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Year Citation  Score
2018 Jahromi AH, Wang C, Adams SR, Zhu W, Narsinh K, Xu H, Gray DL, Tsien RY, Ahrens ET. Fluorous-Soluble Metal Chelate for Sensitive Fluorine-19 Magnetic Resonance Imaging Nanoemulsion Probes. Acs Nano. PMID 30525446 DOI: 10.1021/Acsnano.8B04881  0.625
2018 Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG. Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage. Plos One. 13: e0198464. PMID 30248101 DOI: 10.1371/Journal.Pone.0198464  0.774
2018 Hingorani DV, Whitney MA, Friedman B, Kwon JK, Crisp JL, Xiong Q, Gross L, Kane CJ, Tsien RY, Nguyen QT. Nerve-targeted probes for fluorescence-guided intraoperative imaging. Theranostics. 8: 4226-4237. PMID 30128049 DOI: 10.7150/Thno.23084  0.71
2017 Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. A thrombin receptor - derived imaging agent detects subclinical arthritis in mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 29164814 DOI: 10.1002/Art.40316  0.784
2017 Miampamba M, Liu J, Harootunian A, Gale AJ, Baird S, Chen SL, Nguyen QT, Tsien RY, González JE. Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620. Theranostics. 7: 3369-3386. PMID 28900516 DOI: 10.7150/thno.20678  0.331
2017 Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT. Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncology. 71: 156-162. PMID 28688684 DOI: 10.1016/j.oraloncology.2017.06.009  0.346
2016 Wang Y, An FF, Chan M, Friedman B, Rodriguez EA, Tsien RY, Aras O, Ting R. (18)F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial hemorrhage model. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X16682510. PMID 28054494 DOI: 10.1177/0271678X16682510  0.685
2016 Adams SR, Mackey MR, Ramachandra R, Palida Lemieux SF, Steinbach P, Bushong EA, Butko MT, Giepmans BN, Ellisman MH, Tsien RY. Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species. Cell Chemical Biology. PMID 27818300 DOI: 10.1016/J.Chembiol.2016.10.006  0.767
2016 Rodriguez EA, Campbell RE, Lin JY, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY. The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins. Trends in Biochemical Sciences. PMID 27814948 DOI: 10.1016/J.Tibs.2016.09.010  0.794
2016 Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791138 DOI: 10.1073/Pnas.1611642113  0.702
2016 Adams SR, Yang HC, Savariar EN, Aguilera J, Crisp JL, Jones KA, Whitney MA, Lippman SM, Cohen EE, Tsien RY, Advani SJ. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nature Communications. 7: 13019. PMID 27698471 DOI: 10.1038/Ncomms13019  0.761
2016 Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin JY, Tsien RY. A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein. Nature Methods. PMID 27479328 DOI: 10.1038/Nmeth.3935  0.812
2016 Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi CR, Ellisman MH, Tsien RY. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nature Chemical Biology. PMID 27110681 DOI: 10.1038/Nchembio.2076  0.75
2016 Rodriguez EA, Wang Y, Crisp JL, Vera DR, Tsien RY, Ting R. New dioxaborolane chemistry enables [18F]-positron-emitting, fluorescent [18F]-multimodality biomolecule generation from the solid-phase. Bioconjugate Chemistry. PMID 27064381 DOI: 10.1021/Acs.Bioconjchem.6B00164  0.791
2016 Kislukhin AA, Xu H, Adams SR, Narsinh KH, Tsien RY, Ahrens ET. Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging. Nature Materials. PMID 26974409 DOI: 10.1038/Nmat4585  0.771
2016 Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT. Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. Journal of Surgical Oncology. 113: 138-143. PMID 26799257 DOI: 10.1002/Jso.24129  0.736
2016 Li Y, Barber Q, Paproski RJ, Enterina JR, Rodriguez EA, Tsien RY, Campbell RE, Zemp RJ. Engineering a near-infrared dark chromoprotein optimized for photoacoustic imaging (Conference Presentation) Proceedings of Spie. 9708. DOI: 10.1117/12.2209150  0.754
2016 Rodriguez EA, Tran GN, Gross LA, Crisp JL, Shu X, Lin JY, Tsien RY. Erratum: Corrigendum: A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein Nature Methods. 13: 890-890. DOI: 10.1038/Nmeth1016-890A  0.779
2016 Advani S, Adams S, Yang H, Crisp J, Aguilera J, Nguyen Q, Tsien R. Extracellular Biosensors to Selectively Radiosensitize Head and Neck Cancers International Journal of Radiation Oncology*Biology*Physics. 94: 945. DOI: 10.1016/J.Ijrobp.2015.12.280  0.68
2015 Chen S, Cui J, Jiang T, Olson ES, Cai QY, Yang M, Wu W, Guthrie JM, Robertson JD, Lipton SA, Ma L, Tsien RY, Gu Z. Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26681768 DOI: 10.1177/0271678X15621573  0.348
2015 Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. Plos One. 10: e0139833. PMID 26448434 DOI: 10.1371/Journal.Pone.0139833  0.335
2015 Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, ... Tsien RW, ... Tsien RY, et al. Optogenetics: 10 years after ChR2 in neurons--views from the community. Nature Neuroscience. 18: 1202-12. PMID 26308981 DOI: 10.1038/Nn.4106  0.468
2015 Briggman KL, Kristan WB, González JE, Kleinfeld D, Tsien RY. Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes. Advances in Experimental Medicine and Biology. 859: 149-69. PMID 26238052 DOI: 10.1007/978-3-319-17641-3_6  0.341
2015 Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, Plemper RK, Tsien RY, Lin MZ. Tunable and reversible drug control of protein production via a self-excising degron. Nature Chemical Biology. 11: 713-20. PMID 26214256 DOI: 10.1038/nchembio.1869  0.539
2015 Palida SF, Butko MT, Ngo JT, Mackey MR, Gross LA, Ellisman MH, Tsien RY. PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7736-49. PMID 25995463 DOI: 10.1523/Jneurosci.0004-15.2015  0.77
2015 Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT. Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome. Plos One. 10: e0119600. PMID 25751149 DOI: 10.1371/Journal.Pone.0119600  0.302
2015 Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncology. 51: 470-5. PMID 25735654 DOI: 10.1016/J.Oraloncology.2015.01.014  0.683
2015 Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Research. 75: 1376-87. PMID 25681274 DOI: 10.1158/0008-5472.Can-14-1931  0.778
2015 Woodford CR, Frady EP, Smith RS, Morey B, Canzi G, Palida SF, Araneda RC, Kristan WB, Kubiak CP, Miller EW, Tsien RY. Improved PeT molecules for optically sensing voltage in neurons. Journal of the American Chemical Society. 137: 1817-24. PMID 25584688 DOI: 10.1021/Ja510602Z  0.305
2015 Griffin BA, Adams SR, Tsien RY. How FlAsH got its sparkle: historical recollections of the biarsenical-tetracysteine tag. Methods in Molecular Biology (Clifton, N.J.). 1266: 1-6. PMID 25560064 DOI: 10.1007/978-1-4939-2272-7_1  0.305
2015 Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Annals of Surgical Oncology. 22: 2082-7. PMID 25319581 DOI: 10.1245/S10434-014-4144-1  0.716
2015 Kislukhin AA, Xu H, Adams SR, Narsinh K, Tsien RY, Ahrens ET. Abstract 215: Tracking transplanted cells with paramagnetic fluorinated nanoemulsions Cancer Research. 75: 215-215. DOI: 10.1158/1538-7445.Am2015-215  0.756
2015 Advani S, Yang H, Savariar E, Adams S, Aguilera J, Lippman S, Cohen E, Tsien R. EGFR Targeted Delivery of Ultrapotent Radiosensitizers for Head and Neck Cancer International Journal of Radiation Oncology*Biology*Physics. 93: S183. DOI: 10.1016/J.Ijrobp.2015.07.438  0.663
