Corey R. Hopkins, Ph.D. - Publications

Affiliations: 
2002 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Chemical Biology

196 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Anderson A, Vo BN, Marron Fernandez de Velasco E, Hopkins CR, Weaver CD, Wickman K. . Molecular Pharmacology. PMID 34503975 DOI: 10.1124/molpharm.121.000311  1
2021 Sharma S, Lesiak L, Aretz CD, Du Y, Kumar S, Gautam N, Alnouti Y, Dhuria NV, Chhonker YS, Weaver CD, Hopkins CR. Discovery, synthesis and biological characterization of a series of -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators. Rsc Medicinal Chemistry. 12: 1366-1373. PMID 34458739 DOI: 10.1039/d1md00129a  1
2021 Vo BN, Marron Fernandez de Velasco E, Rose TR, Oberle H, Luo H, Hopkins CR, Wickman K. Bidirectional influence of limbic GIRK channel activation on innate avoidance behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34039657 DOI: 10.1523/JNEUROSCI.2787-20.2021  0.01
2021 Kumar B, Ahmad R, Sharma S, Gowrikumar S, Primeaux M, Rana S, Natarajan A, Oupicky D, Hopkins CR, Dhawan P, Singh AB. PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells. Cancers. 13. PMID 33946505 DOI: 10.3390/cancers13092168  0.01
2020 Vadukoot AK, Sharma S, Aretz CD, Kumar S, Gautam N, Alnouti Y, Aldrich AL, Heim CE, Kielian T, Hopkins CR. Synthesis and SAR Studies of 1-Pyrrolo[2,3-]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors. Acs Medicinal Chemistry Letters. 11: 1848-1854. PMID 33062163 DOI: 10.1021/Acsmedchemlett.9B00369  0.01
2020 Engers DW, Bollinger SR, Felts AS, Vadukoot AK, Williams CH, Blobaum AL, Lindsley CW, Hong CC, Hopkins CR. Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors. Bioorganic & Medicinal Chemistry Letters. 30: 127418. PMID 32750526 DOI: 10.1016/J.Bmcl.2020.127418  1
2020 Burkovetskaya ME, Liu Q, Vadukoot AK, Gautam N, Alnouti Y, Kumar S, Miczek K, Buch S, Hopkins CR, Guo M. KVA-D-88, a novel preferable phosphodiesterase 4B inhibitor, decreases cocaine-mediated reward properties in vivo. Acs Chemical Neuroscience. PMID 32609488 DOI: 10.1021/Acschemneuro.0C00170  0.08
2020 Antonio-Tolentino K, Hopkins CR. Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia - a review. Expert Opinion On Investigational Drugs. 1-7. PMID 32396418 DOI: 10.1080/13543784.2020.1764938  0.01
2019 Belot A, Gourbeyre O, Fay A, Palin A, Besson C, Latour C, Hopkins CR, Tidmarsh GF, Coppin H, Roth MP, Ritter MR, Hong CC, Meynard D. LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA. Haematologica. PMID 31806689 DOI: 10.3324/Haematol.2019.236133  1
2019 Aretz CD, Vadukoot AK, Hopkins CR. Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics. Journal of Medicinal Chemistry. PMID 31034224 DOI: 10.1021/Acs.Jmedchem.8B01891  0.01
2019 Sharma S, Hopkins CR. A review of transient receptor potential channel (TRPC) modulators and diseases. Journal of Medicinal Chemistry. PMID 30943030 DOI: 10.1021/Acs.Jmedchem.8B01954  0.01
2019 Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K. VU0810464, a non-urea GIRK channel activator, exhibits enhanced selectivity for neuronal GIRK channels and reduces stress-induced hyperthermia in mice. British Journal of Pharmacology. PMID 30924523 DOI: 10.1111/Bph.14671  1
2019 Abney KK, Bubser M, Du Y, Kozek KA, Bridges TM, Lindsley CW, Daniels JS, Morrison RD, Wickman K, Hopkins CR, Jones CK, Weaver CD. Correction to Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models. Acs Chemical Neuroscience. PMID 30912639 DOI: 10.1021/Acschemneuro.9B00165  1
2019 Panarese JD, Engers DW, Wu YJ, Bronson JJ, Macor JE, Chun A, Rodriguez AL, Felts AS, Engers JL, Loch MT, Emmitte KA, Castelhano AL, Kates MJ, Nader MA, Jones CK, ... ... Hopkins CR, et al. Discovery of VU2957 (Valiglurax): An mGlu Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease. Acs Medicinal Chemistry Letters. 10: 255-260. PMID 30891122 DOI: 10.1021/Acsmedchemlett.8B00426  1
2019 Aretz C, Morwitzer MJ, Sanford A, Hogan AM, Portillo M, Kharade SV, Kramer M, Mcarthey J, Trigueros RR, Piermarini PM, Denton JS, Hopkins CR. Discovery and characterization of 2-nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines as novel inhibitors of the Aedes aegypti Kir1 (AeKir1) channel. Acs Infectious Diseases. PMID 30832472 DOI: 10.1021/Acsinfecdis.8B00368  1
2019 Sharma S, Kozek KA, Abney KK, Kumar S, Gautam N, Alnouti Y, David Weaver C, Hopkins CR. Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators. Bioorganic & Medicinal Chemistry Letters. PMID 30718161 DOI: 10.1016/J.Bmcl.2019.01.027  0.01
2019 Sharma SH, Pablo JL, Montesinos MS, Greka A, Hopkins CR. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorganic & Medicinal Chemistry Letters. 29: 155-159. PMID 30538066 DOI: 10.1016/J.Bmcl.2018.12.007  0.12
2018 Panarese JD, Engers DW, Wu YJ, Guernon JM, Chun A, Gregro AR, Bender AM, Capstick RA, Wieting JM, Bronson JJ, Macor JE, Westphal R, Soars M, Engers JE, Felts AS, ... ... Hopkins CR, et al. The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu PAM development candidate. Bioorganic & Medicinal Chemistry Letters. PMID 30503632 DOI: 10.1016/J.Bmcl.2018.10.050  1
2018 Abney KK, Bubser M, Du Y, Kozek KA, Bridges TM, Lindsley CW, Daniels JS, Morrison RD, Wickman K, Hopkins CR, Jones CK, Weaver CD. Analgesic effects of the GIRK Activator, VU0466551, alone and in combination with morphine in acute and persistent pain models. Acs Chemical Neuroscience. PMID 30474955 DOI: 10.1021/Acschemneuro.8B00370  1
