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Artis Klapars, Ph.D. - Publications

Affiliations: 
2000 University of Wisconsin, Madison, Madison, WI 
Area:
organic synthesis
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30/48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zultanski SL, Kuhl N, Zhong W, Cohen RD, Reibarkh M, Jurica J, Kim J, Weisel L, Ekkati AR, Klapars A, Gauthier DR, Dunn JMM. Mechanistic Understanding of a Robust and Scalable Synthesis of Per(6-deoxy-6-halo)cyclodextrins, Versatile Intermediates for Cyclodextrin Modification Organic Process Research & Development. DOI: 10.1021/Acs.Oprd.0C00249  0.301
2017 DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. A multifunctional catalyst that stereoselectively assembles prodrugs. Science (New York, N.Y.). 356: 426-430. PMID 28450641 DOI: 10.1126/Science.Aam7936  0.304
2017 Simmons B, Liu Z, Klapars A, Bellomo A, Silverman SM. Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189. Organic Letters. PMID 28418681 DOI: 10.1021/Acs.Orglett.7B00469  0.351
2016 Hyde AM, Liu Z, Kosjek B, Tan L, Klapars A, Ashley ER, Zhong YL, Alvizo O, Agard NJ, Liu G, Gu X, Yasuda N, Limanto J, Huffman MA, Tschaen DM. Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction. Organic Letters. PMID 27802043 DOI: 10.1021/Acs.Orglett.6B02910  0.361
2016 Chung JY, Shevlin M, Klapars A, Journet M. Asymmetric Synthesis of N-Boc-(R)-Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N-Alkylation. Organic Letters. PMID 27015542 DOI: 10.1021/Acs.Orglett.6B00548  0.478
2014 Limanto J, Ashley ER, Yin J, Beutner GL, Grau BT, Kassim AM, Kim MM, Klapars A, Liu Z, Strotman HR, Truppo MD. A highly efficient asymmetric synthesis of vernakalant. Organic Letters. 16: 2716-9. PMID 24786635 DOI: 10.1021/Ol501002A  0.402
2014 Mangion IK, Chen CY, Li H, Maligres P, Chen Y, Christensen M, Cohen R, Jeon I, Klapars A, Krska S, Nguyen H, Reamer RA, Sherry BD, Zavialov I. Enantioselective synthesis of an HCV NS5a antagonist. Organic Letters. 16: 2310-3. PMID 24724971 DOI: 10.1021/Ol500971C  0.311
2014 Maddess ML, Scott JP, Alorati A, Baxter C, Bremeyer N, Brewer S, Campos K, Cleator E, Dieguez-Vazquez A, Gibb A, Gibson A, Howard M, Keen S, Klapars A, Lee J, et al. Enantioselective synthesis of a highly substituted tetrahydrofluorene derivative as a potent and selective estrogen receptor beta agonist Organic Process Research and Development. 18: 528-538. DOI: 10.1021/Op5000489  0.345
2011 Barker G, McGrath JL, Klapars A, Stead D, Zhou G, Campos KR, O'Brien P. Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications. The Journal of Organic Chemistry. 76: 5936-53. PMID 21714542 DOI: 10.1021/Jo2011347  0.426
2011 Yasuda N, Klapars A, Kohmura Y, Campos KR, Ishibashi H, Pollard D, Takezawa A, Waldman JH, Wallace DJ, Chen GY, Mase T. Asymmetric synthesis of a potent hNK-1 receptor antagonist Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 69: 579-587. DOI: 10.5059/Yukigoseikyokaishi.69.579  0.364
2009 Chen YW, Liu Y, Novak T, Frey L, Campos K, Klapars A, Chen CY, Phenix B. Identification and structural elucidation of process impurities generated in the end-game synthesis of taranabant (MK-0364) via cyanuric chloride. Journal of Pharmaceutical and Biomedical Analysis. 49: 702-10. PMID 19188037 DOI: 10.1016/J.Jpba.2009.01.003  0.307
2008 Klapars A, Campos KR, Waldman JH, Zewge D, Dormer PG, Chen CY. Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator. The Journal of Organic Chemistry. 73: 4986-93. PMID 18507444 DOI: 10.1021/Jo8006804  0.431
2007 Warner DL, Hibberd AM, Kalman M, Klapars A, Vedejs E. N-silyl protecting groups for labile aziridines: application toward the synthesis of N-H aziridinomitosenes. The Journal of Organic Chemistry. 72: 8519-22. PMID 17910500 DOI: 10.1021/Jo7013615  0.67
2006 Campos KR, Klapars A, Waldman JH, Dormer PG, Chen CY. Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine. Journal of the American Chemical Society. 128: 3538-9. PMID 16536525 DOI: 10.1021/ja0605265  0.357
