Douglas C. Beshore, Ph.D. - Publications

Affiliations: 
2007 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Natural product synthesis

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Kuduk SD, Beshore DC. SAR studies on carboxylic acid series M(1) selective positive allosteric modulators (PAMs). Current Topics in Medicinal Chemistry. 14: 1738-54. PMID 25176125  0.4
2014 Kuduk SD, Di Marco CN, Saffold JR, Ray WJ, Ma L, Wittmann M, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Beshore DC. Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 24: 1417-20. PMID 24485781 DOI: 10.1016/j.bmcl.2014.01.012  0.4
2012 Kuduk SD, Beshore DC. Novel M(1) allosteric ligands: a patent review. Expert Opinion On Therapeutic Patents. 22: 1385-98. PMID 23092292 DOI: 10.1517/13543776.2012.731395  0.4
2010 Kuduk SD, DiPardo RM, Beshore DC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 2538-41. PMID 20346667 DOI: 10.1016/j.bmcl.2010.02.095  0.4
2010 Beshore DC, Liverton NJ, McIntyre CJ, Claiborne CF, Libby B, Culberson JC, Salata JJ, Regan CP, Lynch JJ, Kiss L, Spencer RH, Kane SA, White RB, Yeh S, Hartman GD, et al. Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorganic & Medicinal Chemistry Letters. 20: 2493-6. PMID 20304642 DOI: 10.1016/j.bmcl.2010.03.005  0.4
2010 Beshore DC, DiPardo RM, Kuduk SD. Preparation of 2,4,5-trisubstituted pyrazolo[4,3-c]quinolin-3-ones Tetrahedron Letters. 51: 970-973. DOI: 10.1016/j.tetlet.2009.12.054  0.4
2009 Smith AB, Atasoylu O, Beshore DC. Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 2009: 2643-2646. PMID 20634903 DOI: 10.1055/s-0029-1217749  0.4
2008 Beshore DC, Smith AB. The lyconadins: enantioselective total syntheses of (+)-lyconadin A and (-)-lyconadin B. Journal of the American Chemical Society. 130: 13778-89. PMID 18798629 DOI: 10.1021/ja804939r  0.4
2008 Regan CP, Kiss L, Stump GL, McIntyre CJ, Beshore DC, Liverton NJ, Dinsmore CJ, Lynch JJ. Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure. The Journal of Pharmacology and Experimental Therapeutics. 324: 322-30. PMID 17967939 DOI: 10.1124/jpet.107.127654  0.4
2007 Beshore DC, Smith AB. Total syntheses of (+)-lyconadin A and (-)-lyconadin B. Journal of the American Chemical Society. 129: 4148-9. PMID 17367142 DOI: 10.1021/ja070336+  0.4
2006 Trotter BW, Nanda KK, Kett NR, Regan CP, Lynch JJ, Stump GL, Kiss L, Wang J, Spencer RH, Kane SA, White RB, Zhang R, Anderson KD, Liverton NJ, McIntyre CJ, ... Beshore DC, et al. Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation. Journal of Medicinal Chemistry. 49: 6954-7. PMID 17125248 DOI: 10.1021/jm060927v  0.4
2003 Beshore DC, Dinsmore CJ. Preparation of ethyl 5-iodo-1H-indole-2-carboxylate Synthetic Communications. 33: 2423-2427. DOI: 10.1081/SCC-120021830  0.4
2002 Bell IM, Gallicchio SN, Abrams M, Beese LS, Beshore DC, Bhimnathwala H, Bogusky MJ, Buser CA, Culberson JC, Davide J, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hamilton KA, et al. 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. Journal of Medicinal Chemistry. 45: 2388-409. PMID 12036349 DOI: 10.1021/jm010531d  0.4
2002 Beshore DC, Dinsmore CJ. Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclization. Organic Letters. 4: 1201-4. PMID 11922818 DOI: 10.1021/ol025644l  0.4
2002 Dinsmore CJ, Beshore DC. Recent advances in the synthesis of diketopiperazines Tetrahedron. 58: 3297-3312. DOI: 10.1016/S0040-4020(02)00239-9  0.4
2002 Dinsmore CJ, Beshore DC. Syntheses and transformations of piperazinone rings. A review Organic Preparations and Procedures International. 34: 367-404.  0.4
2001 Bell IM, Gallicchio SN, Abrams M, Beshore DC, Buser CA, Culberson JC, Davide J, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hartman GD, Heimbrook DC, Homnick CF, Huff JR, et al. Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. Journal of Medicinal Chemistry. 44: 2933-49. PMID 11520202 DOI: 10.1021/jm010156p  0.4
2001 Beshore DC, Bell IM, Dinsmore CJ, Homnick CF, Culberson JC, Robinson RG, Fernandes C, Walsh ES, Abrams MT, Bhimnathwala HG, Davide JP, Ellis-Hutchings MS, Huber HA, Koblan KS, Buser CA, et al. Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase. Bioorganic & Medicinal Chemistry Letters. 11: 1817-21. PMID 11459639 DOI: 10.1016/S0960-894X(01)00340-7  0.4
2000 Bell IM, Beshore DC, Gallicchio SN, Williams TM. Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones Tetrahedron Letters. 41: 1141-1145. DOI: 10.1016/S0040-4039(99)02282-0  0.4
2000 Beshore DC, Dinsmore CJ. Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization Tetrahedron Letters. 41: 8735-8739.  0.4
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