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Year Citation  Score
2018 Jahromi AH, Wang C, Adams SR, Zhu W, Narsinh K, Xu H, Gray DL, Tsien RY, Ahrens ET. Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes. Acs Nano. PMID 30525446 DOI: 10.1021/acsnano.8b04881  0.6
2018 Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG. Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage. Plos One. 13: e0198464. PMID 30248101 DOI: 10.1371/journal.pone.0198464  0.76
2018 Hingorani DV, Whitney MA, Friedman B, Kwon JK, Crisp JL, Xiong Q, Gross L, Kane CJ, Tsien RY, Nguyen QT. Nerve-targeted probes for fluorescence-guided intraoperative imaging. Theranostics. 8: 4226-4237. PMID 30128049 DOI: 10.7150/thno.23084  0.76
2017 Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. A thrombin receptor - derived imaging agent detects subclinical arthritis in mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29164814 DOI: 10.1002/art.40316  0.72
2017 Miampamba M, Liu J, Harootunian A, Gale AJ, Baird S, Chen SL, Nguyen QT, Tsien RY, González JE. Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620. Theranostics. 7: 3369-3386. PMID 28900516 DOI: 10.7150/thno.20678  0.68
2017 Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT. Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncology. 71: 156-162. PMID 28688684 DOI: 10.1016/j.oraloncology.2017.06.009  0.72
2016 Wang Y, An FF, Chan M, Friedman B, Rodriguez EA, Tsien RY, Aras O, Ting R. (18)F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial hemorrhage model. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X16682510. PMID 28054494 DOI: 10.1177/0271678X16682510  0.76
2016 Adams SR, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BN, Ellisman MH, Tsien RY. Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species. Cell Chemical Biology. PMID 27818300 DOI: 10.1016/j.chembiol.2016.10.006  0.88
2016 Rodriguez EA, Campbell RE, Lin JY, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY. The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins. Trends in Biochemical Sciences. PMID 27814948 DOI: 10.1016/j.tibs.2016.09.010  1
2016 Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791138 DOI: 10.1073/pnas.1611642113  0.76
2016 Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nature Communications. 7: 13019. PMID 27698471 DOI: 10.1038/ncomms13019  0.76
2016 Advani SJ, Yang H, Adams SR, Aguilera J, Tsien RY. Molecular Targeting of Cytotoxic Radiosensitizing Chemotherapies. International Journal of Radiation Oncology, Biology, Physics. 96: S111. PMID 27675552 DOI: 10.1016/j.ijrobp.2016.06.273  0.6
2016 Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin JY, Tsien RY. A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein. Nature Methods. PMID 27479328 DOI: 10.1038/nmeth.3935  1
2016 Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nature Chemical Biology. PMID 27110681 DOI: 10.1038/nchembio.2076  1
2016 Rodriguez EA, Wang Y, Crisp JL, Vera DR, Tsien RY, Ting R. New dioxaborolane chemistry enables [18F]-positron-emitting, fluorescent [18F]-multimodality biomolecule generation from the solid-phase. Bioconjugate Chemistry. PMID 27064381 DOI: 10.1021/acs.bioconjchem.6b00164  1
2016 Kislukhin AA, Xu H, Adams SR, Narsinh KH, Tsien RY, Ahrens ET. Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging. Nature Materials. PMID 26974409 DOI: 10.1038/nmat4585  0.44
2016 Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT. Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. Journal of Surgical Oncology. 113: 138-143. PMID 26799257 DOI: 10.1002/jso.24129  0.72
2015 Chen S, Cui J, Jiang T, Olson ES, Cai QY, Yang M, Wu W, Guthrie JM, Robertson JD, Lipton SA, Ma L, Tsien RY, Gu Z. Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26681768 DOI: 10.1177/0271678X15621573  0.52
2015 Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. Plos One. 10: e0139833. PMID 26448434 DOI: 10.1371/journal.pone.0139833  0.68
2015 Malone CD, Olson ES, Mattrey RF, Jiang T, Tsien RY, Nguyen QT. Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. Plos One. 10: e0137104. PMID 26336058 DOI: 10.1371/journal.pone.0137104  1
2015 Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, ... ... Tsien RW, ... ... Tsien RY, et al. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nature Neuroscience. 18: 1202-12. PMID 26308981 DOI: 10.1038/nn.4106  1
2015 Briggman KL, Kristan WB, González JE, Kleinfeld D, Tsien RY. Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes. Advances in Experimental Medicine and Biology. 859: 149-69. PMID 26238052 DOI: 10.1007/978-3-319-17641-3_6  0.52
2015 Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ. Tunable and reversible drug control of protein production via a self-excising degron. Nature Chemical Biology. 11: 713-20. PMID 26214256 DOI: 10.1038/nchembio.1869  1
2015 Palida SF, Butko MT, Ngo JT, Mackey MR, Gross LA, Ellisman MH, Tsien RY. PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7736-49. PMID 25995463 DOI: 10.1523/JNEUROSCI.0004-15.2015  1
2015 Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, ... ... Tsien RY, et al. The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 25823863 DOI: 10.1098/rstb.2014.0164  1
2015 Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT. Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome. Plos One. 10: e0119600. PMID 25751149 DOI: 10.1371/journal.pone.0119600  1
2015 Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncology. 51: 470-5. PMID 25735654 DOI: 10.1016/j.oraloncology.2015.01.014  1
2015 Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Research. 75: 1376-87. PMID 25681274 DOI: 10.1158/0008-5472.CAN-14-1931  1
2015 Woodford CR, Frady EP, Smith RS, Morey B, Canzi G, Palida SF, Araneda RC, Kristan WB, Kubiak CP, Miller EW, Tsien RY. Improved PeT molecules for optically sensing voltage in neurons. Journal of the American Chemical Society. 137: 1817-24. PMID 25584688 DOI: 10.1021/ja510602z  1
2015 Griffin BA, Adams SR, Tsien RY. How FlAsH got its sparkle: historical recollections of the biarsenical-tetracysteine tag. Methods in Molecular Biology (Clifton, N.J.). 1266: 1-6. PMID 25560064 DOI: 10.1007/978-1-4939-2272-7_1  1
2015 Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Annals of Surgical Oncology. 22: 2082-7. PMID 25319581 DOI: 10.1245/s10434-014-4144-1  1
2015 Briggman KL, Kristan WB, González JE, Kleinfeld D, Tsien RY. Monitoring integrated activity of individual neurons using fret-based voltage-sensitive dyes Advances in Experimental Medicine and Biology. 859: 149-169. DOI: 10.1007/978-3-319-17641-3_6  1
2014 Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen QT. Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Head & Neck. PMID 25521629 DOI: 10.1002/hed.23946  1
2014 Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen QT. Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 151: 612-8. PMID 25091190 DOI: 10.1177/0194599814545083  1
2014 Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R. Engineering a memory with LTD and LTP. Nature. 511: 348-52. PMID 24896183 DOI: 10.1038/nature13294  1
2014 Levin RA, Felsen CN, Yang J, Lin JY, Whitney MA, Nguyen QT, Tsien RY. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. Plos One. 9: e97415. PMID 24816650 DOI: 10.1371/journal.pone.0097415  1
2014 Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Annals of Neurology. 75: 303-8. PMID 24740641 DOI: 10.1002/ana.24078  1
2014 Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY. Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. Molecular Cancer Therapeutics. 13: 1514-25. PMID 24737028 DOI: 10.1158/1535-7163.MCT-13-1067  1
2014 Felsen CN, Savariar EN, Whitney M, Tsien RY. Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L764-74. PMID 24508733 DOI: 10.1152/ajplung.00371.2013  1
2014 Ortac I, Simberg D, Yeh YS, Yang J, Messmer B, Trogler WC, Tsien RY, Esener S. Dual-porosity hollow nanoparticles for the immunoprotection and delivery of nonhuman enzymes. Nano Letters. 14: 3023-32. PMID 24471767 DOI: 10.1021/nl404360k  1