2005 Klapars A, Waldman JH, Campos KR, Jensen MS, McLaughlin M, Chung JY, Cvetovich RJ, Chen CY. Mild and practical method for the alpha-arylation of nitriles with heteroaryl halides. The Journal of Organic Chemistry. 70: 10186-9. PMID 16292870 DOI: 10.1021/Jo051737F  0.321
2005 Rink SM, Warner DL, Klapars A, Vedejs E. Sequence-specific DNA interstrand cross-linking by an aziridinomitosene in the absence of exogenous reductant. Biochemistry. 44: 13981-6. PMID 16229487 DOI: 10.1021/Bi050426W  0.628
2005 Klapars A, Campos KR, Chen CY, Volante RP. Preparation of enamides via palladium-catalyzed amidation of enol tosylates. Organic Letters. 7: 1185-8. PMID 15760170 DOI: 10.1021/Ol050117Y  0.301
2004 Klapars A, Vedejs E. Activation of pyridinium salts for electrophilic acylation: A method for conversion of pyridines into 3-acylpyridines Khimiya Geterotsiklicheskikh Soedinenii. 887-894. DOI: 10.1023/B:COHC.0000040772.13427.0b  0.482
2004 Klapars A, Vedejs E. Activation of pyridinium salts for electrophilic acylation: A method for conversion of pyridines into 3-acylpyridines Khimiya Geterotsiklicheskikh Soedinenii. 887-894. DOI: 10.1023/B:Cohc.0000040772.13427.0B  0.579
2003 Vedejs E, Naidu BN, Klapars A, Warner DL, Li VS, Na Y, Kohn H. Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies. Journal of the American Chemical Society. 125: 15796-806. PMID 14677970 DOI: 10.1021/Ja030452M  0.668
2003 Jiang L, Job GE, Klapars A, Buchwald SL. Copper-catalyzed coupling of amides and carbamates with vinyl halides. Organic Letters. 5: 3667-9. PMID 14507200 DOI: 10.1021/Ol035355C  0.327
2003 Zanon J, Klapars A, Buchwald SL. Copper-catalyzed domino halide exchange-cyanation of aryl bromides. Journal of the American Chemical Society. 125: 2890-1. PMID 12617652 DOI: 10.1021/Ja0299708  0.314
2002 Klapars A, Buchwald SL. Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Journal of the American Chemical Society. 124: 14844-5. PMID 12475315 DOI: 10.1021/Ja028865V  0.358
2002 Antilla JC, Klapars A, Buchwald SL. The copper-catalyzed N-arylation of indoles. Journal of the American Chemical Society. 124: 11684-8. PMID 12296734 DOI: 10.1021/Ja027433H  0.383
2002 Klapars A, Huang X, Buchwald SL. A general and efficient copper catalyst for the amidation of aryl halides. Journal of the American Chemical Society. 124: 7421-8. PMID 12071751 DOI: 10.1021/Ja0260465  0.306
2002 Kwong FY, Klapars A, Buchwald SL. Copper-catalyzed coupling of alkylamines and aryl iodides: an efficient system even in an air atmosphere. Organic Letters. 4: 581-4. PMID 11843596 DOI: 10.1021/Ol0171867  0.306
2001 Wolter M, Klapars A, Buchwald SL. Synthesis of N-aryl hydrazides by copper-catalyzed coupling of hydrazides with aryl iodides. Organic Letters. 3: 3803-5. PMID 11700143 DOI: 10.1021/Ol0168216  0.398
2001 Vedejs E, Klapars A, Warner DL, Weiss AH. Reductive deprotection of N-tritylaziridines. The Journal of Organic Chemistry. 66: 7542-6. PMID 11681978 DOI: 10.1021/jo0106243  0.64
2000 Vedejs E, Klapars A, Naidu BN, Piotrowski DW, Tucci FC. Enantiocontrolled synthesis of (1S,2S)-6-desmethyl- (methylaziridino)mitosene [8] Journal of the American Chemical Society. 122: 5401-5402. DOI: 10.1021/ja994504c  0.443
1996 Vedejs E, Lin S, Klapars A, Wang J. Heteroarene-2-sulfonyl chlorides (BtsCl; ThsCl): Reagents for nitrogen protection of >99% racemization-free phenylglycine activation with SOCl2 Journal of the American Chemical Society. 118: 9796-9797. DOI: 10.1021/Ja961485N  0.494
Low-probability matches (unlikely to be authored by this person)
2009 Wallace DJ, Campos KR, Shultz CS, Klapars A, Zewge D, Crump BR, Phenix BD, McWilliams JC, Krska S, Sun Y, Chen CY, Spindler F. New efficient asymmetric synthesis of taranabant, a CB1R inverse agonist for the treatment of obesity Organic Process Research and Development. 13: 84-90. DOI: 10.1021/Op800270E  0.296
2001 Klapars A, Antilla JC, Huang X, Buchwald SL. A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles. Journal of the American Chemical Society. 123: 7727-9. PMID 11481007 DOI: 10.1021/Ja016226Z  0.293