2014 Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen QT. Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Head & Neck. PMID 25521629 DOI: 10.1002/Hed.23946  0.731
2014 Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen QT. Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 151: 612-8. PMID 25091190 DOI: 10.1177/0194599814545083  0.71
2014 Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R. Engineering a memory with LTD and LTP. Nature. 511: 348-52. PMID 24896183 DOI: 10.1038/Nature13294  0.426
2014 Levin RA, Felsen CN, Yang J, Lin JY, Whitney MA, Nguyen QT, Tsien RY. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. Plos One. 9: e97415. PMID 24816650 DOI: 10.1371/Journal.Pone.0097415  0.545
2014 Crisp JL, Savariar EN, Glasgow HL, Ellies LG, Whitney MA, Tsien RY. Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. Molecular Cancer Therapeutics. 13: 1514-25. PMID 24737028 DOI: 10.1158/1535-7163.Mct-13-1067  0.786
2014 Felsen CN, Savariar EN, Whitney M, Tsien RY. Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L764-74. PMID 24508733 DOI: 10.1152/Ajplung.00371.2013  0.687
2014 Weinstain R, Savariar EN, Felsen CN, Tsien RY. In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides. Journal of the American Chemical Society. 136: 874-7. PMID 24377760 DOI: 10.1021/Ja411547J  0.725
2014 Inagaki HK, Jung Y, Hoopfer ED, Wong AM, Mishra N, Lin JY, Tsien RY, Anderson DJ. Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship. Nature Methods. 11: 325-32. PMID 24363022 DOI: 10.1038/Nmeth.2765  0.453
2014 Hauff SJ, Raju SC, Orosco RK, Nashi N, Savariar EN, Tsien RY, Nguyen QT. Fluorescence Imaging of Head and Neck Squamous Cell Carcinoma Otolaryngology–Head and Neck Surgery. 151: P56-P57. DOI: 10.1177/0194599814541627A88  0.71
2014 Metildi CA, Kaushal S, Felsen CN, Nguyen QT, Hoffman RM, Tsien RY, Bouvet M. Abstract 4311: Fluorescence-guided surgery of pancreatic cancer using activatable cell penetrating peptides (ACPPs) in orthotopic mouse models Cancer Research. 74: 4311-4311. DOI: 10.1158/1538-7445.Am2014-4311  0.332
2014 Felsen CN, Savariar EN, Whitney M, Tsien RY. Upregulated Matrix Metalloproteinase 2/9 Activity in Murine Asthma Detected with Activatable Cell-Penetrating Peptides Journal of Allergy and Clinical Immunology. 133: AB402. DOI: 10.1016/J.Jaci.2013.12.1062  0.698
2013 Lin JY, Knutsen PM, Muller A, Kleinfeld D, Tsien RY. ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nature Neuroscience. 16: 1499-508. PMID 23995068 DOI: 10.1038/Nn.3502  0.473
2013 Lin JY, Sann SB, Zhou K, Nabavi S, Proulx CD, Malinow R, Jin Y, Tsien RY. Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI). Neuron. 79: 241-53. PMID 23889931 DOI: 10.1016/J.Neuron.2013.05.022  0.46
2013 Tsien RY. Very long-term memories may be stored in the pattern of holes in the perineuronal net. Proceedings of the National Academy of Sciences of the United States of America. 110: 12456-61. PMID 23832785 DOI: 10.1073/pnas.1310158110  0.303
2013 Weinstain R, Kanter J, Friedman B, Ellies LG, Baker ME, Tsien RY. Fluorescent ligand for human progesterone receptor imaging in live cells. Bioconjugate Chemistry. 24: 766-71. PMID 23600997 DOI: 10.1021/Bc3006418  0.349
2013 Butko MT, Savas JN, Friedman B, Delahunty C, Ebner F, Yates JR, Tsien RY. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proceedings of the National Academy of Sciences of the United States of America. 110: E726-35. PMID 23382246 DOI: 10.1073/Pnas.1300424110  0.751
2013 Shani E, Weinstain R, Zhang Y, Castillejo C, Kaiserli E, Chory J, Tsien RY, Estelle M. Gibberellins accumulate in the elongating endodermal cells of Arabidopsis root. Proceedings of the National Academy of Sciences of the United States of America. 110: 4834-9. PMID 23382232 DOI: 10.1073/Pnas.1300436110  0.482
2013 Orosco RK, Tsien RY, Nguyen QT. Fluorescence imaging in surgery. Ieee Reviews in Biomedical Engineering. 6: 178-87. PMID 23335674 DOI: 10.1109/RBME.2013.2240294  0.356
2013 Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Research. 73: 855-64. PMID 23188503 DOI: 10.1158/0008-5472.Can-12-2969  0.718
2013 Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen QT, Tsien RY. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angewandte Chemie (International Ed. in English). 52: 325-30. PMID 23080482 DOI: 10.1002/Anie.201205721  0.796
2013 Orosco RK, Weissbrod PA, Nashi N, Bouvet M, Tsien RY, Nguyen QT. Fluorescence-Guided Thyroidectomy in a Transgenic Murine Model of Papillary Thyroid Carcinoma Otolaryngology–Head and Neck Surgery. 149: P64-P64. DOI: 10.1177/0194599813495815a94  0.36
2013 Crisp JL, Savariar EN, Hasselmann JP, Chung H, Tsien RY, Ellies LG. Abstract A005: MMP FRET ACPP imaging of mammary tumors in a mouse model of postmenopausal obesity Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A005  0.782
2012 Butko MT, Yang J, Geng Y, Kim HJ, Jeon NL, Shu X, Mackey MR, Ellisman MH, Tsien RY, Lin MZ. Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. Nature Neuroscience. 15: 1742-51. PMID 23103964 DOI: 10.1038/Nn.3246  0.798
2012 Ou HD, Kwiatkowski W, Deerinck TJ, Noske A, Blain KY, Land HS, Soria C, Powers CJ, May AP, Shu X, Tsien RY, Fitzpatrick JA, Long JA, Ellisman MH, Choe S, et al. A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors. Cell. 151: 304-19. PMID 23063122 DOI: 10.1016/J.Cell.2012.08.035  0.517
2012 Lam AJ, St-Pierre F, Gong Y, Marshall JD, Cranfill PJ, Baird MA, McKeown MR, Wiedenmann J, Davidson MW, Schnitzer MJ, Tsien RY, Lin MZ. Improving FRET dynamic range with bright green and red fluorescent proteins. Nature Methods. 9: 1005-12. PMID 22961245 DOI: 10.1016/J.Bpj.2012.11.3773  0.613
2012 Olson ES, Whitney MA, Friedman B, Aguilera TA, Crisp JL, Baik FM, Jiang T, Baird SM, Tsimikas S, Tsien RY, Nguyen QT. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 595-605. PMID 22534729 DOI: 10.1039/C2Ib00161F  0.798
2012 Qi YB, Garren EJ, Shu X, Tsien RY, Jin Y. Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG. Proceedings of the National Academy of Sciences of the United States of America. 109: 7499-504. PMID 22532663 DOI: 10.1073/Pnas.1204096109  0.573
2012 Miller EW, Lin JY, Frady EP, Steinbach PA, Kristan WB, Tsien RY. Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires. Proceedings of the National Academy of Sciences of the United States of America. 109: 2114-9. PMID 22308458 DOI: 10.1073/Pnas.1120694109  0.49
2012 Deerinck T, Bushong E, Tsien R, Ellisman M, Shu X. Advances in Correlated Light and Electron Microscopy Imaging Probes Microscopy and Microanalysis. 18: 834-835. DOI: 10.1017/S1431927612006022  0.545
2011 Li H, Foss SM, Dobryy YL, Park CK, Hires SA, Shaner NC, Tsien RY, Osborne LC, Voglmaier SM. Concurrent imaging of synaptic vesicle recycling and calcium dynamics. Frontiers in Molecular Neuroscience. 4: 34. PMID 22065946 DOI: 10.3389/Fnmol.2011.00034  0.791
2011 Shu X, Lev-Ram V, Deerinck TJ, Qi Y, Ramko EB, Davidson MW, Jin Y, Ellisman MH, Tsien RY. A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms. Plos Biology. 9: e1001041. PMID 21483721 DOI: 10.1371/Journal.Pbio.1001041  0.622