2014 Weinstain R, Savariar EN, Felsen CN, Tsien RY. In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides. Journal of the American Chemical Society. 136: 874-7. PMID 24377760 DOI: 10.1021/ja411547j  1
2014 Inagaki HK, Jung Y, Hoopfer ED, Wong AM, Mishra N, Lin JY, Tsien RY, Anderson DJ. Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship. Nature Methods. 11: 325-32. PMID 24363022 DOI: 10.1038/nmeth.2765  1
2013 Lin JY, Knutsen PM, Muller A, Kleinfeld D, Tsien RY. ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nature Neuroscience. 16: 1499-508. PMID 23995068 DOI: 10.1038/nn.3502  1
2013 Nguyen QT, Tsien RY. Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nature Reviews. Cancer. 13: 653-62. PMID 23924645 DOI: 10.1038/nrc3566  1
2013 Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 79: 241-53. PMID 23889931 DOI: 10.1016/j.neuron.2013.05.022  0.6
2013 Tsien RY. Very long-term memories may be stored in the pattern of holes in the perineuronal net. Proceedings of the National Academy of Sciences of the United States of America. 110: 12456-61. PMID 23832785 DOI: 10.1073/pnas.1310158110  1
2013 Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY. Fluorescent ligand for human progesterone receptor imaging in live cells. Bioconjugate Chemistry. 24: 766-71. PMID 23600997 DOI: 10.1021/bc3006418  1
2013 Butko MT, Savas JN, Friedman B, Delahunty C, Ebner F, Yates JR, Tsien RY. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proceedings of the National Academy of Sciences of the United States of America. 110: E726-35. PMID 23382246 DOI: 10.1073/pnas.1300424110  1
2013 Shani E, Weinstain R, Zhang Y, Castillejo C, Kaiserli E, Chory J, Tsien RY, Estelle M. Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root. Proceedings of the National Academy of Sciences of the United States of America. 110: 4834-9. PMID 23382232 DOI: 10.1073/pnas.1300436110  1
2013 Orosco RK, Tsien RY, Nguyen QT. Fluorescence imaging in surgery. Ieee Reviews in Biomedical Engineering. 6: 178-87. PMID 23335674 DOI: 10.1109/RBME.2013.2240294  1
2013 Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Research. 73: 855-64. PMID 23188503 DOI: 10.1158/0008-5472.CAN-12-2969  1
2013 Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen QT, Tsien RY. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angewandte Chemie (International Ed. in English). 52: 325-30. PMID 23080482 DOI: 10.1002/anie.201205721  1
2012 Butko MT, Yang J, Geng Y, Kim HJ, Jeon NL, Shu X, Mackey MR, Ellisman MH, Tsien RY, Lin MZ. Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. Nature Neuroscience. 15: 1742-51. PMID 23103964 DOI: 10.1038/nn.3246  1
2012 Ou HD, Kwiatkowski W, Deerinck TJ, Noske A, Blain KY, Land HS, Soria C, Powers CJ, May AP, Shu X, Tsien RY, Fitzpatrick JA, Long JA, Ellisman MH, Choe S, et al. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell. 151: 304-19. PMID 23063122 DOI: 10.1016/j.cell.2012.08.035  1
2012 Lam AJ, St-Pierre F, Gong Y, Marshall JD, Cranfill PJ, Baird MA, McKeown MR, Wiedenmann J, Davidson MW, Schnitzer MJ, Tsien RY, Lin MZ. Improving FRET dynamic range with bright green and red fluorescent proteins. Nature Methods. 9: 1005-12. PMID 22961245 DOI: 10.1038/nmeth.2171  1
2012 Chen B, Friedman B, Whitney MA, Winkle JA, Lei IF, Olson ES, Cheng Q, Pereira B, Zhao L, Tsien RY, Lyden PD. Thrombin activity associated with neuronal damage during acute focal ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7622-31. PMID 22649241 DOI: 10.1523/JNEUROSCI.0369-12.2012  1
2012 Olson ES, Whitney MA, Friedman B, Aguilera TA, Crisp JL, Baik FM, Jiang T, Baird SM, Tsimikas S, Tsien RY, Nguyen QT. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 595-605. PMID 22534729 DOI: 10.1039/c2ib00161f  1
2012 Qi YB, Garren EJ, Shu X, Tsien RY, Jin Y. Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG. Proceedings of the National Academy of Sciences of the United States of America. 109: 7499-504. PMID 22532663 DOI: 10.1073/pnas.1204096109  1
2012 Miller EW, Lin JY, Frady EP, Steinbach PA, Kristan WB, Tsien RY. Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires. Proceedings of the National Academy of Sciences of the United States of America. 109: 2114-9. PMID 22308458 DOI: 10.1073/pnas.1120694109  1
2011 Li H, Foss SM, Dobryy YL, Park CK, Hires SA, Shaner NC, Tsien RY, Osborne LC, Voglmaier SM. Concurrent imaging of synaptic vesicle recycling and calcium dynamics. Frontiers in Molecular Neuroscience. 4: 34. PMID 22065946 DOI: 10.3389/fnmol.2011.00034  1
2011 Shu X, Lev-Ram V, Deerinck TJ, Qi Y, Ramko EB, Davidson MW, Jin Y, Ellisman MH, Tsien RY. A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms. Plos Biology. 9: e1001041. PMID 21483721 DOI: 10.1371/journal.pbio.1001041  1
2011 Shu X, Lev-Ram V, Olson ES, Aguilera TA, Jiang T, Whitney M, Crisp JL, Steinbach P, Deerinck T, Ellisman MH, Ellies LG, Nguyen QT, Tsien RY. Spiers Memorial Lecture. Breeding and building molecular spies. Faraday Discussions. 149: 9; discussion 63-77. PMID 21413170 DOI: 10.1039/c0fd90021d  1
2011 Wu AP, Whitney MA, Crisp JL, Friedman B, Tsien RY, Nguyen QT. Improved facial nerve identification with novel fluorescently labeled probe. The Laryngoscope. 121: 805-10. PMID 21328585 DOI: 10.1002/lary.21411  1
2011 Whitney MA, Crisp JL, Nguyen LT, Friedman B, Gross LA, Steinbach P, Tsien RY, Nguyen QT. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nature Biotechnology. 29: 352-6. PMID 21297616 DOI: 10.1038/nbt.1764  1
2011 Shen J, Whitney MA, Crisp J, Jiang T, Steinbach P, Levins R, Tsien RY, Nguyen QT. Visualizing transgenic murine papillary thyroid cancer with novel nerve peptide and protease-dependent tumor-targeting peptides Laryngoscope. 121: S293. DOI: 10.1002/lary.22249  1
2010 Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nature Protocols. 5: 1666-77. PMID 20885379 DOI: 10.1038/nprot.2010.129  1
2010 Ting R, Aguilera TA, Crisp JL, Hall DJ, Eckelman WC, Vera DR, Tsien RY. Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes. Bioconjugate Chemistry. 21: 1811-9. PMID 20873712 DOI: 10.1021/bc1001328  1
2010 De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman M, Butko MT, Tsien RY, Taylor P. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. The Journal of Biological Chemistry. 285: 28674-82. PMID 20615874 DOI: 10.1074/jbc.M110.139519  1
2010 Tsien RY. Nobel lecture: constructing and exploiting the fluorescent protein paintbox. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 77-93. PMID 20473386 DOI: 10.1039/b926500g  1
2010 Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies LG, Tsien RY. Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides. The Journal of Biological Chemistry. 285: 22532-41. PMID 20460372 DOI: 10.1074/jbc.M110.138297  1
2010 Ouyang M, Huang H, Shaner NC, Remacle AG, Shiryaev SA, Strongin AY, Tsien RY, Wang Y. Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Research. 70: 2204-12. PMID 20197470 DOI: 10.1158/0008-5472.CAN-09-3698  1
2010 Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proceedings of the National Academy of Sciences of the United States of America. 107: 4317-22. PMID 20160097 DOI: 10.1073/pnas.0910261107  1
2010 Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proceedings of the National Academy of Sciences of the United States of America. 107: 4311-6. PMID 20160077 DOI: 10.1073/pnas.0910283107  1
2010 Lin MZ, Tsien RY. TimeSTAMP tagging of newly synthesized proteins. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 26.5. PMID 20155731 DOI: 10.1002/0471140864.ps2605s59  1
2010 Tsien RY. The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008. Journal of Visualized Experiments : Jove. PMID 20072108 DOI: 10.3791/1575  1
2009 Tsien RY. Indicators based on fluorescence resonance energy transfer (FRET). Cold Spring Harbor Protocols. 2009: pdb.top57. PMID 20147227 DOI: 10.1101/pdb.top57  1
2009 Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 382-93. PMID 20023745 DOI: 10.1039/b904890a  1