2018 Rusconi Trigueros R, Hopkins CR, Denton JS, Piermarini PM. Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval . Insects. 9. PMID 30445675 DOI: 10.3390/Insects9040163  1
2018 Bollinger S, Engers DW, Panarese JD, West M, Engers JL, Loch MT, Rodriguez AL, Blobaum AL, Jones CK, Thompson Gray A, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. The discovery, SAR and biological characterization of a novel series of 6-((1H-pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). Journal of Medicinal Chemistry. PMID 30247901 DOI: 10.1021/Acs.Jmedchem.8B00994  1
2018 Piermarini PM, Inocente EA, Acosta N, Hopkins CR, Denton JS, Michel AP. Inward rectifier potassium (Kir) channels in the soybean aphid Aphis glycines: Functional characterization, pharmacology, and toxicology. Journal of Insect Physiology. 110: 57-65. PMID 30196125 DOI: 10.1016/J.Jinsphys.2018.09.001  1
2018 Kozek KA, Du Y, Sharma S, Prael FJ, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD. Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-gated, Inwardly-rectifying, Potassium (GIRK) Channels. Acs Chemical Neuroscience. PMID 30136838 DOI: 10.1021/Acschemneuro.8B00287  1
2018 Engers DW, Bollinger SR, Engers JL, Panarese JD, Breiner MM, Gregro A, Blobaum AL, Bronson JJ, Wu YJ, Macor JE, Rodriguez AL, Zamorano R, Conn PJ, Lindsley CW, Niswender CM, ... Hopkins CR, et al. Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu positive allosteric modulators that mitigate CYP1A2 induction liability. Bioorganic & Medicinal Chemistry Letters. PMID 29958762 DOI: 10.1016/J.Bmcl.2018.06.034  1
2018 Kharade SV, Kurata H, Bender A, Blobaum AL, Figueroa EE, Duran AM, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, et al. Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Molecular Pharmacology. PMID 29895592 DOI: 10.1124/Mol.118.112359  1
2017 Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, ... ... Hopkins CR, et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science (New York, N.Y.). 358: 1332-1336. PMID 29217578 DOI: 10.1126/Science.Aal4178  1
2017 Wieting JM, Vadukoot AK, Sharma SH, Abney KK, Bridges TM, Daniels JS, Morrison RD, Wickman K, Weaver CD, Hopkins CR. Discovery and characterization of 1H-pyrazol-5-yl-2-phenylacetamides as novel, non-urea containing GIRK1/2 potassium channel activators. Acs Chemical Neuroscience. PMID 28697302 DOI: 10.1021/Acschemneuro.7B00217  1
2017 Lindsley CW, Hopkins CR. The Return of D4 Dopamine Receptor Antagonists in Drug Discovery. Journal of Medicinal Chemistry. PMID 28489950 DOI: 10.1021/Acs.Jmedchem.7B00151  1
2017 Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, ... ... Hopkins C, et al. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223516 DOI: 10.1073/Pnas.1615255114  1
2016 Jeffries DE, Witt JO, McCollum AL, Temple KJ, Hurtado MA, Harp JM, Blobaum AL, Lindsley CW, Hopkins CR. Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists. Bioorganic & Medicinal Chemistry Letters. 26: 5757-5764. PMID 28327307 DOI: 10.1016/J.Bmcl.2016.10.049  1
2016 Swale DR, Engers DW, Bollinger SR, Gross A, Inocente EA, Days E, Kanga F, Johnson RM, Yang L, Bloomquist JR, Hopkins CR, Piermarini PM, Denton JS. An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria. Scientific Reports. 6: 36954. PMID 27849039 DOI: 10.1038/Srep36954  1
2016 Sebastianutto I, Maslava N, Hopkins CR, Cenci MA. Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists. Neurobiology of Disease. PMID 27597526 DOI: 10.1016/J.Nbd.2016.09.001  1
2016 Hopkins CR. Inhibitors of the Bone Morphogenetic Protein (BMP) Signaling Pathway: A Patent Review (2008-2015). Expert Opinion On Therapeutic Patents. PMID 27476794 DOI: 10.1080/13543776.2016.1217330  0.01
2016 Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ. Development and antiparkinsonian activity of VU0418506, a selective positive allosteric modulator of metabotropic glutamate receptor 4 homomers without activity at mGlu2/4 heteromers. Acs Chemical Neuroscience. PMID 27441572 DOI: 10.1021/Acschemneuro.6B00036  1
2016 Gogliotti RD, Blobaum AL, Morrison RM, Daniels JS, Salovich JM, Cheung YY, Rodriguez AL, Loch MT, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4). Bioorganic & Medicinal Chemistry Letters. PMID 27234146 DOI: 10.1016/J.Bmcl.2016.05.029  1
2016 Wood MR, Noetzel MJ, Engers JL, Bollinger KA, Melancon BJ, Tarr JC, Han C, West M, Gregro AR, Lamsal A, Chang S, Ajmera S, Smith E, Chase P, Hodder PS, ... ... Hopkins CR, et al. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorganic & Medicinal Chemistry Letters. PMID 27185330 DOI: 10.1016/J.Bmcl.2016.05.010  1
2016 Swale DR, Kurata H, Kharade SV, Sheehan JH, Raphemot RR, Voigtritter KR, Figueroa E, Meiler J, Flobaum AL, Lindsley CW, Hopkins CR, Denton JS. ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. Acs Chemical Neuroscience. PMID 27184474 DOI: 10.1021/Acschemneuro.6B00111  1
2016 Gogliotti RD, Engers DW, Garcia-Barrantes PM, Panarese JD, Gentry PR, Blobaum AL, Morrison RD, Daniels JS, Thompson AD, Jones CK, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. Bioorganic & Medicinal Chemistry Letters. PMID 27131990 DOI: 10.1016/J.Bmcl.2016.04.041  1
2016 Witt JO, McCollum AL, Hurtado MA, Huseman ED, Jeffries DE, Temple KJ, Plumley HC, Blobaum AL, Lindsley CW, Hopkins CR. Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 27080176 DOI: 10.1016/J.Bmcl.2016.03.102  1