2011 Shu X, Lev-Ram V, Olson ES, Aguilera TA, Jiang T, Whitney M, Crisp JL, Steinbach P, Deerinck T, Ellisman MH, Ellies LG, Nguyen QT, Tsien RY. Spiers Memorial Lecture. Breeding and building molecular spies. Faraday Discussions. 149: 9; discussion 63-77. PMID 21413170 DOI: 10.1039/C0Fd90021D  0.79
2011 Wu AP, Whitney MA, Crisp JL, Friedman B, Tsien RY, Nguyen QT. Improved facial nerve identification with novel fluorescently labeled probe. The Laryngoscope. 121: 805-10. PMID 21328585 DOI: 10.1002/Lary.21411  0.7
2011 Whitney MA, Crisp JL, Nguyen LT, Friedman B, Gross LA, Steinbach P, Tsien RY, Nguyen QT. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nature Biotechnology. 29: 352-6. PMID 21297616 DOI: 10.1038/Nbt.1764  0.714
2011 Olson ES, Tsien RY, Savariar EN, Crisp JL, Jiang T, Aguilera TA, Whitney MA, Steinbach P, Ellies LG, Nguyen QT. Abstract IA1: Building molecules to guide anticancer therapy Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Ia1  0.801
2011 Metildi CA, Nguyen QT, Kaushal S, Cao HST, Snyder CS, Hoffman RM, Tsien RY, Bouvet M. Abstract 5279: Imaging of pancreatic cancer with activated cell penetrating peptide dendrimers Cancer Research. 71: 5279-5279. DOI: 10.1158/1538-7445.Am2011-5279  0.358
2011 Ellisman M, Shu X, Lev-Ram V, Deerinck T, Tsien R, Lamont S, Martinez J, Berlanga M, Bushong E, Martone M, Larson S. Bridging Gaps in Imaging by Applying EM Tomography and Serial Block Face SEM, Including a New Genetically Encoded Tag for Correlated Light and 3D Electron Microscopy of Intact Cells, Tissues and Organisms: Integrating the Resulting Correlated Image Data Using the Whole Brain Catalog Microscopy and Microanalysis. 17: 2-3. DOI: 10.1017/S1431927611000882  0.547
2011 Shen J, Whitney MA, Crisp J, Jiang T, Steinbach P, Levins R, Tsien RY, Nguyen QT. Visualizing transgenic murine papillary thyroid cancer with novel nerve peptide and protease-dependent tumor-targeting peptides Laryngoscope. 121: S293. DOI: 10.1002/lary.22249  0.7
2010 Hoffmann C, Gaietta G, Zürn A, Adams SR, Terrillon S, Ellisman MH, Tsien RY, Lohse MJ. Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nature Protocols. 5: 1666-77. PMID 20885379 DOI: 10.1038/Nprot.2010.129  0.365
2010 Ting R, Aguilera TA, Crisp JL, Hall DJ, Eckelman WC, Vera DR, Tsien RY. Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes. Bioconjugate Chemistry. 21: 1811-9. PMID 20873712 DOI: 10.1021/Bc1001328  0.776
2010 De Jaco A, Lin MZ, Dubi N, Comoletti D, Miller MT, Camp S, Ellisman M, Butko MT, Tsien RY, Taylor P. Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. The Journal of Biological Chemistry. 285: 28674-82. PMID 20615874 DOI: 10.1074/Jbc.M110.139519  0.772
2010 Tsien RY. Nobel lecture: constructing and exploiting the fluorescent protein paintbox. Integrative Biology : Quantitative Biosciences From Nano to Macro. 2: 77-93. PMID 20473386 DOI: 10.1039/b926500g  0.388
2010 Whitney M, Crisp JL, Olson ES, Aguilera TA, Gross LA, Ellies LG, Tsien RY. Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides. The Journal of Biological Chemistry. 285: 22532-41. PMID 20460372 DOI: 10.1074/Jbc.M110.138297  0.784
2010 Ouyang M, Huang H, Shaner NC, Remacle AG, Shiryaev SA, Strongin AY, Tsien RY, Wang Y. Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. Cancer Research. 70: 2204-12. PMID 20197470 DOI: 10.1158/0008-5472.Can-09-3698  0.687
2010 Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proceedings of the National Academy of Sciences of the United States of America. 107: 4317-22. PMID 20160097 DOI: 10.1073/Pnas.0910261107  0.679
2010 Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proceedings of the National Academy of Sciences of the United States of America. 107: 4311-6. PMID 20160077 DOI: 10.1073/Pnas.0910283107  0.697
2010 Lin MZ, Tsien RY. TimeSTAMP tagging of newly synthesized proteins. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 26.5. PMID 20155731 DOI: 10.1002/0471140864.ps2605s59  0.564
2010 Tsien RY. The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008. Journal of Visualized Experiments : Jove. PMID 20072108 DOI: 10.3791/1575  0.429
2010 Groth RD, Yang NJ, Lin MZ, Tsien RY, Tsien RW. Activity-dependent synthesis of αCaMKII in hippocampal neurons studied with Time-STAMP F1000research. 1. DOI: 10.7490/F1000Research.58.1  0.617
2010 Deerinck T, Bushong E, Lev-Ram V, Shu X, Tsien R, Ellisman M. Enhancing Serial Block-Face Scanning Electron Microscopy to Enable High Resolution 3-D Nanohistology of Cells and Tissues Microscopy and Microanalysis. 16: 1138-1139. DOI: 10.1017/S1431927610055170  0.527
2010 Shu X, Lev-Ram V, Gaietta GM, Deerinck TJ, Ramko EB, Davidson MW, Ellisman MH, Tsien R. Genetically Encoded Singlet Oxygen Generator (SOG) Requiring No Exogenous Cofactors Biophysical Journal. 98: 612a. DOI: 10.1016/J.Bpj.2009.12.3338  0.598
2010 Lin MZ, McKeown MR, Leung Ng H, Alber T, Tsien R. Functional and Structural Characterization of A New Monomeric Far-Red Fluorescent Protein Biophysical Journal. 98: 215a. DOI: 10.1016/J.Bpj.2009.12.1158  0.616
2009 Tsien RY. Indicators based on fluorescence resonance energy transfer (FRET). Cold Spring Harbor Protocols. 2009: pdb.top57. PMID 20147227 DOI: 10.1101/pdb.top57  0.433
2009 Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 382-93. PMID 20023745 DOI: 10.1039/B904890A  0.665
2009 Aguilera TA, Olson ES, Timmers MM, Jiang T, Tsien RY. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 371-81. PMID 20023744 DOI: 10.1039/B904878B  0.671
2009 Lin MZ, McKeown MR, Ng HL, Aguilera TA, Shaner NC, Campbell RE, Adams SR, Gross LA, Ma W, Alber T, Tsien RY. Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chemistry & Biology. 16: 1169-79. PMID 19942140 DOI: 10.1016/J.Chembiol.2009.10.009  0.812
2009 Tsien RY. Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture). Angewandte Chemie (International Ed. in English). 48: 5612-26. PMID 19565590 DOI: 10.1002/anie.200901916  0.388
2009 Shu X, Royant A, Lin MZ, Aguilera TA, Lev-Ram V, Steinbach PA, Tsien RY. Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome. Science (New York, N.Y.). 324: 804-7. PMID 19423828 DOI: 10.1126/Science.1168683  0.804
2009 Lin JY, Lin MZ, Steinbach P, Tsien RY. Characterization of engineered channelrhodopsin variants with improved properties and kinetics. Biophysical Journal. 96: 1803-14. PMID 19254539 DOI: 10.1016/J.Bpj.2008.11.034  0.618
2009 Shaner NC, Lin MZ, Mckeown MR, Steinbach PA, Hazelwood KL, Davidson MW, Tsien RY. Evaluating and improving the photostability of fluorescent proteins Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7191. DOI: 10.1117/12.814684  0.755
2009 Shimomura O, Chalfie M, Tsien R. Cover Picture: Discovery of Green Fluorescent Protein (GFP) (Nobel Lecture) / GFP: Lighting Up Life (Nobel Lecture) / Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture) (Angew. Chem. Int. Ed. 31/2009) Angewandte Chemie International Edition. 48: 5555-5555. DOI: 10.1002/Anie.200990159  0.389
2008 Vorasubin N, Nguyen QT, Olson E, Aguilera TA, Jiang T, Tsien RY. Cell Penetrating Peptide Uptake by Human Tissue. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 139: P35. PMID 29400176 DOI: 10.1016/J.Otohns.2008.05.116  0.652