2009 Aguilera TA, Olson ES, Timmers MM, Jiang T, Tsien RY. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 371-81. PMID 20023744 DOI: 10.1039/b904878b  1
2009 Dempsey GT, Bates M, Kowtoniuk WE, Liu DR, Tsien RY, Zhuang X. Photoswitching mechanism of cyanine dyes. Journal of the American Chemical Society. 131: 18192-3. PMID 19961226 DOI: 10.1021/ja904588g  1
2009 Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams SR, Gross LA, Ma W, Alber T, Tsien RY. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chemistry & Biology. 16: 1169-79. PMID 19942140 DOI: 10.1016/j.chembiol.2009.10.009  1
2009 Tsien RY. Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture). Angewandte Chemie (International Ed. in English). 48: 5612-26. PMID 19565590 DOI: 10.1002/anie.200901916  1
2009 Shu X, Royant A, Lin MZ, Aguilera TA, Lev-Ram V, Steinbach PA, Tsien RY. Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome. Science (New York, N.Y.). 324: 804-7. PMID 19423828 DOI: 10.1126/science.1168683  1
2009 Madani F, Lind J, Damberg P, Adams SR, Tsien RY, Gräslund AO. Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy. Journal of the American Chemical Society. 131: 4613-5. PMID 19281235 DOI: 10.1021/ja809315x  1
2009 Lin JY, Lin MZ, Steinbach P, Tsien RY. Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophysical Journal. 96: 1803-14. PMID 19254539 DOI: 10.1016/j.bpj.2008.11.034  1
2009 Shimomura O, Chalfie M, Tsien RY. Scientists awarded nobel prize for work with GFP Luminescence. 24: 1. PMID 19206082 DOI: 10.1002/bio.1113  1
2009 Shaner NC, Lin MZ, Mckeown MR, Steinbach PA, Hazelwood KL, Davidson MW, Tsien RY. Evaluating and improving the photostability of fluorescent proteins Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7191. DOI: 10.1117/12.814684  1
2008 Vorasubin N, Nguyen QT, Olson E, Aguilera TA, Jiang T, Tsien RY. Cell Penetrating Peptide Uptake by Human Tissue. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 139: P35. PMID 29400176 DOI: 10.1016/j.otohns.2008.05.116  0.68
2008 Wallace DJ, Meyer zum Alten Borgloh S, Astori S, Yang Y, Bausen M, Kügler S, Palmer AE, Tsien RY, Sprengel R, Kerr JN, Denk W, Hasan MT. Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor. Nature Methods. 5: 797-804. PMID 19160514 DOI: 10.1038/nmeth.1242  1
2008 Adams SR, Tsien RY. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nature Protocols. 3: 1527-34. PMID 18772880 DOI: 10.1038/nprot.2008.144  1
2008 Lin MZ, Glenn JS, Tsien RY. A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals. Proceedings of the National Academy of Sciences of the United States of America. 105: 7744-9. PMID 18511556 DOI: 10.1073/pnas.0803060105  1
2008 Shaner NC, Lin MZ, McKeown MR, Steinbach PA, Hazelwood KL, Davidson MW, Tsien RY. Improving the photostability of bright monomeric orange and red fluorescent proteins. Nature Methods. 5: 545-51. PMID 18454154 DOI: 10.1038/nmeth.1209  1
2008 Hires SA, Zhu Y, Tsien RY. Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters. Proceedings of the National Academy of Sciences of the United States of America. 105: 4411-6. PMID 18332427 DOI: 10.1073/pnas.0712008105  1
2008 Chalfie M, Shimomura O, Tsien RY. Green fluorescent protein: Invaluable tool of cell research | Grün fluoreszierendes protein: Unschätzbares werkzeug der zellforscher Chemie in Unserer Zeit. 42: 425-427. DOI: 10.1002/ciuz.200890069  1
2008 Shimomura O, Chalfie M, Tsien RY. How the Jellyfish's green light revolutionised bioscience Chemistry Bulletin / Huaxue Tongbao. 71: 803-808.  1
2007 Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chemistry & Biology. 14: 1031-42. PMID 17884635 DOI: 10.1016/j.chembiol.2007.07.017  1
2007 Tour O, Adams SR, Kerr RA, Meijer RM, Sejnowski TJ, Tsien RW, Tsien RY. Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator. Nature Chemical Biology. 3: 423-31. PMID 17572670 DOI: 10.1038/nchembio.2007.4  1
2007 Ai HW, Shaner NC, Cheng Z, Tsien RY, Campbell RE. Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins. Biochemistry. 46: 5904-10. PMID 17444659 DOI: 10.1021/bi700199g  1
2007 Ray P, Tsien R, Gambhir SS. Construction and validation of improved triple fusion reporter gene vectors for molecular imaging of living subjects. Cancer Research. 67: 3085-93. PMID 17409415 DOI: 10.1158/0008-5472.CAN-06-2402  1
2007 Hauser CT, Tsien RY. A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure. Proceedings of the National Academy of Sciences of the United States of America. 104: 3693-7. PMID 17360414 DOI: 10.1073/pnas.0611713104  1
2007 Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of Biological Chemistry. 282: 6733-42. PMID 17189263 DOI: 10.1074/jbc.M608086200  1
2006 Wang L, Tsien RY. Evolving proteins in mammalian cells using somatic hypermutation. Nature Protocols. 1: 1346-50. PMID 17406421 DOI: 10.1038/nprot.2006.243  1
2006 Palmer AE, Tsien RY. Measuring calcium signaling using genetically targetable fluorescent indicators. Nature Protocols. 1: 1057-65. PMID 17406387 DOI: 10.1038/nprot.2006.172  1
2006 Tsien RY. Breeding and building molecules to spy on cells and tumors. The Keio Journal of Medicine. 55: 127-40. PMID 17191067 DOI: 10.2302/kjm.55.127  1
2006 Dunn TA, Wang CT, Colicos MA, Zaccolo M, DiPilato LM, Zhang J, Tsien RY, Feller MB. Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12807-15. PMID 17151284 DOI: 10.1523/JNEUROSCI.3238-06.2006  1
2006 Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, Adams SR, Tsien RY, Ellisman MH. Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proceedings of the National Academy of Sciences of the United States of America. 103: 17777-82. PMID 17101980 DOI: 10.1073/pnas.0608509103  1
2006 Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12923-8. PMID 16905651 DOI: 10.1073/pnas.0600137103  1
2006 Shu X, Shaner NC, Yarbrough CA, Tsien RY, Remington SJ. Novel chromophores and buried charges control color in mFruits. Biochemistry. 45: 9639-47. PMID 16893165 DOI: 10.1021/bi060773l  1
2006 Palmer AE, Giacomello M, Kortemme T, Hires SA, Lev-Ram V, Baker D, Tsien RY. Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chemistry & Biology. 13: 521-30. PMID 16720273 DOI: 10.1016/j.chembiol.2006.03.007  1
2006 Giepmans BN, Adams SR, Ellisman MH, Tsien RY. The fluorescent toolbox for assessing protein location and function. Science (New York, N.Y.). 312: 217-24. PMID 16614209 DOI: 10.1126/science.1124618  1
2006 Babendure JR, Babendure JL, Ding JH, Tsien RY. Control of mammalian translation by mRNA structure near caps. Rna (New York, N.Y.). 12: 851-61. PMID 16540693 DOI: 10.1261/rna.2309906  1
2006 Sun M, Oakes JL, Ananthanarayanan SK, Hawley KH, Tsien RY, Adams SR, Yengo CM. Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer. The Journal of Biological Chemistry. 281: 5711-7. PMID 16377637 DOI: 10.1074/jbc.M508103200  1
2006 Zacharias DA, Tsien RY. Molecular biology and mutation of green fluorescent protein. Methods of Biochemical Analysis. 47: 83-120. PMID 16335711 DOI: 10.1002/0471739499.ch5  1
2006 Tsien RY, Ernst L, Waggoner A. Fluorophores for confocal microscopy: Photophysics and photochemistry Handbook of Biological Confocal Microscopy: Third Edition. 338-352. DOI: 10.1007/978-0-387-45524-2_16  1
2005 Shaner NC, Steinbach PA, Tsien RY. A guide to choosing fluorescent proteins. Nature Methods. 2: 905-9. PMID 16299475 DOI: 10.1038/nmeth819  1
2005 Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 437: 569-73. PMID 16177793 DOI: 10.1038/nature04140  1
2005 Martin BR, Giepmans BN, Adams SR, Tsien RY. Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nature Biotechnology. 23: 1308-14. PMID 16155565 DOI: 10.1038/nbt1136  1
2005 Goldstein JC, Muñoz-Pinedo C, Ricci JE, Adams SR, Kelekar A, Schuler M, Tsien RY, Green DR. Cytochrome c is released in a single step during apoptosis. Cell Death and Differentiation. 12: 453-62. PMID 15933725 DOI: 10.1038/sj.cdd.4401596  1
