☰

Douglas C. Beshore, Ph.D. - Publications

Affiliations: 
2007 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Natural product synthesis
Tree Info Similar researchers PubMed Report error

10/31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Beshore DC, Haidle AM, Arasappan A, Lim YH, Raheem I, Roecker AJ, Shockley SE, Simov V. Building a Culture of Medicinal Chemistry Knowledge Sharing. Journal of Medicinal Chemistry. PMID 35192762 DOI: 10.1021/acs.jmedchem.1c02144  0.546
2016 Beshore DC, Johnson AW, DiPardo RM, Pitts DR, Cofre V, Kuduk SD. 2,5-Disubstituted Pyrazolo[4,3-c]cinnolin-3-ones Journal of Heterocyclic Chemistry. 54: 1558-1571. DOI: 10.1002/Jhet.2744  0.35
2010 Beshore DC, DiPardo RM, Kuduk SD. Preparation of 2,4,5-trisubstituted pyrazolo[4,3-c]quinolin-3-ones Tetrahedron Letters. 51: 970-973. DOI: 10.1016/J.Tetlet.2009.12.054  0.32
2009 Smith AB, Atasoylu O, Beshore DC. Construction of 5,6-Ring Fused 2-Pyridones: An Effective Annulation Tactic Achieved in Water. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 2009: 2643-2646. PMID 20634903 DOI: 10.1055/S-0029-1217749  0.563
2008 Beshore DC, Smith AB. The lyconadins: enantioselective total syntheses of (+)-lyconadin A and (-)-lyconadin B. Journal of the American Chemical Society. 130: 13778-89. PMID 18798629 DOI: 10.1021/Ja804939R  0.314
2002 Bell IM, Gallicchio SN, Abrams M, Beese LS, Beshore DC, Bhimnathwala H, Bogusky MJ, Buser CA, Culberson JC, Davide J, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hamilton KA, et al. 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. Journal of Medicinal Chemistry. 45: 2388-409. PMID 12036349 DOI: 10.1021/Jm010531D  0.308
2001 Bell IM, Gallicchio SN, Abrams M, Beshore DC, Buser CA, Culberson JC, Davide J, Ellis-Hutchings M, Fernandes C, Gibbs JB, Graham SL, Hartman GD, Heimbrook DC, Homnick CF, Huff JR, et al. Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. Journal of Medicinal Chemistry. 44: 2933-49. PMID 11520202 DOI: 10.1021/Jm010156P  0.306
2001 Beshore DC, Bell IM, Dinsmore CJ, Homnick CF, Culberson JC, Robinson RG, Fernandes C, Walsh ES, Abrams MT, Bhimnathwala HG, Davide JP, Ellis-Hutchings MS, Huber HA, Koblan KS, Buser CA, et al. Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase. Bioorganic & Medicinal Chemistry Letters. 11: 1817-21. PMID 11459639 DOI: 10.1016/S0960-894X(01)00340-7  0.323
2000 Bell IM, Beshore DC, Gallicchio SN, Williams TM. Efficient synthesis of 1-heterocyclic-3-aminopyrrolidinones Tetrahedron Letters. 41: 1141-1145. DOI: 10.1016/S0040-4039(99)02282-0  0.343
2000 Beshore DC, Dinsmore CJ. Efficient synthesis of unsymmetrical 1,4-disubstituted-2,3-diketopiperazines via tandem reductive amination-cyclization Tetrahedron Letters. 41: 8735-8739. DOI: 10.1016/S0040-4039(00)01565-3  0.343
Low-probability matches (unlikely to be authored by this person)
2014 Kuduk SD, Di Marco CN, Saffold JR, Ray WJ, Ma L, Wittmann M, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT, Beshore DC. Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 24: 1417-20. PMID 24485781 DOI: 10.1016/J.Bmcl.2014.01.012  0.3
2018 Salter R, Beshore DC, Colletti SL, Evans L, Gong Y, Helmy R, Liu Y, Maciolek CM, Martin G, Pajkovic N, Phipps R, Small J, Steele J, de Vries R, Williams H, et al. Microbial Biotransformation - An Important Tool for the Study of Drug Metabolism. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-38. PMID 30118378 DOI: 10.1080/00498254.2018.1512018  0.299
2006 Trotter BW, Nanda KK, Kett NR, Regan CP, Lynch JJ, Stump GL, Kiss L, Wang J, Spencer RH, Kane SA, White RB, Zhang R, Anderson KD, Liverton NJ, McIntyre CJ, ... Beshore DC, et al. Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation. Journal of Medicinal Chemistry. 49: 6954-7. PMID 17125248 DOI: 10.1021/Jm060927V  0.298
2002 Beshore DC, Dinsmore CJ. Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclization. Organic Letters. 4: 1201-4. PMID 11922818 DOI: 10.1021/Ol025644L  0.297
2002 Dinsmore CJ, Beshore DC. Syntheses and transformations of piperazinone rings. A review Organic Preparations and Procedures International. 34: 367-404. DOI: 10.1080/00304940209458075  0.293
2020 Yu W, Liu J, Yu Y, Zhang V, Clausen D, Kelly J, Wolkenberg S, Beshore D, Duffy JL, Chang CC, Myers RW, Klein DJ, Fells J, Holloway K, Wu J, et al. Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorganic & Medicinal Chemistry Letters. 127197. PMID 32331932 DOI: 10.1016/J.Bmcl.2020.127197  0.29