2008 Wallace DJ, Meyer zum Alten Borgloh S, Astori S, Yang Y, Bausen M, Kügler S, Palmer AE, Tsien RY, Sprengel R, Kerr JN, Denk W, Hasan MT. Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor. Nature Methods. 5: 797-804. PMID 19160514 DOI: 10.1038/Nmeth.1242  0.65
2008 Adams SR, Tsien RY. Preparation of the membrane-permeant biarsenicals FlAsH-EDT2 and ReAsH-EDT2 for fluorescent labeling of tetracysteine-tagged proteins. Nature Protocols. 3: 1527-34. PMID 18772880 DOI: 10.1038/nprot.2008.144  0.321
2008 Lin MZ, Glenn JS, Tsien RY. A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals. Proceedings of the National Academy of Sciences of the United States of America. 105: 7744-9. PMID 18511556 DOI: 10.1073/Pnas.0803060105  0.562
2008 Shaner NC, Lin MZ, McKeown MR, Steinbach PA, Hazelwood KL, Davidson MW, Tsien RY. Improving the photostability of bright monomeric orange and red fluorescent proteins. Nature Methods. 5: 545-51. PMID 18454154 DOI: 10.1038/Nmeth.1209  0.777
2008 Hires SA, Zhu Y, Tsien RY. Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters. Proceedings of the National Academy of Sciences of the United States of America. 105: 4411-6. PMID 18332427 DOI: 10.1073/Pnas.0712008105  0.714
2008 Nguyen QT, Olson E, Aguilera TA, Vorasubin N, Jiang T, Tsien RY. R419 – Surgery with Molecular Fluorescence Imaging Guidance Otolaryngology–Head and Neck Surgery. 139: P183-P184. DOI: 10.1016/J.Otohns.2008.05.573  0.673
2007 Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chemistry & Biology. 14: 1031-42. PMID 17884635 DOI: 10.1016/J.Chembiol.2007.07.017  0.585
2007 Tour O, Adams SR, Kerr RA, Meijer RM, Sejnowski TJ, Tsien RW, Tsien RY. Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator. Nature Chemical Biology. 3: 423-31. PMID 17572670 DOI: 10.1038/Nchembio.2007.4  0.786
2007 Ai HW, Shaner NC, Cheng Z, Tsien RY, Campbell RE. Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins. Biochemistry. 46: 5904-10. PMID 17444659 DOI: 10.1021/Bi700199G  0.818
2007 Hauser CT, Tsien RY. A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure. Proceedings of the National Academy of Sciences of the United States of America. 104: 3693-7. PMID 17360414 DOI: 10.1073/pnas.0611713104  0.428
2007 Kunkel MT, Toker A, Tsien RY, Newton AC. Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. The Journal of Biological Chemistry. 282: 6733-42. PMID 17189263 DOI: 10.1074/Jbc.M608086200  0.368
2006 Wang L, Tsien RY. Evolving proteins in mammalian cells using somatic hypermutation. Nature Protocols. 1: 1346-50. PMID 17406421 DOI: 10.1038/Nprot.2006.243  0.363
2006 Palmer AE, Tsien RY. Measuring calcium signaling using genetically targetable fluorescent indicators. Nature Protocols. 1: 1057-65. PMID 17406387 DOI: 10.1038/Nprot.2006.172  0.65
2006 Dunn TA, Wang CT, Colicos MA, Zaccolo M, DiPilato LM, Zhang J, Tsien RY, Feller MB. Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12807-15. PMID 17151284 DOI: 10.1523/Jneurosci.3238-06.2006  0.782
2006 Gaietta GM, Giepmans BN, Deerinck TJ, Smith WB, Ngan L, Llopis J, Adams SR, Tsien RY, Ellisman MH. Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy. Proceedings of the National Academy of Sciences of the United States of America. 103: 17777-82. PMID 17101980 DOI: 10.1073/pnas.0608509103  0.67
2006 Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12923-8. PMID 16905651 DOI: 10.1073/Pnas.0600137103  0.369
2006 Shu X, Shaner NC, Yarbrough CA, Tsien RY, Remington SJ. Novel chromophores and buried charges control color in mFruits. Biochemistry. 45: 9639-47. PMID 16893165 DOI: 10.1021/Bi060773L  0.791
2006 Palmer AE, Giacomello M, Kortemme T, Hires SA, Lev-Ram V, Baker D, Tsien RY. Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chemistry & Biology. 13: 521-30. PMID 16720273 DOI: 10.1016/J.Chembiol.2006.03.007  0.79
2006 Giepmans BN, Adams SR, Ellisman MH, Tsien RY. The fluorescent toolbox for assessing protein location and function. Science (New York, N.Y.). 312: 217-24. PMID 16614209 DOI: 10.1126/science.1124618  0.428
2006 Babendure JR, Babendure JL, Ding JH, Tsien RY. Control of mammalian translation by mRNA structure near caps. Rna (New York, N.Y.). 12: 851-61. PMID 16540693 DOI: 10.1261/Rna.2309906  0.771
2006 Zacharias DA, Tsien RY. Molecular biology and mutation of green fluorescent protein. Methods of Biochemical Analysis. 47: 83-120. PMID 16335711 DOI: 10.1002/0471739499.ch5  0.353
2006 Tsien RY, Ernst L, Waggoner A. Fluorophores for confocal microscopy: Photophysics and photochemistry Handbook of Biological Confocal Microscopy: Third Edition. 338-352. DOI: 10.1007/978-0-387-45524-2_16  0.57
2005 Shaner NC, Steinbach PA, Tsien RY. A guide to choosing fluorescent proteins. Nature Methods. 2: 905-9. PMID 16299475 DOI: 10.1038/Nmeth819  0.71
2005 Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 437: 569-73. PMID 16177793 DOI: 10.1038/Nature04140  0.35
2005 Martin BR, Giepmans BN, Adams SR, Tsien RY. Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nature Biotechnology. 23: 1308-14. PMID 16155565 DOI: 10.1038/Nbt1136  0.621
2005 Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, Tsien RY, Chien S. Visualizing the mechanical activation of Src. Nature. 434: 1040-5. PMID 15846350 DOI: 10.1038/Nature03469  0.316
2005 Hoffmann C, Gaietta G, Bünemann M, Adams SR, Oberdorff-Maass S, Behr B, Vilardaga JP, Tsien RY, Ellisman MH, Lohse MJ. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nature Methods. 2: 171-6. PMID 15782185 DOI: 10.1038/Nmeth742  0.349
2005 Tsien RY. Building and breeding molecules to spy on cells and tumors. Febs Letters. 579: 927-32. PMID 15680976 DOI: 10.1016/j.febslet.2004.11.025  0.378
2005 Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. The Journal of Biological Chemistry. 280: 5581-7. PMID 15583002 DOI: 10.1074/Jbc.M411534200  0.404
2004 Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proceedings of the National Academy of Sciences of the United States of America. 101: 17867-72. PMID 15601762 DOI: 10.1073/Pnas.0408191101  0.372
2004 Palmer AE, Jin C, Reed JC, Tsien RY. Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor. Proceedings of the National Academy of Sciences of the United States of America. 101: 17404-9. PMID 15585581 DOI: 10.1073/Pnas.0408030101  0.619
2004 Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nature Biotechnology. 22: 1567-72. PMID 15558047 DOI: 10.1038/Nbt1037  0.817
2004 Wang L, Jackson WC, Steinbach PA, Tsien RY. Evolution of new nonantibody proteins via iterative somatic hypermutation. Proceedings of the National Academy of Sciences of the United States of America. 101: 16745-9. PMID 15556995 DOI: 10.1073/Pnas.0407752101  0.425
2004 Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, ... Tsien RY, et al. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Molecular Cell. 15: 355-66. PMID 15304216 DOI: 10.1016/J.Molcel.2004.06.038  0.765
2004 Furuta T, Takeuchi H, Isozaki M, Takahashi Y, Kanehara M, Sugimoto M, Watanabe T, Noguchi K, Dore TM, Kurahashi T, Iwamura M, Tsien RY. Bhc-cNMPs as either water-soluble or membrane-permeant photoreleasable cyclic nucleotides for both one- and two-photon excitation. Chembiochem : a European Journal of Chemical Biology. 5: 1119-28. PMID 15300837 DOI: 10.1002/Cbic.200300814  0.302