2005 Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, Tsien RY, Chien S. Visualizing the mechanical activation of Src. Nature. 434: 1040-5. PMID 15846350 DOI: 10.1038/nature03469  1
2005 Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nature Methods. 2: 171-6. PMID 15782185 DOI: 10.1038/nmeth742  1
2005 Tsien RY. Building and breeding molecules to spy on cells and tumors. Febs Letters. 579: 927-32. PMID 15680976 DOI: 10.1016/j.febslet.2004.11.025  1
2005 Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. The Journal of Biological Chemistry. 280: 5581-7. PMID 15583002 DOI: 10.1074/jbc.M411534200  1
2004 Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proceedings of the National Academy of Sciences of the United States of America. 101: 17867-72. PMID 15601762 DOI: 10.1073/pnas.0408191101  1
2004 Palmer AE, Jin C, Reed JC, Tsien RY. Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor. Proceedings of the National Academy of Sciences of the United States of America. 101: 17404-9. PMID 15585581 DOI: 10.1073/pnas.0408030101  1
2004 Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nature Biotechnology. 22: 1567-72. PMID 15558047 DOI: 10.1038/nbt1037  1
2004 Wang L, Jackson WC, Steinbach PA, Tsien RY. Evolution of new nonantibody proteins via iterative somatic hypermutation. Proceedings of the National Academy of Sciences of the United States of America. 101: 16745-9. PMID 15556995 DOI: 10.1073/pnas.0407752101  1
2004 Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, ... Tsien RY, et al. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Molecular Cell. 15: 355-66. PMID 15304216 DOI: 10.1016/j.molcel.2004.06.038  1
2004 Furuta T, Takeuchi H, Isozaki M, Takahashi Y, Kanehara M, Sugimoto M, Watanabe T, Noguchi K, Dore TM, Kurahashi T, Iwamura M, Tsien RY. Bhc-cNMPs as either water-soluble or membrane-permeant photoreleasable cyclic nucleotides for both one- and two-photon excitation. Chembiochem : a European Journal of Chemical Biology. 5: 1119-28. PMID 15300837 DOI: 10.1002/cbic.200300814  1
2004 Hasan MT, Friedrich RW, Euler T, Larkum ME, Giese G, Both M, Duebel J, Waters J, Bujard H, Griesbeck O, Tsien RY, Nagai T, Miyawaki A, Denk W. Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control. Plos Biology. 2: e163. PMID 15208716 DOI: 10.1371/journal.pbio.0020163  1
2004 Dooley CT, Dore TM, Hanson GT, Jackson WC, Remington SJ, Tsien RY. Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. The Journal of Biological Chemistry. 279: 22284-93. PMID 14985369 DOI: 10.1074/jbc.M312847200  1
2004 Ray P, De A, Min JJ, Tsien RY, Gambhir SS. Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Research. 64: 1323-30. PMID 14973078 DOI: 10.1158/0008-5472.CAN-03-1816  1
2004 Ju W, Morishita W, Tsui J, Gaietta G, Deerinck TJ, Adams SR, Garner CC, Tsien RY, Ellisman MH, Malenka RC. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nature Neuroscience. 7: 244-53. PMID 14770185 DOI: 10.1038/nn1189  1
2004 Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ. Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. The Journal of Biological Chemistry. 279: 13044-53. PMID 14722062 DOI: 10.1074/jbc.M312846200  1
2004 Remington SJ, Hanson GT, Canon M, Aggeler R, Oglesbe D, Capaldi RA, Tsien RY. Third generation GFP biosensors for real time readout of pH and redox potential in living cells Proceedings of Spie - the International Society For Optical Engineering. 5329: 1-12. DOI: 10.1117/12.530285  1
2004 Ifarraguerri A, Thompson B, Tsai PS, Friedman B, Schaffer CB, Lev-Ram V, Tsien RY, Squier JA, Kleinfeld D. Quantitative analysis of volumetric TPLSM data 2004 2nd Ieee International Symposium On Biomedical Imaging: Macro to Nano. 1: 804-807.  1
2003 Gao W, Xing B, Tsien RY, Rao J. Novel fluorogenic substrates for imaging beta-lactamase gene expression. Journal of the American Chemical Society. 125: 11146-7. PMID 16220906 DOI: 10.1021/ja036126o  1
2003 Tsien RY. Breeding molecules to spy on cells. Harvey Lectures. 99: 77-93. PMID 15984552  1
2003 Sosinsky GE, Gaietta GM, Hand G, Deerinck TJ, Han A, Mackey M, Adams SR, Bouwer J, Tsien RY, Ellisman MH. Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics. Cell Communication & Adhesion. 10: 181-6. PMID 14681013  1
2003 Lev-Ram V, Mehta SB, Kleinfeld D, Tsien RY. Reversing cerebellar long-term depression. Proceedings of the National Academy of Sciences of the United States of America. 100: 15989-93. PMID 14671315 DOI: 10.1073/pnas.2636935100  1
2003 Hasegawa S, Jackson WC, Tsien RY, Rao J. Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 14892-6. PMID 14645710 DOI: 10.1073/pnas.2036553100  1
2003 Babendure JR, Adams SR, Tsien RY. Aptamers switch on fluorescence of triphenylmethane dyes. Journal of the American Chemical Society. 125: 14716-7. PMID 14640641 DOI: 10.1021/ja037994o  1
2003 Tour O, Meijer RM, Zacharias DA, Adams SR, Tsien RY. Genetically targeted chromophore-assisted light inactivation. Nature Biotechnology. 21: 1505-8. PMID 14625562 DOI: 10.1038/nbt914  1
2003 Tsien RY. Imagining imaging's future. Nature Reviews. Molecular Cell Biology. SS16-21. PMID 14587522  1
2003 Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. All-optical histology using ultrashort laser pulses. Neuron. 39: 27-41. PMID 12848930 DOI: 10.1016/S0896-6273(03)00370-2  1
2003 Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of Cell Biology. 161: 899-909. PMID 12782683 DOI: 10.1083/jcb.200302125  1
2003 Yu D, Baird GS, Tsien RY, Davis RL. Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 64-72. PMID 12514202  1
2003 Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. All optical histology: Serial ablation and multiphoton imaging of neuronal tissue with femtosecond laser pulses Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-Leos. 2: 485-486.  1
2003 Tsai PS, Friedman B, Lev-Ram V, Xiong Q, Tsien RY, Kleinfeld D, Ifarraguerri AI, Thompson BD, Squier JA. All optical histology of brain tissue: Serial ablation and multiphoton imaging with femtosecond laser pulses Osa Trends in Optics and Photonics Series. 88: 204-207.  1
2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, ... ... Tsien RY, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/nature01304  0.6
2002 Zhang J, Campbell RE, Ting AY, Tsien RY. Creating new fluorescent probes for cell biology. Nature Reviews. Molecular Cell Biology. 3: 906-18. PMID 12461557 DOI: 10.1038/nrm976  1
2002 Campbell RE, Tour O, Palmer AE, Steinbach PA, Baird GS, Zacharias DA, Tsien RY. A monomeric red fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 99: 7877-82. PMID 12060735 DOI: 10.1073/pnas.082243699  1
2002 Lev-Ram V, Wong ST, Storm DR, Tsien RY. A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proceedings of the National Academy of Sciences of the United States of America. 99: 8389-93. PMID 12048250 DOI: 10.1073/pnas.122206399  1
2002 Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. Journal of the American Chemical Society. 124: 6063-76. PMID 12022841 DOI: 10.1021/ja017687n  1
2002 Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (New York, N.Y.). 296: 913-6. PMID 11988576 DOI: 10.1126/science.1068539  1
2002 Gaietta G, Deerinck TJ, Adams SR, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH. Multicolor and electron microscopic imaging of connexin trafficking. Science (New York, N.Y.). 296: 503-7. PMID 11964472 DOI: 10.1126/science.1068793  1
2001 Ting AY, Kain KH, Klemke RL, Tsien RY. Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 15003-8. PMID 11752449 DOI: 10.1073/pnas.211564598  1
2001 Zhang J, Ma Y, Taylor SS, Tsien RY. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America. 98: 14997-5002. PMID 11752448 DOI: 10.1073/pnas.211566798  1
2001 Chan FK, Siegel RM, Zacharias D, Swofford R, Holmes KL, Tsien RY, Lenardo MJ. Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein. Cytometry. 44: 361-8. PMID 11500853 DOI: 10.1002/1097-0320(20010801)44:4<361::AID-CYTO1128>3.0.CO;2-3  1
