Alec D. Lebsack, Ph.D. - Publications

2002 University of California, Irvine, Irvine, CA 
synthesis of natural products

15/18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Rech JC, Bhattacharya A, Branstetter BJ, Love CJ, Leenaerts JE, Cooymans LP, Eckert WA, Ao H, Wang Q, Chaplan SR, Wickenden AD, Lebsack AD, Breitenbucher JG. The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 27595421 DOI: 10.1016/j.bmcl.2016.08.029  1
2016 Blevitt JM, Hack MD, Herman K, Chang L, Keith JM, Mirzadegan T, Rao NL, Lebsack AD, Milla ME. A Single Amino Acid Difference between Mouse and Human 5-lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. The Journal of Biological Chemistry. PMID 27129215 DOI: 10.1074/jbc.M116.725325  1
2015 Song J, Liu X, Zhu J, Tootoonchi M, Keith JM, Meduna SP, Dvorak CA, Eccles W, Krawczuk PJ, Blevitt JM, Wu J, Rao NL, Lebsack AD, Milla ME. Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform. Journal of Biomolecular Screening. PMID 26442913 DOI: 10.1177/1087057115607815  1
2015 Canham SM, Hafensteiner BD, Lebsack AD, May-Dracka TL, Nam S, Stearns BA, Overman LE. Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids. Tetrahedron. 71: 6424-6436. PMID 26257440 DOI: 10.1016/J.Tet.2015.02.080  1
2015 Canham SM, Hafensteiner BD, Lebsack AD, May-Dracka TL, Nam S, Stearns BA, Overman LE. Stereocontrolled enantioselective total synthesis of the [2+2] quadrigemine alkaloids Tetrahedron. DOI: 10.1016/j.tet.2015.02.080  1
2011 Maher MP, Bhattacharya A, Ao H, Swanson N, Wu NT, Freedman J, Kansagara M, Scott B, Li DH, Eckert WA, Liu Y, Sepassi K, Rizzolio M, Fitzgerald A, Liu J, ... ... Lebsack AD, et al. Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist. European Journal of Pharmacology. 663: 40-50. PMID 21575625 DOI: 10.1016/J.Ejphar.2011.05.001  1
2011 Liu J, Fitzgerald AE, Lebsack AD, Mani NS. Scale-up synthesis of a TRPV1 antagonist featuring a facile thiazolo[5,4-d]pyrimidine formation Organic Process Research and Development. 15: 382-388. DOI: 10.1021/op1002984  1
2010 Hawryluk NA, Merit JE, Lebsack AD, Branstetter BJ, Hack MD, Swanson N, Ao H, Maher MP, Bhattacharya A, Wang Q, Freedman JM, Scott BP, Wickenden AD, Chaplan SR, Breitenbucher JG. Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 7137-41. PMID 20947352 DOI: 10.1016/j.bmcl.2010.09.023  1
2010 Lebsack AD, Rech JC, Branstetter BJ, Hawryluk NA, Merit JE, Allison B, Rynberg R, Buma J, Rizzolio M, Swanson N, Ao H, Maher MP, Herrmann M, Freedman J, Scott BP, et al. 1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties. Bioorganic & Medicinal Chemistry Letters. 20: 7142-6. PMID 20932750 DOI: 10.1016/j.bmcl.2010.09.006  1
2009 Venkatraman S, Lebsack AD, Alves K, Gardner MF, James J, Lingham RB, Maniar S, Mumford RA, Si Q, Stock N, Treonze KM, Wang B, Zunic J, Munoz B. Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist. Bioorganic & Medicinal Chemistry Letters. 19: 5803-6. PMID 19713111 DOI: 10.1016/j.bmcl.2009.07.111  1
2009 Lebsack AD, Branstetter BJ, Hack MD, Xiao W, Peterson ML, Nasser N, Maher MP, Ao H, Bhattacharya A, Kansagara M, Scott BP, Luo L, Rynberg R, Rizzolio M, Chaplan SR, et al. Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 40-6. PMID 19038548 DOI: 10.1016/j.bmcl.2008.11.024  1
2004 Lebsack AD, Gunzner J, Wang B, Pracitto R, Schaffhauser H, Santini A, Aiyar J, Bezverkov R, Munoz B, Liu W, Venkatraman S. Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the alpha 2 delta-1 subunit of voltage gated calcium channel. Bioorganic & Medicinal Chemistry Letters. 14: 2463-7. PMID 15109633 DOI: 10.1016/j.bmcl.2004.03.008  1
2004 Burke BJ, Lebsack AD, Overman LE. Scope and limitations of the thionium ion-initiated prins-pinacol synthesis of carbocycles Synlett. 1387-1393. DOI: 10.1055/S-2004-825613  1
2002 Lebsack AD, Link JT, Overman LE, Stearns BA. Enantioselective total synthesis of quadrigemine C and psycholeine. Journal of the American Chemical Society. 124: 9008-9. PMID 12148978 DOI: 10.1021/Ja0267425  1
2001 Lebsack AD, Overman LE, Valentekovich RJ. Enantioselective total synthesis of shahamin K. Journal of the American Chemical Society. 123: 4851-2. PMID 11457302 DOI: 10.1021/Ja015802O  1
Low-probability matches
2021 Tichenor MS, Wiener JJM, Rao NL, Pooley Deckhut C, Barbay JK, Kreutter KD, Bacani GM, Wei J, Chang L, Murrey HE, Wang W, Ahn K, Huber M, Rex E, Coe KJ, ... ... Lebsack AD, et al. Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity. Acs Medicinal Chemistry Letters. 12: 782-790. PMID 34055226 DOI: 10.1021/acsmedchemlett.1c00044  0.01
2019 Damm-Ganamet KL, Arora N, Becart S, Edwards JP, Lebsack AD, McAllister H, Nelen MI, Rao N, Westover L, Wiener JJM, Mirzadegan T. Accelerating Lead Identification by High Throughput Virtual Screening: Prospective Case Studies from the Pharmaceutical Industry. Journal of Chemical Information and Modeling. PMID 30817167 DOI: 10.1021/acs.jcim.8b00941  0.01
2017 Blevitt JM, Hack MD, Herman KL, Jackson PF, Krawczuk PJ, Lebsack AD, Liu AX, Mirzadegan T, Nelen MI, Patrick AN, Steinbacher S, Milla ME, Lumb KJ. Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. Journal of Medicinal Chemistry. PMID 28300404 DOI: 10.1021/Acs.Jmedchem.6B01836  0.01
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