Lewis D. Pennington, Ph.D. - Publications

Affiliations: 
2002 University of California, Irvine, Irvine, CA 
Area:
synthesis of natural products

28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Pennington LD, Bartberger MD, Croghan MD, Andrews KL, Ashton KS, Bourbeau MP, Chen J, Chmait S, Cupples R, Fotsch C, Helmering J, Hong FT, Hungate RW, Jordan SR, Kong K, et al. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N→S (nN→σ*S-X) Interaction for Conformational Constraint. Journal of Medicinal Chemistry. PMID 26551034 DOI: 10.1021/acs.jmedchem.5b01367  1
2015 Beno BR, Yeung KS, Bartberger MD, Pennington LD, Meanwell NA. A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design. Journal of Medicinal Chemistry. 58: 4383-438. PMID 25734370 DOI: 10.1021/jm501853m  1
2014 Cheung EY, Pennington LD, Bartberger MD, Staples RJ. 2,2'-Bi[benzo[b]thiophene]: an unexpected isolation of the benzo[b]thiophene dimer. Acta Crystallographica. Section C, Structural Chemistry. 70: 547-9. PMID 24898955 DOI: 10.1107/S2053229614009401  1
2014 Nishimura N, Norman MH, Liu L, Yang KC, Ashton KS, Bartberger MD, Chmait S, Chen J, Cupples R, Fotsch C, Helmering J, Jordan SR, Kunz RK, Pennington LD, Poon SF, et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series. Journal of Medicinal Chemistry. 57: 3094-116. PMID 24611879 DOI: 10.1021/jm5000497  1
2014 St Jean DJ, Ashton KS, Bartberger MD, Chen J, Chmait S, Cupples R, Galbreath E, Helmering J, Hong FT, Jordan SR, Liu L, Kunz RK, Michelsen K, Nishimura N, Pennington LD, et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. Journal of Medicinal Chemistry. 57: 325-38. PMID 24405213 DOI: 10.1021/jm4016747  1
2014 Ashton KS, Andrews KL, Bryan MC, Bryan MC, Chen J, Chen K, Chen M, Chmait S, Croghan M, Cupples R, Fotsch C, Helmering J, Jordan SR, Kurzeja RJ, Michelsen K, ... Pennington LD, et al. Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. Journal of Medicinal Chemistry. 57: 309-24. PMID 24405172 DOI: 10.1021/jm4016735  1
2013 Lloyd DJ, St Jean DJ, Kurzeja RJ, Wahl RC, Michelsen K, Cupples R, Chen M, Wu J, Sivits G, Helmering J, Komorowski R, Ashton KS, Pennington LD, Fotsch C, Vazir M, et al. Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors. Nature. 504: 437-40. PMID 24226772 DOI: 10.1038/nature12724  1
2013 Pennington LD, Whittington DA, Bartberger MD, Jordan SR, Monenschein H, Nguyen TT, Yang BH, Xue QM, Vounatsos F, Wahl RC, Chen K, Wood S, Citron M, Patel VF, Hitchcock SA, et al. Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity. Bioorganic & Medicinal Chemistry Letters. 23: 4459-64. PMID 23769639 DOI: 10.1016/j.bmcl.2013.05.028  1
2012 Kaller MR, Harried SS, Albrecht B, Amarante P, Babu-Khan S, Bartberger MD, Brown J, Brown R, Chen K, Cheng Y, Citron M, Croghan MD, Graceffa R, Hickman D, Judd T, ... ... Pennington LD, et al. A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase. Acs Medicinal Chemistry Letters. 3: 886-91. PMID 24900403 DOI: 10.1021/ml3000148  1
2012 Harrington PE, Croghan MD, Fotsch C, Frohn M, Lanman BA, Pennington LD, Pickrell AJ, Reed AB, Sham KK, Tasker A, Arnett HA, Fiorino M, Lee MR, McElvain M, Morrison HG, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. Acs Medicinal Chemistry Letters. 3: 74-8. PMID 24900374 DOI: 10.1021/ml200252b  1
2012 Monenschein H, Horne DB, Bartberger MD, Hitchcock SA, Nguyen TT, Patel VF, Pennington LD, Zhong W. Structure guided P1' modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters. 22: 3607-11. PMID 22572583 DOI: 10.1016/j.bmcl.2012.04.060  1
2012 Dineen TA, Weiss MM, Williamson T, Acton P, Babu-Khan S, Bartberger MD, Brown J, Chen K, Cheng Y, Citron M, Croghan MD, Dunn RT, Esmay J, Graceffa RF, Harried SS, ... ... Pennington LD, et al. Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. Journal of Medicinal Chemistry. 55: 9025-44. PMID 22468684 DOI: 10.1021/jm300118s  1
2012 Weiss MM, Williamson T, Babu-Khan S, Bartberger MD, Brown J, Chen K, Cheng Y, Citron M, Croghan MD, Dineen TA, Esmay J, Graceffa RF, Harried SS, Hickman D, Hitchcock SA, ... ... Pennington LD, et al. Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid. Journal of Medicinal Chemistry. 55: 9009-24. PMID 22468639 DOI: 10.1021/jm300119p  1
