X, Hopkins CR. Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. Chemmedchem. 10: 57-61. PMID 25209672 DOI: 10.1002/cmdc.201402277  1
2014 Raphemot R, Rouhier MF, Swale DR, Days E, Weaver CD, Lovell KM, Konkel LC, Engers DW, Bollinger SR, Bollinger SF, Hopkins C, Piermarini PM, Denton JS. Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels. Plos One. 9: e110772. PMID 25375326 DOI: 10.1371/journal.pone.0110772  1
2014 Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, et al. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. The Journal of Pharmacology and Experimental Therapeutics. 351: 549-58. PMID 25271257 DOI: 10.1124/jpet.114.216903  1
2014 Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, ... ... Hopkins CR, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. Acs Chemical Neuroscience. 5: 1221-37. PMID 25225882 DOI: 10.1021/cn500153z  1
2014 Berry CB, Bubser M, Jones CK, Hayes JP, Wepy JA, Locuson CW, Daniels JS, Lindsley CW, Hopkins CR. Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. Acs Medicinal Chemistry Letters. 5: 1060-4. PMID 25221667 DOI: 10.1021/ml500267c  1
2014 Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW. Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. Acs Chemical Biology. 9: 2334-46. PMID 25137254 DOI: 10.1021/cb500560h  1
2013 Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A. Inhibition of the TRPC5 ion channel protects the kidney filter. The Journal of Clinical Investigation. 123: 5298-309. PMID 24231357 DOI: 10.1172/JCI71165  1
2013 Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins CR, Lindsley CW, Lin Z, Babcock JJ, McManus OB, Neubig RR. Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. Cellular Signalling. 25: 2848-55. PMID 24041654 DOI: 10.1016/j.cellsig.2013.09.007  1
2013 Raphemot R, Rouhier MF, Hopkins CR, Gogliotti RD, Lovell KM, Hine RM, Ghosalkar D, Longo A, Beyenbach KW, Denton JS, Piermarini PM. Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels. Plos One. 8: e64905. PMID 23734226 DOI: 10.1371/journal.pone.0064905  1
2013 Yu H, Lin Z, Mattmann ME, Zou B, Terrenoire C, Zhang H, Wu M, McManus OB, Kass RS, Lindsley CW, Hopkins CR, Li M. Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 8732-7. PMID 23650380 DOI: 10.1073/pnas.1300684110  1
2013 Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorganic & Medicinal Chemistry Letters. 23: 3248-52. PMID 23639540 DOI: 10.1016/j.bmcl.2013.03.113  1
2013 Hopkins CR. Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia? Acs Chemical Neuroscience. 4: 211-3. PMID 23421671 DOI: 10.1021/cn400023y  1
2013 Sheffler DJ, Sevel C, Le U, Lovell KM, Tarr JC, Carrington SJ, Cho HP, Digby GJ, Niswender CM, Conn PJ, Hopkins CR, Wood MR, Lindsley CW. Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorganic & Medicinal Chemistry Letters. 23: 223-7. PMID 23200253 DOI: 10.1016/j.bmcl.2012.10.132  1
2013 Le U, Melancon BJ, Bridges TM, Vinson PN, Utley TJ, Lamsal A, Rodriguez AL, Venable D, Sheffler DJ, Jones CK, Blobaum AL, Wood MR, Daniels JS, Conn PJ, Niswender CM, ... ... Hopkins CR, et al. Discovery of a selective Mâ‚„ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorganic & Medicinal Chemistry Letters. 23: 346-50. PMID 23177787 DOI: 10.1016/j.bmcl.2012.10.073  1
2012 Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E, Sidorov VY, Engers DW, Zou B, Afshartous D, George AL, Campbell CM, Balser JR, et al. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. The Journal of Biological Chemistry. 287: 39613-25. PMID 23033485 DOI: 10.1074/jbc.M112.380162  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on Suvorexant. Acs Chemical Neuroscience. 3: 647-8. PMID 23024835 DOI: 10.1021/cn300086a  1
2012 Mattmann ME, Yu H, Lin Z, Xu K, Huang X, Long S, Wu M, McManus OB, Engers DW, Le UM, Li M, Lindsley CW, Hopkins CR. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorganic & Medicinal Chemistry Letters. 22: 5936-41. PMID 22910039 DOI: 10.1016/j.bmcl.2012.07.060  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on Potiga (Ezogabine). Acs Chemical Neuroscience. 3: 632. PMID 22896808 DOI: 10.1021/cn3000789  1