2019 Haidar Ahmad IA, Chen W, Halsey HM, Klapars A, Limanto J, Pirrone GF, Nowak T, Bennett R, Hartman R, Makarov AA, Mangion I, Regalado EL. Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances. The Analyst. PMID 30830135 DOI: 10.1039/C8An02499E  0.287
2019 Hyde AM, Calabria R, Arvary R, Wang X, Klapars A. Investigating the Underappreciated Hydrolytic Instability of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Related Unsaturated Nitrogenous Bases Organic Process Research & Development. 23: 1860-1871. DOI: 10.1021/Acs.Oprd.9B00187  0.282
2018 Pirrone GF, Mathew RM, Makarov AA, Bernardoni F, Klapars A, Hartman R, Limanto J, Regalado EL. Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1080: 42-49. PMID 29477066 DOI: 10.1016/J.Jchromb.2018.02.006  0.271
2004 Klapars A, Parris S, Anderson KW, Buchwald SL. Synthesis of medium ring nitrogen heterocycles via a tandem copper-catalyzed C-N bond formation-ring-expansion process. Journal of the American Chemical Society. 126: 3529-33. PMID 15025480 DOI: 10.1021/Ja038565T  0.267
2020 Blum SP, Karakaya T, Schollmeyer D, Waldvogel SR, Klapars A. Metal-free Electrochemical Synthesis of Sulfonamides Directly from (Hetero)arenes, SO2 and Amines. Angewandte Chemie (International Ed. in English). PMID 33372349 DOI: 10.1002/anie.202016164  0.264
2021 Klapars A, Chung JYL, Limanto J, Calabria R, Campeau LC, Campos KR, Chen W, Dalby SM, Davis TA, DiRocco DA, Hyde AM, Kassim AM, Larsen MU, Liu G, Maligres PE, et al. Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods. Chemical Science. 12: 9031-9036. PMID 34276931 DOI: 10.1039/d1sc01978c  0.257
2003 Huang X, Anderson KW, Zim D, Jiang L, Klapars A, Buchwald SL. Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions. Journal of the American Chemical Society. 125: 6653-5. PMID 12769573 DOI: 10.1021/Ja035483W  0.256
2011 Campos KR, Klapars A, Kohmura Y, Pollard D, Ishibashi H, Kato S, Takezawa A, Waldman JH, Wallace DJ, Chen CY, Yasuda N. Enantioselective, biocatalytic reduction of 3-substituted cyclopentenones: application to the asymmetric synthesis of an hNK-1 receptor antagonist. Organic Letters. 13: 1004-7. PMID 21302901 DOI: 10.1021/ol1030348  0.23
2015 McLaughlin M, Dermenjian RK, Jin Y, Klapars A, Reddy MV, Williams MJ. Evaluation and Control of Mutagenic Impurities in a Development Compound: Purge Factor Estimates vs Measured Amounts Organic Process Research and Development. 19: 1531-1535. DOI: 10.1021/Acs.Oprd.5B00263  0.223
2020 Salehi Marzijarani N, Lam YH, Wang X, Klapars A, Qi J, Song Z, Sherry BD, Liu Z, Ji Y. New Mechanism for Cinchona Alkaloid-Catalysis Allows for an Efficient Thiophosphorylation Reaction. Journal of the American Chemical Society. PMID 33180475 DOI: 10.1021/jacs.0c09192  0.214
2021 McIntosh JA, Benkovics T, Silverman SM, Huffman MA, Kong J, Maligres PE, Itoh T, Yang H, Verma D, Pan W, Ho HI, Vroom J, Knight AM, Hurtak JA, Klapars A, et al. Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19. Acs Central Science. 7: 1980-1985. PMID 34963891 DOI: 10.1021/acscentsci.1c00608  0.179
2021 Rein J, Annand JR, Wismer MK, Fu J, Siu JC, Klapars A, Strotman NA, Kalyani D, Lehnherr D, Lin S. Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor. Acs Central Science. 7: 1347-1355. PMID 34471679 DOI: 10.1021/acscentsci.1c00328  0.158
2021 Johnson HC, Zhang S, Fryszkowska A, Ruccolo S, Robaire SA, Klapars A, Patel NR, Whittaker AM, Huffman MA, Strotman NA. Biocatalytic oxidation of alcohols using galactose oxidase and a manganese(III) activator for the synthesis of islatravir. Organic & Biomolecular Chemistry. PMID 33533375 DOI: 10.1039/d0ob02395g  0.151
2006 Campos K, Klapars A, Waldman J, Dormer P, Chen C. Enantioselective Pd-Catalyzed Arylation ofN-Boc-Pyrrolidine Synfacts. 2006: 0595-0595. DOI: 10.1055/s-2006-934526  0.121
2016 Yin J, Maguire CK, Yasuda N, Brunskill APJ, Klapars A. Impact of Lead Impurities in Zinc Dust on the Selective Reduction of a Dibromoimidazole Derivative Organic Process Research & Development. 21: 94-97. DOI: 10.1021/ACS.OPRD.6B00370  0.11
2010 Klapars A. Glucokinase Activator The Art of Process Chemistry. 223-239. DOI: 10.1002/9783527633562.ch8  0.08
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