2004 Hasan MT, Friedrich RW, Euler T, Larkum ME, Giese G, Both M, Duebel J, Waters J, Bujard H, Griesbeck O, Tsien RY, Nagai T, Miyawaki A, Denk W. Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control. Plos Biology. 2: e163. PMID 15208716 DOI: 10.1371/Journal.Pbio.0020163  0.39
2004 Dooley CT, Dore TM, Hanson GT, Jackson WC, Remington SJ, Tsien RY. Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. The Journal of Biological Chemistry. 279: 22284-93. PMID 14985369 DOI: 10.1074/Jbc.M312847200  0.781
2004 Ray P, De A, Min JJ, Tsien RY, Gambhir SS. Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Research. 64: 1323-30. PMID 14973078 DOI: 10.1158/0008-5472.Can-03-1816  0.357
2004 Hanson GT, Aggeler R, Oglesbee D, Cannon M, Capaldi RA, Tsien RY, Remington SJ. Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. The Journal of Biological Chemistry. 279: 13044-53. PMID 14722062 DOI: 10.1074/Jbc.M312846200  0.638
2004 Remington SJ, Hanson GT, Canon M, Aggeler R, Oglesbe D, Capaldi RA, Tsien RY. Third generation GFP biosensors for real time readout of pH and redox potential in living cells Proceedings of Spie - the International Society For Optical Engineering. 5329: 1-12. DOI: 10.1117/12.530285  0.65
2003 Gao W, Xing B, Tsien RY, Rao J. Novel fluorogenic substrates for imaging beta-lactamase gene expression. Journal of the American Chemical Society. 125: 11146-7. PMID 16220906 DOI: 10.1021/Ja036126O  0.757
2003 Sosinsky GE, Gaietta GM, Hand G, Deerinck TJ, Han A, Mackey M, Adams SR, Bouwer J, Tsien RY, Ellisman MH. Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics. Cell Communication & Adhesion. 10: 181-6. PMID 14681013 DOI: 10.1080/Cac.10.4-6.181.186  0.367
2003 Hasegawa S, Jackson WC, Tsien RY, Rao J. Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 14892-6. PMID 14645710 DOI: 10.1073/Pnas.2036553100  0.686
2003 Babendure JR, Adams SR, Tsien RY. Aptamers switch on fluorescence of triphenylmethane dyes. Journal of the American Chemical Society. 125: 14716-7. PMID 14640641 DOI: 10.1021/Ja037994O  0.79
2003 Tour O, Meijer RM, Zacharias DA, Adams SR, Tsien RY. Genetically targeted chromophore-assisted light inactivation. Nature Biotechnology. 21: 1505-8. PMID 14625562 DOI: 10.1038/Nbt914  0.793
2003 Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of Cell Biology. 161: 899-909. PMID 12782683 DOI: 10.1083/Jcb.200302125  0.42
2003 Yu D, Baird GS, Tsien RY, Davis RL. Detection of calcium transients in Drosophila mushroom body neurons with camgaroo reporters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 64-72. PMID 12514202 DOI: 10.1523/Jneurosci.23-01-00064.2003  0.647
2003 Zhang J, Campbell RE, Ting AY, Tsien RY. Erratum: Creating New Fluorescent Probes For Cell Biology Nature Reviews Molecular Cell Biology. 4: 80-80. DOI: 10.1038/Nrm1031  0.715
2002 Zhang J, Campbell RE, Ting AY, Tsien RY. Creating new fluorescent probes for cell biology. Nature Reviews. Molecular Cell Biology. 3: 906-18. PMID 12461557 DOI: 10.1038/Nrm976  0.736
2002 Campbell RE, Tour O, Palmer AE, Steinbach PA, Baird GS, Zacharias DA, Tsien RY. A monomeric red fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 99: 7877-82. PMID 12060735 DOI: 10.1073/Pnas.082243699  0.8
2002 Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY. New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications. Journal of the American Chemical Society. 124: 6063-76. PMID 12022841 DOI: 10.1021/Ja017687N  0.782
2002 Gaietta G, Deerinck TJ, Adams SR, Bouwer J, Tour O, Laird DW, Sosinsky GE, Tsien RY, Ellisman MH. Multicolor and electron microscopic imaging of connexin trafficking. Science (New York, N.Y.). 296: 503-7. PMID 11964472 DOI: 10.1126/Science.1068793  0.354
2001 Ting AY, Kain KH, Klemke RL, Tsien RY. Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 15003-8. PMID 11752449 DOI: 10.1073/Pnas.211564598  0.618
2001 Zhang J, Ma Y, Taylor SS, Tsien RY. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America. 98: 14997-5002. PMID 11752448 DOI: 10.1073/Pnas.211566798  0.447
2001 Chan FK, Siegel RM, Zacharias D, Swofford R, Holmes KL, Tsien RY, Lenardo MJ. Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein. Cytometry. 44: 361-8. PMID 11500853 DOI: 10.1002/1097-0320(20010801)44:4<361::AID-CYTO1128>3.0.CO;2-3  0.38
2001 Burdette SC, Walkup GK, Spingler B, Tsien RY, Lippard SJ. Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution. Journal of the American Chemical Society. 123: 7831-41. PMID 11493056 DOI: 10.1021/Ja010059L  0.319
2001 Ando H, Furuta T, Tsien RY, Okamoto H. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nature Genetics. 28: 317-25. PMID 11479592 DOI: 10.1038/ng583  0.32
2001 Griesbeck O, Baird GS, Campbell RE, Zacharias DA, Tsien RY. Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications. The Journal of Biological Chemistry. 276: 29188-94. PMID 11387331 DOI: 10.1074/Jbc.M102815200  0.743
2001 Honda A, Adams SR, Sawyer CL, Lev-Ram V, Tsien RY, Dostmann WR. Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proceedings of the National Academy of Sciences of the United States of America. 98: 2437-42. PMID 11226257 DOI: 10.1073/pnas.051631298  0.418
2000 Siegel RM, Chan FK, Zacharias DA, Swofford R, Holmes KL, Tsien RY, Lenardo MJ. Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Science's Stke : Signal Transduction Knowledge Environment. 2000: pl1. PMID 11752595 DOI: 10.1126/stke.2000.38.pl1  0.389
2000 Heikal AA, Hess ST, Baird GS, Tsien RY, Webb WW. Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine). Proceedings of the National Academy of Sciences of the United States of America. 97: 11996-2001. PMID 11050231 DOI: 10.1073/Pnas.97.22.11996  0.676
2000 Gross LA, Baird GS, Hoffman RC, Baldridge KK, Tsien RY. The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proceedings of the National Academy of Sciences of the United States of America. 97: 11990-5. PMID 11050230 DOI: 10.1073/Pnas.97.22.11990  0.655
2000 Baird GS, Zacharias DA, Tsien RY. Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proceedings of the National Academy of Sciences of the United States of America. 97: 11984-9. PMID 11050229 DOI: 10.1073/Pnas.97.22.11984  0.686
2000 Griffin BA, Adams SR, Jones J, Tsien RY. Fluorescent labeling of recombinant proteins in living cells with FlAsH. Methods in Enzymology. 327: 565-78. PMID 11045009 DOI: 10.1016/S0076-6879(00)27302-3  0.41
2000 Wu MM, Llopis J, Adams SR, McCaffery JM, Teter K, Kulomaa MS, Machen TE, Moore HP, Tsien RY. Studying organelle physiology with fusion protein-targeted avidin and fluorescent biotin conjugates. Methods in Enzymology. 327: 546-64. PMID 11045008 DOI: 10.1016/S0076-6879(00)27301-1  0.333
2000 Miyawaki A, Tsien RY. Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods in Enzymology. 327: 472-500. PMID 11045004 DOI: 10.1016/S0076-6879(00)27297-2  0.42
2000 Allen GJ, Chu SP, Schumacher K, Shimazaki CT, Vafeados D, Kemper A, Hawke SD, Tallman G, Tsien RY, Harper JF, Chory J, Schroeder JI. Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant. Science (New York, N.Y.). 289: 2338-42. PMID 11009417 DOI: 10.1126/Science.289.5488.2338  0.492