2016 Engers DW, Blobaum AL, Gogliotti RD, Cheung YY, Salovich JM, Garcia-Barrantes PM, Daniels JS, Morrison R, Jones CK, Soars MG, Zhuo X, Hurley J, Macor JE, Bronson JJ, Conn PJ, ... ... Hopkins CR, et al. Discovery, Synthesis and Pre-Clinical Characterization of N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4). Acs Chemical Neuroscience. PMID 27075300 DOI: 10.1021/Acschemneuro.6B00035  1
2016 Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ. Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. Chemical Reviews. PMID 26882314 DOI: 10.1021/Acs.Chemrev.5B00656  1
2015 Hover LD, Owens P, Munden AL, Wang J, Chambless LB, Hopkins CR, Hong CC, Moses HL, Abel TW. Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma. Neuro-Oncology. PMID 26683138 DOI: 10.1093/Neuonc/Nov310  1
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, ... ... Hopkins CR, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/J.Cell.2015.05.023  1
2015 Klar R, Walker AG, Ghose D, Grueter BA, Engers DW, Hopkins CR, Lindsley CW, Xiang Z, Conn PJ, Niswender CM. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7600-15. PMID 25972184 DOI: 10.1523/Jneurosci.4543-14.2015  1
2015 Bollinger SR, Engers DW, Ennis EA, Wright J, Locuson CW, Lindsley CW, Blakely RD, Hopkins CR. Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorganic & Medicinal Chemistry Letters. 25: 1757-60. PMID 25801932 DOI: 10.1016/J.Bmcl.2015.02.058  1
2015 Iderberg H, Maslava N, Thompson AD, Bubser M, Niswender CM, Hopkins CR, Lindsley CW, Conn PJ, Jones CK, Cenci MA. Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist. Neuropharmacology. 95: 121-9. PMID 25749357 DOI: 10.1016/J.Neuropharm.2015.02.023  1
2015 Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. Acs Chemical Neuroscience. 6: 417-27. PMID 25560927 DOI: 10.1021/Cn5001809  1
2015 Wen W, Wang Y, Li Z, Tseng PY, McManus OB, Wu M, Li M, Lindsley CW, Dong X, Hopkins CR. Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. Chemmedchem. 10: 57-61. PMID 25209672 DOI: 10.1002/Cmdc.201402277  1
2015 Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong CC, Moses HL. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene. 34: 2437-49. PMID 24998846 DOI: 10.1038/Onc.2014.189  1
2015 Hopkins CR. Job Stress: Risk Factors, Health Effects and Coping Strategies Job Stress: Risk Factors, Health Effects and Coping Strategies. 1-145.  1
2015 Hopkins CR. Preface Job Stress: Risk Factors, Health Effects and Coping Strategies. vii-ix.  1
2014 Raphemot R, Rouhier MF, Swale DR, Days E, Weaver CD, Lovell KM, Konkel LC, Engers DW, Bollinger SR, Bollinger SF, Hopkins C, Piermarini PM, Denton JS. Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels. Plos One. 9: e110772. PMID 25375326 DOI: 10.1371/Journal.Pone.0110772  1
2014 Tsugawa D, Oya Y, Masuzaki R, Ray K, Engers DW, Dib M, Do N, Kuramitsu K, Ho K, Frist A, Yu PB, Bloch KD, Lindsley CW, Hopkins CR, Hong CC, et al. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. The Journal of Pharmacology and Experimental Therapeutics. 351: 549-58. PMID 25271257 DOI: 10.1124/Jpet.114.216903  1
2014 Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, ... ... Hopkins CR, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. Acs Chemical Neuroscience. 5: 1221-37. PMID 25225882 DOI: 10.1021/Cn500153Z  1
2014 Berry CB, Bubser M, Jones CK, Hayes JP, Wepy JA, Locuson CW, Daniels JS, Lindsley CW, Hopkins CR. Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. Acs Medicinal Chemistry Letters. 5: 1060-4. PMID 25221667 DOI: 10.1021/Ml500267C  1
2014 Cho HP, Garcia-Barrantes PM, Brogan JT, Hopkins CR, Niswender CM, Rodriguez AL, Venable DF, Morrison RD, Bubser M, Daniels JS, Jones CK, Conn PJ, Lindsley CW. Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. Acs Chemical Biology. 9: 2334-46. PMID 25137254 DOI: 10.1021/Cb500560H  1
2014 Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong CC, Moses HL. Abstract 2676: Inhibition of bmp signaling suppresses metastasis in mammary cancer Cancer Research. 74: 2676-2676. DOI: 10.1158/1538-7445.Am2014-2676  1
2014 Racsko J, Marmor F, Hopkins CR, Petracek P, Silverman FP, Fritts R, Liu X, Woolard D, Lopez J, Leep D, Pienaar J. Use of S-abscisic acid (ConTego™ SL) in vegetable production Acta Horticulturae. 1042: 243-253.  1
2013 Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A. Inhibition of the TRPC5 ion channel protects the kidney filter. The Journal of Clinical Investigation. 123: 5298-309. PMID 24231357 DOI: 10.1172/Jci71165  1
2013 Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins CR, Lindsley CW, Lin Z, Babcock JJ, McManus OB, Neubig RR. Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. Cellular Signalling. 25: 2848-55. PMID 24041654 DOI: 10.1016/J.Cellsig.2013.09.007  1
2013 Raphemot R, Rouhier MF, Hopkins CR, Gogliotti RD, Lovell KM, Hine RM, Ghosalkar D, Longo A, Beyenbach KW, Denton JS, Piermarini PM. Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels. Plos One. 8: e64905. PMID 23734226 DOI: 10.1371/Journal.Pone.0064905  1
2013 Yu H, Lin Z, Mattmann ME, Zou B, Terrenoire C, Zhang H, Wu M, McManus OB, Kass RS, Lindsley CW, Hopkins CR, Li M. Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 8732-7. PMID 23650380 DOI: 10.1073/Pnas.1300684110  1
2013 Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorganic & Medicinal Chemistry Letters. 23: 3248-52. PMID 23639540 DOI: 10.1016/J.Bmcl.2013.03.113  1
2013 Hopkins CR. Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia? Acs Chemical Neuroscience. 4: 211-3. PMID 23421671 DOI: 10.1021/Cn400023Y  1