2001 Burdette SC, Walkup GK, Spingler B, Tsien RY, Lippard SJ. Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution. Journal of the American Chemical Society. 123: 7831-41. PMID 11493056 DOI: 10.1021/ja010059l  1
2001 Ando H, Furuta T, Tsien RY, Okamoto H. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nature Genetics. 28: 317-25. PMID 11479592 DOI: 10.1038/ng583  1
2001 Wu MM, Grabe M, Adams S, Tsien RY, Moore HP, Machen TE. Mechanisms of pH regulation in the regulated secretory pathway. The Journal of Biological Chemistry. 276: 33027-35. PMID 11402049 DOI: 10.1074/jbc.M103917200  1
2001 Griesbeck O, Baird GS, Campbell RE, Zacharias DA, Tsien RY. Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications. The Journal of Biological Chemistry. 276: 29188-94. PMID 11387331 DOI: 10.1074/jbc.M102815200  1
2001 Honda A, Adams SR, Sawyer CL, Lev-Ram V, Tsien RY, Dostmann WR. Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proceedings of the National Academy of Sciences of the United States of America. 98: 2437-42. PMID 11226257 DOI: 10.1073/pnas.051631298  1
2001 Chan FKM, Siegel RM, Zacharias D, Swofford R, Holmes KL, Tsien RY, Lenardo MJ. Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells Communications in Clinical Cytometry. 46: 338-348.  1
2000 Siegel RM, Chan FK, Zacharias DA, Swofford R, Holmes KL, Tsien RY, Lenardo MJ. Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Science's Stke : Signal Transduction Knowledge Environment. 2000: pl1. PMID 11752595 DOI: 10.1126/stke.2000.38.pl1  1
2000 Heikal AA, Hess ST, Baird GS, Tsien RY, Webb WW. Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine). Proceedings of the National Academy of Sciences of the United States of America. 97: 11996-2001. PMID 11050231 DOI: 10.1073/pnas.97.22.11996  1
2000 Gross LA, Baird GS, Hoffman RC, Baldridge KK, Tsien RY. The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proceedings of the National Academy of Sciences of the United States of America. 97: 11990-5. PMID 11050230 DOI: 10.1073/pnas.97.22.11990  1
2000 Baird GS, Zacharias DA, Tsien RY. Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proceedings of the National Academy of Sciences of the United States of America. 97: 11984-9. PMID 11050229 DOI: 10.1073/pnas.97.22.11984  1
2000 Griffin BA, Adams SR, Jones J, Tsien RY. Fluorescent labeling of recombinant proteins in living cells with FlAsH. Methods in Enzymology. 327: 565-78. PMID 11045009 DOI: 10.1016/S0076-6879(00)27302-3  1
2000 Wu MM, Llopis J, Adams SR, McCaffery JM, Teter K, Kulomaa MS, Machen TE, Moore HP, Tsien RY. Studying organelle physiology with fusion protein-targeted avidin and fluorescent biotin conjugates. Methods in Enzymology. 327: 546-64. PMID 11045008 DOI: 10.1016/S0076-6879(00)27301-1  1
2000 Miyawaki A, Tsien RY. Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods in Enzymology. 327: 472-500. PMID 11045004 DOI: 10.1016/S0076-6879(00)27297-2  1
2000 Allen GJ, Chu SP, Schumacher K, Shimazaki CT, Vafeados D, Kemper A, Hawke SD, Tallman G, Tsien RY, Harper JF, Chory J, Schroeder JI. Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant. Science (New York, N.Y.). 289: 2338-42. PMID 11009417 DOI: 10.1126/science.289.5488.2338  1
2000 Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. The Journal of Biological Chemistry. 275: 36062-6. PMID 10967126 DOI: 10.1074/jbc.M007204200  1
2000 Kerr R, Lev-Ram V, Baird G, Vincent P, Tsien RY, Schafer WR. Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron. 26: 583-94. PMID 10896155  1
2000 Siegel RM, Frederiksen JK, Zacharias DA, Chan FK, Johnson M, Lynch D, Tsien RY, Lenardo MJ. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (New York, N.Y.). 288: 2354-7. PMID 10875918 DOI: 10.1126/science.288.5475.2354  1
2000 Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nature Cell Biology. 2: 318-25. PMID 10854321 DOI: 10.1038/35014006  1
2000 Zacharias DA, Baird GS, Tsien RY. Recent advances in technology for measuring and manipulating cell signals. Current Opinion in Neurobiology. 10: 416-21. PMID 10851181 DOI: 10.1016/S0959-4388(00)00101-X  1
2000 Llopis J, Westin S, Ricote M, Wang Z, Cho CY, Kurokawa R, Mullen TM, Rose DW, Rosenfeld MG, Tsien RY, Glass CK, Wang J. Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription. Proceedings of the National Academy of Sciences of the United States of America. 97: 4363-8. PMID 10760302 DOI: 10.1073/pnas.97.8.4363  1
2000 Wu MM, Llopis J, Adams S, McCaffery JM, Kulomaa MS, Machen TE, Moore HP, Tsien RY. Organelle pH studies using targeted avidin and fluorescein-biotin. Chemistry & Biology. 7: 197-209. PMID 10712929 DOI: 10.1016/S1074-5521(00)00088-0  1
2000 Thomas D, Lipp P, Tovey SC, Berridge MJ, Li W, Tsien RY, Bootman MD. Microscopic properties of elementary Ca2+ release sites in non-excitable cells. Current Biology : Cb. 10: 8-15. PMID 10660296 DOI: 10.1016/S0960-9822(99)00258-4  1
2000 Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T. A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nature Cell Biology. 2: 25-9. PMID 10620803 DOI: 10.1038/71345  1
2000 Walkup GK, Burdette SC, Lippard SJ, Tsien RY. A new cell-permeable fluorescent probe for Zn2+ [5] Journal of the American Chemical Society. 122: 5644-5645. DOI: 10.1021/ja000868p  1
1999 Allen GJ, Kwak JM, Chu SP, Llopis J, Tsien RY, Harper JF, Schroeder JI. Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells. The Plant Journal : For Cell and Molecular Biology. 19: 735-47. PMID 10571859 DOI: 10.1046/j.1365-313X.1999.00574.x  1
1999 Tsien RY. Rosy dawn for fluorescent proteins. Nature Biotechnology. 17: 956-7. PMID 10504692 DOI: 10.1038/13648  1
1999 Baird GS, Zacharias DA, Tsien RY. Circular permutation and receptor insertion within green fluorescent proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 11241-6. PMID 10500161 DOI: 10.1073/pnas.96.20.11241  1
1999 Yao Y, Ferrer-Montiel AV, Montal M, Tsien RY. Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger. Cell. 98: 475-85. PMID 10481912 DOI: 10.1016/S0092-8674(00)81976-5  1
1999 Cacciatore TW, Brodfuehrer PD, Gonzalez JE, Jiang T, Adams SR, Tsien RY, Kristan WB, Kleinfeld D. Identification of neural circuits by imaging coherent electrical activity with FRET-based dyes. Neuron. 23: 449-59. PMID 10433258 DOI: 10.1016/S0896-6273(00)80799-0  1
1999 Fan GY, Fujisaki H, Miyawaki A, Tsay RK, Tsien RY, Ellisman MH. Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons. Biophysical Journal. 76: 2412-20. PMID 10233058 DOI: 10.1016/S0006-3495(99)77396-0  1
1999 Li CJ, Heim R, Lu P, Pu Y, Tsien RY, Chang DC. Dynamic redistribution of calmodulin in HeLa cells during cell division as revealed by a GFP-calmodulin fusion protein technique. Journal of Cell Science. 112: 1567-77. PMID 10212150  1
1999 Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG. Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. The Journal of Cell Biology. 145: 279-89. PMID 10209024 DOI: 10.1083/jcb.145.2.279  1
1999 Miyawaki A, Griesbeck O, Heim R, Tsien RY. Dynamic and quantitative Ca2+ measurements using improved cameleons. Proceedings of the National Academy of Sciences of the United States of America. 96: 2135-40. PMID 10051607 DOI: 10.1073/pnas.96.5.2135  1
1999 Furuta T, Wang SS, Dantzker JL, Dore TM, Bybee WJ, Callaway EM, Denk W, Tsien RY. Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis. Proceedings of the National Academy of Sciences of the United States of America. 96: 1193-200. PMID 9990000 DOI: 10.1073/pnas.96.4.1193  1
1999 Brown EB, Shear JB, Adams SR, Tsien RY, Webb WW. Photolysis of caged calcium in femtoliter volumes using two-photon excitation. Biophysical Journal. 76: 489-99. PMID 9876162 DOI: 10.1016/S0006-3495(99)77217-6  1
1998 Raz E, Zlokarnik G, Tsien RY, Driever W. beta-lactamase as a marker for gene expression in live zebrafish embryos. Developmental Biology. 203: 290-4. PMID 9808780 DOI: 10.1006/dbio.1998.8999  1
1998 Tsien RY. The green fluorescent protein. Annual Review of Biochemistry. 67: 509-44. PMID 9759496 DOI: 10.1146/annurev.biochem.67.1.509  1