2002 Dinsmore CJ, Beshore DC. Recent advances in the synthesis of diketopiperazines Tetrahedron. 58: 3297-3312. DOI: 10.1016/S0040-4020(02)00239-9  0.288
2014 Kuduk SD, Beshore DC. SAR studies on carboxylic acid series M(1) selective positive allosteric modulators (PAMs). Current Topics in Medicinal Chemistry. 14: 1738-54. PMID 25176125 DOI: 10.2174/1568026614666140826120224  0.284
2010 Kuduk SD, DiPardo RM, Beshore DC, Ray WJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Hartman GD, Bilodeau MT. Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 20: 2538-41. PMID 20346667 DOI: 10.1016/J.Bmcl.2010.02.095  0.284
2018 Beshore DC, N Di Marco C, Chang RK, Greshock TJ, Ma L, Wittmann M, Seager MA, Koeplinger KA, Thompson CD, Fuerst J, Hartman GD, Bilodeau MT, Ray WJ, Kuduk SD. MK-7622: A First-in-Class M Positive Allosteric Modulator Development Candidate. Acs Medicinal Chemistry Letters. 9: 652-656. PMID 30034595 DOI: 10.1021/Acsmedchemlett.8B00095  0.282
2017 Sanders JM, Beshore DC, Culberson JC, Fells JI, Imbriglio JE, Gunaydin H, Haidle AM, Labroli M, Mattioni BE, Sciammetta N, Shipe WD, Sheridan RP, Suen LM, Verras A, Walji AM, et al. Informing the selection of screening hit series with in silico absorption, distribution, metabolism, excretion, and toxicity profiles. Journal of Medicinal Chemistry. PMID 28418656 DOI: 10.1021/Acs.Jmedchem.6B01577  0.271
2003 Beshore DC, Dinsmore CJ. Preparation of ethyl 5-iodo-1H-indole-2-carboxylate Synthetic Communications. 33: 2423-2427. DOI: 10.1081/Scc-120021830  0.269
2010 Beshore DC, Liverton NJ, McIntyre CJ, Claiborne CF, Libby B, Culberson JC, Salata JJ, Regan CP, Lynch JJ, Kiss L, Spencer RH, Kane SA, White RB, Yeh S, Hartman GD, et al. Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorganic & Medicinal Chemistry Letters. 20: 2493-6. PMID 20304642 DOI: 10.1016/J.Bmcl.2010.03.005  0.267
2018 Uslaner JM, Kuduk SD, Wittmann M, Lange HS, Fox SV, Min C, Pajkovic N, Harris D, Cilissen C, Mahon C, Mostoller K, Warrington S, Beshore DC. Preclinical to Human Translational Pharmacology of the Novel MPositive Allosteric Modulator MK-7622. The Journal of Pharmacology and Experimental Therapeutics. PMID 29563325 DOI: 10.1124/Jpet.117.245894  0.261
2012 Kuduk SD, Beshore DC. Novel M(1) allosteric ligands: a patent review. Expert Opinion On Therapeutic Patents. 22: 1385-98. PMID 23092292 DOI: 10.1517/13543776.2012.731395  0.255
2008 Regan CP, Kiss L, Stump GL, McIntyre CJ, Beshore DC, Liverton NJ, Dinsmore CJ, Lynch JJ. Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure. The Journal of Pharmacology and Experimental Therapeutics. 324: 322-30. PMID 17967939 DOI: 10.1124/Jpet.107.127654  0.25
2017 Homsher MF, Beshore DC, Cassaday J, Squadroni B, Mohammed E, Hartnett M, Day S, Ma L, Pechter D, Smith MD, Monsma F, Zuck P, Finley MF, Uebele VN, Hermes JD. High-Throughput Agonist Shift Assay Development for the Analysis of M1-Positive Allosteric Modulators. Slas Discovery. 2472555217705373. PMID 28426939 DOI: 10.1177/2472555217705373  0.159
2021 Beshore DC, Adam GC, Barnard RJO, Burlein C, Gallicchio SN, Holloway MK, Krosky D, Lemaire W, Myers RW, Patel S, Plotkin MA, Powell DA, Rada V, Cox CD, Coleman PJ, et al. Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction. Acs Medicinal Chemistry Letters. 12: 540-547. PMID 33854701 DOI: 10.1021/acsmedchemlett.1c00074  0.113
2023 Kleiner VA, O Fischmann T, Howe JA, Beshore DC, Eddins MJ, Hou Y, Mayhood T, Klein D, Nahas DD, Lucas BJ, Xi H, Murray E, Ma DY, Getty K, Fearns R. Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Communications Biology. 6: 649. PMID 37337079 DOI: 10.1038/s42003-023-04990-0  0.085
2022 Moore KP, Schwaid AG, Tudor M, Park S, Beshore DC, Converso A, Shipe WD, Anand R, Lan P, Moningka R, Rothman DM, Sun W, Chi A, Cornella-Taracido I, Adam GC, et al. A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. Acs Chemical Biology. PMID 36044633 DOI: 10.1021/acschembio.2c00515  0.085
2007 Beshore DC, Smith AB. Total syntheses of (+)-lyconadin A and (-)-lyconadin B. Journal of the American Chemical Society. 129: 4148-9. PMID 17367142 DOI: 10.1021/ja070336+  0.063
Hide low-probability matches.