2012 Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Acs Chemical Neuroscience. 3: 482-91. PMID 22860217 DOI: 10.1021/cn300029t  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on BMS-708163. Acs Chemical Neuroscience. 3: 149-50. PMID 22860183 DOI: 10.1021/cn3000179  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on Begacestat (GSI-953). Acs Chemical Neuroscience. 3: 3-4. PMID 22860177 DOI: 10.1021/cn200124u  1
2012 Ao A, Hao J, Hopkins CR, Hong CC. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. Plos One. 7: e41627. PMID 22848549 DOI: 10.1371/journal.pone.0041627  1
2012 Cheung YY, Yu H, Xu K, Zou B, Wu M, McManus OB, Li M, Lindsley CW, Hopkins CR. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. Journal of Medicinal Chemistry. 55: 6975-9. PMID 22793372 DOI: 10.1021/jm300700v  1
2012 Salovich JM, Vinson PN, Sheffler DJ, Lamsal A, Utley TJ, Blobaum AL, Bridges TM, Le U, Jones CK, Wood MR, Daniels JS, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR. Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor. Bioorganic & Medicinal Chemistry Letters. 22: 5084-8. PMID 22738637 DOI: 10.1016/j.bmcl.2012.05.109  1
2012 Mueller R, Dawson ES, Niswender CM, Butkiewicz M, Hopkins CR, Weaver CD, Lindsley CW, Conn PJ, Meiler J. Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators. Journal of Molecular Modeling. 18: 4437-46. PMID 22592386 DOI: 10.1007/s00894-012-1441-0  1
2012 Lindsley CW, Hopkins CR. Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature. Expert Opinion On Therapeutic Patents. 22: 461-81. PMID 22506633 DOI: 10.1517/13543776.2012.679437  1
2012 Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, Conn PJ, Lindsley CW. Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. Journal of Medicinal Chemistry. 55: 1445-64. PMID 22148748 DOI: 10.1021/jm201139r  1
2012 Jones CK, Bubser M, Thompson AD, Dickerson JW, Turle-Lorenzo N, Amalric M, Blobaum AL, Bridges TM, Morrison RD, Jadhav S, Engers DW, Italiano K, Bode J, Daniels JS, Lindsley CW, ... Hopkins CR, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 340: 404-21. PMID 22088953 DOI: 10.1124/jpet.111.187443  1
2011 Robichaud AJ, Engers DW, Lindsley CW, Hopkins CR. Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. Acs Chemical Neuroscience. 2: 433-49. PMID 22860170 DOI: 10.1021/cn200043e  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on STX209 (arbaclofen). Acs Chemical Neuroscience. 2: 381. PMID 22860166 DOI: 10.1021/cn200061g  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on RG1678. Acs Chemical Neuroscience. 2: 685-6. PMID 22860161 DOI: 10.1021/cn200108z  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on viibryd (Vilazodone). Acs Chemical Neuroscience. 2: 554. PMID 22860155 DOI: 10.1021/cn200084v  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on Telcagepant (MK-0974). Acs Chemical Neuroscience. 2: 334-5. PMID 22816019 DOI: 10.1021/cn200059f  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on ELND006: another γ-secretase inhibitor fails in the clinic. Acs Chemical Neuroscience. 2: 279-80. PMID 22778871 DOI: 10.1021/cn2000469  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720). Acs Chemical Neuroscience. 2: 116-7. PMID 22778861 DOI: 10.1021/cn100113g  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on latuda (lurasidone; SM-13,496). Acs Chemical Neuroscience. 2: 58-9. PMID 22778856 DOI: 10.1021/cn1001123  1
2011 Xiang Z, Thompson AD, Brogan JT, Schulte ML, Melancon BJ, Mi D, Lewis LM, Zou B, Yang L, Morrison R, Santomango T, Byers F, Brewer K, Aldrich JS, Yu H, ... ... Hopkins CR, et al. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. Acs Chemical Neuroscience. 2: 730-742. PMID 22368764 DOI: 10.1021/cn200090z  1
2011 Raphemot R, Lonergan DF, Nguyen TT, Utley T, Lewis LM, Kadakia R, Weaver CD, Gogliotti R, Hopkins C, Lindsley CW, Denton JS. Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1. Frontiers in Pharmacology. 2: 75. PMID 22275899 DOI: 10.3389/fphar.2011.00075  1
