Brian A. Lanman, Ph.D. - Publications

Affiliations: 
2004 Harvard University, Cambridge, MA, United States 
Area:
synthesis of natural products

21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Pettus LH, Andrews KL, Booker SK, Chen J, Cee VJ, Chavez F, Chen Y, Eastwood H, Guerrero N, Herberich BJ, Hickman D, Lanman BA, Laszlo Iii J, Lee MR, Lipford JR, et al. Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable pan-Pim Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 27285051 DOI: 10.1021/acs.jmedchem.6b00610  1
2016 Cee VJ, Chavez F, Herberich B, Lanman BA, Pettus LH, Reed AB, Wu B, Wurz RP, Andrews KL, Chen J, Hickman D, Laszlo J, Lee MR, Guerrero N, Mattson BK, et al. Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors. Acs Medicinal Chemistry Letters. 7: 408-12. PMID 27096050 DOI: 10.1021/acsmedchemlett.5b00403  1
2015 Wu B, Wang HL, Cee VJ, Lanman BA, Nixey T, Pettus L, Reed AB, Wurz RP, Guerrero N, Sastri C, Winston J, Lipford JR, Lee MR, Mohr C, Andrews KL, et al. Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 775-80. PMID 25616902 DOI: 10.1016/j.bmcl.2014.12.091  1
2015 Wurz RP, Pettus LH, Jackson C, Wu B, Wang HL, Herberich B, Cee V, Lanman BA, Reed AB, Chavez F, Nixey T, Laszlo J, Wang P, Nguyen Y, Sastri C, et al. The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 847-55. PMID 25599837 DOI: 10.1016/j.bmcl.2014.12.067  1
2015 Wang HL, Cee VJ, Chavez F, Lanman BA, Reed AB, Wu B, Guerrero N, Lipford JR, Sastri C, Winston J, Andrews KL, Huang X, Lee MR, Mohr C, Xu Y, et al. The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 834-40. PMID 25597005 DOI: 10.1016/j.bmcl.2014.12.068  1
2014 Lanman BA, Reed AB, Cee VJ, Hong FT, Pettus LH, Wurz RP, Andrews KL, Jiang J, McCarter JD, Mullady EL, San Miguel T, Subramanian R, Wang L, Whittington DA, Wu T, et al. Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511. Bioorganic & Medicinal Chemistry Letters. 24: 5630-4. PMID 25466188 DOI: 10.1016/j.bmcl.2014.10.085  1
2012 Harrington PE, Croghan MD, Fotsch C, Frohn M, Lanman BA, Pennington LD, Pickrell AJ, Reed AB, Sham KK, Tasker A, Arnett HA, Fiorino M, Lee MR, McElvain M, Morrison HG, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. Acs Medicinal Chemistry Letters. 3: 74-8. PMID 24900374 DOI: 10.1021/ml200252b  1
2012 Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, et al. Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511. Journal of Medicinal Chemistry. 55: 7796-816. PMID 22897589 DOI: 10.1021/jm300846z  1
2012 Smith AL, D'Angelo ND, Bo YY, Booker SK, Cee VJ, Herberich B, Hong FT, Jackson CL, Lanman BA, Liu L, Nishimura N, Pettus LH, Reed AB, Tadesse S, Tamayo NA, et al. Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases. Journal of Medicinal Chemistry. 55: 5188-219. PMID 22548365 DOI: 10.1021/jm300184s  1
2012 Reed AB, Lanman BA, Neira S, Harrington PE, Sham KK, Frohn M, Pickrell AJ, Tasker AS, Gore A, Fiorino M, Itano A, McElvain M, Middleton S, Morrison H, Xu H, et al. Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups. Bioorganic & Medicinal Chemistry Letters. 22: 1779-83. PMID 22257889 DOI: 10.1016/j.bmcl.2011.12.073  1
2012 Pennington LD, Croghan MD, Sham KK, Pickrell AJ, Harrington PE, Frohn MJ, Lanman BA, Reed AB, Lee MR, Xu H, McElvain M, Xu Y, Zhang X, Fiorino M, Horner M, et al. Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. Bioorganic & Medicinal Chemistry Letters. 22: 527-31. PMID 22104144 DOI: 10.1016/j.bmcl.2011.10.085  1
2012 Frohn M, Cee VJ, Lanman BA, Pickrell AJ, Golden J, Rivenzon-Segal D, Middleton S, Fiorino M, Xu H, Schrag M, Xu Y, McElvain M, Muller K, Siu J, Bürli R. Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity. Bioorganic & Medicinal Chemistry Letters. 22: 628-33. PMID 22100314 DOI: 10.1016/j.bmcl.2011.10.069  1
2011 Lanman BA, Cee VJ, Cheruku SR, Frohn M, Golden J, Lin J, Lobera M, Marantz Y, Muller KM, Neira SC, Pickrell AJ, Rivenzon-Segal D, Schutz N, Sharadendu A, Yu X, et al. Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1). Acs Medicinal Chemistry Letters. 2: 102-6. PMID 24900287 DOI: 10.1021/ml100228m  1
2011 Pennington LD, Sham KK, Pickrell AJ, Harrington PE, Frohn MJ, Lanman BA, Reed AB, Croghan MD, Lee MR, Xu H, McElvain M, Xu Y, Zhang X, Fiorino M, Horner M, et al. 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. Acs Medicinal Chemistry Letters. 2: 752-7. PMID 24900263 DOI: 10.1021/ml2001399  1
2010 Lanman BA. Conivaptan (Vaprisol): Vasopressin V1a and V2 Antagonist for Hyponatremia Modern Drug Synthesis. 175-190. DOI: 10.1002/9780470768594.ch13  1
2007 Lanman BA, Overman LE, Paulini R, White NS. On the structure of palau'amine: evidence for the revised relative configuration from chemical synthesis. Journal of the American Chemical Society. 129: 12896-900. PMID 17902668 DOI: 10.1021/ja074939x  1
2006 Lanman BA, Overman LE. EVALUATION OF STRATEGIES FOR THE SYNTHESIS OF THE GUANIDINE HEMIAMINAL PORTION OF PALAU'AMINE. Heterocycles. 70: 557-570. PMID 19079749  1
2004 Lanman BA, Myers AG. Efficient, stereoselective synthesis of trans-2,5-disubstituted morpholines. Organic Letters. 6: 1045-7. PMID 15012096 DOI: 10.1021/ol049861t  1
2002 Myers AG, Lanman BA. A solid-supported, enantioselective synthesis suitable for the rapid preparation of large numbers of diverse structural analogues of (-)-saframycin A. Journal of the American Chemical Society. 124: 12969-71. PMID 12405822 DOI: 10.1021/ja027729n  1
2000 Myers AG, Zhong B, Kung DW, Movassaghi M, Lanman BA, Kwon S. Synthesis of C-protected alpha-amino aldehydes of high enantiomeric excess from highly epimerizable N-protected alpha-amino aldehydes. Organic Letters. 2: 3337-40. PMID 11029204  1
2000 Myers AG, Zhong B, Movassaghi M, Kung DW, Lanman BA, Kwon S. Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess Tetrahedron Letters. 41: 1359-1362. DOI: 10.1016/S0040-4039(99)02293-5  1
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