1998 Tsien RY, Miyawaki A. Seeing the machinery of live cells. Science (New York, N.Y.). 280: 1954-5. PMID 9669950 DOI: 10.1126/science.280.5371.1954  1
1998 Griffin BA, Adams SR, Tsien RY. Specific covalent labeling of recombinant protein molecules inside live cells. Science (New York, N.Y.). 281: 269-72. PMID 9657724 DOI: 10.1126/science.281.5374.269  1
1998 Llopis J, McCaffery JM, Miyawaki A, Farquhar MG, Tsien RY. Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proceedings of the National Academy of Sciences of the United States of America. 95: 6803-8. PMID 9618493 DOI: 10.1073/pnas.95.12.6803  1
1998 Li W, Llopis J, Whitney M, Zlokarnik G, Tsien RY. Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature. 392: 936-41. PMID 9582076 DOI: 10.1038/31965  1
1998 Jiang T, Sweeney G, Rudolf MT, Klip A, Traynor-Kaplan A, Tsien RY. Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate. The Journal of Biological Chemistry. 273: 11017-24. PMID 9556583 DOI: 10.1074/jbc.273.18.11017  1
1998 Zlokarnik G, Negulescu PA, Knapp TE, Mere L, Burres N, Feng L, Whitney M, Roemer K, Tsien RY. Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter. Science (New York, N.Y.). 279: 84-8. PMID 9417030 DOI: 10.1126/science.279.5347.84  1
1997 Lev-Ram V, Nebyelul Z, Ellisman MH, Huang PL, Tsien RY. Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase. Learning & Memory (Cold Spring Harbor, N.Y.). 4: 169-77. PMID 10456061  1
1997 Adams SR, Lev-Ram V, Tsien RY. A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators. Chemistry & Biology. 4: 867-78. PMID 9384535  1
1997 Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M, Tsien RY. Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature. 388: 882-7. PMID 9278050 DOI: 10.1038/42264  1
1997 Wachter RM, King BA, Heim R, Kallio K, Tsien RY, Boxer SG, Remington SJ. Crystal structure and photodynamic behavior of the blue emission variant Y66H/Y145F of green fluorescent protein. Biochemistry. 36: 9759-65. PMID 9245407 DOI: 10.1021/bi970563w  1
1997 Yao Y, Tsien RY. Calcium current activated by depletion of calcium stores in Xenopus oocytes Journal of General Physiology. 109: 703-715. PMID 9222897 DOI: 10.1085/jgp.109.6.703  1
1997 Lev-Ram V, Jiang T, Wood J, Lawrence DS, Tsien RY. Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression. Neuron. 18: 1025-38. PMID 9208868 DOI: 10.1016/S0896-6273(00)80340-2  1
1997 González JE, Tsien RY. Improved indicators of cell membrane potential that use fluorescence resonance energy transfer. Chemistry & Biology. 4: 269-77. PMID 9195864  1
1997 Brejc K, Sixma TK, Kitts PA, Kain SR, Tsien RY, Ormö M, Remington SJ. Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 2306-11. PMID 9122190 DOI: 10.1073/pnas.94.6.2306  1
1997 Li W, Schultz C, Llopis J, Tsien RY. Membrane-permeant esters of inositol polyphosphates, chemical syntheses and biological applications Tetrahedron. 53: 12017-12040. DOI: 10.1016/S0040-4020(97)00714-X  1
1997 Tsien RY, Vincent P, Hempel CM, Selverston AI, Heim R, Miyawaki LA. Fluorescence imaging of camp gradients and protein localizations in living cells Faseb Journal. 11: A1297.  1
1996 Arancio O, Lev-Ram V, Tsien RY, Kandel ER, Hawkins RD. Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons. Journal of Physiology, Paris. 90: 321-2. PMID 9089501 DOI: 10.1016/S0928-4257(97)87907-7  1
1996 Arancio O, Kiebler M, Lee CJ, Lev-Ram V, Tsien RY, Kandel ER, Hawkins RD. Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. Cell. 87: 1025-35. PMID 8978607 DOI: 10.1016/S0092-8674(00)81797-3  1
1996 Scheenen WJ, Makings LR, Gross LR, Pozzan T, Tsien RY. Photodegradation of indo-1 and its effect on apparent Ca2+ concentrations. Chemistry & Biology. 3: 765-74. PMID 8939693 DOI: 10.1016/S1074-5521(96)90253-7  1
1996 Hempel CM, Vincent P, Adams SR, Tsien RY, Selverston AI. Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuitm. Nature. 384: 166-9. PMID 8906791 DOI: 10.1038/384166a0  1
1996 Ormö M, Cubitt AB, Kallio K, Gross LA, Tsien RY, Remington SJ. Crystal structure of the Aequorea victoria green fluorescent protein. Science (New York, N.Y.). 273: 1392-5. PMID 8703075  1
1996 Rizzuto R, Brini M, De Giorgi F, Rossi R, Heim R, Tsien RY, Pozzan T. Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Current Biology : Cb. 6: 183-8. PMID 8673465 DOI: 10.1016/S0960-9822(02)00451-7  1
1996 Heim R, Tsien RY. Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer Current Biology. 6: 178-182. PMID 8673464  1
1995 Cubitt AB, Heim R, Adams SR, Boyd AE, Gross LA, Tsien RY. Understanding, improving and using green fluorescent proteins Trends in Biochemical Sciences. 20: 448-455. PMID 8578587 DOI: 10.1016/S0968-0004(00)89099-4  1
1995 González JE, Tsien RY. Voltage sensing by fluorescence resonance energy transfer in single cells. Biophysical Journal. 69: 1272-80. PMID 8534797 DOI: 10.1016/S0006-3495(95)80029-9  1
1995 Heim R, Cubitt AB, Tsien RY. Improved green fluorescence [4] Nature. 373: 663-664. PMID 7854443 DOI: 10.1038/373663B0  1
1995 Bacskai BJ, Wallén P, Lev-Ram V, Grillner S, Tsien RY. Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron. 14: 19-28. PMID 7826636 DOI: 10.1016/0896-6273(95)90237-6  1
1995 Randriamampita C, Tsien RY. Degradation of a calcium influx factor (CIF) can be blocked by phosphatase inhibitors or chelation of Ca2+ Journal of Biological Chemistry. 270: 29-32. PMID 7814389 DOI: 10.1074/jbc.270.1.29  1
1995 Lev-Ram V, Makings LR, Keitz PF, Kao JP, Tsien RY. Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients. Neuron. 15: 407-15. PMID 7646893 DOI: 10.1016/0896-6273(95)90044-6  1
1995 Wen W, Meinkotht JL, Tsien RY, Taylor SS. Identification of a signal for rapid export of proteins from the nucleus Cell. 82: 463-473. PMID 7634336 DOI: 10.1016/0092-8674(95)90435-2  1
1995 Randriamampita C, Tsien RY. Calcium entry signal? [10] Nature. 373: 482.  1
1994 Gurantz D, Harootunian AT, Tsien RY, Dionne VE, Margiotta JF. VIP modulates neuronal nicotinic acetylcholine receptor function by a cyclic AMP-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3540-7. PMID 8207470  1
1994 Asmis R, Randriamampita C, Tsien RY, Dennis EA. Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells Biochemical Journal. 298: 543-551. PMID 8141766 DOI: 10.1042/BJ2980543  1
1994 Makings LR, Tsien RY. Caged nitric oxide: Stable organic molecules from which nitric oxide can be photoreleased Journal of Biological Chemistry. 269: 6282-6285. PMID 8119976  1
1994 Schultz C, Vajanaphanich M, Genieser HG, Jastorff B, Barrett KE, Tsien RY. Membrane-permeant derivatives of cyclic AMP optimized for high potency, prolonged activity, or rapid reversibility Molecular Pharmacology. 46: 702-708. PMID 7969049  1
1994 Ranganathan R, Bacskai BJ, Tsien RY, Zuker CS. Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function. Neuron. 13: 837-48. PMID 7946332 DOI: 10.1016/0896-6273(94)90250-X  1
1994 Civitelli R, Bacskai BJ, Mahaut-Smith MP, Adams SR, Avioli LV, Tsien RY. Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 9: 1407-17. PMID 7817824 DOI: 10.1002/jbmr.5650090912  1
1994 Heim R, Prasher DC, Tsien RY. Wavelength mutations and posttranslational autoxidation of green fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 91: 12501-4. PMID 7809066 DOI: 10.1073/pnas.91.26.12501  1
1994 Deerinck TJ, Martone ME, Lev-Ram V, Green DP, Tsien RY, Spector DL, Huang S, Ellisman MH. Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. The Journal of Cell Biology. 126: 901-10. PMID 7519623 DOI: 10.1083/jcb.126.4.901  1
1993 Tsien RY, Bacskai BJ, Adams SR. FRET for studying intracellular signalling. Trends in Cell Biology. 3: 242-5. PMID 14731760 DOI: 10.1016/0962-8924(93)90124-J  1
1993 Adams SR, Tsien RY. Controlling cell chemistry with caged compounds Annual Review of Physiology. 55: 755-784. PMID 8466191  1
1993 LaMorte VJ, Harootunian AT, Spiegel AM, Tsien RY, Feramisco JR. Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2. The Journal of Cell Biology. 121: 91-9. PMID 8458876  1