2000 Kerr R, Lev-Ram V, Baird G, Vincent P, Tsien RY, Schafer WR. Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron. 26: 583-94. PMID 10896155 DOI: 10.1016/S0896-6273(00)81196-4  0.698
2000 Zacharias DA, Baird GS, Tsien RY. Recent advances in technology for measuring and manipulating cell signals. Current Opinion in Neurobiology. 10: 416-21. PMID 10851181 DOI: 10.1016/S0959-4388(00)00101-X  0.632
2000 Thomas D, Lipp P, Tovey SC, Berridge MJ, Li W, Tsien RY, Bootman MD. Microscopic properties of elementary Ca2+ release sites in non-excitable cells. Current Biology : Cb. 10: 8-15. PMID 10660296 DOI: 10.1016/S0960-9822(99)00258-4  0.31
2000 Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T. A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nature Cell Biology. 2: 25-9. PMID 10620803 DOI: 10.1038/71345  0.598
2000 Walkup GK, Burdette SC, Lippard SJ, Tsien RY. A new cell-permeable fluorescent probe for Zn2+ [5] Journal of the American Chemical Society. 122: 5644-5645. DOI: 10.1021/Ja000868P  0.381
1999 Allen GJ, Kwak JM, Chu SP, Llopis J, Tsien RY, Harper JF, Schroeder JI. Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells. The Plant Journal : For Cell and Molecular Biology. 19: 735-47. PMID 10571859 DOI: 10.1046/J.1365-313X.1999.00574.X  0.37
1999 Tsien RY. Rosy dawn for fluorescent proteins. Nature Biotechnology. 17: 956-7. PMID 10504692 DOI: 10.1038/13648  0.394
1999 Baird GS, Zacharias DA, Tsien RY. Circular permutation and receptor insertion within green fluorescent proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 11241-6. PMID 10500161 DOI: 10.1073/Pnas.96.20.11241  0.69
1999 Yao Y, Ferrer-Montiel AV, Montal M, Tsien RY. Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger. Cell. 98: 475-85. PMID 10481912 DOI: 10.1016/S0092-8674(00)81976-5  0.322
1999 Cacciatore TW, Brodfuehrer PD, Gonzalez JE, Jiang T, Adams SR, Tsien RY, Kristan WB, Kleinfeld D. Identification of neural circuits by imaging coherent electrical activity with FRET-based dyes. Neuron. 23: 449-59. PMID 10433258 DOI: 10.1016/S0896-6273(00)80799-0  0.302
1999 Fan GY, Fujisaki H, Miyawaki A, Tsay RK, Tsien RY, Ellisman MH. Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons. Biophysical Journal. 76: 2412-20. PMID 10233058 DOI: 10.1016/S0006-3495(99)77396-0  0.318
1999 Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG. Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. The Journal of Cell Biology. 145: 279-89. PMID 10209024 DOI: 10.1083/jcb.145.2.279  0.344
1999 Miyawaki A, Griesbeck O, Heim R, Tsien RY. Dynamic and quantitative Ca2+ measurements using improved cameleons. Proceedings of the National Academy of Sciences of the United States of America. 96: 2135-40. PMID 10051607 DOI: 10.1073/pnas.96.5.2135  0.398
1999 Furuta T, Wang SS, Dantzker JL, Dore TM, Bybee WJ, Callaway EM, Denk W, Tsien RY. Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis. Proceedings of the National Academy of Sciences of the United States of America. 96: 1193-200. PMID 9990000 DOI: 10.1073/pnas.96.4.1193  0.593
1999 Brown EB, Shear JB, Adams SR, Tsien RY, Webb WW. Photolysis of caged calcium in femtoliter volumes using two-photon excitation. Biophysical Journal. 76: 489-99. PMID 9876162 DOI: 10.1016/S0006-3495(99)77217-6  0.301
1999 Tsien RY, Miyawaki A, Kerr R, Baird G, Griffin BA, Adams SR, Zlokarnik G, Whitney M, Negulescu PA, Li W-. Imaging Protein Interactions and Gene Expression in Individual Cells by Fluorescence Resonance Energy Transfer Microscopy and Microanalysis. 5: 1036-1037. DOI: 10.1017/S143192760001850X  0.352
1998 Tsien RY. The green fluorescent protein. Annual Review of Biochemistry. 67: 509-44. PMID 9759496 DOI: 10.1146/annurev.biochem.67.1.509  0.398
1998 Tsien RY, Miyawaki A. Seeing the machinery of live cells. Science (New York, N.Y.). 280: 1954-5. PMID 9669950 DOI: 10.1126/science.280.5371.1954  0.331
1998 Griffin BA, Adams SR, Tsien RY. Specific covalent labeling of recombinant protein molecules inside live cells. Science (New York, N.Y.). 281: 269-72. PMID 9657724 DOI: 10.1126/science.281.5374.269  0.417
1998 Llopis J, McCaffery JM, Miyawaki A, Farquhar MG, Tsien RY. Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proceedings of the National Academy of Sciences of the United States of America. 95: 6803-8. PMID 9618493 DOI: 10.1073/pnas.95.12.6803  0.345
1998 Li W, Llopis J, Whitney M, Zlokarnik G, Tsien RY. Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature. 392: 936-41. PMID 9582076 DOI: 10.1038/31965  0.306
1998 Zlokarnik G, Negulescu PA, Knapp TE, Mere L, Burres N, Feng L, Whitney M, Roemer K, Tsien RY. Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter. Science (New York, N.Y.). 279: 84-8. PMID 9417030 DOI: 10.1126/science.279.5347.84  0.316
1998 Miyawaki A, Llopis J, Heim R, McCafFery JM, Adams JA, Ikura M, Fujisaki H, Fan GY, Ellisman MH, Tsien RY. Fluorescent Indicators for Calcium Based on Green Fluorescent Proteins (GFPs) and Calmodulin Microscopy and Microanalysis. 4: 446-447. DOI: 10.1017/S1431927600022352  0.4
1998 Fan GY, Fujisaki H, Tsay R-, Tsien RY, Ellisman MH. Video-Rate Scanning Two-Photon Excitation Fluorescence Microscopy Microscopy and Microanalysis. 4: 424-425. DOI: 10.1017/S1431927600022248  0.33
1997 Adams SR, Lev-Ram V, Tsien RY. A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators. Chemistry & Biology. 4: 867-78. PMID 9384535 DOI: 10.1016/S1074-5521(97)90119-8  0.355
1997 Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M, Tsien RY. Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature. 388: 882-7. PMID 9278050 DOI: 10.1038/42264  0.419
1997 Wachter RM, King BA, Heim R, Kallio K, Tsien RY, Boxer SG, Remington SJ. Crystal structure and photodynamic behavior of the blue emission variant Y66H/Y145F of green fluorescent protein. Biochemistry. 36: 9759-65. PMID 9245407 DOI: 10.1021/Bi970563W  0.633
1997 Dickson RM, Cubitt AB, Tsien RY, Moerner WE. On/off blinking and switching behaviour of single molecules of green fluorescent protein. Nature. 388: 355-8. PMID 9237752 DOI: 10.1038/41048  0.382
1997 Yao Y, Tsien RY. Calcium current activated by depletion of calcium stores in Xenopus oocytes Journal of General Physiology. 109: 703-715. PMID 9222897 DOI: 10.1085/jgp.109.6.703  0.307
1997 Lev-Ram V, Jiang T, Wood J, Lawrence DS, Tsien RY. Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression. Neuron. 18: 1025-38. PMID 9208868 DOI: 10.1016/S0896-6273(00)80340-2  0.313
1997 González JE, Tsien RY. Improved indicators of cell membrane potential that use fluorescence resonance energy transfer. Chemistry & Biology. 4: 269-77. PMID 9195864 DOI: 10.1016/S1074-5521(97)90070-3  0.382
1997 Brejc K, Sixma TK, Kitts PA, Kain SR, Tsien RY, Ormö M, Remington SJ. Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 2306-11. PMID 9122190 DOI: 10.1073/Pnas.94.6.2306  0.614
1997 Tsien RY, Vincent P, Hempel CM, Selverston AI, Heim R, Miyawaki LA. Fluorescence imaging of camp gradients and protein localizations in living cells Faseb Journal. 11: A1297.  0.53
1996 Scheenen WJ, Makings LR, Gross LR, Pozzan T, Tsien RY. Photodegradation of indo-1 and its effect on apparent Ca2+ concentrations. Chemistry & Biology. 3: 765-74. PMID 8939693 DOI: 10.1016/S1074-5521(96)90253-7  0.577