2013 Sheffler DJ, Sevel C, Le U, Lovell KM, Tarr JC, Carrington SJ, Cho HP, Digby GJ, Niswender CM, Conn PJ, Hopkins CR, Wood MR, Lindsley CW. Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism. Bioorganic & Medicinal Chemistry Letters. 23: 223-7. PMID 23200253 DOI: 10.1016/J.Bmcl.2012.10.132  1
2013 Le U, Melancon BJ, Bridges TM, Vinson PN, Utley TJ, Lamsal A, Rodriguez AL, Venable D, Sheffler DJ, Jones CK, Blobaum AL, Wood MR, Daniels JS, Conn PJ, Niswender CM, ... ... Hopkins CR, et al. Discovery of a selective Mâ‚„ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorganic & Medicinal Chemistry Letters. 23: 346-50. PMID 23177787 DOI: 10.1016/J.Bmcl.2012.10.073  1
2012 Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E, Sidorov VY, Engers DW, Zou B, Afshartous D, George AL, Campbell CM, Balser JR, et al. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. The Journal of Biological Chemistry. 287: 39613-25. PMID 23033485 DOI: 10.1074/Jbc.M112.380162  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on Suvorexant. Acs Chemical Neuroscience. 3: 647-8. PMID 23024835 DOI: 10.1021/Cn300086A  1
2012 Mattmann ME, Yu H, Lin Z, Xu K, Huang X, Long S, Wu M, McManus OB, Engers DW, Le UM, Li M, Lindsley CW, Hopkins CR. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorganic & Medicinal Chemistry Letters. 22: 5936-41. PMID 22910039 DOI: 10.1016/J.Bmcl.2012.07.060  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on Potiga (Ezogabine). Acs Chemical Neuroscience. 3: 632. PMID 22896808 DOI: 10.1021/Cn3000789  1
2012 Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Acs Chemical Neuroscience. 3: 482-91. PMID 22860217 DOI: 10.1021/Cn300029T  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on BMS-708163. Acs Chemical Neuroscience. 3: 149-50. PMID 22860183 DOI: 10.1021/Cn3000179  1
2012 Hopkins CR. ACS chemical neuroscience molecule spotlight on Begacestat (GSI-953). Acs Chemical Neuroscience. 3: 3-4. PMID 22860177 DOI: 10.1021/Cn200124U  1
2012 Ao A, Hao J, Hopkins CR, Hong CC. DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. Plos One. 7: e41627. PMID 22848549 DOI: 10.1371/Journal.Pone.0041627  1
2012 Cheung YY, Yu H, Xu K, Zou B, Wu M, McManus OB, Li M, Lindsley CW, Hopkins CR. Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor. Journal of Medicinal Chemistry. 55: 6975-9. PMID 22793372 DOI: 10.1021/Jm300700V  1
2012 Salovich JM, Vinson PN, Sheffler DJ, Lamsal A, Utley TJ, Blobaum AL, Bridges TM, Le U, Jones CK, Wood MR, Daniels JS, Conn PJ, Niswender CM, Lindsley CW, Hopkins CR. Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor. Bioorganic & Medicinal Chemistry Letters. 22: 5084-8. PMID 22738637 DOI: 10.1016/J.Bmcl.2012.05.109  1
2012 Mueller R, Dawson ES, Niswender CM, Butkiewicz M, Hopkins CR, Weaver CD, Lindsley CW, Conn PJ, Meiler J. Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators. Journal of Molecular Modeling. 18: 4437-46. PMID 22592386 DOI: 10.1007/S00894-012-1441-0  1
2012 Lindsley CW, Hopkins CR. Metabotropic glutamate receptor 4 (mGlu4)-positive allosteric modulators for the treatment of Parkinson's disease: historical perspective and review of the patent literature. Expert Opinion On Therapeutic Patents. 22: 461-81. PMID 22506633 DOI: 10.1517/13543776.2012.679437  1
2012 Melancon BJ, Hopkins CR, Wood MR, Emmitte KA, Niswender CM, Christopoulos A, Conn PJ, Lindsley CW. Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery. Journal of Medicinal Chemistry. 55: 1445-64. PMID 22148748 DOI: 10.1021/Jm201139R  1
2012 Jones CK, Bubser M, Thompson AD, Dickerson JW, Turle-Lorenzo N, Amalric M, Blobaum AL, Bridges TM, Morrison RD, Jadhav S, Engers DW, Italiano K, Bode J, Daniels JS, Lindsley CW, ... Hopkins CR, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 340: 404-21. PMID 22088953 DOI: 10.1124/Jpet.111.187443  1
2012 Ogugbue CE, Hopkins CR, Greenly LR, Wilson RK, Gates GE. Lowering tubing in Jonah field offset production decline Society of Petroleum Engineers - Spe Americas Unconventional Resources Conference 2012. 84-94.  1
2011 Robichaud AJ, Engers DW, Lindsley CW, Hopkins CR. Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. Acs Chemical Neuroscience. 2: 433-49. PMID 22860170 DOI: 10.1021/Cn200043E  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on STX209 (arbaclofen). Acs Chemical Neuroscience. 2: 381. PMID 22860166 DOI: 10.1021/Cn200061G  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on RG1678. Acs Chemical Neuroscience. 2: 685-6. PMID 22860161 DOI: 10.1021/Cn200108Z  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on viibryd (Vilazodone). Acs Chemical Neuroscience. 2: 554. PMID 22860155 DOI: 10.1021/Cn200084V  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on Telcagepant (MK-0974). Acs Chemical Neuroscience. 2: 334-5. PMID 22816019 DOI: 10.1021/Cn200059F  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on ELND006: another γ-secretase inhibitor fails in the clinic. Acs Chemical Neuroscience. 2: 279-80. PMID 22778871 DOI: 10.1021/Cn2000469  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on gilenya (fingolimod; FTY720). Acs Chemical Neuroscience. 2: 116-7. PMID 22778861 DOI: 10.1021/Cn100113G  1
2011 Hopkins CR. ACS chemical neuroscience molecule spotlight on latuda (lurasidone; SM-13,496). Acs Chemical Neuroscience. 2: 58-9. PMID 22778856 DOI: 10.1021/Cn1001123  1
2011 Xiang Z, Thompson AD, Brogan JT, Schulte ML, Melancon BJ, Mi D, Lewis LM, Zou B, Yang L, Morrison R, Santomango T, Byers F, Brewer K, Aldrich JS, Yu H, ... ... Hopkins CR, et al. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. Acs Chemical Neuroscience. 2: 730-742. PMID 22368764 DOI: 10.1021/Cn200090Z  1