2012 Pennington LD, Croghan MD, Sham KK, Pickrell AJ, Harrington PE, Frohn MJ, Lanman BA, Reed AB, Lee MR, Xu H, McElvain M, Xu Y, Zhang X, Fiorino M, Horner M, et al. Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. Bioorganic & Medicinal Chemistry Letters. 22: 527-31. PMID 22104144 DOI: 10.1016/j.bmcl.2011.10.085  1
2011 Pennington LD, Sham KK, Pickrell AJ, Harrington PE, Frohn MJ, Lanman BA, Reed AB, Croghan MD, Lee MR, Xu H, McElvain M, Xu Y, Zhang X, Fiorino M, Horner M, et al. 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. Acs Medicinal Chemistry Letters. 2: 752-7. PMID 24900263 DOI: 10.1021/ml2001399  1
2009 Corminboeuf O, Overman LE, Pennington LD. A unified strategy for enantioselective total synthesis of cladiellin and briarellin diterpenes: total synthesis of briarellins E and F and the putative structure of alcyonin and revision of its structure assignment. The Journal of Organic Chemistry. 74: 5458-70. PMID 19534538 DOI: 10.1021/jo9010156  1
2006 Hitchcock SA, Pennington LD. Structure-brain exposure relationships. Journal of Medicinal Chemistry. 49: 7559-83. PMID 17181137 DOI: 10.1021/jm060642i  1
2003 Overman LE, Pennington LD. Strategic use of pinacol-terminated Prins cyclizations in target-oriented total synthesis. The Journal of Organic Chemistry. 68: 7143-57. PMID 12968864 DOI: 10.1021/jo034982c  1
2003 Corminboeuf O, Overman LE, Pennington LD. Enantioselective total synthesis of briarellins E and F: the first total syntheses of briarellin diterpenes. Journal of the American Chemical Society. 125: 6650-2. PMID 12769572 DOI: 10.1021/ja035445c  1
2003 Corminboeuf O, Overman LE, Pennington LD. Total synthesis of the reputed structure of alcyonin and reassignment of its structure. Organic Letters. 5: 1543-6. PMID 12713319 DOI: 10.1021/ol034384k  1
2001 MacMillan DW, Overman LE, Pennington LD. A general strategy for the synthesis of cladiellin diterpenes: enantioselective total syntheses of 6-acetoxycladiell-7(16),11-dien-3-ol (deacetoxyalcyonin acetate), cladiell-11-ene-3,6,7-triol, sclerophytin A, and the initially purported structure of sclerophytin A. Journal of the American Chemical Society. 123: 9033-44. PMID 11552811 DOI: 10.1021/ja016351a  1
2001 Gallou F, MacMillan DW, Overman LE, Paquette LA, Pennington LD, Yang J. Enantioselective syntheses of authentic sclerophytin A, sclerophytin B, and cladiell-11-ene-3,6,7-triol. Organic Letters. 3: 135-7. PMID 11429857 DOI: 10.1021/ol000345m  1
2000 Overman LE, Pennington LD. Total synthesis of the supposed structure of (-)-sclerophytin A and an improved route to (-)-7-deacetoxyalcyonin acetate. Organic Letters. 2: 2683-6. PMID 10990427  1
2000 Overman LE, Pennington LD. A new strategy for synthesis of attached rings Canadian Journal of Chemistry. 78: 732-738.  1
1998 Grese TA, Pennington LD, Sluka JP, Adrian MD, Cole HW, Fuson TR, Magee DE, Phillips DL, Rowley ER, Shetler PK, Short LL, Venugopalan M, Yang NN, Sato M, Glasebrook AL, et al. Synthesis and pharmacology of conformationally restricted raloxifene analogues: highly potent selective estrogen receptor modulators. Journal of Medicinal Chemistry. 41: 1272-83. PMID 9548817 DOI: 10.1021/jm970688z  1
1997 Grese TA, Cho S, Finley DR, Godfrey AG, Jones CD, Lugar CW, Martin MJ, Matsumoto K, Pennington LD, Winter MA, Adrian MD, Cole HW, Magee DE, Phillips DL, Rowley ER, et al. Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene. Journal of Medicinal Chemistry. 40: 146-67. PMID 9003514 DOI: 10.1021/jm9606352  1
1997 Martin MJ, Grese TA, Glasebrook AL, Matsumoto K, Pennington LD, Phillips DL, Short LL. Versatile raloxifene triflates Bioorganic and Medicinal Chemistry Letters. 7: 887-892. DOI: 10.1016/S0960-894X(97)00130-3  1
1995 Grese TA, Pennington LD. Novel methodology for the synthesis of estrogenic and antiestrogenic isoflav-3-enes Tetrahedron Letters. 36: 8913-8916. DOI: 10.1016/0040-4039(95)01916-6  1
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