2011 Yu H, Wu M, Townsend SD, Zou B, Long S, Daniels JS, McManus OB, Li M, Lindsley CW, Hopkins CR. Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. Acs Chemical Neuroscience. 2: 572-577. PMID 22125664 DOI: 10.1021/cn200065b  1
2011 Utley T, Haddenham D, Salovich JM, Zamorano R, Vinson PN, Lindsley CW, Hopkins CR, Niswender CM. Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator. Bioorganic & Medicinal Chemistry Letters. 21: 6955-9. PMID 22030026 DOI: 10.1016/j.bmcl.2011.09.131  1
2011 Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, ... ... Hopkins CR, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. Journal of Medicinal Chemistry. 54: 7639-47. PMID 21966889 DOI: 10.1021/jm200956q  1
2011 Miller M, Shi J, Zhu Y, Kustov M, Tian JB, Stevens A, Wu M, Xu J, Long S, Yang P, Zholos AV, Salovich JM, Weaver CD, Hopkins CR, Lindsley CW, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. The Journal of Biological Chemistry. 286: 33436-46. PMID 21795696 DOI: 10.1074/jbc.M111.274167  1
2011 Cross EE, Thomason RT, Martinez M, Hopkins CR, Hong CC, Bader DM. Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors. Acs Chemical Biology. 6: 952-61. PMID 21740033 DOI: 10.1021/cb200205z  1
2011 Wang HR, Wu M, Yu H, Long S, Stevens A, Engers DW, Sackin H, Daniels JS, Dawson ES, Hopkins CR, Lindsley CW, Li M, McManus OB. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. Acs Chemical Biology. 6: 845-56. PMID 21615117 DOI: 10.1021/cb200146a  1
2011 Wood MR, Hopkins CR, Brogan JT, Conn PJ, Lindsley CW. "Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology. Biochemistry. 50: 2403-10. PMID 21341760 DOI: 10.1021/bi200129s  1
2011 Cheung YY, Zamorano R, Blobaum AL, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGluâ‚„. Acs Combinatorial Science. 13: 159-65. PMID 21338051 DOI: 10.1021/co1000508  1
2011 Engers DW, Field JR, Le U, Zhou Y, Bolinger JD, Zamorano R, Blobaum AL, Jones CK, Jadhav S, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. Journal of Medicinal Chemistry. 54: 1106-10. PMID 21247167 DOI: 10.1021/jm101271s  1
2011 Lindsley CW, Hopkins CR, Sulikowski GA. Biomimetic Synthesis of Lignans Biomimetic Organic Synthesis. 2: 677-693. DOI: 10.1002/9783527634606.ch18  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on dimebon. Acs Chemical Neuroscience. 1: 587-8. PMID 22778847 DOI: 10.1021/cn1000588  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on semagacestat (LY450139). Acs Chemical Neuroscience. 1: 533-4. PMID 22778845 DOI: 10.1021/cn1000606  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Sabril. Acs Chemical Neuroscience. 1: 475. PMID 22778839 DOI: 10.1021/cn100025k  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Fanapt. Acs Chemical Neuroscience. 1: 410. PMID 22778835 DOI: 10.1021/cn100024g  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on savella. Acs Chemical Neuroscience. 1: 345. PMID 22778830 DOI: 10.1021/cn1000233  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Saphris. Acs Chemical Neuroscience. 1: 263-4. PMID 22778826 DOI: 10.1021/cn100022a  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Valdoxen. Acs Chemical Neuroscience. 1: 772-3. PMID 22778814 DOI: 10.1021/cn100062j  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Lorcaserin. Acs Chemical Neuroscience. 1: 718-9. PMID 22778808 DOI: 10.1021/cn100059u  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Saredutant. Acs Chemical Neuroscience. 1: 653-4. PMID 22776916 DOI: 10.1021/cn100061r  1
2010 Bridges TM, Kennedy JP, Hopkins CR, Conn PJ, Lindsley CW. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 5617-22. PMID 20801651 DOI: 10.1016/j.bmcl.2010.08.042  1
2010 Engers DW, Gentry PR, Williams R, Bolinger JD, Weaver CD, Menon UN, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorganic & Medicinal Chemistry Letters. 20: 5175-8. PMID 20667732 DOI: 10.1016/j.bmcl.2010.07.007  1
2010 Salovich JM, Lindsley CW, Hopkins CR. Synthesis of 2,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence. Tetrahedron Letters. 51: 3796-3799. PMID 20606711 DOI: 10.1016/j.tetlet.2010.05.060  1