1996 Hempel CM, Vincent P, Adams SR, Tsien RY, Selverston AI. Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuitm. Nature. 384: 166-9. PMID 8906791 DOI: 10.1038/384166a0  0.485
1996 Ormö M, Cubitt AB, Kallio K, Gross LA, Tsien RY, Remington SJ. Crystal structure of the Aequorea victoria green fluorescent protein. Science (New York, N.Y.). 273: 1392-5. PMID 8703075 DOI: 10.1126/Science.273.5280.1392  0.64
1996 Rizzuto R, Brini M, De Giorgi F, Rossi R, Heim R, Tsien RY, Pozzan T. Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Current Biology : Cb. 6: 183-8. PMID 8673465 DOI: 10.1016/S0960-9822(02)00451-7  0.576
1996 Heim R, Tsien RY. Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer Current Biology. 6: 178-182. PMID 8673464 DOI: 10.1016/S0960-9822(02)00450-5  0.4
1995 Cubitt AB, Heim R, Adams SR, Boyd AE, Gross LA, Tsien RY. Understanding, improving and using green fluorescent proteins Trends in Biochemical Sciences. 20: 448-455. PMID 8578587 DOI: 10.1016/S0968-0004(00)89099-4  0.425
1995 González JE, Tsien RY. Voltage sensing by fluorescence resonance energy transfer in single cells. Biophysical Journal. 69: 1272-80. PMID 8534797 DOI: 10.1016/S0006-3495(95)80029-9  0.387
1995 Heim R, Cubitt AB, Tsien RY. Improved green fluorescence [4] Nature. 373: 663-664. PMID 7854443 DOI: 10.1038/373663B0  0.371
1995 Bacskai BJ, Wallén P, Lev-Ram V, Grillner S, Tsien RY. Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron. 14: 19-28. PMID 7826636 DOI: 10.1016/0896-6273(95)90237-6  0.529
1995 Randriamampita C, Tsien RY. Degradation of a calcium influx factor (CIF) can be blocked by phosphatase inhibitors or chelation of Ca2+ Journal of Biological Chemistry. 270: 29-32. PMID 7814389 DOI: 10.1074/jbc.270.1.29  0.325
1995 Lev-Ram V, Makings LR, Keitz PF, Kao JP, Tsien RY. Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients. Neuron. 15: 407-15. PMID 7646893 DOI: 10.1016/0896-6273(95)90044-6  0.3
1994 Ranganathan R, Bacskai BJ, Tsien RY, Zuker CS. Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function. Neuron. 13: 837-48. PMID 7946332 DOI: 10.1016/0896-6273(94)90250-X  0.573
1994 Vajanaphanich M, Schultz C, Rudolf MT, Wasserman M, Enyedi P, Craxton A, Shears SB, Tsien RY, Barrett KE, Traynor-Kaplan A. Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4. Nature. 371: 711-4. PMID 7935818 DOI: 10.1038/371711A0  0.304
1994 Civitelli R, Bacskai BJ, Mahaut-Smith MP, Adams SR, Avioli LV, Tsien RY. Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 9: 1407-17. PMID 7817824 DOI: 10.1002/Jbmr.5650090912  0.603
1994 Heim R, Prasher DC, Tsien RY. Wavelength mutations and posttranslational autoxidation of green fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 91: 12501-4. PMID 7809066 DOI: 10.1073/Pnas.91.26.12501  0.415
1994 Deerinck TJ, Martone ME, Lev-Ram V, Green DP, Tsien RY, Spector DL, Huang S, Ellisman MH. Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. The Journal of Cell Biology. 126: 901-10. PMID 7519623 DOI: 10.1083/Jcb.126.4.901  0.363
1993 Tsien RY, Bacskai BJ, Adams SR. FRET for studying intracellular signalling. Trends in Cell Biology. 3: 242-5. PMID 14731760 DOI: 10.1016/0962-8924(93)90124-J  0.516
1993 Randriamampita C, Tsien RY. Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx Nature. 364: 809-814. PMID 8355806 DOI: 10.1038/364809A0  0.324
1993 Adams SR, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY. Confocal imaging of cAMP signals in Aplysia neurons. The Japanese Journal of Physiology. 43: S91-3. PMID 8271521  0.468
1993 Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (New York, N.Y.). 260: 222-6. PMID 7682336 DOI: 10.1126/Science.7682336  0.556
1992 Sammak PJ, Adams SR, Harootunian AT, Schliwa M, Tsien RY. Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging. The Journal of Cell Biology. 117: 57-72. PMID 1348251 DOI: 10.1083/Jcb.117.1.57  0.366
1991 Harootunian AT, Kao JPY, Paranjape S, Tsien RY. Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3 Science. 251: 75-78. PMID 1986413 DOI: 10.1126/Science.1986413  0.323
1991 Adams SR, Harootunian AT, Buechler YJ, Taylor SS, Tsien RY. Fluorescence ratio imaging of cyclic AMP in single cells Nature. 349: 694-697. PMID 1847505 DOI: 10.1038/349694A0  0.418
1991 Harootunian AT, Kao JPY, Paranjape S, Adams SR, Potter BVL, Tsien RY. Cytosolic Ca2+ oscillations in REF52 fibroblasts: Ca2+-stimulated IP3 production or voltage-dependent Ca2+ channels as key positive feedback elements Cell Calcium. 12: 153-164. PMID 1647875 DOI: 10.1016/0143-4160(91)90017-9  0.315
1990 Tsien RW, Tsien RY. Calcium channels, stores, and oscillations. Annual Review of Cell Biology. 6: 715-60. PMID 2177344 DOI: 10.1146/annurev.cb.06.110190.003435  0.476
1990 Kao JP, Alderton JM, Tsien RY, Steinhardt RA. Active involvement of Ca2+ in mitotic progression of Swiss 3T3 fibroblasts. The Journal of Cell Biology. 111: 183-96. PMID 2114410 DOI: 10.1083/Jcb.111.1.183  0.318
1990 Harootunian AT, Kao JPY, Adams SR, Tsien RY. Imaging and manipulation of cytosolic ions and messengers during cell activation Journal of Cell Science. 97: 1-4. PMID 2084112 DOI: 10.1242/Jcs.1990.Supplement_13.1  0.324
1989 Tsien RY. Fluorescence ratio imaging of dynamic intracellular signals Acta Physiologica Scandinavica, Supplement. 582: 6. PMID 2816449 DOI: 10.1117/12.962706  0.419
1989 Havran WL, Poenie M, Tigelaar RE, Tsien RY, Allison JP. Phenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones. Journal of Immunology (Baltimore, Md. : 1950). 142: 1422-8. PMID 2783942  0.65
1989 Tsien R, Pozzan T. Measurement of cytosolic free Ca2+ with quin2. Methods in Enzymology. 172: 230-62. PMID 2747529 DOI: 10.1016/S0076-6879(89)72017-6  0.56
1989 Tsien RY. Fluorescent probes of cell signaling Annual Review of Neuroscience. 12: 227-253. PMID 2648950 DOI: 10.1146/Annurev.Ne.12.030189.001303  0.4
1988 Langlet C, Guimezanes A, Kaldy P, Boyer C, Buferne M, Poenie M, Tsien R, Leo O, Bluestone J, Leserman L. Role of Ti/CD3, Thy-1, and Ly-6 in cytolytic T-cell activation analyzed with Ti loss variants. Annals of the New York Academy of Sciences. 532: 33-43. PMID 2902820 DOI: 10.1111/J.1749-6632.1988.Tb36323.X  0.649
1988 Ambler SK, Poenie M, Tsien RY, Taylor P. Agonist-stimulated oscillations and cycling of intracellular free calcium in individual cultured muscle cells. The Journal of Biological Chemistry. 263: 1952-9. PMID 2892835  0.668
1988 Lipscombe D, Madison DV, Poenie M, Reuter H, Tsien RW, Tsien RY. Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron. 1: 355-65. PMID 2856095 DOI: 10.1016/0896-6273(88)90185-7  0.736
1988 Tsien RY. Fluorescence measurement and photochemical manipulation of cytosolic free calcium Trends in Neurosciences. 11: 419-424. PMID 2469158 DOI: 10.1016/0166-2236(88)90192-0  0.396
1988 Ratto GM, Payne R, Owen WG, Tsien RY. The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 3240-6. PMID 2459322 DOI: 10.1523/Jneurosci.08-09-03240.1988  0.607
1988 Lipscombe D, Madison DV, Poenie M, Reuter H, Tsien RY, Tsien RW. Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. 85: 2398-402. PMID 2451249 DOI: 10.1073/Pnas.85.7.2398  0.729
1988 Adams SR, Kao JPY, Grynkiewicz G, Minta A, Tsien RY. Biologically useful chelators that release Ca2+ upon illumination Journal of the American Chemical Society. 110: 3212-3220. DOI: 10.1021/Ja00218A034  0.319