2011 Raphemot R, Lonergan DF, Nguyen TT, Utley T, Lewis LM, Kadakia R, Weaver CD, Gogliotti R, Hopkins C, Lindsley CW, Denton JS. Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1. Frontiers in Pharmacology. 2: 75. PMID 22275899 DOI: 10.3389/Fphar.2011.00075  1
2011 Yu H, Wu M, Townsend SD, Zou B, Long S, Daniels JS, McManus OB, Li M, Lindsley CW, Hopkins CR. Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. Acs Chemical Neuroscience. 2: 572-577. PMID 22125664 DOI: 10.1021/Cn200065B  1
2011 Utley T, Haddenham D, Salovich JM, Zamorano R, Vinson PN, Lindsley CW, Hopkins CR, Niswender CM. Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator. Bioorganic & Medicinal Chemistry Letters. 21: 6955-9. PMID 22030026 DOI: 10.1016/J.Bmcl.2011.09.131  1
2011 Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, Bogenpohl J, Smith Y, Morrison R, Daniels JS, Weaver CD, ... ... Hopkins CR, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. Journal of Medicinal Chemistry. 54: 7639-47. PMID 21966889 DOI: 10.1021/Jm200956Q  1
2011 Miller M, Shi J, Zhu Y, Kustov M, Tian JB, Stevens A, Wu M, Xu J, Long S, Yang P, Zholos AV, Salovich JM, Weaver CD, Hopkins CR, Lindsley CW, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. The Journal of Biological Chemistry. 286: 33436-46. PMID 21795696 DOI: 10.1074/Jbc.M111.274167  1
2011 Cross EE, Thomason RT, Martinez M, Hopkins CR, Hong CC, Bader DM. Application of small organic molecules reveals cooperative TGFβ and BMP regulation of mesothelial cell behaviors. Acs Chemical Biology. 6: 952-61. PMID 21740033 DOI: 10.1021/Cb200205Z  1
2011 Llobet A, Gallop JL, Burden JJ, Camdere G, Chandra P, Vallis Y, Hopkins CR, Lagnado L, McMahon HT. Endophilin drives the fast mode of vesicle retrieval in a ribbon synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8512-9. PMID 21653855 DOI: 10.1523/Jneurosci.6223-09.2011  1
2011 Wang HR, Wu M, Yu H, Long S, Stevens A, Engers DW, Sackin H, Daniels JS, Dawson ES, Hopkins CR, Lindsley CW, Li M, McManus OB. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. Acs Chemical Biology. 6: 845-56. PMID 21615117 DOI: 10.1021/Cb200146A  1
2011 Wood MR, Hopkins CR, Brogan JT, Conn PJ, Lindsley CW. "Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology. Biochemistry. 50: 2403-10. PMID 21341760 DOI: 10.1021/Bi200129S  1
2011 Cheung YY, Zamorano R, Blobaum AL, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGluâ‚„. Acs Combinatorial Science. 13: 159-65. PMID 21338051 DOI: 10.1021/Co1000508  1
2011 Engers DW, Field JR, Le U, Zhou Y, Bolinger JD, Zamorano R, Blobaum AL, Jones CK, Jadhav S, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. Journal of Medicinal Chemistry. 54: 1106-10. PMID 21247167 DOI: 10.1021/Jm101271S  1
2011 Lindsley CW, Hopkins CR, Sulikowski GA. Biomimetic Synthesis of Lignans Biomimetic Organic Synthesis. 2: 677-693. DOI: 10.1002/9783527634606.ch18  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on dimebon. Acs Chemical Neuroscience. 1: 587-8. PMID 22778847 DOI: 10.1021/Cn1000588  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on semagacestat (LY450139). Acs Chemical Neuroscience. 1: 533-4. PMID 22778845 DOI: 10.1021/Cn1000606  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Sabril. Acs Chemical Neuroscience. 1: 475. PMID 22778839 DOI: 10.1021/Cn100025K  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Fanapt. Acs Chemical Neuroscience. 1: 410. PMID 22778835 DOI: 10.1021/Cn100024G  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on savella. Acs Chemical Neuroscience. 1: 345. PMID 22778830 DOI: 10.1021/Cn1000233  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Saphris. Acs Chemical Neuroscience. 1: 263-4. PMID 22778826 DOI: 10.1021/Cn100022A  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Valdoxen. Acs Chemical Neuroscience. 1: 772-3. PMID 22778814 DOI: 10.1021/Cn100062J  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Lorcaserin. Acs Chemical Neuroscience. 1: 718-9. PMID 22778808 DOI: 10.1021/Cn100059U  1
2010 Hopkins CR. ACS chemical neuroscience molecule spotlight on Saredutant. Acs Chemical Neuroscience. 1: 653-4. PMID 22776916 DOI: 10.1021/Cn100061R  1
2010 Bridges TM, Kennedy JP, Hopkins CR, Conn PJ, Lindsley CW. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 5617-22. PMID 20801651 DOI: 10.1016/J.Bmcl.2010.08.042  1
2010 Engers DW, Gentry PR, Williams R, Bolinger JD, Weaver CD, Menon UN, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorganic & Medicinal Chemistry Letters. 20: 5175-8. PMID 20667732 DOI: 10.1016/J.Bmcl.2010.07.007  1
2010 Salovich JM, Lindsley CW, Hopkins CR. Synthesis of 2,3-diarylsubstituted indazoles utilizing a Suzuki cross-coupling/deprotection/N-arylation sequence. Tetrahedron Letters. 51: 3796-3799. PMID 20606711 DOI: 10.1016/J.Tetlet.2010.05.060  1
2010 Williams R, Zhou Y, Niswender CM, Luo Q, Conn PJ, Lindsley CW, Hopkins CR. Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4. Acs Chemical Neuroscience. 1: 411-419. PMID 20582156 DOI: 10.1021/Cn9000318  1
2010 Bridges TM, LeBois EP, Hopkins CR, Wood MR, Jones CK, Conn PJ, Lindsley CW. The antipsychotic potential of muscarinic allosteric modulation. Drug News & Perspectives. 23: 229-40. PMID 20520852 DOI: 10.1358/Dnp.2010.23.4.1416977  1
2010 Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. Acs Chemical Biology. 5: 245-53. PMID 20020776 DOI: 10.1021/Cb9002865  1