1993 Schultz C, Vajanaphanich M, Harootunian AT, Sammak PJ, Barrett KE, Tsien RY. Acetoxymethyl esters of phosphates, enhancement of the permeability and potency of cAMP Journal of Biological Chemistry. 268: 6316-6322. PMID 8384207  1
1993 Randriamampita C, Tsien RY. Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx Nature. 364: 809-814. PMID 8355806 DOI: 10.1038/364809A0  1
1993 Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy MR. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Molecular and Cellular Biology. 13: 4852-9. PMID 8336722 DOI: 10.1128/MCB.13.8.4852  1
1993 Harootunian AT, Adams SR, Wen W, Meinkoth JL, Taylor SS, Tsien RY. Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion Molecular Biology of the Cell. 4: 993-1002. PMID 8298196 DOI: 10.1091/mbc.4.10.993  1
1993 Adams SR, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY. Confocal imaging of cAMP signals in Aplysia neurons. The Japanese Journal of Physiology. 43: S91-3. PMID 8271521  1
1993 Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (New York, N.Y.). 260: 222-6. PMID 7682336  1
1992 Sammak PJ, Adams SR, Harootunian AT, Schliwa M, Tsien RY. Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging. The Journal of Cell Biology. 117: 57-72. PMID 1348251  1
1992 Tsien RY. Intracellular signal transduction in four dimensions: From molecular design to physiology American Journal of Physiology - Cell Physiology. 263. PMID 1329539  1
1991 Harootunian AT, Kao JPY, Paranjape S, Tsien RY. Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3 Science. 251: 75-78. PMID 1986413  1
1991 Adams SR, Harootunian AT, Buechler YJ, Taylor SS, Tsien RY. Fluorescence ratio imaging of cyclic AMP in single cells Nature. 349: 694-697. PMID 1847505  1
1991 Harootunian AT, Kao JPY, Paranjape S, Adams SR, Potter BVL, Tsien RY. Cytosolic Ca2+ oscillations in REF52 fibroblasts: Ca2+-stimulated IP3 production or voltage-dependent Ca2+ channels as key positive feedback elements Cell Calcium. 12: 153-164. PMID 1647875 DOI: 10.1016/0143-4160(91)90017-9  1
1990 Tsien RY, Harootunian AT. Practical design criteria for a dynamic ratio imaging system Cell Calcium. 11: 93-109. PMID 2354507 DOI: 10.1016/0143-4160(90)90063-Z  1
1990 Tsien RW, Tsien RY. Calcium channels, stores, and oscillations. Annual Review of Cell Biology. 6: 715-60. PMID 2177344 DOI: 10.1146/annurev.cb.06.110190.003435  1
1990 Kao JP, Alderton JM, Tsien RY, Steinhardt RA. Active involvement of Ca2+ in mitotic progression of Swiss 3T3 fibroblasts. The Journal of Cell Biology. 111: 183-96. PMID 2114410  1
1990 Harootunian AT, Kao JPY, Adams SR, Tsien RY. Imaging and manipulation of cytosolic ions and messengers during cell activation Journal of Cell Science. 97: 1-4. PMID 2084112  1
1990 Negulescu PA, Harootunian A, Tsien RY, Machen TE. Fluorescence measurements of cytosolic free Na concentration, influx and efflux in gastric cells Cell Regulation. 1: 259-268. PMID 1712635  1
1989 Tsien RY. Fluorescence ratio imaging of dynamic intracellular signals Acta Physiologica Scandinavica, Supplement. 582: 6. PMID 2816449 DOI: 10.1117/12.962706  1
1989 Minta A, Tsien RY. Fluorescent indicators for cytosolic sodium Journal of Biological Chemistry. 264: 19449-19457. PMID 2808435  1
1989 Havran WL, Poenie M, Tigelaar RE, Tsien RY, Allison JP. Phenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones. Journal of Immunology (Baltimore, Md. : 1950). 142: 1422-8. PMID 2783942  1
1989 Tsien R, Pozzan T. Measurement of cytosolic free Ca2+ with quin2. Methods in Enzymology. 172: 230-62. PMID 2747529 DOI: 10.1016/S0076-6879(89)72017-6  1
1989 Tsien RY. Fluorescent probes of cell signaling Annual Review of Neuroscience. 12: 227-253. PMID 2648950  1
1989 Tsien RY. Fluorescent indicators of ion concentrations Methods in Cell Biology. 30: 127-156. PMID 2538708  1
1989 Kao JPY, Harootunian AT, Tsien RY. Photochemically generated cytosolic calcium pulses and their detection by fluo-3 Journal of Biological Chemistry. 264: 8179-8184. PMID 2498309  1
1989 Minta A, Kao JPY, Tsien RY. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores Journal of Biological Chemistry. 264: 8171-8178. PMID 2498308  1
1989 Harootunian AT, Kao JPY, Eckert BK, Tsien RY. Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes Journal of Biological Chemistry. 264: 19458-19467. PMID 2478559  1
1989 Kawanishi T, Blank LM, Harootunian AT, Smith MT, Tsien RY. Ca2+ oscillations induced by hormonal stimulation of individual fura-2-loaded hepatocytes Journal of Biological Chemistry. 264: 12859-12866. PMID 2473983  1
1989 Adams SR, Kao JPY, Tsien RY. Biologically useful chelators that take up Ca2+ upon illumination Journal of the American Chemical Society. 111: 7957-7968.  1
1988 Kao JP, Tsien RY. Ca2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements Biophysical Journal. 53: 635-639. PMID 3382715  1
1988 Harootunian AT, Kao JPY, Tsien RY. Agonist-induced calcium oscillations in depolarized fibroblasts and their manipulation by photoreleased Ins(1,4,5)P3, Ca++, and Ca++ buffer Cold Spring Harbor Symposia On Quantitative Biology. 53: 935-943. PMID 3267115  1
1988 Langlet C, Guimezanes A, Kaldy P, Boyer C, Buferne M, Poenie M, Tsien R, Leo O, Bluestone J, Leserman L. Role of Ti/CD3, Thy-1, and Ly-6 in cytolytic T-cell activation analyzed with Ti loss variants. Annals of the New York Academy of Sciences. 532: 33-43. PMID 2902820 DOI: 10.1111/j.1749-6632.1988.tb36323.x  1
1988 Ambler SK, Poenie M, Tsien RY, Taylor P. Agonist-stimulated oscillations and cycling of intracellular free calcium in individual cultured muscle cells. The Journal of Biological Chemistry. 263: 1952-9. PMID 2892835  1
1988 Lipscombe D, Madison DV, Poenie M, Reuter H, Tsien RW, Tsien RY. Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron. 1: 355-65. PMID 2856095 DOI: 10.1016/0896-6273(88)90185-7  1
1988 Tsien RY. Fluorescence measurement and photochemical manipulation of cytosolic free calcium Trends in Neurosciences. 11: 419-424. PMID 2469158 DOI: 10.1016/0166-2236(88)90192-0  1
1988 Ratto GM, Payne R, Owen WG, Tsien RY. The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 3240-6. PMID 2459322  1
1988 Lipscombe D, Madison DV, Poenie M, Reuter H, Tsien RY, Tsien RW. Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. 85: 2398-402. PMID 2451249 DOI: 10.1073/pnas.85.7.2398  1
1988 Adams SR, Kao JPY, Grynkiewicz G, Minta A, Tsien RY. Biologically useful chelators that release Ca2+ upon illumination Journal of the American Chemical Society. 110: 3212-3220.  1
1987 Paradiso AM, Tsien RY, Machen TE. Digital image processing of intracellular pH in gastric oxyntic and chief cells Nature. 325: 447-450. PMID 3808046  1
1987 Poenie M, Tsien RY, Schmitt-Verhulst AM. Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets. The Embo Journal. 6: 2223-32. PMID 3499312  1
1987 Chen WS, Lazar CS, Poenie M, Tsien RY, Gill GN, Rosenfeld MG. Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature. 328: 820-3. PMID 3498122 DOI: 10.1038/328820a0  1
1987 Chused TM, Wilson HA, Greenblatt D, Ishida Y, Edison LJ, Tsien RY, Finkelman FD. Flow cytometric analysis of murine splenic B lymphocyte cytosolic free calcium response to anti-IgM and anti-IgD. Cytometry. 8: 396-404. PMID 3497786 DOI: 10.1002/cyto.990080409  1
1987 Wilson HA, Greenblatt D, Poenie M, Finkelman FD, Tsien RY. Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium. The Journal of Experimental Medicine. 166: 601-6. PMID 3496421  1
1987 Paradiso AM, Tsien RY, Demarest JR, Machen TE. Na-H and Cl-HCO3 exchange in rabbit oxyntic cells using fluorescence microscopy American Journal of Physiology - Cell Physiology. 253: 22/1. PMID 3037913  1
1987 Havran WL, Poenie M, Kimura J, Tsien R, Weiss A, Allison JP. Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature. 330: 170-3. PMID 2959867 DOI: 10.1038/330170a0  1
1987 Schmitt-Verhulst AM, Guimezanes A, Boyer C, Poenie M, Tsien R, Buferne M, Hua C, Leserman L. Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone. Nature. 325: 628-31. PMID 2880301 DOI: 10.1038/325628a0  1