2010 Williams R, Zhou Y, Niswender CM, Luo Q, Conn PJ, Lindsley CW, Hopkins CR. Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4. Acs Chemical Neuroscience. 1: 411-419. PMID 20582156 DOI: 10.1021/cn9000318  1
2010 Bridges TM, LeBois EP, Hopkins CR, Wood MR, Jones CK, Conn PJ, Lindsley CW. The antipsychotic potential of muscarinic allosteric modulation. Drug News & Perspectives. 23: 229-40. PMID 20520852 DOI: 10.1358/dnp.2010.23.4.1416977  1
2010 Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. Acs Chemical Biology. 5: 245-53. PMID 20020776 DOI: 10.1021/cb9002865  1
2010 Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorganic & Medicinal Chemistry Letters. 20: 558-62. PMID 20004578 DOI: 10.1016/j.bmcl.2009.11.089  1
2009 Hopkins CR, Lindsley CW, Niswender CM. mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease. Future Medicinal Chemistry. 1: 501-13. PMID 20161443 DOI: 10.4155/fmc.09.38  1
2009 Lindsley CW, Niswender CM, Engers DW, Hopkins CR. Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease. Current Topics in Medicinal Chemistry. 9: 949-63. PMID 19754407 DOI: 10.2174/156802609789378272  1
2009 Williams R, Johnson KA, Gentry PR, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Hopkins CR. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorganic & Medicinal Chemistry Letters. 19: 4967-70. PMID 19640716 DOI: 10.1016/j.bmcl.2009.07.072  1
2009 Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). Journal of Medicinal Chemistry. 52: 4115-8. PMID 19469556 DOI: 10.1021/jm9005065  1
2008 Hopkins CR. Molecule of the month Current Topics in Medicinal Chemistry. 8: 1710-1711. DOI: 10.2174/156802608786786561  1
2006 Hopkins CR, O'neil SV, Laufersweiler MC, Wang Y, Pokross M, Mekel M, Evdokimov A, Walter R, Kontoyianni M, Petrey ME, Sabatakos G, Roesgen JT, Richardson E, Demuth TP. Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. Bioorganic & Medicinal Chemistry Letters. 16: 5659-63. PMID 16919947 DOI: 10.1016/j.bmcl.2006.08.003  1
2006 Maier JA, Brugel TA, Sabat M, Golebiowski A, Laufersweiler MJ, VanRens JC, Hopkins CR, De B, Hsieh LC, Brown KK, Easwaran V, Janusz MJ. Development of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase. Bioorganic & Medicinal Chemistry Letters. 16: 3646-50. PMID 16682201 DOI: 10.1016/j.bmcl.2006.04.072  1
2005 Hopkins CR, Czekaj M, Kaye SS, Gao Z, Pribish J, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Luo Y, Lim HK, Vaz R, Rebello S, Maignan S, et al. Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase. Bioorganic & Medicinal Chemistry Letters. 15: 2734-7. PMID 15911249 DOI: 10.1016/j.bmcl.2005.04.002  1
2005 Hopkins CR, Collar N. Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation Tetrahedron Letters. 46: 1845-1848. DOI: 10.1016/j.tetlet.2005.01.105  1
2004 Hopkins C, Neuenschwander K, Scotese A, Jackson S, Nieduzak T, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Maignan S, Mathieu M. Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation Bioorganic and Medicinal Chemistry Letters. 14: 4819-4823. PMID 15341931 DOI: 10.1016/j.bmcl.2004.07.051  1
2004 Hopkins CR, Collar N. An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating Tetrahedron Letters. 45: 8631-8633. DOI: 10.1016/j.tetlet.2004.09.152  1
2004 Hopkins CR, Collar N. 6-Substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)-methanesulfonamide and alkynes Tetrahedron Letters. 45: 8087-8090. DOI: 10.1016/j.tetlet.2004.08.155  1
2004 Majid T, Hopkins CR, Pedgrift B, Collar N. Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes Tetrahedron Letters. 45: 2137-2139. DOI: 10.1016/j.tetlet.2004.01.045  1
2002 Wipf P, Hopkins CR, Phillips EO, Lazo JS. Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin Tetrahedron. 58: 6367-6372. DOI: 10.1016/S0040-4020(02)00636-1  1
2001 Wipf P, Hopkins CR. Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine. The Journal of Organic Chemistry. 66: 3133-9. PMID 11325279 DOI: 10.1021/jo015512q  1
1999 Wipf P, Hopkins CR. Efficient Synthesis of 1,4-Dihydro-2H-isoquinoline-3,5,8-triones via Cyclobutene Ring Expansion. The Journal of Organic Chemistry. 64: 6881-6887. PMID 11674700 DOI: 10.1021/jo990089v  1
Show low-probability matches.