2010 Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorganic & Medicinal Chemistry Letters. 20: 558-62. PMID 20004578 DOI: 10.1016/J.Bmcl.2009.11.089  1
2009 Hopkins CR, Lindsley CW, Niswender CM. mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease. Future Medicinal Chemistry. 1: 501-13. PMID 20161443 DOI: 10.4155/Fmc.09.38  1
2009 Lindsley CW, Niswender CM, Engers DW, Hopkins CR. Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease. Current Topics in Medicinal Chemistry. 9: 949-63. PMID 19754407 DOI: 10.2174/156802609789378272  1
2009 Williams R, Johnson KA, Gentry PR, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Hopkins CR. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorganic & Medicinal Chemistry Letters. 19: 4967-70. PMID 19640716 DOI: 10.1016/J.Bmcl.2009.07.072  1
2009 Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). Journal of Medicinal Chemistry. 52: 4115-8. PMID 19469556 DOI: 10.1021/Jm9005065  1
2008 Schonteich E, Wilson GM, Burden J, Hopkins CR, Anderson K, Goldenring JR, Prekeris R. The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. Journal of Cell Science. 121: 3824-33. PMID 18957512 DOI: 10.1242/Jcs.032441  1
2008 Hopkins CR. Molecule of the month Current Topics in Medicinal Chemistry. 8: 1710-1711. DOI: 10.2174/156802608786786561  1
2007 Deinhardt K, Reversi A, Berninghausen O, Hopkins CR, Schiavo G. Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport. Traffic (Copenhagen, Denmark). 8: 1736-49. PMID 17897318 DOI: 10.1111/J.1600-0854.2007.00645.X  1
2006 Hopkins CR, O'neil SV, Laufersweiler MC, Wang Y, Pokross M, Mekel M, Evdokimov A, Walter R, Kontoyianni M, Petrey ME, Sabatakos G, Roesgen JT, Richardson E, Demuth TP. Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. Bioorganic & Medicinal Chemistry Letters. 16: 5659-63. PMID 16919947 DOI: 10.1016/J.Bmcl.2006.08.003  1
2006 Deinhardt K, Berninghausen O, Willison HJ, Hopkins CR, Schiavo G. Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. The Journal of Cell Biology. 174: 459-71. PMID 16880274 DOI: 10.1083/Jcb.200508170  1
2006 Maier JA, Brugel TA, Sabat M, Golebiowski A, Laufersweiler MJ, VanRens JC, Hopkins CR, De B, Hsieh LC, Brown KK, Easwaran V, Janusz MJ. Development of N-4,6-pyrimidine-N-alkyl-N'-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase. Bioorganic & Medicinal Chemistry Letters. 16: 3646-50. PMID 16682201 DOI: 10.1016/J.Bmcl.2006.04.072  1
2005 Doyotte A, Russell MR, Hopkins CR, Woodman PG. Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects. Journal of Cell Science. 118: 3003-17. PMID 16014378 DOI: 10.1242/jcs.02421  1
2005 Hopkins CR, Czekaj M, Kaye SS, Gao Z, Pribish J, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Luo Y, Lim HK, Vaz R, Rebello S, Maignan S, et al. Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase. Bioorganic & Medicinal Chemistry Letters. 15: 2734-7. PMID 15911249 DOI: 10.1016/J.Bmcl.2005.04.002  1
2005 Hopkins CR, Collar N. Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation Tetrahedron Letters. 46: 1845-1848. DOI: 10.1016/J.Tetlet.2005.01.105  1
2004 Hopkins C, Neuenschwander K, Scotese A, Jackson S, Nieduzak T, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Maignan S, Mathieu M. Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation Bioorganic and Medicinal Chemistry Letters. 14: 4819-4823. PMID 15341931 DOI: 10.1016/J.Bmcl.2004.07.051  1
2004 Hopkins CR, Collar N. An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating Tetrahedron Letters. 45: 8631-8633. DOI: 10.1016/J.Tetlet.2004.09.152  1
2004 Hopkins CR, Collar N. 6-Substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)-methanesulfonamide and alkynes Tetrahedron Letters. 45: 8087-8090. DOI: 10.1016/J.Tetlet.2004.08.155  1
2004 Majid T, Hopkins CR, Pedgrift B, Collar N. Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes Tetrahedron Letters. 45: 2137-2139. DOI: 10.1016/J.Tetlet.2004.01.045  1
2002 Hume AN, Collinson LM, Hopkins CR, Strom M, Barral DC, Bossi G, Griffiths GM, Seabra MC. The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic (Copenhagen, Denmark). 3: 193-202. PMID 11886590 DOI: 10.1034/J.1600-0854.2002.030305.X  1
2002 Wipf P, Hopkins CR, Phillips EO, Lazo JS. Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin Tetrahedron. 58: 6367-6372. DOI: 10.1016/S0040-4020(02)00636-1  1
2001 Futter CE, Collinson LM, Backer JM, Hopkins CR. Human VPS34 is required for internal vesicle formation within multivesicular endosomes. The Journal of Cell Biology. 155: 1251-64. PMID 11756475 DOI: 10.1083/Jcb.200108152  1
2001 Wipf P, Hopkins CR. Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine. The Journal of Organic Chemistry. 66: 3133-9. PMID 11325279 DOI: 10.1021/Jo015512Q  1
2001 Hume AN, Collinson LM, Rapak A, Gomes AQ, Hopkins CR, Seabra MC. Rab27a regulates the peripheral distribution of melanosomes in melanocytes. The Journal of Cell Biology. 152: 795-808. PMID 11266470 DOI: 10.1083/jcb.152.4.795  1
2001 Marks B, Stowell MH, Vallis Y, Mills IG, Gibson A, Hopkins CR, McMahon HT. GTPase activity of dynamin and resulting conformation change are essential for endocytosis. Nature. 410: 231-5. PMID 11242086 DOI: 10.1038/35065645  1
2001 Ford MG, Pearse BM, Higgins MK, Vallis Y, Owen DJ, Gibson A, Hopkins CR, Evans PR, McMahon HT. Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science (New York, N.Y.). 291: 1051-5. PMID 11161218 DOI: 10.1126/science.291.5506.1051  1