1987 Gurney AM, Tsien RY, Lester HA. Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. 84: 3496-500. PMID 2437582  1
1986 Poenie M, Alderton J, Steinhardt R, Tsien R. Calcium rises abruptly and briefly throughout the cell at the onset of anaphase. Science (New York, N.Y.). 233: 886-9. PMID 3755550 DOI: 10.1126/SCIENCE.3755550  1
1986 Tsien RY. New tetracarboxylate chelators for fluorescence measurement and photochemical manipulation of cytosolic free calcium concentrations Society of General Physiologists Series. 40: 327-345. PMID 3520839  1
1986 Tsien RY, Zucker RS. Control of cytoplasmic calcium with photolabile tetracarboxylate 2-nitrobenzhydrol chelators. Biophysical Journal. 50: 843-53. PMID 3098316 DOI: 10.1016/S0006-3495(86)83525-1  1
1986 Drummond IA, McClure SA, Poenie M, Tsien RY, Steinhardt RA. Large changes in intracellular pH and calcium observed during heat shock are not responsible for the induction of heat shock proteins in Drosophila melanogaster. Molecular and Cellular Biology. 6: 1767-75. PMID 3097504  1
1986 LaBaer J, Tsien RY, Fahey KA, DeFranco AL. Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium Journal of Immunology. 137: 1836-1844. PMID 2427581  1
1986 Tsien RY, Poenie M. Fluorescence ratio imaging: a new window into intracellular ionic signaling Trends in Biochemical Sciences. 11: 450-455. DOI: 10.1016/0968-0004(86)90245-8  1
1985 Williams DA, Fogarty KE, Tsien RY, Fay FS. Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2 Nature. 318: 558-561. PMID 3934562  1
1985 Arslan P, Di Virgilio F, Beltrame M, Tsien RY, Pozzan T. Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. The Journal of Biological Chemistry. 260: 2719-27. PMID 3919006  1
1985 Tsien RY, Rink TJ, Poenie M. Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium. 6: 145-57. PMID 3874696 DOI: 10.1016/0143-4160(85)90041-7  1
1985 Poenie M, Alderton J, Tsien RY, Steinhardt RA. Changes of free calcium levels with stages of the cell division cycle. Nature. 315: 147-9. PMID 3838803 DOI: 10.1038/315147a0  1
1985 Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. The Journal of Biological Chemistry. 260: 3440-50. PMID 3838314  1
1985 Vergara J, Tsien RY, Delay M. Inositol 1,4,5-trisphosphate: A possible chemical link in excitation-contraction coupling in muscle Proceedings of the National Academy of Sciences of the United States of America. 82: 6352-6356. PMID 2994073  1
1985 DeFranco AL, LaBaer J, Fahey KA, Tsien RY. Crosslinkage of membrane IgM causes an increase in cytoplasmic calcium via phosphoinositide hydrolysis Federation Proceedings. 44.  1
1984 Tsien RY. Measuring and manipulating cytosolic Ca2+ with trapped indicators Kroc Foundation Series. 17: 147-155. PMID 6439833  1
1984 Tsien RY, Pozzan T, Rink TJ. Calcium activities and fluxes inside small intact cells as measured with intracellularly trapped chelators. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 17: 535-41. PMID 6328935  1
1984 Meldolesi J, Huttner WB, Tsien RY, Pozzan T. Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin. Proceedings of the National Academy of Sciences of the United States of America. 81: 620-4. PMID 6141561 DOI: 10.1073/pnas.81.2.620  1
1984 Paradiso AM, Tsien RY, Machen TE. Na+-H+ exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH indicator Proceedings of the National Academy of Sciences of the United States of America. 81: 7436-7440. PMID 6095295  1
1984 Tsien RY, Pozzan T, Rink TJ. Measuring and manipulating cytosolic Ca2+ with trapped indicators Trends in Biochemical Sciences. 9: 263-266. DOI: 10.1016/0968-0004(84)90160-9  1
1983 Moolenaar WH, Tsien RY, Van der Saag PT, De Laat SW. Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts Nature. 304: 645-648. PMID 6410286 DOI: 10.1038/304645a0  1
1983 Pozzan T, Lew DP, Wollheim CB, Tsien RY. Is cytosolic ionized calcium regulating neutrophil activation? Science (New York, N.Y.). 221: 1413-5. PMID 6310757 DOI: 10.1126/science.6310757  0.4
1983 Tsien RY, Pozzan T, Rink TJ. CALCIUM ACTIVITIES INSIDE SMALL INTACT CELLS SUCH AS LYMPHOCYTES. Electrochemical Society Extended Abstracts. 83: 1002.  1
1982 Tsien RY, Hladky SB. Ion repulsion within membranes Biophysical Journal. 39: 49-56. PMID 7104450  1
1982 Rink TJ, Tsien RY. Cytoplasmic free [Ca2+] in very small intact cells. Biochemical Society Transactions. 10: 209. PMID 6982838  1
1982 Tsien RY, Pozzan T, Rink TJ. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. The Journal of Cell Biology. 94: 325-34. PMID 6980885 DOI: 10.1083/jcb.94.2.325  1
1982 Rink TJ, Smith SW, Tsien RY. Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion. Febs Letters. 148: 21-6. PMID 6816632 DOI: 10.1016/0014-5793(82)81234-9  1
1982 Rink TJ, Tsien RY, Pozzan T. Cytoplasmic pH and free Mg2+ in lymphocytes. The Journal of Cell Biology. 95: 189-96. PMID 6815204 DOI: 10.1083/jcb.95.1.189  1
1982 Pozzan T, Arslan P, Tsien RY, Rink TJ. Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes. The Journal of Cell Biology. 94: 335-40. PMID 6809769 DOI: 10.1083/jcb.94.2.335  1
1982 Tsien RY, Pozzan T, Rink TJ. T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature. 295: 68-71. PMID 6799829 DOI: 10.1038/295068a0  1
1982 Lew VL, Tsien RY, Miner C, Bookchin RM. Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator Nature. 298: 478-481. PMID 6283392 DOI: 10.1038/298478a0  1
1981 Tsien RY, Rink TJ. Ca2+-selective electrodes: a novel PVC-gelled neutral carrier mixture compared with other currently available sensors. Journal of Neuroscience Methods. 4: 73-86. PMID 7253701 DOI: 10.1016/0165-0270(81)90020-0  1
1981 Tsien RY. A non-disruptive technique for loading calcium buffers and indicators into cells Nature. 290: 527-528. PMID 7219539 DOI: 10.1038/290527a0  1
1981 Alvarez-Leefmans FJ, Rink TJ, Tsien RY. Free calcium ions in neurones of Helix aspersa measured with ion-selective micro-electrodes. The Journal of Physiology. 315: 531-48. PMID 6273543 DOI: 10.1113/jphysiol.1981.sp013762  1
1981 Pozzan T, Rink TJ, Tsien RY. Cytoplasmic pH and free Ma2+ in pig mesenteric lymphocytes Journal of Physiology. 102P.  1
1980 Marban E, Rink TJ, Tsien RW, Tsien RY. Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature. 286: 845-50. PMID 7412868 DOI: 10.1038/286845a0  1
1980 Tsien RY, Rink TJ. Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium. Biochimica Et Biophysica Acta. 599: 623-38. PMID 7407109  1
1980 Rink TJ, Tsien RY, Warner AE. Free calcium in Xenopus embryos measured with ion-selective microelectrodes. Nature. 283: 658-60. PMID 7354852 DOI: 10.1038/283658a0  1
1980 Tsien RY. New calcium indicators and buffers with high selectivity against magnesium and protons: Design, synthesis, and properties of prototype structures Biochemistry. 19: 2396-2404. PMID 6770893  1
1980 Rink TJ, Montecucco C, Hesketh TR, Tsien RY. Lymphocyte membrane potential assessed with fluorescent probes. Biochimica Et Biophysica Acta. 595: 15-30. PMID 6153065 DOI: 10.1016/0005-2736(80)90243-6  1
1980 Tsien RY. Liquid sensors for ion-selective microelectrodes Trends in Neurosciences. 3: 219-221. DOI: 10.1016/0166-2236(80)90082-X  1
1978 Tsien RY. A virial expansion for discrete charges buried in a membrane Biophysical Journal. 24: 561-567. PMID 728530  1
1978 Ashley CC, Rink TJ, Tsien RY. Changes in free Ca during muscle contraction, measured with an intracellular Ca-selective electrode [proceedings]. The Journal of Physiology. 280: 27P. PMID 690875  1
1978 Tsien RY, Hladky SB. A quantitative resolution of the spectra of a membrane potential indicator, diS-C3-(5), bound to cell components and to red blood cells The Journal of Membrane Biology. 38: 73-97. PMID 625049 DOI: 10.1007/BF01875163  1
1975 Tsien RY, Green DP, Levinson SR, Rudy B, Sanders JK. A pharmacologically active derivative of tetrodotoxin. Proceedings of the Royal Society of London. Series B, Biological Sciences. 191: 555-9. PMID 1784  1
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