1987 Poenie M, Tsien RY, Schmitt-Verhulst AM. Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets. The Embo Journal. 6: 2223-32. PMID 3499312 DOI: 10.1002/J.1460-2075.1987.Tb02494.X  0.7
1987 Chen WS, Lazar CS, Poenie M, Tsien RY, Gill GN, Rosenfeld MG. Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature. 328: 820-3. PMID 3498122 DOI: 10.1038/328820a0  0.669
1987 Chused TM, Wilson HA, Greenblatt D, Ishida Y, Edison LJ, Tsien RY, Finkelman FD. Flow cytometric analysis of murine splenic B lymphocyte cytosolic free calcium response to anti-IgM and anti-IgD. Cytometry. 8: 396-404. PMID 3497786 DOI: 10.1002/cyto.990080409  0.349
1987 Wilson HA, Greenblatt D, Poenie M, Finkelman FD, Tsien RY. Crosslinkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium. The Journal of Experimental Medicine. 166: 601-6. PMID 3496421 DOI: 10.1084/Jem.166.2.601  0.696
1987 Havran WL, Poenie M, Kimura J, Tsien R, Weiss A, Allison JP. Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Nature. 330: 170-3. PMID 2959867 DOI: 10.1038/330170A0  0.645
1987 Schmitt-Verhulst AM, Guimezanes A, Boyer C, Poenie M, Tsien R, Buferne M, Hua C, Leserman L. Pleiotropic loss of activation pathways in a T-cell receptor alpha-chain deletion variant of a cytolytic T-cell clone. Nature. 325: 628-31. PMID 2880301 DOI: 10.1038/325628a0  0.673
1987 Gurney AM, Tsien RY, Lester HA. Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. 84: 3496-500. PMID 2437582 DOI: 10.1073/Pnas.84.10.3496  0.328
1986 Poenie M, Alderton J, Steinhardt R, Tsien R. Calcium rises abruptly and briefly throughout the cell at the onset of anaphase. Science (New York, N.Y.). 233: 886-9. PMID 3755550 DOI: 10.1126/SCIENCE.3755550  0.707
1986 Drummond IA, McClure SA, Poenie M, Tsien RY, Steinhardt RA. Large changes in intracellular pH and calcium observed during heat shock are not responsible for the induction of heat shock proteins in Drosophila melanogaster. Molecular and Cellular Biology. 6: 1767-75. PMID 3097504 DOI: 10.1128/Mcb.6.5.1767  0.644
1986 Tsien RY, Poenie M. Fluorescence ratio imaging: a new window into intracellular ionic signaling Trends in Biochemical Sciences. 11: 450-455. DOI: 10.1016/0968-0004(86)90245-8  0.716
1985 Arslan P, Di Virgilio F, Beltrame M, Tsien RY, Pozzan T. Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. The Journal of Biological Chemistry. 260: 2719-27. PMID 3919006  0.502
1985 Tsien RY, Rink TJ, Poenie M. Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium. 6: 145-57. PMID 3874696 DOI: 10.1016/0143-4160(85)90041-7  0.79
1985 Poenie M, Alderton J, Tsien RY, Steinhardt RA. Changes of free calcium levels with stages of the cell division cycle. Nature. 315: 147-9. PMID 3838803 DOI: 10.1038/315147a0  0.701
1985 Grynkiewicz G, Poenie M, Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. The Journal of Biological Chemistry. 260: 3440-50. PMID 3838314  0.705
1984 Tsien RY. Measuring and manipulating cytosolic Ca2+ with trapped indicators Kroc Foundation Series. 17: 147-155. PMID 6439833 DOI: 10.1016/0968-0004(84)90160-9  0.337
1984 Tsien RY, Pozzan T, Rink TJ. Calcium activities and fluxes inside small intact cells as measured with intracellularly trapped chelators. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 17: 535-41. PMID 6328935  0.627
1984 Meldolesi J, Huttner WB, Tsien RY, Pozzan T. Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin. Proceedings of the National Academy of Sciences of the United States of America. 81: 620-4. PMID 6141561 DOI: 10.1073/Pnas.81.2.620  0.462
1984 Tsien RY, Pozzan T, Rink TJ. Measuring and manipulating cytosolic Ca2+ with trapped indicators Trends in Biochemical Sciences. 9: 263-266. DOI: 10.1016/0968-0004(84)90160-9  0.53
1983 Pozzan T, Lew DP, Wollheim CB, Tsien RY. Is cytosolic ionized calcium regulating neutrophil activation? Science (New York, N.Y.). 221: 1413-5. PMID 6310757 DOI: 10.1126/science.6310757  0.548
1983 Tsien RY, Pozzan T, Rink TJ. CALCIUM ACTIVITIES INSIDE SMALL INTACT CELLS SUCH AS LYMPHOCYTES. Electrochemical Society Extended Abstracts. 83: 1002.  0.527
1982 Rink TJ, Tsien RY. Cytoplasmic free [Ca2+] in very small intact cells. Biochemical Society Transactions. 10: 209. PMID 6982838  0.557
1982 Tsien RY, Pozzan T, Rink TJ. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. The Journal of Cell Biology. 94: 325-34. PMID 6980885 DOI: 10.1083/jcb.94.2.325  0.702
1982 Rink TJ, Smith SW, Tsien RY. Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion. Febs Letters. 148: 21-6. PMID 6816632 DOI: 10.1016/0014-5793(82)81234-9  0.588
1982 Rink TJ, Tsien RY, Pozzan T. Cytoplasmic pH and free Mg2+ in lymphocytes. The Journal of Cell Biology. 95: 189-96. PMID 6815204 DOI: 10.1083/jcb.95.1.189  0.647
1982 Pozzan T, Arslan P, Tsien RY, Rink TJ. Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes. The Journal of Cell Biology. 94: 335-40. PMID 6809769 DOI: 10.1083/jcb.94.2.335  0.679
1982 Tsien RY, Pozzan T, Rink TJ. T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature. 295: 68-71. PMID 6799829 DOI: 10.1038/295068a0  0.681
1982 Lew VL, Tsien RY, Miner C, Bookchin RM. Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator Nature. 298: 478-481. PMID 6283392 DOI: 10.1038/298478a0  0.323
1981 Tsien RY, Rink TJ. Ca2+-selective electrodes: a novel PVC-gelled neutral carrier mixture compared with other currently available sensors. Journal of Neuroscience Methods. 4: 73-86. PMID 7253701 DOI: 10.1016/0165-0270(81)90020-0  0.508
1981 Tsien RY. A non-disruptive technique for loading calcium buffers and indicators into cells Nature. 290: 527-528. PMID 7219539 DOI: 10.1038/290527a0  0.318
1981 Alvarez-Leefmans FJ, Rink TJ, Tsien RY. Free calcium ions in neurones of Helix aspersa measured with ion-selective micro-electrodes. The Journal of Physiology. 315: 531-48. PMID 6273543 DOI: 10.1113/jphysiol.1981.sp013762  0.747
1981 Pozzan T, Rink TJ, Tsien RY. Cytoplasmic pH and free Ma2+ in pig mesenteric lymphocytes Journal of Physiology. 102P.  0.481
1980 Marban E, Rink TJ, Tsien RW, Tsien RY. Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature. 286: 845-50. PMID 7412868 DOI: 10.1038/286845a0  0.65
1980 Tsien RY, Rink TJ. Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium. Biochimica Et Biophysica Acta. 599: 623-38. PMID 7407109  0.546
1980 Rink TJ, Tsien RY, Warner AE. Free calcium in Xenopus embryos measured with ion-selective microelectrodes. Nature. 283: 658-60. PMID 7354852 DOI: 10.1038/283658a0  0.606
1980 Tsien RY. New calcium indicators and buffers with high selectivity against magnesium and protons: Design, synthesis, and properties of prototype structures Biochemistry. 19: 2396-2404. PMID 6770893 DOI: 10.1021/Bi00552A018  0.33
1980 Rink TJ, Montecucco C, Hesketh TR, Tsien RY. Lymphocyte membrane potential assessed with fluorescent probes. Biochimica Et Biophysica Acta. 595: 15-30. PMID 6153065 DOI: 10.1016/0005-2736(80)90243-6  0.539
1978 Ashley CC, Rink TJ, Tsien RY. Changes in free Ca during muscle contraction, measured with an intracellular Ca-selective electrode [proceedings]. The Journal of Physiology. 280: 27P. PMID 690875  0.525
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