1999 Wipf P, Hopkins CR. Efficient Synthesis of 1,4-Dihydro-2H-isoquinoline-3,5,8-triones via Cyclobutene Ring Expansion. The Journal of Organic Chemistry. 64: 6881-6887. PMID 11674700 DOI: 10.1021/Jo990089V  1
1998 Gibson A, Futter CE, Maxwell S, Allchin EH, Shipman M, Kraehenbuhl JP, Domingo D, Odorizzi G, Trowbridge IS, Hopkins CR. Sorting mechanisms regulating membrane protein traffic in the apical transcytotic pathway of polarized MDCK cells. The Journal of Cell Biology. 143: 81-94. PMID 9763422 DOI: 10.1083/Jcb.143.1.81  1
1998 Futter CE, Gibson A, Allchin EH, Maxwell S, Ruddock LJ, Odorizzi G, Domingo D, Trowbridge IS, Hopkins CR. In polarized MDCK cells basolateral vesicles arise from clathrin-gamma-adaptin-coated domains on endosomal tubules. The Journal of Cell Biology. 141: 611-23. PMID 9566963 DOI: 10.1083/Jcb.141.3.611  1
1998 Hirst J, Futter CE, Hopkins CR. The kinetics of mannose 6-phosphate receptor trafficking in the endocytic pathway in HEp-2 cells: the receptor enters and rapidly leaves multivesicular endosomes without accumulating in a prelysosomal compartment. Molecular Biology of the Cell. 9: 809-16. PMID 9529379  1
1998 Lai A, Gibson A, Hopkins CR, Trowbridge IS. Signal-dependent trafficking of β-amyloid precursor protein-transferrin receptor chimeras in Madin-Darby canine kidney cells Journal of Biological Chemistry. 273: 3732-3739. PMID 9452505 DOI: 10.1074/jbc.273.6.3732  1
1996 Odorizzi G, Pearse A, Domingo D, Trowbridge IS, Hopkins CR. Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism. The Journal of Cell Biology. 135: 139-52. PMID 8858169 DOI: 10.1083/Jcb.135.1.139  1
1996 Futter CE, Pearse A, Hewlett LJ, Hopkins CR. Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes Journal of Cell Biology. 132: 1011-1023. PMID 8601581 DOI: 10.1083/jcb.132.6.1011  1
1995 Stinchcombe JC, Nomoto H, Cutler DF, Hopkins CR. Anterograde and retrograde traffic between the rough endoplasmic reticulum and the Golgi complex Journal of Cell Biology. 131: 1387-1401. PMID 8522599 DOI: 10.1083/jcb.131.6.1387  1
1995 Futter CE, Connolly CN, Cutler DF, Hopkins CR. Newly synthesized transferrin receptors can be detected in the endosome before they appear on the cell surface. The Journal of Biological Chemistry. 270: 10999-1003. PMID 7738042 DOI: 10.1074/jbc.270.18.10999  1
1995 Hopkins CR, Reading CC. Thyroid and parathyroid imaging Seminars in Ultrasound, Ct, and Mri. 16: 279-295. PMID 7576775 DOI: 10.1016/0887-2171(95)90033-0  1
1995 Knight A, Hughson E, Hopkins CR, Cutler DF. Membrane protein trafficking through the common apical endosome compartment of polarized Caco-2 cells Molecular Biology of the Cell. 6: 597-610. PMID 7545032  1
1994 Hopkins CR. Internalization of polypeptide growth factor receptors and the regulation of transcription Biochemical Pharmacology. 47: 151-154. PMID 8311840 DOI: 10.1016/0006-2952(94)90449-9  1
1994 Greg Odorizzi C, Trowbridge IS, Xue L, Hopkins CR, Davis CD, Collawn JF. Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment Journal of Cell Biology. 126: 317-330. PMID 8034737 DOI: 10.1083/Jcb.126.2.317  1
1994 Connolly CN, Futter CE, Gibson A, Hopkins CR, Cutler DF. Transport into and out of the Golgi complex studied by transfecting cells with cDNAs encoding horseradish peroxidase. The Journal of Cell Biology. 127: 641-52. PMID 7962049 DOI: 10.1083/jcb.127.3.641  1
1994 Hopkins CR, Gibson A, Shipman M, Strickland DK, Trowbridge IS. In migrating fibroblasts, recycling receptors are concentrated in narrow tubules in the pericentriolar area, and then routed to the plasma membrane of the leading lamella Journal of Cell Biology. 125: 1265-1274. PMID 7515888 DOI: 10.1083/jcb.125.6.1265  1
1993 Trowbridge IS, Collawn JF, Hopkins CR. Signal-dependent membrane protein trafficking in the endocytic pathway Annual Review of Cell Biology. 9: 129-161. PMID 8280459 DOI: 10.1146/Annurev.Cb.09.110193.001021  1
1993 Futter CE, Felder S, Schlessinger J, Ullrich A, Hopkins CR. Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor. The Journal of Cell Biology. 120: 77-83. PMID 8093248  1
1993 Beaumelle B, Alami M, Hopkins CR. ATP-dependent translocation of ricin across the membrane of purified endosomes Journal of Biological Chemistry. 268: 23661-23669. PMID 7901210  1
1992 Hopkins CR. Selective membrane protein trafficking: vectorial flow and filter Trends in Biochemical Sciences. 17: 27-32. PMID 1585453 DOI: 10.1016/0968-0004(92)90423-7  1
1992 Koch G, Hopkins CR. Are molecular filters really necessary? [1] Trends in Biochemical Sciences. 17: 211-212. PMID 1502721  1
1992 Hopkins CR. Reply from Hopkins Trends in Biochemical Sciences. 17: 212. DOI: 10.1016/0968-0004(92)90378-M  1
1991 Miller K, Shipman M, Trowbridge IS, Hopkins CR. Transferrin receptors promote the formation of clathrin lattices Cell. 65: 621-632. PMID 1903330 DOI: 10.1016/0092-8674(91)90094-F  1
1991 Segawa A, Terakawa S, Yamashina S, Hopkins CR. Exocytosis in living salivary glands: Direct visualization by video-enhanced microscopy and confocal laser microscopy European Journal of Cell Biology. 54: 322-330. PMID 1879441  1
1991 Hopkins CR. Polarity signals Cell. 66: 827-829. PMID 1653646 DOI: 10.1016/0092-8674(91)90427-Z  1
1990 Hopkins CR, Gibson A, Shipman M, Miller K. Movement of internalized ligand-receptor complexes along a continuous endosomal reticulum Nature. 346: 335-339. PMID 2374607 DOI: 10.1038/346335a0  1
1990 Felder S, Miller K, Moehren G, Ullrich A, Schlessinger J, Hopkins CR. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body. Cell. 61: 623-34. PMID 2344614 DOI: 10.1016/0092-8674(90)90474-S  1
1990 Hughson EJ, Hopkins CR. Endocytic pathways in polarized Caco-2 cells: identification of an endosomal compartment accessible from both apical and basolateral surfaces Journal of Cell Biology. 110: 337-348. PMID 2298809  1
1990 Beaumelle BD, Gibson A, Hopkins CR. Isolation and preliminary characterization of the major membrane boundaries of the endocytic pathway in lymphocytes Journal of Cell Biology. 111: 1811-1823. PMID 2121741  1
1989 Futter CE, Hopkins CR. Subfractionation of the endocytic pathway: isolation of compartments involved in the processing of internalised epidermal growth factor-receptor complexes Journal of Cell Science. 94: 685-694. PMID 2630563  1
1989 Beaumelle BD, Hopkins CR. High-yield isolation of functionally competent endosomes from mouse lymphocytes Biochemical Journal. 264: 137-149. PMID 2604710  1
1989 Hughson EJ, Cutler DF, Hopkins CR. Basolateral secretion of kappa light chain in the polarised epithelial cell line, Caco-2 Journal of Cell Science. 94: 327-332. PMID 2516089  1
1989 Campo JJ, Swank WG, Hopkins CR. Brood habitat use by eastern wild turkeys in eastern Texas Journal of Wildlife Management. 53: 479-482.  1
1988 De Brabander M, Nuydens R, Geerts H, Hopkins CR. Dynamic behavior of the transferrin receptor followed in living epidermoid carcinoma (A431) cells with nanovid microscopy Cell Motility and the Cytoskeleton. 9: 30-47. PMID 2895685  1
1987 Winder WW, Yang HT, Jaussi AW, Hopkins CR. Epinephrine, glucose, and lactate infusion in exercising adrenodemedullated rats Journal of Applied Physiology. 62: 1442-1447. PMID 3298192  1
1987 Beardmore J, Howell KE, Miller K, Hopkins CR. Isolation of an endocytic compartment from A431 cells using a density modification procedure employing a receptor-specific monoclonal antibody complexed with colloidal gold Journal of Cell Science. 87: Pt 4/-. PMID 2888775  1
1986 Miller K, Beardmore J, Kanety H, Schlessinger J, Hopkins CR. Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells Journal of Cell Biology. 102: 500-509. PMID 2868013 DOI: 10.1083/JCB.102.2.500  1
1986 Hopkins CR. Membrane boundaries involved in the uptake and intracellular processing of cell surface receptors Trends in Biochemical Sciences. 11: 473-477. DOI: 10.1016/0968-0004(86)90250-1  1
1985 Hopkins CR, Miller K, Beardmore JM. Receptor-mediated endocytosis of transferrin and epidermal growth factor receptors: A comparison of constitutive and ligand-induced uptake Journal of Cell Science. 173-186. PMID 3011821  1
1985 Hopkins CR. The appearance and internalization of transferrin receptors at the margins of spreading human tumor cells Cell. 40: 199-208. PMID 2981629 DOI: 10.1016/0092-8674(85)90323-X  1
1984 Beardmore J, Hopkins CR. Uptake and intracellular processing of epidermal-growth-factor-receptor complexes Biochemical Society Transactions. 12: 165-168. PMID 6144597  1
1983 Hopkins CR. Intracellular routing of transferrin and transferrin receptors in epidermoid carcinoma A431 cells Cell. 35: 321-330. PMID 6313227 DOI: 10.1016/0092-8674(83)90235-0  1
1983 Hopkins CR. The importance of the endosome in intracellular traffic Nature. 304: 684-685. PMID 6310401  1
1983 Hopkins CR, Trowbridge IS. Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells Journal of Cell Biology. 97: 508-521. PMID 6309862  1
1982 Semoff S, Hogan BL, Hopkins CR. Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy Embo Journal. 1: 1171-1175. PMID 7188248 DOI: 10.1002/J.1460-2075.1982.Tb00009.X  1
1982 Kramer IM, Hopkins CR. Studies on the kinetics of dopamine-regulated prolactin secretion Molecular and Cellular Endocrinology. 28: 191-198. PMID 7128924 DOI: 10.1016/0303-7207(82)90031-4  1
1982 Goyns MH, Hopkins CR. Mitogenic effect of putrescine on quiescent granulosa cells Cellular and Molecular Biology. 28: 61-66. PMID 7083278  1
1982 Gregory H, Taylor CL, Hopkins CR. Luteinizing hormone release from dissociated pituitary cells by dimerization of occupied LHRH receptors Nature. 300: 269-271. PMID 6292723  1
1981 Sheterline P, Hopkins CR. Transmembrane linkage between surface glycoproteins and components of the cytoplasm in neutrophil leukocytes Journal of Cell Biology. 90: 743-754. PMID 7197281  1
1981 Goyns MH, Hopkins CR. Inhibition of epidermal growth factor-induced mitogenesis in bovine granuldsa cells by trifluoperazine Biochemical and Biophysical Research Communications. 102: 1107-1114. PMID 6976170 DOI: 10.1016/S0006-291X(81)80126-X  1
1981 Hopkins CR, Boothroyd B. Early events following the binding of epidermal growth factor to surface receptors on ovarian granulosa cells European Journal of Cell Biology. 24: 259-265. PMID 6269856  1
1981 Tolson ND, Boothroyd B, Hopkins CR. Cell surface labelling with gold colloid particulates: The use of avidin and staphylococcal protein A-coated gold in conjunction with biotin and fc-bearing ligands Journal of Microscopy. 123: 215-226. PMID 6173487  1
1981 Hopkins CR, Semoff S, Gregory H. Regulation of gonadotropin secretion in the anterior pituitary Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 296: 73-81. PMID 6121349  1
1980 Hopkins CR. Epidermal growth factor and mitogenesis Nature. 286: 205-206. PMID 6250047  1
1980 Hopkins CR. Proportional representation on the trustee board Representation. 20: 35-42. DOI: 10.1080/00344898008459296  1
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